| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 0 | 17,878,594 | +17,878,594 | 0.00 | 14.29 | +14.29 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 4,885,446 | +4,885,446 | 0.00 | 0.87 | +0.87 | buy |
| Omega Fund Management, LLC | 0 | 3,289,661 | +3,289,661 | 0.00 | 17.13 | +17.13 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 2,961,263 | +2,961,263 | 0.00 | 0.01 | +0.01 | buy |
| EcoR1 Capital, LLC | 0 | 2,823,126 | +2,823,126 | 0.00 | 1.57 | +1.57 | buy |
| Alphabet Inc. | 0 | 2,823,126 | +2,823,126 | 0.00 | 1.36 | +1.36 | buy |
| Enavate Sciences GP, LLC | 0 | 2,626,946 | +2,626,946 | 0.00 | 9.29 | +9.29 | buy |
| CITADEL ADVISORS LLC | 0 | 2,538,141 | +2,538,141 | 0.00 | 0.02 | +0.02 | buy |
| BlackRock, Inc. | 0 | 2,048,552 | +2,048,552 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 0 | 1,961,317 | +1,961,317 | 0.00 | 1.46 | +1.46 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,866,141 | +1,866,141 | 0.00 | 0.64 | +0.64 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,487,621 | +1,487,621 | 0.00 | 0.03 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,082,362 | +1,082,362 | 0.00 | 0.20 | +0.20 | buy |
| Laurion Capital Management LP | 0 | 1,045,800 | +1,045,800 | 0.00 | 1.65 | +1.65 | buy |
| Octagon Capital Advisors LP | 0 | 1,043,110 | +1,043,110 | 0.00 | 1.89 | +1.89 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 885,042 | +885,042 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 647,599 | +647,599 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 0 | 564,625 | +564,625 | 0.00 | 1.43 | +1.43 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 541,602 | +541,602 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 501,228 | +501,228 | 0.00 | 0.57 | +0.57 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 457,414 | +457,414 | 0.00 | 0.77 | +0.77 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 412,000 | +412,000 | 0.00 | 0.15 | +0.15 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 369,563 | +369,563 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 0 | 282,312 | +282,312 | 0.00 | 0.27 | +0.27 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 279,350 | +279,350 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 245,231 | +245,231 | 0.00 | 0.57 | +0.57 | buy |
| STEMPOINT CAPITAL LP | 0 | 186,614 | +186,614 | 0.00 | 0.44 | +0.44 | buy |
| STATE STREET CORP | 0 | 176,695 | +176,695 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 162,077 | +162,077 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 130,628 | +130,628 | 0.00 | 0.38 | +0.38 | buy |
| TD ASSET MANAGEMENT INC | 0 | 130,062 | +130,062 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 103,707 | +103,707 | 0.00 | 0.01 | +0.01 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 96,551 | +96,551 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 0 | 95,957 | +95,957 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 52,226 | +52,226 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 23,384 | +23,384 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |