| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 334,330 | 3,274,124 | +2,939,794 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,584,004 | 5,101,096 | +1,517,092 | 0.03 | 0.03 | +0.00 | buy |
| FMR LLC | 7,482,365 | 8,622,468 | +1,140,103 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 452,381 | 1,285,462 | +833,081 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 259,184 | 1,083,298 | +824,114 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 633,851 | 1,034,600 | +400,749 | 0.11 | 0.13 | +0.02 | buy |
| Saturn V Capital Management LP | 0 | 390,084 | +390,084 | 0.00 | 1.45 | +1.45 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 295,973 | +295,973 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 25,281 | 295,657 | +270,376 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 267,225 | +267,225 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 41,034 | 235,593 | +194,559 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 172,520 | +172,520 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 124,542 | 291,364 | +166,822 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 164,160 | +164,160 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 0 | 156,738 | +156,738 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 162,579 | 318,457 | +155,878 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 134,545 | +134,545 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 646,118 | 760,007 | +113,889 | 0.23 | 0.23 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 87,943 | +87,943 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 17,552 | 103,258 | +85,706 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 29,173 | 114,594 | +85,421 | 0.08 | 0.29 | +0.20 | buy |
| Alpine Global Management, LLC | 0 | 65,728 | +65,728 | 0.00 | 0.11 | +0.11 | buy |
| SG Americas Securities, LLC | 0 | 57,607 | +57,607 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 62,301 | 111,828 | +49,527 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,391 | 53,250 | +41,859 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 8,487 | 49,310 | +40,823 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 22,089 | 60,110 | +38,021 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 110,194 | 144,994 | +34,800 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 32,500 | +32,500 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 136,828 | 168,686 | +31,858 | 0.04 | 0.04 | -0.00 | buy |
| PDT Partners, LLC | 0 | 31,322 | +31,322 | 0.00 | 0.03 | +0.03 | buy |
| Corton Capital Inc. | 0 | 31,184 | +31,184 | 0.00 | 0.16 | +0.16 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 30,800 | +30,800 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 8,007 | 36,797 | +28,790 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 28,292 | +28,292 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 34,711 | 62,792 | +28,081 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,994 | 34,125 | +27,131 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,943 | 58,480 | +23,537 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 19,700 | +19,700 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 121,391 | 139,637 | +18,246 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 10,422 | 28,532 | +18,110 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 16,878 | +16,878 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 107,709 | 124,418 | +16,709 | 0.01 | 0.01 | -0.00 | buy |
| SkyOak Wealth, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 0 | 13,445 | +13,445 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 1,422 | 9,304 | +7,882 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,540 | 8,241 | +6,701 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,496 | 6,095 | +4,599 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 22,026 | 25,756 | +3,730 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,918 | 9,098 | +3,180 | 0.04 | 0.04 | +0.00 | buy |
| AMALGAMATED BANK | 508 | 2,910 | +2,402 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,849 | 5,221 | +2,372 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,636 | 3,686 | +1,050 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 3 | 94 | +91 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 91 | +91 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 12 | 59 | +47 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 9 | 16 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 8 | 14 | +6 | 0.00 | 0.00 | 0.00 | buy |
| WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 3,309,123 | 3,309,123 | 0 | 0.55 | 0.42 | -0.13 | hold |
| ORBIMED ADVISORS LLC | 1,500,000 | 1,500,000 | 0 | 0.38 | 0.29 | -0.09 | hold |
| SOFTBANK GROUP CORP. | 7,646,916 | 7,646,916 | 0 | 0.55 | 0.38 | -0.17 | hold |
| Legacy Private Trust Co. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORGES BANK | 110,000 | 110,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ICONIQ Capital, LLC | 3,398,628 | 3,398,628 | 0 | 0.81 | 0.72 | -0.10 | hold |
| EcoR1 Capital, LLC | 2,071,450 | 2,071,450 | 0 | 0.72 | 0.62 | -0.10 | hold |
| Avior Wealth Management, LLC | 174 | 174 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IEQ CAPITAL, LLC | 82,853 | 82,853 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Avidity Partners Management LP | 1,800,000 | 1,800,000 | 0 | 0.88 | 0.75 | -0.13 | hold |
| Windmill Hill Asset Management Ltd | 26,121 | 26,121 | 0 | 0.13 | 0.11 | -0.02 | hold |
| MIC Capital Management UK LLP | 4,460,700 | 4,460,700 | 0 | 11.65 | 9.53 | -2.12 | hold |
| JOHNSON & JOHNSON | 1,849,445 | 1,849,445 | 0 | 0.58 | 4.54 | +3.96 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 921 | 0 | -921 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 2,200 | 600 | -1,600 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 7,331 | 0 | -7,331 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 10,000 | 0 | -10,000 | 0.17 | 0.00 | -0.17 | sell |
| XTX Topco Ltd | 12,352 | 0 | -12,352 | 0.02 | 0.00 | -0.02 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 12,576 | 0 | -12,576 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 14,187 | 0 | -14,187 | 0.00 | 0.00 | -0.00 | sell |
| Addis & Hill, Inc | 314,821 | 300,000 | -14,821 | 3.57 | 2.45 | -1.12 | sell |
| Qube Research & Technologies Ltd | 18,242 | 0 | -18,242 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 248,595 | 226,585 | -22,010 | 0.03 | 0.02 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 29,821 | 0 | -29,821 | 0.03 | 0.00 | -0.03 | sell |
| JANE STREET GROUP, LLC | 40,697 | 0 | -40,697 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 68,458 | 20,708 | -47,750 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 50,734 | 0 | -50,734 | 0.00 | 0.00 | -0.00 | sell |
| Wildcat Capital Management, LLC | 54,894 | 0 | -54,894 | 0.27 | 0.00 | -0.27 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 65,973 | 10,854 | -55,119 | 0.08 | 0.01 | -0.07 | sell |
| Nan Fung Group Holdings Ltd | 63,315 | 0 | -63,315 | 0.81 | 0.00 | -0.81 | sell |
| Logos Global Management LP | 382,345 | 300,000 | -82,345 | 0.65 | 0.34 | -0.31 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 752,924 | 669,486 | -83,438 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 91,656 | 0 | -91,656 | 0.11 | 0.00 | -0.11 | sell |
| Hudson Bay Capital Management LP | 98,300 | 0 | -98,300 | 0.01 | 0.00 | -0.01 | sell |
| Artal Group S.A. | 2,924,052 | 2,824,052 | -100,000 | 1.04 | 0.71 | -0.32 | sell |
| Auour Investments LLC | 105,087 | 0 | -105,087 | 0.53 | 0.00 | -0.53 | sell |
| MILLENNIUM MANAGEMENT LLC | 136,526 | 0 | -136,526 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 138,900 | 0 | -138,900 | 0.00 | 0.00 | -0.00 | sell |