| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MAVERICK CAPITAL LTD | 0 | 396,311 | +396,311 | 0.00 | 0.55 | +0.55 | buy |
| Logos Global Management LP | 0 | 250,000 | +250,000 | 0.00 | 1.66 | +1.66 | buy |
| CITADEL ADVISORS LLC | 2,008 | 186,168 | +184,160 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 3,778 | 124,783 | +121,005 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,114,784 | 1,232,877 | +118,093 | 3.63 | 3.55 | -0.08 | buy |
| Affinity Asset Advisors, LLC | 65,000 | 165,000 | +100,000 | 0.61 | 1.24 | +0.63 | buy |
| GOLDMAN SACHS GROUP INC | 105,509 | 166,188 | +60,679 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 12,222 | 65,801 | +53,579 | 0.00 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 304,013 | 357,199 | +53,186 | 0.57 | 0.57 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 51,186 | +51,186 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 50,524 | +50,524 | 0.00 | 0.27 | +0.27 | buy |
| MPM BioImpact LLC | 88,045 | 137,208 | +49,163 | 1.08 | 1.29 | +0.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 38,100 | +38,100 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 15,072 | 49,516 | +34,444 | 0.02 | 0.05 | +0.03 | buy |
| MORGAN STANLEY | 201,409 | 235,071 | +33,662 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 33,181 | +33,181 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 357,650 | 390,829 | +33,179 | 0.94 | 0.80 | -0.14 | buy |
| Walleye Capital LLC | 0 | 31,721 | +31,721 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 32,525 | 57,125 | +24,600 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Darwin Global Management, Ltd. | 3,057,412 | 3,077,219 | +19,807 | 12.10 | 12.14 | +0.05 | buy |
| ORBIMED ADVISORS LLC | 0 | 13,300 | +13,300 | 0.00 | 0.04 | +0.04 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 12,733 | +12,733 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 10,427 | 22,640 | +12,213 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 12,171 | +12,171 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| Capricorn Fund Managers Ltd | 0 | 6,400 | +6,400 | 0.00 | 0.08 | +0.08 | buy |
| Mariner, LLC | 0 | 3,835 | +3,835 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 52,000 | 55,763 | +3,763 | 0.01 | 0.01 | -0.00 | buy |
| Entropy Technologies, LP | 0 | 3,700 | +3,700 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 0 | 3,100 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 1,645 | 4,364 | +2,719 | 0.02 | 0.04 | +0.03 | buy |
| Jain Global LLC | 0 | 2,101 | +2,101 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 8,033 | 9,554 | +1,521 | 0.35 | 0.34 | -0.02 | buy |
| R Squared Ltd | 0 | 1,338 | +1,338 | 0.00 | 0.11 | +0.11 | buy |
| Virtus Investment Advisers, LLC | 1,929 | 2,369 | +440 | 0.08 | 0.08 | +0.00 | buy |
| Bayforest Capital Ltd | 0 | 307 | +307 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 2,489 | 2,773 | +284 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,767 | 3,029 | +262 | 0.00 | 0.00 | -0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1 | 47 | +46 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 83 | 113 | +30 | 0.01 | 0.01 | -0.00 | buy |
| WEST PACES ADVISORS INC. | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 4 | 13 | +9 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 13 | 17 | +4 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 715,332 | 715,332 | 0 | 1.13 | 0.94 | -0.19 | hold |
| Duquesne Family Office LLC | 106,100 | 106,100 | 0 | 0.58 | 0.38 | -0.20 | hold |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 1,900 | 1,900 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Independent Advisor Alliance | 1,319 | 1,319 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |
| High Net Worth Advisory Group LLC | 3,500 | 3,500 | 0 | 0.13 | 0.11 | -0.02 | hold |
| Artia Global Partners LP | 24,989 | 24,989 | 0 | 0.90 | 0.73 | -0.17 | hold |
| BARCLAYS PLC | 6,822 | 6,822 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 1,707 | 1,686 | -21 | 0.01 | 0.01 | -0.00 | sell |
| Rossby Financial, LCC | 55 | 20 | -35 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 70 | 0 | -70 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 16,048 | 15,924 | -124 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 657 | 470 | -187 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 349 | 0 | -349 | 0.01 | 0.00 | -0.01 | sell |
| SG Americas Securities, LLC | 2,144 | 913 | -1,231 | 0.00 | 0.00 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 1,300 | 0 | -1,300 | 0.00 | 0.00 | -0.00 | sell |
| Merit Financial Group, LLC | 1,415 | 0 | -1,415 | 0.00 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 7,883 | 6,289 | -1,594 | 0.03 | 0.02 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 1,596 | 0 | -1,596 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 1,608 | 6 | -1,602 | 0.01 | 0.00 | -0.01 | sell |
| ROYAL BANK OF CANADA | 2,257 | 0 | -2,257 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 2,372 | 0 | -2,372 | 0.05 | 0.00 | -0.05 | sell |
| Convergence Financial, LLC | 2,968 | 0 | -2,968 | 0.05 | 0.00 | -0.05 | sell |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6,004 | 2,008 | -3,996 | 1.39 | 0.09 | -1.30 | sell |
| Amundi | 4,210 | 0 | -4,210 | 0.00 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 116,684 | 110,000 | -6,684 | 3.30 | 2.62 | -0.68 | sell |
| Squarepoint Ops LLC | 16,981 | 8,785 | -8,196 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,600 | 9,820 | -9,780 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 10,692 | 0 | -10,692 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 15,058 | 4,333 | -10,725 | 0.04 | 0.01 | -0.03 | sell |
| HRT FINANCIAL LP | 10,922 | 0 | -10,922 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 15,981 | 0 | -15,981 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 20,294 | 0 | -20,294 | 0.09 | 0.00 | -0.09 | sell |
| TD ASSET MANAGEMENT INC | 33,410 | 13,010 | -20,400 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 23,708 | 0 | -23,708 | 0.04 | 0.00 | -0.04 | sell |
| PFM Health Sciences, LP | 59,432 | 34,803 | -24,629 | 1.00 | 0.47 | -0.53 | sell |
| ADAR1 Capital Management, LLC | 26,880 | 0 | -26,880 | 0.26 | 0.00 | -0.26 | sell |
| Longaeva Partners L.P. | 33,492 | 0 | -33,492 | 0.26 | 0.00 | -0.26 | sell |
| FRED ALGER MANAGEMENT, LLC | 62,574 | 2,119 | -60,455 | 0.04 | 0.00 | -0.04 | sell |
| MILLENNIUM MANAGEMENT LLC | 570,088 | 494,564 | -75,524 | 0.07 | 0.05 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 151,979 | 0 | -151,979 | 0.48 | 0.00 | -0.48 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 281,805 | 105,859 | -175,946 | 0.01 | 0.00 | -0.00 | sell |
| Holocene Advisors, LP | 494,495 | 251,035 | -243,460 | 0.19 | 0.09 | -0.10 | sell |
| UBS Group AG | 768,359 | 224,989 | -543,370 | 0.02 | 0.01 | -0.02 | sell |