| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 0 | 3,027,704 | +3,027,704 | 0.00 | 9.86 | +9.86 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,741 | 558,882 | +538,141 | 0.00 | 0.06 | +0.06 | buy |
| RTW INVESTMENTS, LP | 312,500 | 715,332 | +402,832 | 0.28 | 1.15 | +0.86 | buy |
| PERCEPTIVE ADVISORS LLC | 49,788 | 414,239 | +364,451 | 0.11 | 1.21 | +1.11 | buy |
| Point72 Asset Management, L.P. | 3,100 | 284,437 | +281,337 | 0.00 | 0.07 | +0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 233,813 | +233,813 | 0.00 | 0.48 | +0.48 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 195,312 | 383,091 | +187,779 | 0.24 | 0.96 | +0.72 | buy |
| UBS Group AG | 11,334 | 128,752 | +117,418 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 87,760 | +87,760 | 0.00 | 1.61 | +1.61 | buy |
| Holocene Advisors, LP | 0 | 84,067 | +84,067 | 0.00 | 0.03 | +0.03 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 79,394 | +79,394 | 0.00 | 0.05 | +0.05 | buy |
| Western Standard LLC | 0 | 60,026 | +60,026 | 0.00 | 4.43 | +4.43 | buy |
| GOLDMAN SACHS GROUP INC | 3,706 | 44,599 | +40,893 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 39,839 | +39,839 | 0.00 | 0.48 | +0.48 | buy |
| JANE STREET GROUP, LLC | 0 | 32,318 | +32,318 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 28,013 | +28,013 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 24,703 | +24,703 | 0.00 | 2.12 | +2.12 | buy |
| Quadrature Capital Ltd | 3,830 | 24,832 | +21,002 | 0.00 | 0.04 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.23 | +0.23 | buy |
| PFM Health Sciences, LP | 0 | 19,823 | +19,823 | 0.00 | 0.32 | +0.32 | buy |
| Woodline Partners LP | 0 | 18,041 | +18,041 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 0 | 17,989 | +17,989 | 0.00 | 0.46 | +0.46 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 15,538 | +15,538 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 14,328 | +14,328 | 0.00 | 1.13 | +1.13 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 11,897 | +11,897 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 3,031 | 13,221 | +10,190 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 9,163 | +9,163 | 0.00 | 0.25 | +0.25 | buy |
| HRT FINANCIAL LP | 0 | 8,164 | +8,164 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 6,198 | +6,198 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 187,500 | 192,700 | +5,200 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 0 | 4,176 | +4,176 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 3,152 | +3,152 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 3,119 | +3,119 | 0.00 | 0.04 | +0.04 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 3,049 | +3,049 | 0.00 | 0.07 | +0.07 | buy |
| SG Americas Securities, LLC | 0 | 2,755 | +2,755 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 13,273 | 15,740 | +2,467 | 0.00 | 0.00 | +0.00 | buy |
| Yeomans Consulting Group, Inc. | 0 | 2,399 | +2,399 | 0.00 | 0.11 | +0.11 | buy |
| ROYAL BANK OF CANADA | 0 | 2,092 | +2,092 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 1,739 | +1,739 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 1,463 | +1,463 | 0.00 | 0.02 | +0.02 | buy |
| Independent Advisor Alliance | 0 | 1,319 | +1,319 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 673 | +673 | 0.00 | 0.05 | +0.05 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 645 | +645 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1 | 549 | +548 | 0.00 | 0.02 | +0.02 | buy |
| Farther Finance Advisors, LLC | 0 | 101 | +101 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 1,831 | 1,882 | +51 | 0.04 | 0.08 | +0.04 | buy |
| GAMMA Investing LLC | 1,758 | 1,779 | +21 | 0.01 | 0.01 | +0.01 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| High Net Worth Advisory Group LLC | 3,500 | 3,500 | 0 | 0.06 | 0.13 | +0.07 | hold |
| Rossby Financial, LCC | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 52 | 50 | -2 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 41 | 0 | -41 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 1,706 | 1,598 | -108 | 0.00 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 4,010 | 2,137 | -1,873 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,812 | 0 | -2,812 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,000 | 500 | -4,500 | 0.03 | 0.01 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 15,625 | 10,445 | -5,180 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 10,827 | 5,055 | -5,772 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 7,266 | 0 | -7,266 | 0.07 | 0.00 | -0.07 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 11,549 | 2,448 | -9,101 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 9,809 | 0 | -9,809 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 210,000 | 40,354 | -169,646 | 0.83 | 0.27 | -0.56 | sell |
| Vestal Point Capital, LP | 312,500 | 0 | -312,500 | 1.05 | 0.00 | -1.05 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 875,000 | 432,484 | -442,516 | 0.80 | 0.71 | -0.09 | sell |