| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 226,278 | 1,036,569 | +810,291 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 53,282 | 700,000 | +646,718 | 0.06 | 0.48 | +0.42 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 460,985 | +460,985 | 0.00 | 0.50 | +0.50 | buy |
| ARMISTICE CAPITAL, LLC | 1,328,000 | 1,764,000 | +436,000 | 0.39 | 0.37 | -0.02 | buy |
| Granahan Investment Management, LLC | 231,040 | 558,526 | +327,486 | 0.10 | 0.15 | +0.05 | buy |
| Catalio Capital Management, LP | 0 | 318,407 | +318,407 | 0.00 | 0.46 | +0.46 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 286,518 | +286,518 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 90,819 | 191,152 | +100,333 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,528,762 | 2,617,827 | +89,065 | 0.02 | 0.01 | -0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 85,624 | +85,624 | 0.00 | 0.14 | +0.14 | buy |
| NORTHERN TRUST CORP | 102,258 | 186,482 | +84,224 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 1,922,656 | 2,002,701 | +80,045 | 1.61 | 1.11 | -0.51 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 77,140 | +77,140 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 14,248 | 88,895 | +74,647 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 2,088,297 | 2,154,040 | +65,743 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 50,450 | 114,655 | +64,205 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 2,185,923 | 2,250,000 | +64,077 | 1.59 | 1.00 | -0.59 | buy |
| Jump Financial, LLC | 0 | 62,000 | +62,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 579,234 | 622,351 | +43,117 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 42,220 | +42,220 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 26,485 | +26,485 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 22,606 | +22,606 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 19,872 | +19,872 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 11,504 | +11,504 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 82,172 | 93,339 | +11,167 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 82,172 | 93,339 | +11,167 | 0.05 | 0.02 | -0.03 | buy |
| PROFUND ADVISORS LLC | 0 | 11,001 | +11,001 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 2,626 | +2,626 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 212 | 2,099 | +1,887 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,696 | +1,696 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 1,350 | +1,350 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 378 | +378 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 700 | 1,000 | +300 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 240,300 | 240,587 | +287 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 197 | +197 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 4 | 37 | +33 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,885,446 | 4,885,446 | 0 | 0.52 | 0.39 | -0.13 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 400,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 100,000 | 0 | 0.03 | 0.02 | -0.02 | hold |
| Sio Capital Management, LLC | 130,628 | 130,628 | 0 | 0.17 | 0.17 | +0.00 | hold |
| Casdin Capital, LLC | 282,312 | 282,312 | 0 | 0.19 | 0.11 | -0.08 | hold |
| Cormorant Asset Management, LP | 17,878,594 | 17,878,594 | 0 | 8.07 | 6.98 | -1.09 | hold |
| EcoR1 Capital, LLC | 2,823,126 | 2,823,126 | 0 | 1.08 | 1.07 | -0.01 | hold |
| Omega Fund Management, LLC | 3,289,661 | 3,289,661 | 0 | 18.05 | 13.50 | -4.55 | hold |
| Alphabet Inc. | 2,823,126 | 2,823,126 | 0 | 0.63 | 0.02 | -0.61 | hold |
| Aisling Capital Management LP | 1,018,018 | 1,018,018 | 0 | 1.91 | 1.64 | -0.27 | hold |
| Avidity Partners Management LP | 43,853 | 43,853 | 0 | 0.08 | 0.05 | -0.03 | hold |
| Enavate Sciences GP, LLC | 2,626,946 | 2,626,946 | 0 | 6.69 | 5.80 | -0.89 | hold |
| Accent Capital Management, LLC | 335 | 0 | -335 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 290,806 | 286,518 | -4,288 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 249,161 | 244,441 | -4,720 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 17,347 | 10,728 | -6,619 | 0.02 | 0.01 | -0.01 | sell |
| Bellevue Group AG | 6,982 | 0 | -6,982 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,692 | 27,984 | -7,708 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 11,793 | 0 | -11,793 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 13,351 | 0 | -13,351 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 57,572 | 42,730 | -14,842 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 16,280 | 0 | -16,280 | 0.04 | 0.00 | -0.04 | sell |
| Squarepoint Ops LLC | 43,190 | 19,662 | -23,528 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,818,348 | 2,789,302 | -29,046 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 29,148 | 0 | -29,148 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 101,900 | 58,600 | -43,300 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 320,874 | 273,530 | -47,344 | 0.01 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 48,122 | 0 | -48,122 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 59,743 | 0 | -59,743 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 167,573 | 102,085 | -65,488 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 71,925 | 0 | -71,925 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 78,187 | 0 | -78,187 | 0.19 | 0.00 | -0.19 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 80,884 | 0 | -80,884 | 0.02 | 0.00 | -0.02 | sell |
| Woodline Partners LP | 103,707 | 0 | -103,707 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 110,000 | 0 | -110,000 | 0.01 | 0.00 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 437,889 | 300,000 | -137,889 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 265,954 | 105,480 | -160,474 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 636,522 | 384,941 | -251,581 | 0.06 | 0.02 | -0.03 | sell |
| Ikarian Capital, LLC | 270,231 | 0 | -270,231 | 0.35 | 0.00 | -0.35 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 541,181 | 0 | -541,181 | 0.08 | 0.00 | -0.08 | sell |
| Octagon Capital Advisors LP | 719,000 | 0 | -719,000 | 0.71 | 0.00 | -0.71 | sell |
| Paradigm Biocapital Advisors LP | 868,213 | 0 | -868,213 | 0.16 | 0.00 | -0.16 | sell |