| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 1,114,784 | +1,114,784 | 0.00 | 3.63 | +3.63 | buy |
| UBS Group AG | 128,752 | 768,359 | +639,607 | 0.00 | 0.02 | +0.02 | buy |
| Holocene Advisors, LP | 84,067 | 494,495 | +410,428 | 0.03 | 0.19 | +0.16 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 281,805 | +281,805 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 28,013 | 201,409 | +173,396 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 0 | 116,684 | +116,684 | 0.00 | 3.30 | +3.30 | buy |
| Duquesne Family Office LLC | 0 | 106,100 | +106,100 | 0.00 | 0.58 | +0.58 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 233,813 | 304,013 | +70,200 | 0.48 | 0.57 | +0.09 | buy |
| GOLDMAN SACHS GROUP INC | 44,599 | 105,509 | +60,910 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 52,000 | +52,000 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 20,000 | 65,000 | +45,000 | 0.23 | 0.61 | +0.38 | buy |
| PFM Health Sciences, LP | 19,823 | 59,432 | +39,609 | 0.32 | 1.00 | +0.68 | buy |
| Longaeva Partners L.P. | 0 | 33,492 | +33,492 | 0.00 | 0.26 | +0.26 | buy |
| TD ASSET MANAGEMENT INC | 0 | 33,410 | +33,410 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,448 | 32,525 | +30,077 | 0.00 | 0.00 | +0.00 | buy |
| Darwin Global Management, Ltd. | 3,027,704 | 3,057,412 | +29,708 | 9.86 | 12.10 | +2.24 | buy |
| Aquatic Capital Management LLC | 0 | 20,294 | +20,294 | 0.00 | 0.09 | +0.09 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 19,600 | +19,600 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 16,981 | +16,981 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 15,072 | +15,072 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 15,058 | +15,058 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 558,882 | 570,088 | +11,206 | 0.06 | 0.07 | +0.00 | buy |
| Blackstone Inc. | 0 | 10,692 | +10,692 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 8,033 | +8,033 | 0.00 | 0.35 | +0.35 | buy |
| Voleon Capital Management LP | 0 | 7,883 | +7,883 | 0.00 | 0.03 | +0.03 | buy |
| Artia Global Partners LP | 17,989 | 24,989 | +7,000 | 0.46 | 0.90 | +0.44 | buy |
| Amundi | 0 | 4,210 | +4,210 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 3,778 | +3,778 | 0.00 | 0.00 | +0.00 | buy |
| Convergence Financial, LLC | 0 | 2,968 | +2,968 | 0.00 | 0.05 | +0.05 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 3,049 | 6,004 | +2,955 | 0.07 | 1.39 | +1.32 | buy |
| HRT FINANCIAL LP | 8,164 | 10,922 | +2,758 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 4,176 | 6,822 | +2,646 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 2,489 | +2,489 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 2,372 | +2,372 | 0.00 | 0.05 | +0.05 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 1,900 | +1,900 | 0.00 | 0.07 | +0.07 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 1,596 | +1,596 | 0.00 | 0.00 | +0.00 | buy |
| Merit Financial Group, LLC | 0 | 1,415 | +1,415 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,300 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 15,538 | 15,981 | +443 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 15,740 | 16,048 | +308 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 87,760 | 88,045 | +285 | 1.61 | 1.08 | -0.52 | buy |
| GSA CAPITAL PARTNERS LLP | 1,463 | 1,645 | +182 | 0.02 | 0.02 | -0.00 | buy |
| ROYAL BANK OF CANADA | 2,092 | 2,257 | +165 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 0 | 83 | +83 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 1,882 | 1,929 | +47 | 0.08 | 0.08 | +0.00 | buy |
| Rossby Financial, LCC | 13 | 55 | +42 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 645 | 657 | +12 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 1,598 | 1,608 | +10 | 0.01 | 0.01 | -0.00 | buy |
| Bell Investment Advisors, Inc | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 715,332 | 715,332 | 0 | 1.15 | 1.13 | -0.01 | hold |
| Independent Advisor Alliance | 1,319 | 1,319 | 0 | 0.01 | 0.00 | -0.00 | hold |
| High Net Worth Advisory Group LLC | 3,500 | 3,500 | 0 | 0.13 | 0.13 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 70 | 70 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 10,445 | 10,427 | -18 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 50 | 22 | -28 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 1,779 | 1,707 | -72 | 0.01 | 0.01 | -0.00 | sell |
| Farther Finance Advisors, LLC | 101 | 15 | -86 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 549 | 349 | -200 | 0.02 | 0.01 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 500 | 0 | -500 | 0.01 | 0.00 | -0.01 | sell |
| SG Americas Securities, LLC | 2,755 | 2,144 | -611 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 673 | 0 | -673 | 0.05 | 0.00 | -0.05 | sell |
| Quadrature Capital Ltd | 24,832 | 23,708 | -1,124 | 0.04 | 0.04 | +0.00 | sell |
| Brooklyn Investment Group | 1,739 | 0 | -1,739 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 2,137 | 1 | -2,136 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 5,055 | 2,008 | -3,047 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 3,119 | 0 | -3,119 | 0.04 | 0.00 | -0.04 | sell |
| Y-Intercept (Hong Kong) Ltd | 3,152 | 0 | -3,152 | 0.01 | 0.00 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 6,198 | 0 | -6,198 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 9,163 | 0 | -9,163 | 0.25 | 0.00 | -0.25 | sell |
| AMERIPRISE FINANCIAL INC | 13,221 | 2,767 | -10,454 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 11,897 | 0 | -11,897 | 0.05 | 0.00 | -0.05 | sell |
| ADAR1 Capital Management, LLC | 39,839 | 26,880 | -12,959 | 0.48 | 0.26 | -0.22 | sell |
| Exome Asset Management LLC | 14,328 | 0 | -14,328 | 1.13 | 0.00 | -1.13 | sell |
| FRED ALGER MANAGEMENT, LLC | 79,394 | 62,574 | -16,820 | 0.05 | 0.04 | -0.01 | sell |
| Woodline Partners LP | 18,041 | 0 | -18,041 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 32,318 | 12,222 | -20,096 | 0.01 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 24,703 | 0 | -24,703 | 2.12 | 0.00 | -2.12 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 383,091 | 357,650 | -25,441 | 0.96 | 0.94 | -0.01 | sell |
| Soleus Capital Management, L.P. | 40,354 | 0 | -40,354 | 0.27 | 0.00 | -0.27 | sell |
| Western Standard LLC | 60,026 | 0 | -60,026 | 4.43 | 0.00 | -4.43 | sell |
| MARSHALL WACE, LLP | 192,700 | 0 | -192,700 | 0.03 | 0.00 | -0.03 | sell |
| PERCEPTIVE ADVISORS LLC | 414,239 | 151,979 | -262,260 | 1.21 | 0.48 | -0.74 | sell |
| Point72 Asset Management, L.P. | 284,437 | 0 | -284,437 | 0.07 | 0.00 | -0.07 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 432,484 | 0 | -432,484 | 0.71 | 0.00 | -0.71 | sell |