| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARMISTICE CAPITAL, LLC | 412,000 | 1,000,000 | +588,000 | 0.15 | 0.31 | +0.16 | buy |
| Laurion Capital Management LP | 1,045,800 | 1,464,938 | +419,138 | 1.65 | 1.25 | -0.40 | buy |
| Paradigm Biocapital Advisors LP | 1,866,141 | 2,261,749 | +395,608 | 0.64 | 0.76 | +0.12 | buy |
| HighVista Strategies LLC | 0 | 229,263 | +229,263 | 0.00 | 0.74 | +0.74 | buy |
| VANGUARD GROUP INC | 647,599 | 791,095 | +143,496 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 94,651 | +94,651 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 162,077 | 240,300 | +78,223 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 74,300 | +74,300 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 54,192 | +54,192 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 176,695 | 218,278 | +41,583 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 52,226 | 93,369 | +41,143 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,048,552 | 2,084,837 | +36,285 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 35,952 | +35,952 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 26,472 | +26,472 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 23,584 | +23,584 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 541,602 | 561,987 | +20,385 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 12,922 | +12,922 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 11,515 | +11,515 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 8,585 | +8,585 | 0.00 | 0.05 | +0.05 | buy |
| XTX Topco Ltd | 23,384 | 28,633 | +5,249 | 0.01 | 0.01 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,885,446 | 4,885,446 | 0 | 0.87 | 0.78 | -0.08 | hold |
| Novo Holdings A/S | 1,961,317 | 1,961,317 | 0 | 1.46 | 1.91 | +0.44 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,082,362 | 1,082,362 | 0 | 0.20 | 0.21 | +0.01 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 100,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| Sio Capital Management, LLC | 130,628 | 130,628 | 0 | 0.38 | 0.27 | -0.11 | hold |
| Casdin Capital, LLC | 282,312 | 282,312 | 0 | 0.27 | 0.22 | -0.05 | hold |
| Cormorant Asset Management, LP | 17,878,594 | 17,878,594 | 0 | 14.29 | 12.69 | -1.60 | hold |
| EcoR1 Capital, LLC | 2,823,126 | 2,823,126 | 0 | 1.57 | 1.61 | +0.04 | hold |
| Omega Fund Management, LLC | 3,289,661 | 3,289,661 | 0 | 17.13 | 14.37 | -2.76 | hold |
| Alphabet Inc. | 2,823,126 | 2,823,126 | 0 | 1.36 | 1.37 | +0.01 | hold |
| Aisling Capital Management LP | 564,625 | 564,625 | 0 | 1.43 | 1.48 | +0.04 | hold |
| Woodline Partners LP | 103,707 | 103,707 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Octagon Capital Advisors LP | 1,043,110 | 1,043,110 | 0 | 1.89 | 1.63 | -0.25 | hold |
| Enavate Sciences GP, LLC | 2,626,946 | 2,626,946 | 0 | 9.29 | 6.49 | -2.80 | hold |
| FNY Investment Advisers, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 279,350 | 279,046 | -304 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,000 | 0 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 2,538,141 | 2,530,324 | -7,817 | 0.02 | 0.02 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 130,062 | 117,150 | -12,912 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 245,231 | 220,231 | -25,000 | 0.57 | 0.36 | -0.22 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 96,551 | 67,034 | -29,517 | 0.03 | 0.02 | -0.01 | sell |
| NORTHERN TRUST CORP | 95,957 | 58,034 | -37,923 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,961,263 | 2,907,003 | -54,260 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 885,042 | 803,134 | -81,908 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,487,621 | 1,400,000 | -87,621 | 0.03 | 0.03 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 186,614 | 86,517 | -100,097 | 0.44 | 0.19 | -0.25 | sell |
| MILLENNIUM MANAGEMENT LLC | 369,563 | 241,415 | -128,148 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 501,228 | 226,248 | -274,980 | 0.57 | 0.21 | -0.36 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 457,414 | 0 | -457,414 | 0.77 | 0.00 | -0.77 | sell |