| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Alphabet Inc. | 11,862,498 | 15,062,498 | +3,200,000 | 4.87 | 4.19 | -0.68 | buy |
| ARK Investment Management LLC | 3,138,270 | 5,993,354 | +2,855,084 | 0.16 | 0.29 | +0.13 | buy |
| VANGUARD GROUP INC | 4,054,911 | 5,801,445 | +1,746,534 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,925,346 | 3,924,370 | -976 | 0.00 | 0.00 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 3,519,029 | 3,364,663 | -154,366 | 0.02 | 0.02 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 3,519,029 | 3,364,663 | -154,366 | 0.30 | 0.23 | -0.07 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 3,090,083 | +3,090,083 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,221,159 | 2,522,590 | +301,431 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 1,324,350 | 2,074,350 | +750,000 | 0.42 | 0.53 | +0.11 | buy |
| Avidity Partners Management LP | 0 | 1,990,000 | +1,990,000 | 0.00 | 0.50 | +0.50 | buy |
| MWG Management Ltd. | 1,792,210 | 1,792,210 | 0 | 13.36 | 9.29 | -4.07 | hold |
| BAKER BROS. ADVISORS LP | 1,028,466 | 1,028,466 | 0 | 0.10 | 0.09 | -0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 887,503 | 916,861 | +29,358 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 885,314 | 885,314 | 0 | 0.14 | 0.11 | -0.04 | hold |
| STATE STREET CORP | 759,758 | 778,782 | +19,024 | 0.00 | 0.00 | -0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 750,000 | +750,000 | 0.00 | 0.03 | +0.03 | buy |
| EcoR1 Capital, LLC | 0 | 700,000 | +700,000 | 0.00 | 0.12 | +0.12 | buy |
| Greenwich Wealth Management LLC | 513,001 | 578,001 | +65,000 | 0.45 | 0.32 | -0.13 | buy |
| Samsara BioCapital, LLC | 470,304 | 540,304 | +70,000 | 0.65 | 0.59 | -0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 268,362 | 508,078 | +239,716 | 0.01 | 0.01 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 500,000 | +500,000 | 0.00 | 0.07 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 134,544 | 435,317 | +300,773 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 470,596 | 421,420 | -49,176 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 367,175 | 367,175 | 0 | 0.32 | 0.19 | -0.13 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 53,292 | 362,400 | +309,108 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 20,306 | 360,000 | +339,694 | 0.02 | 0.21 | +0.19 | buy |
| NORTHERN TRUST CORP | 344,927 | 339,998 | -4,929 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 330,500 | +330,500 | 0.00 | 0.02 | +0.02 | buy |
| Deep Track Capital, LP | 0 | 303,716 | +303,716 | 0.00 | 0.06 | +0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 296,188 | 297,823 | +1,635 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 73,980 | 205,242 | +131,262 | 0.12 | 0.23 | +0.11 | buy |
| MORGAN STANLEY | 211,734 | 198,466 | -13,268 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 46,000 | 164,000 | +118,000 | 0.00 | 0.00 | +0.00 | buy |
| WESTWOOD HOLDINGS GROUP INC | 0 | 159,351 | +159,351 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vestmark Advisory Solutions, Inc. | 144,288 | 147,484 | +3,196 | 0.06 | 0.04 | -0.02 | buy |
| FIL Ltd | 146,942 | 138,276 | -8,666 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 52,742 | 129,022 | +76,280 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 116,887 | 116,887 | 0 | 0.02 | 0.02 | +0.00 | hold |
| CITADEL ADVISORS LLC | 0 | 108,198 | +108,198 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 114,246 | 105,963 | -8,283 | 0.00 | 0.00 | -0.00 | sell |
| TrueMark Investments, LLC | 75,030 | 85,183 | +10,153 | 0.66 | 0.55 | -0.11 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64,547 | 74,928 | +10,381 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 61,295 | +61,295 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 71,523 | 59,566 | -11,957 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 50,858 | 52,512 | +1,654 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF MONTREAL /CAN/ | 45,000 | 46,637 | +1,637 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 39,837 | 46,214 | +6,377 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 10,935 | 43,970 | +33,035 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 31,412 | 42,523 | +11,111 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 45,519 | 42,081 | -3,438 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 59,116 | 41,000 | -18,116 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 51,149 | 38,180 | -12,969 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 37,360 | 37,950 | +590 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 17,100 | 34,000 | +16,900 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 29,538 | 33,738 | +4,200 | 0.19 | 0.17 | -0.02 | buy |
| Cinctive Capital Management LP | 0 | 33,033 | +33,033 | 0.00 | 0.01 | +0.01 | buy |
| BRANDYWINE MANAGERS, LLC | 32,977 | 32,977 | 0 | 0.32 | 0.23 | -0.09 | hold |
| Verition Fund Management LLC | 0 | 29,515 | +29,515 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 29,241 | +29,241 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 54,235 | 27,590 | -26,645 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 26,668 | +26,668 | 0.00 | 0.00 | +0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 20,000 | 26,500 | +6,500 | 0.02 | 0.02 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 22,370 | 22,880 | +510 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,258 | 22,378 | +11,120 | 0.02 | 0.02 | +0.00 | buy |
| HighTower Advisors, LLC | 21,117 | 22,286 | +1,169 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,585 | 21,312 | -25,273 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 21,262 | 21,262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 21,175 | +21,175 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 20,101 | 20,715 | +614 | 0.00 | 0.00 | -0.00 | buy |
| OPPENHEIMER & CO INC | 20,598 | 20,176 | -422 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 19,663 | 19,496 | -167 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 17,890 | 17,633 | -257 | 0.00 | 0.00 | -0.00 | sell |
| Clarius Group, LLC | 16,080 | 16,080 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ProShare Advisors LLC | 12,756 | 15,276 | +2,520 | 0.00 | 0.00 | -0.00 | buy |
| RED LIGHTHOUSE INVESTMENT MANAGEMENT, LLC | 14,950 | 14,950 | 0 | 0.06 | 0.04 | -0.01 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 16,160 | 12,906 | -3,254 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKET INC. | 12,261 | 12,047 | -214 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 10,229 | 11,810 | +1,581 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 13,570 | 11,609 | -1,961 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 0 | 10,611 | +10,611 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 68,306 | 10,443 | -57,863 | 0.01 | 0.00 | -0.01 | sell |
| BROWN BROTHERS HARRIMAN & CO | 10,065 | 10,065 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,440 | 8,423 | -17 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 35,235 | 7,997 | -27,238 | 0.30 | 0.05 | -0.25 | sell |
| Tower Research Capital LLC (TRC) | 21,011 | 7,063 | -13,948 | 0.00 | 0.00 | -0.00 | sell |
| CHELSEA COUNSEL CO | 5,000 | 5,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 4,837 | +4,837 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,336 | 4,336 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,511 | 3,978 | -2,533 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,901 | 3,901 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 0 | 3,576 | +3,576 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,203 | 2,203 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 5,613 | 1,347 | -4,266 | 0.00 | 0.00 | -0.00 | sell |
| First Horizon Advisors, Inc. | 810 | 1,134 | +324 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 1,732 | 1,114 | -618 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 1,314 | 651 | -663 | 0.00 | 0.00 | -0.00 | sell |
| Fairman Group, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 398 | 398 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BENJAMIN EDWARDS INC | 314 | 307 | -7 | 0.00 | 0.00 | -0.00 | sell |