| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 3,584,004 | +3,584,004 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 6,373,129 | 7,482,365 | +1,109,236 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.40 | +0.40 | buy |
| SOROS CAPITAL MANAGEMENT LLC | 0 | 904,016 | +904,016 | 0.00 | 3.41 | +3.41 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 752,924 | +752,924 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 688,169 | +688,169 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 0 | 646,118 | +646,118 | 0.00 | 0.23 | +0.23 | buy |
| BAKER BROS. ADVISORS LP | 0 | 633,851 | +633,851 | 0.00 | 0.11 | +0.11 | buy |
| Artal Group S.A. | 2,552,702 | 2,924,052 | +371,350 | 1.48 | 1.04 | -0.45 | buy |
| Addis & Hill, Inc | 0 | 314,821 | +314,821 | 0.00 | 3.57 | +3.57 | buy |
| Pier Capital, LLC | 0 | 249,336 | +249,336 | 0.00 | 0.47 | +0.47 | buy |
| LMR Partners LLP | 0 | 187,811 | +187,811 | 0.00 | 0.07 | +0.07 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 136,828 | +136,828 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 136,526 | +136,526 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 13,600 | 138,900 | +125,300 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 141,478 | 259,184 | +117,706 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 110,194 | +110,194 | 0.00 | 0.00 | +0.00 | buy |
| Auour Investments LLC | 0 | 105,087 | +105,087 | 0.00 | 0.53 | +0.53 | buy |
| Hudson Bay Capital Management LP | 0 | 98,300 | +98,300 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 0 | 91,656 | +91,656 | 0.00 | 0.11 | +0.11 | buy |
| IEQ CAPITAL, LLC | 0 | 82,853 | +82,853 | 0.00 | 0.02 | +0.02 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 65,973 | +65,973 | 0.00 | 0.08 | +0.08 | buy |
| Nan Fung Group Holdings Ltd | 0 | 63,315 | +63,315 | 0.00 | 0.81 | +0.81 | buy |
| CITIGROUP INC | 5,746 | 68,458 | +62,712 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 62,301 | +62,301 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 50,000 | 110,000 | +60,000 | 0.00 | 0.00 | +0.00 | buy |
| Wildcat Capital Management, LLC | 0 | 54,894 | +54,894 | 0.00 | 0.27 | +0.27 | buy |
| ROYAL BANK OF CANADA | 0 | 50,734 | +50,734 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 29,173 | +29,173 | 0.00 | 0.08 | +0.08 | buy |
| Windmill Hill Asset Management Ltd | 0 | 26,121 | +26,121 | 0.00 | 0.13 | +0.13 | buy |
| UBS Group AG | 0 | 25,281 | +25,281 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 22,089 | +22,089 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 22,026 | +22,026 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 18,242 | +18,242 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 436,877 | 452,381 | +15,504 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 14,187 | +14,187 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 12,576 | +12,576 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 12,352 | +12,352 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 11,391 | +11,391 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 10,000 | +10,000 | 0.00 | 0.17 | +0.17 | buy |
| WELLS FARGO & COMPANY/MN | 27,355 | 34,943 | +7,588 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,849 | +2,849 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 15,720 | 17,552 | +1,832 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 105,990 | 107,709 | +1,719 | 0.01 | 0.01 | -0.00 | buy |
| Avior Wealth Management, LLC | 0 | 174 | +174 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,900 | 6,994 | +94 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,558 | 2,636 | +78 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 8 | +8 | 0.00 | 0.00 | 0.00 | buy |
| CWM, LLC | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 3,309,123 | 3,309,123 | 0 | 0.70 | 0.55 | -0.15 | hold |
| ORBIMED ADVISORS LLC | 1,500,000 | 1,500,000 | 0 | 0.51 | 0.38 | -0.13 | hold |
| Ameritas Investment Partners, Inc. | 1,540 | 1,540 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SOFTBANK GROUP CORP. | 7,646,916 | 7,646,916 | 0 | 0.70 | 0.55 | -0.15 | hold |
| Legacy Private Trust Co. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 150,000 | 150,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 8,487 | 8,487 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ICONIQ Capital, LLC | 3,398,628 | 3,398,628 | 0 | 1.08 | 0.81 | -0.27 | hold |
| EcoR1 Capital, LLC | 2,071,450 | 2,071,450 | 0 | 0.92 | 0.72 | -0.19 | hold |
| Logos Global Management LP | 382,345 | 382,345 | 0 | 0.72 | 0.65 | -0.07 | hold |
| MIC Capital Management UK LLP | 4,460,700 | 4,460,700 | 0 | 14.76 | 11.65 | -3.11 | hold |
| JOHNSON & JOHNSON | 1,849,445 | 1,849,445 | 0 | 0.72 | 0.58 | -0.14 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 921 | 921 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,422 | 1,422 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 8,007 | 8,007 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quarry LP | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 7,394 | 7,331 | -63 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 6,328 | 5,918 | -410 | 0.07 | 0.04 | -0.03 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,449 | 1,496 | -953 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 3,200 | 2,200 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,709 | 508 | -1,201 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 45,200 | 41,034 | -4,166 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 126,444 | 121,391 | -5,053 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129,912 | 124,542 | -5,370 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 6,308 | 0 | -6,308 | 0.00 | 0.00 | -0.00 | sell |
| Ghisallo Capital Management LLC | 10,000 | 0 | -10,000 | 0.02 | 0.00 | -0.02 | sell |
| BARCLAYS PLC | 20,539 | 10,422 | -10,117 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 263,000 | 248,595 | -14,405 | 0.04 | 0.03 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 46,883 | 29,821 | -17,062 | 0.07 | 0.03 | -0.03 | sell |
| CITADEL ADVISORS LLC | 1,843,291 | 1,823,983 | -19,308 | 0.03 | 0.02 | -0.01 | sell |
| JPMORGAN CHASE & CO | 61,117 | 34,711 | -26,406 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 380,954 | 334,330 | -46,624 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 89,339 | 40,697 | -48,642 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 92,293 | 0 | -92,293 | 0.08 | 0.00 | -0.08 | sell |
| SCOGGIN MANAGEMENT LP | 125,000 | 0 | -125,000 | 2.30 | 0.00 | -2.30 | sell |
| GMT CAPITAL CORP | 140,666 | 0 | -140,666 | 0.09 | 0.00 | -0.09 | sell |
| Avidity Partners Management LP | 1,990,632 | 1,800,000 | -190,632 | 1.30 | 0.88 | -0.42 | sell |
| Alphabet Inc. | 404,732 | 0 | -404,732 | 0.32 | 0.00 | -0.32 | sell |
| GOLDMAN SACHS GROUP INC | 592,422 | 162,579 | -429,843 | 0.00 | 0.00 | -0.00 | sell |
| HHLR ADVISORS, LTD. | 1,699,313 | 0 | -1,699,313 | 0.58 | 0.00 | -0.58 | sell |