| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,322,736 | +1,322,736 | 0.00 | 0.04 | +0.04 | buy |
| BRAIDWELL LP | 0 | 1,322,277 | +1,322,277 | 0.00 | 0.67 | +0.67 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 660,938 | +660,938 | 0.00 | 0.13 | +0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 44,100 | 593,722 | +549,622 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 2,084,245 | 2,502,981 | +418,736 | 0.03 | 0.04 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,002,831 | 3,369,147 | +366,316 | 0.66 | 0.83 | +0.17 | buy |
| Novo Holdings A/S | 1,307,829 | 1,638,298 | +330,469 | 1.08 | 1.77 | +0.69 | buy |
| JANUS HENDERSON GROUP PLC | 2,330,738 | 2,540,785 | +210,047 | 0.02 | 0.02 | +0.00 | buy |
| Laurion Capital Management LP | 255,301 | 454,182 | +198,881 | 0.12 | 0.20 | +0.08 | buy |
| Artal Group S.A. | 603,435 | 801,716 | +198,281 | 0.28 | 0.32 | +0.05 | buy |
| Omega Fund Management, LLC | 2,157,623 | 2,355,904 | +198,281 | 23.46 | 23.83 | +0.37 | buy |
| Vestal Point Capital, LP | 0 | 175,000 | +175,000 | 0.00 | 0.23 | +0.23 | buy |
| STATE STREET CORP | 0 | 112,215 | +112,215 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 111,186 | +111,186 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 100,421 | 197,799 | +97,378 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 15,589 | 82,101 | +66,512 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 416,182 | 481,755 | +65,573 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 27,361 | +27,361 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 23,559 | +23,559 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 14,894 | +14,894 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,576 | +14,576 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 14,110 | 28,323 | +14,213 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 12,051 | +12,051 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 12,041 | +12,041 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 10,367 | +10,367 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 9,730 | +9,730 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,517 | 22,929 | +7,412 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 5,821 | +5,821 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 0 | 5,053 | +5,053 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4,781 | +4,781 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 3,369 | +3,369 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,031 | +1,031 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,023 | +1,023 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 38,960 | 39,933 | +973 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 623 | +623 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 599 | +599 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 10,319 | 10,319 | 0 | 0.75 | 0.92 | +0.17 | hold |
| Blackstone Inc. | 696,110 | 696,110 | 0 | 0.04 | 0.05 | +0.00 | hold |
| D1 Capital Partners L.P. | 2,506,607 | 2,506,607 | 0 | 0.59 | 0.60 | +0.01 | hold |
| Steward Partners Investment Advisory, LLC | 323 | 0 | -323 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 603 | 0 | -603 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,490 | 507 | -983 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 15,000 | 863 | -14,137 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 25,750 | 0 | -25,750 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Middle East FZE | 28,578 | 0 | -28,578 | 0.03 | 0.00 | -0.03 | sell |
| ExodusPoint Capital Management, LP | 34,172 | 0 | -34,172 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 91,889 | 49,177 | -42,712 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 189,062 | 60,843 | -128,219 | 0.03 | 0.01 | -0.02 | sell |