| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| INFINITUM ASSET MANAGEMENT, LLC | 3,868,923 | 4,123,923 | +255,000 | 13.13 | 12.28 | -0.85 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,703,452 | 4,106,035 | +402,583 | 2.07 | 2.06 | -0.01 | buy |
| HHLR ADVISORS, LTD. | 4,484,672 | 3,929,117 | -555,555 | 2.02 | 2.55 | +0.52 | sell |
| FMR LLC | 3,407,549 | 3,703,572 | +296,023 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 1.34 | 1.25 | -0.09 | hold |
| BlackRock, Inc. | 2,046,138 | 2,372,838 | +326,700 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,971,054 | 1,971,054 | 0 | 5.68 | 4.96 | -0.71 | hold |
| Novo Holdings A/S | 1,942,142 | 1,942,142 | 0 | 2.31 | 3.03 | +0.73 | hold |
| VANGUARD GROUP INC | 2,029,531 | 1,869,266 | -160,265 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 1.92 | 1.47 | -0.45 | hold |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 0.91 | 13.56 | +12.66 | hold |
| STATE STREET CORP | 1,027,628 | 1,091,980 | +64,352 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 716,288 | 753,519 | +37,231 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 431,939 | 742,526 | +310,587 | 0.00 | 0.00 | +0.00 | buy |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.68 | 0.88 | +0.21 | hold |
| Fund 1 Investments, LLC | 619,851 | 565,851 | -54,000 | 1.40 | 1.65 | +0.24 | sell |
| CITADEL ADVISORS LLC | 0 | 458,502 | +458,502 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 497,601 | 450,920 | -46,681 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 286,104 | 281,952 | -4,152 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 243,486 | 250,588 | +7,102 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 231,167 | 245,599 | +14,432 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 242,828 | +242,828 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 233,324 | +233,324 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 216,660 | +216,660 | 0.00 | 0.01 | +0.01 | buy |
| Rosalind Advisors, Inc. | 0 | 215,871 | +215,871 | 0.00 | 1.58 | +1.58 | buy |
| Squarepoint Ops LLC | 128,307 | 186,492 | +58,185 | 0.01 | 0.01 | +0.00 | buy |
| Hidden Lake Asset Management LP | 314,036 | 152,448 | -161,588 | 2.31 | 1.67 | -0.64 | sell |
| Affinity Asset Advisors, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.22 | +0.22 | buy |
| Woodline Partners LP | 296,916 | 147,386 | -149,530 | 0.03 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 129,935 | 129,173 | -762 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 118,485 | +118,485 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 103,255 | +103,255 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.10 | 0.13 | +0.03 | hold |
| MARSHALL WACE, LLP | 180,223 | 98,984 | -81,239 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 392,022 | 97,590 | -294,432 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 81,746 | 82,278 | +532 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 91,718 | 77,479 | -14,239 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 63,283 | 73,111 | +9,828 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 13,991 | 69,394 | +55,403 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 36,136 | 60,129 | +23,993 | 0.01 | 0.01 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 59,454 | 56,659 | -2,795 | 0.21 | 0.21 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 45,977 | 56,521 | +10,544 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 47,663 | 53,618 | +5,955 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 53,424 | +53,424 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 36,942 | 51,437 | +14,495 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 7,454 | 45,558 | +38,104 | 0.00 | 0.03 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 43,030 | +43,030 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 40,300 | +40,300 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 35,500 | 40,000 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 39,235 | 38,255 | -980 | 0.45 | 0.62 | +0.17 | sell |
| TWO SIGMA ADVISERS, LP | 43,800 | 37,100 | -6,700 | 0.00 | 0.00 | -0.00 | sell |
| Anson Funds Management LP | 99,887 | 35,366 | -64,521 | 0.20 | 0.10 | -0.11 | sell |
| ALPS ADVISORS INC | 0 | 33,896 | +33,896 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 32,487 | +32,487 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,179 | 32,280 | +17,101 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 32,007 | +32,007 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 33,803 | 31,456 | -2,347 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 34,361 | 28,878 | -5,483 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 28,200 | 28,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 0 | 26,253 | +26,253 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 20,400 | 24,221 | +3,821 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 27,768 | 22,115 | -5,653 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,561 | 21,681 | +3,120 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,972 | 21,531 | +1,559 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 15,016 | 16,892 | +1,876 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 17,110 | 16,657 | -453 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 16,635 | +16,635 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,355 | 16,115 | +1,760 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,246 | 15,378 | +2,132 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 14,790 | 15,275 | +485 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 14,158 | 14,743 | +585 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 12,763 | +12,763 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 12,304 | +12,304 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,823 | 11,475 | -348 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 11,300 | +11,300 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 11,007 | +11,007 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 10,962 | 11,007 | +45 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 10,984 | +10,984 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 4,816 | 10,894 | +6,078 | 0.03 | 0.06 | +0.03 | buy |
| CITIGROUP INC | 10,037 | 8,093 | -1,944 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 0 | 7,963 | +7,963 | 0.00 | 0.08 | +0.08 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,255 | 7,881 | +1,626 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,783 | 7,783 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 7,111 | 6,727 | -384 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 42,268 | 5,473 | -36,795 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,258 | 4,743 | +1,485 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 3,100 | 4,300 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,854 | +2,854 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 41,449 | 2,800 | -38,649 | 0.05 | 0.00 | -0.05 | sell |
| Tower Research Capital LLC (TRC) | 1,283 | 2,370 | +1,087 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,352 | 2,352 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 2,068 | 2,068 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 1,568 | 2,006 | +438 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,287 | 1,111 | -176 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 963 | 927 | -36 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 873 | 811 | -62 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 807 | +807 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 14 | 468 | +454 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 190 | 413 | +223 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 368 | 368 | 0 | 0.00 | 0.00 | +0.00 | hold |