| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ROYCE & ASSOCIATES LP | 0 | 636,522 | +636,522 | 0.00 | 0.06 | +0.06 | buy |
| Laurion Capital Management LP | 1,464,938 | 1,922,656 | +457,718 | 1.25 | 1.61 | +0.36 | buy |
| Aisling Capital Management LP | 564,625 | 1,018,018 | +453,393 | 1.48 | 1.91 | +0.44 | buy |
| ARMISTICE CAPITAL, LLC | 1,000,000 | 1,328,000 | +328,000 | 0.31 | 0.39 | +0.09 | buy |
| Ensign Peak Advisors, Inc | 0 | 320,874 | +320,874 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 249,161 | +249,161 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 231,040 | +231,040 | 0.00 | 0.10 | +0.10 | buy |
| Novo Holdings A/S | 1,961,317 | 2,185,923 | +224,606 | 1.91 | 1.59 | -0.32 | buy |
| Hudson Bay Capital Management LP | 0 | 110,000 | +110,000 | 0.00 | 0.01 | +0.01 | buy |
| Tidal Investments LLC | 0 | 82,172 | +82,172 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 82,172 | +82,172 | 0.00 | 0.05 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 94,651 | 167,573 | +72,922 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 26,472 | 90,819 | +64,347 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 53,282 | +53,282 | 0.00 | 0.06 | +0.06 | buy |
| Ikarian Capital, LLC | 220,231 | 270,231 | +50,000 | 0.36 | 0.35 | -0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 48,122 | +48,122 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 58,034 | 102,258 | +44,224 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 43,853 | +43,853 | 0.00 | 0.08 | +0.08 | buy |
| Qube Research & Technologies Ltd | 35,952 | 71,925 | +35,973 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 11,515 | 43,190 | +31,675 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 28,633 | 59,743 | +31,110 | 0.01 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 29,148 | +29,148 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 74,300 | 101,900 | +27,600 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 241,415 | 265,954 | +24,539 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 0 | 17,347 | +17,347 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 561,987 | 579,234 | +17,247 | 0.00 | 0.00 | -0.00 | buy |
| Diametric Capital, LP | 0 | 16,280 | +16,280 | 0.00 | 0.04 | +0.04 | buy |
| Brevan Howard Capital Management LP | 0 | 14,248 | +14,248 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 67,034 | 80,884 | +13,850 | 0.02 | 0.02 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 11,793 | +11,793 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 279,046 | 290,806 | +11,760 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 218,278 | 226,278 | +8,000 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 0 | 6,982 | +6,982 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,084,837 | 2,088,297 | +3,460 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 12,922 | 13,351 | +429 | 0.00 | 0.00 | -0.00 | buy |
| Accent Capital Management, LLC | 0 | 335 | +335 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 212 | +212 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,885,446 | 4,885,446 | 0 | 0.78 | 0.52 | -0.27 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 100,000 | 0 | 0.03 | 0.03 | +0.01 | hold |
| Sio Capital Management, LLC | 130,628 | 130,628 | 0 | 0.27 | 0.17 | -0.10 | hold |
| Casdin Capital, LLC | 282,312 | 282,312 | 0 | 0.22 | 0.19 | -0.03 | hold |
| Cormorant Asset Management, LP | 17,878,594 | 17,878,594 | 0 | 12.69 | 8.07 | -4.62 | hold |
| EcoR1 Capital, LLC | 2,823,126 | 2,823,126 | 0 | 1.61 | 1.08 | -0.53 | hold |
| Omega Fund Management, LLC | 3,289,661 | 3,289,661 | 0 | 14.37 | 18.05 | +3.67 | hold |
| Alphabet Inc. | 2,823,126 | 2,823,126 | 0 | 1.37 | 0.63 | -0.74 | hold |
| Rockefeller Capital Management L.P. | 700 | 700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 103,707 | 103,707 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Enavate Sciences GP, LLC | 2,626,946 | 2,626,946 | 0 | 6.49 | 6.69 | +0.20 | hold |
| FMR LLC | 240,300 | 240,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITADEL ADVISORS LLC | 2,530,324 | 2,528,762 | -1,562 | 0.02 | 0.02 | -0.01 | sell |
| Persistent Asset Partners Ltd | 8,585 | 0 | -8,585 | 0.05 | 0.00 | -0.05 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 54,192 | 35,692 | -18,500 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 23,584 | 0 | -23,584 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 25,000 | 0 | -25,000 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 93,369 | 50,450 | -42,919 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 117,150 | 57,572 | -59,578 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 86,517 | 0 | -86,517 | 0.19 | 0.00 | -0.19 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,907,003 | 2,818,348 | -88,655 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 229,263 | 78,187 | -151,076 | 0.74 | 0.19 | -0.55 | sell |
| ADAR1 Capital Management, LLC | 226,248 | 0 | -226,248 | 0.21 | 0.00 | -0.21 | sell |
| Octagon Capital Advisors LP | 1,043,110 | 719,000 | -324,110 | 1.63 | 0.71 | -0.92 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 803,134 | 437,889 | -365,245 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,082,362 | 541,181 | -541,181 | 0.21 | 0.08 | -0.13 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,400,000 | 400,000 | -1,000,000 | 0.03 | 0.01 | -0.02 | sell |
| Paradigm Biocapital Advisors LP | 2,261,749 | 868,213 | -1,393,536 | 0.76 | 0.16 | -0.60 | sell |