| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 0 | 5,104,097 | +5,104,097 | 0.00 | 0.20 | +0.20 | buy |
| Siren, L.L.C. | 6,288,783 | 8,497,822 | +2,209,039 | 0.34 | 0.46 | +0.12 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 818,156 | +818,156 | 0.00 | 0.19 | +0.19 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 771,418 | +771,418 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,307,688 | 2,036,692 | +729,004 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 583,758 | 1,195,310 | +611,552 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 511,084 | +511,084 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 738,272 | 1,240,241 | +501,969 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 412,201 | +412,201 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 0 | 274,103 | +274,103 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 107,250 | 354,850 | +247,600 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 198,851 | +198,851 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 197,363 | +197,363 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 239,309 | 381,494 | +142,185 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 129,156 | +129,156 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 113,913 | 221,848 | +107,935 | 0.01 | 0.01 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.17 | +0.17 | buy |
| Brevan Howard Capital Management LP | 0 | 97,075 | +97,075 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 72,106 | 160,319 | +88,213 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,003,746 | 1,086,865 | +83,119 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 80,000 | +80,000 | 0.00 | 0.10 | +0.10 | buy |
| Quadrature Capital Ltd | 11,385 | 85,324 | +73,939 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 70,000 | +70,000 | 0.00 | 0.03 | +0.03 | buy |
| Voleon Capital Management LP | 31,291 | 93,863 | +62,572 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 57,642 | +57,642 | 0.00 | 0.00 | +0.00 | buy |
| SkyOak Wealth, LLC | 100,000 | 150,000 | +50,000 | 0.03 | 0.05 | +0.02 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 91,700 | 140,200 | +48,500 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 46,042 | +46,042 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 32,762 | +32,762 | 0.00 | 0.02 | +0.02 | buy |
| BlackRock, Inc. | 2,024,944 | 2,054,316 | +29,372 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 23,755 | +23,755 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 12,385 | 33,541 | +21,156 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Management, LLC | 86,400 | 102,400 | +16,000 | 0.01 | 0.01 | +0.00 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 16,000 | +16,000 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 185,361 | 196,881 | +11,520 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 180,856 | 191,677 | +10,821 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 10,100 | +10,100 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 388,919 | 398,719 | +9,800 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 35 | 5,380 | +5,345 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 43,832 | 48,793 | +4,961 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 512,470 | 516,182 | +3,712 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 29,600 | 33,300 | +3,700 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 30,924 | 34,507 | +3,583 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 27,227 | 29,651 | +2,424 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 38,837 | 39,810 | +973 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 8,119 | 8,715 | +596 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,282 | 3,737 | +455 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,498,269 | 3,498,658 | +389 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 264 | +264 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 5 | 21 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 39,181 | 39,182 | +1 | 0.00 | 0.00 | +0.00 | buy |
| WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 3,309,123 | 3,309,123 | 0 | 0.06 | 0.08 | +0.02 | hold |
| FEDERATED HERMES, INC. | 314,119 | 314,119 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 225,000 | 225,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RHUMBLINE ADVISERS | 2,581 | 2,581 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 76,706 | 76,706 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legacy Private Trust Co. | 19,000 | 19,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HBK Sorce Advisory LLC | 17,037 | 17,037 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMG National Trust Bank | 43,379 | 43,379 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 335,267 | 335,267 | 0 | 0.02 | 0.02 | -0.00 | hold |
| ICONIQ Capital, LLC | 2,559,090 | 2,559,090 | 0 | 0.07 | 0.11 | +0.04 | hold |
| Capital Advisors, Ltd. LLC | 145 | 145 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Parallel Advisors, LLC | 279 | 279 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AlphaCore Capital LLC | 638,784 | 638,784 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Centerpoint Advisors, LLC | 220 | 220 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ikarian Capital, LLC | 1,278,408 | 1,278,408 | 0 | 0.30 | 0.36 | +0.06 | hold |
| Woodline Partners LP | 14,957 | 14,957 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 1,320 | 1,320 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIC Capital Management UK LLP | 4,460,700 | 4,460,700 | 0 | 1.81 | 2.47 | +0.66 | hold |
| JOHNSON & JOHNSON | 1,849,445 | 1,849,445 | 0 | 0.60 | 0.55 | -0.04 | hold |
| Addis & Hill, Inc | 163,386 | 163,386 | 0 | 0.18 | 0.19 | +0.02 | hold |
| Lunate Capital Ltd | 2,124,143 | 2,124,143 | 0 | 1.44 | 3.44 | +2.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,466 | 1,466 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 19 | 18 | -1 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 319 | 298 | -21 | 0.00 | 0.00 | -0.00 | sell |
| OPTIMA CAPITAL LLC | 270 | 0 | -270 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 533 | 0 | -533 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 592 | 0 | -592 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 1,022 | 167 | -855 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 5,177 | 3,146 | -2,031 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 64,903 | 62,032 | -2,871 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 14,960 | 11,387 | -3,573 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 4,000 | 0 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| SIG BROKERAGE, LP | 33,146 | 27,483 | -5,663 | 0.02 | 0.02 | -0.00 | sell |
| Creative Planning | 10,881 | 0 | -10,881 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 44,270 | 33,044 | -11,226 | 0.00 | 0.00 | +0.00 | sell |
| IEQ CAPITAL, LLC | 13,173 | 0 | -13,173 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 17,719 | 4,068 | -13,651 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 275,112 | 260,391 | -14,721 | 0.00 | 0.00 | +0.00 | sell |
| RBF Capital, LLC | 105,174 | 90,000 | -15,174 | 0.01 | 0.01 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 50,600 | 33,100 | -17,500 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 227,594 | 205,929 | -21,665 | 0.00 | 0.00 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 22,177 | 0 | -22,177 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 185,832 | 156,214 | -29,618 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 145,385 | 110,875 | -34,510 | 0.10 | 0.06 | -0.04 | sell |
| AQR CAPITAL MANAGEMENT LLC | 94,170 | 55,995 | -38,175 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 66,076 | 17,178 | -48,898 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,445,902 | 1,388,998 | -56,904 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 97,408 | 25,489 | -71,919 | 0.01 | 0.00 | -0.00 | sell |