| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 0 | 1,480,881 | +1,480,881 | 0.00 | 0.80 | +0.80 | buy |
| MILLENNIUM MANAGEMENT LLC | 141,951 | 1,071,489 | +929,538 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 645,000 | +645,000 | 0.00 | 0.46 | +0.46 | buy |
| Point72 Asset Management, L.P. | 750,235 | 1,098,143 | +347,908 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,339,254 | 4,557,920 | +218,666 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 96,100 | +96,100 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 17,794 | 81,009 | +63,215 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 499,301 | 550,029 | +50,728 | 0.94 | 0.62 | -0.32 | buy |
| Shay Capital LLC | 0 | 43,296 | +43,296 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,710 | 50,337 | +39,627 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 36,624 | +36,624 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 34,741 | +34,741 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 24,648 | +24,648 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 23,123 | +23,123 | 0.00 | 0.18 | +0.18 | buy |
| Privium Fund Management B.V. | 138,115 | 160,198 | +22,083 | 0.21 | 0.14 | -0.06 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 20,300 | +20,300 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,821,966 | 1,842,232 | +20,266 | 0.00 | 0.00 | -0.00 | buy |
| Soltis Investment Advisors LLC | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 567,383 | 586,516 | +19,133 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 147,807 | 163,172 | +15,365 | 0.03 | 0.02 | -0.01 | buy |
| STATE STREET CORP | 457,403 | 469,728 | +12,325 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 2,003 | 9,864 | +7,861 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 34,527 | 40,211 | +5,684 | 0.00 | 0.00 | -0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 25,197 | 30,192 | +4,995 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,655 | 5,865 | +4,210 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 785 | 4,135 | +3,350 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 16,100 | 18,900 | +2,800 | 0.02 | 0.01 | -0.02 | buy |
| COMERICA BANK | 0 | 1,761 | +1,761 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 169,505 | 170,448 | +943 | 0.23 | 0.11 | -0.12 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,477 | 14,101 | +624 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 376 | +376 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 694 | 820 | +126 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 93 | +93 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,387 | 2,387 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,735 | 1,735 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 15,970 | 15,970 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 139,835 | 139,835 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Sterling Capital Management LLC | 27 | 27 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 546,554 | 546,554 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Novo Holdings A/S | 1,122,581 | 1,122,581 | 0 | 0.45 | 0.30 | -0.15 | hold |
| CAXTON CORP | 17,851 | 17,851 | 0 | 0.71 | 1.22 | +0.51 | hold |
| Laurion Capital Management LP | 260,228 | 260,228 | 0 | 0.11 | 0.07 | -0.04 | hold |
| Blackstone Inc. | 1,158,617 | 1,158,617 | 0 | 0.04 | 0.02 | -0.02 | hold |
| CITADEL ADVISORS LLC | 2,723,363 | 2,723,363 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Omega Fund Management, LLC | 1,184,636 | 1,184,636 | 0 | 5.06 | 2.43 | -2.63 | hold |
| IFP Advisors, Inc | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 197 | 197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 955,515 | 955,515 | 0 | 0.26 | 0.15 | -0.11 | hold |
| Allostery Investments LP | 5,054 | 5,054 | 0 | 0.07 | 0.03 | -0.04 | hold |
| Siren, L.L.C. | 603,435 | 603,435 | 0 | 0.18 | 0.12 | -0.06 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,040 | 6,040 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 2,527 | 2,527 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,425 | 10,425 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,187 | 4,187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 623 | 623 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 50,660 | 50,644 | -16 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 33 | 0 | -33 | 0.00 | 0.00 | 0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 396 | 339 | -57 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,102 | 979 | -123 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 11,715 | 11,544 | -171 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 185 | 0 | -185 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 11,565 | 11,340 | -225 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 245 | 0 | -245 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,011 | 6,632 | -379 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 416 | 0 | -416 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 13,771 | 12,711 | -1,060 | 0.05 | 0.15 | +0.09 | sell |
| Brooklyn Investment Group | 1,465 | 0 | -1,465 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 24,924 | 23,327 | -1,597 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 1,726 | 0 | -1,726 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 13,226 | 11,370 | -1,856 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 63,874 | 56,174 | -7,700 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 214,284 | 206,093 | -8,191 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 55,161 | 46,667 | -8,494 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 10,960 | 0 | -10,960 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 11,156 | 0 | -11,156 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 90,901 | 79,108 | -11,793 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 13,371 | 0 | -13,371 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 14,223 | 0 | -14,223 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 393,083 | 378,083 | -15,000 | 0.66 | 0.37 | -0.29 | sell |
| VANGUARD GROUP INC | 1,118,879 | 1,099,285 | -19,594 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 20,400 | 0 | -20,400 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 858,691 | 837,014 | -21,677 | 0.04 | 0.02 | -0.02 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 65,000 | 38,400 | -26,600 | 0.01 | 0.00 | -0.01 | sell |
| Aristides Capital LLC | 29,285 | 0 | -29,285 | 0.06 | 0.00 | -0.06 | sell |
| UBS Group AG | 51,054 | 0 | -51,054 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 52,616 | 0 | -52,616 | 0.30 | 0.00 | -0.30 | sell |
| Walleye Capital LLC | 61,930 | 0 | -61,930 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 1,200,000 | 1,136,249 | -63,751 | 0.47 | 0.28 | -0.19 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 76,981 | 0 | -76,981 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 130,000 | 0 | -130,000 | 0.15 | 0.00 | -0.15 | sell |
| Verition Fund Management LLC | 709,900 | 414,863 | -295,037 | 0.02 | 0.01 | -0.02 | sell |
| Altium Capital Management LLC | 405,000 | 0 | -405,000 | 0.83 | 0.00 | -0.83 | sell |
| D1 Capital Partners L.P. | 2,203,900 | 978,652 | -1,225,248 | 0.24 | 0.05 | -0.19 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,234,834 | 0 | -1,234,834 | 0.15 | 0.00 | -0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,209,615 | 237,953 | -1,971,662 | 0.03 | 0.00 | -0.02 | sell |