| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 3,200,000 | 5,050,211 | +1,850,211 | 2.28 | 1.70 | -0.58 | buy |
| ORBIMED ADVISORS LLC | 2,125,000 | 3,602,450 | +1,477,450 | 0.43 | 0.45 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 4,763,198 | 6,184,134 | +1,420,936 | 1.27 | 0.73 | -0.54 | buy |
| GOLDMAN SACHS GROUP INC | 781,855 | 1,949,885 | +1,168,030 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 908,024 | 1,612,780 | +704,756 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 0 | 402,924 | +402,924 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,187,722 | 3,568,242 | +380,520 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 133,257 | 465,515 | +332,258 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 160,288 | 491,532 | +331,244 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 245,904 | +245,904 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 862,892 | 1,103,584 | +240,692 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 92,608 | 319,090 | +226,482 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,907,563 | 5,110,871 | +203,308 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 1,000,000 | 1,200,000 | +200,000 | 0.59 | 0.43 | -0.16 | buy |
| ExodusPoint Capital Management, LP | 0 | 112,172 | +112,172 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 83,230 | 172,703 | +89,473 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,144 | 100,607 | +89,463 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 26,205 | 112,982 | +86,777 | 0.00 | 0.01 | +0.01 | buy |
| 683 Capital Management, LLC | 1,120,000 | 1,200,000 | +80,000 | 0.92 | 0.64 | -0.29 | buy |
| ADAR1 Capital Management, LLC | 1,393,161 | 1,467,350 | +74,189 | 1.03 | 0.51 | -0.53 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,445,887 | 1,513,777 | +67,890 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 29,861 | 93,163 | +63,302 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,774,317 | 3,834,999 | +60,682 | 0.03 | 0.02 | -0.01 | buy |
| Creative Planning | 10,358 | 67,079 | +56,721 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 47,988 | +47,988 | 0.00 | 0.02 | +0.02 | buy |
| Bleakley Financial Group, LLC | 0 | 47,964 | +47,964 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 281,083 | 321,737 | +40,654 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 457,052 | 493,666 | +36,614 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 340,859 | 377,059 | +36,200 | 0.79 | 0.49 | -0.29 | buy |
| AXQ CAPITAL, LP | 0 | 26,119 | +26,119 | 0.00 | 0.02 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,555 | 37,071 | +25,516 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 24,221 | +24,221 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 11,463 | 34,269 | +22,806 | 0.01 | 0.01 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 16,560 | +16,560 | 0.00 | 0.03 | +0.03 | buy |
| E Fund Management Co., Ltd. | 0 | 12,683 | +12,683 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 192,550 | 205,000 | +12,450 | 0.35 | 0.24 | -0.11 | buy |
| Virtu Financial LLC | 0 | 11,901 | +11,901 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 13,388 | 24,388 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,872 | 43,132 | +9,260 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 826 | 9,485 | +8,659 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 38,054 | 45,161 | +7,107 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 57,166 | 63,051 | +5,885 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 12,538 | 15,585 | +3,047 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 69,369 | 72,082 | +2,713 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,462 | +2,462 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 11,234 | 13,620 | +2,386 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,188 | 16,504 | +2,316 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 337,386 | 339,623 | +2,237 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,765 | 4,865 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,257 | 37,071 | +1,814 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 14,330 | 15,991 | +1,661 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 1,355 | +1,355 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 240 | 1,456 | +1,216 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 16,436 | 17,565 | +1,129 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,893 | 12,952 | +1,059 | 0.01 | 0.01 | -0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 5,872 | 6,639 | +767 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 27,230 | 27,910 | +680 | 0.07 | 0.04 | -0.03 | buy |
| Rockefeller Capital Management L.P. | 700 | 1,141 | +441 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 312 | 600 | +288 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 50 | 331 | +281 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,547 | 3,807 | +260 | 0.00 | 0.00 | -0.00 | buy |
| Key FInancial Inc | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,434 | 1,628 | +194 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 555 | 640 | +85 | 0.00 | 0.00 | -0.00 | buy |
| Fortitude Family Office, LLC | 124 | 205 | +81 | 0.00 | 0.00 | -0.00 | buy |
| Bare Financial Services, Inc | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 731 | 801 | +70 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 56 | +56 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,121 | 5,121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 13,400 | 13,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 61,810 | 61,810 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 5,000,000 | 5,000,000 | 0 | 0.51 | 0.30 | -0.20 | hold |
| CAXTON CORP | 13,943 | 13,943 | 0 | 3.24 | 1.99 | -1.25 | hold |
| Blackstone Inc. | 904,959 | 904,959 | 0 | 0.04 | 0.02 | -0.02 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 136,377 | 136,377 | 0 | 0.03 | 0.02 | -0.02 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,250,000 | 1,250,000 | 0 | 0.31 | 0.19 | -0.11 | hold |
| Sunbelt Securities, Inc. | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 203 | 203 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 513,011 | 513,011 | 0 | 0.66 | 0.42 | -0.24 | hold |
| Soltis Investment Advisors LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Frazier Life Sciences Management, L.P. | 4,424,725 | 4,424,725 | 0 | 1.18 | 0.65 | -0.53 | hold |
| Burkehill Global Management, LP | 125,000 | 125,000 | 0 | 0.08 | 0.04 | -0.05 | hold |
| True Wealth Design, LLC | 226 | 226 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vestal Point Capital, LP | 4,475,000 | 4,475,000 | 0 | 1.63 | 0.72 | -0.91 | hold |
| Smartleaf Asset Management LLC | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 16,373 | 16,373 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 5,631 | 5,631 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,887 | 19,887 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 34,297 | 34,297 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 217 | 207 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Rialto Wealth Management, LLC | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 57 | 0 | -57 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 290 | 200 | -90 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 35,721 | 35,584 | -137 | 0.00 | 0.00 | -0.00 | sell |