| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 4,763,198 | 6,184,134 | +1,420,936 | 1.27 | 0.73 | -0.54 | buy |
| BlackRock, Inc. | 4,907,563 | 5,110,871 | +203,308 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 3,200,000 | 5,050,211 | +1,850,211 | 2.28 | 1.70 | -0.58 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,000,000 | 5,000,000 | 0 | 0.51 | 0.30 | -0.20 | hold |
| JANUS HENDERSON GROUP PLC | 5,509,635 | 4,976,429 | -533,206 | 0.02 | 0.01 | -0.01 | sell |
| Vestal Point Capital, LP | 4,475,000 | 4,475,000 | 0 | 1.63 | 0.72 | -0.91 | hold |
| Frazier Life Sciences Management, L.P. | 4,424,725 | 4,424,725 | 0 | 1.18 | 0.65 | -0.53 | hold |
| CITADEL ADVISORS LLC | 3,774,317 | 3,834,999 | +60,682 | 0.03 | 0.02 | -0.01 | buy |
| ORBIMED ADVISORS LLC | 2,125,000 | 3,602,450 | +1,477,450 | 0.43 | 0.45 | +0.02 | buy |
| STATE STREET CORP | 3,187,722 | 3,568,242 | +380,520 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 3,197,760 | 2,750,532 | -447,228 | 0.12 | 0.06 | -0.06 | sell |
| GOLDMAN SACHS GROUP INC | 781,855 | 1,949,885 | +1,168,030 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 3,300,000 | 1,875,000 | -1,425,000 | 0.32 | 0.11 | -0.22 | sell |
| Point72 Asset Management, L.P. | 1,894,722 | 1,680,449 | -214,273 | 0.03 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 908,024 | 1,612,780 | +704,756 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,635,026 | 1,589,585 | -45,441 | 0.03 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,445,887 | 1,513,777 | +67,890 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 1,393,161 | 1,467,350 | +74,189 | 1.03 | 0.51 | -0.53 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,250,000 | 1,250,000 | 0 | 0.31 | 0.19 | -0.11 | hold |
| 683 Capital Management, LLC | 1,120,000 | 1,200,000 | +80,000 | 0.92 | 0.64 | -0.29 | buy |
| Nantahala Capital Management, LLC | 1,000,000 | 1,200,000 | +200,000 | 0.59 | 0.43 | -0.16 | buy |
| DIMENSIONAL FUND ADVISORS LP | 862,892 | 1,103,584 | +240,692 | 0.00 | 0.00 | -0.00 | buy |
| Octagon Capital Advisors LP | 1,725,000 | 1,100,000 | -625,000 | 2.14 | 0.70 | -1.45 | sell |
| Blackstone Inc. | 904,959 | 904,959 | 0 | 0.04 | 0.02 | -0.02 | hold |
| Ikarian Capital, LLC | 513,011 | 513,011 | 0 | 0.66 | 0.42 | -0.24 | hold |
| NORTHERN TRUST CORP | 457,052 | 493,666 | +36,614 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 160,288 | 491,532 | +331,244 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 133,257 | 465,515 | +332,258 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 402,924 | +402,924 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 340,859 | 377,059 | +36,200 | 0.79 | 0.49 | -0.29 | buy |
| AQR CAPITAL MANAGEMENT LLC | 337,386 | 339,623 | +2,237 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 281,083 | 321,737 | +40,654 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 92,608 | 319,090 | +226,482 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 245,904 | +245,904 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 257,417 | 228,201 | -29,216 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 192,550 | 205,000 | +12,450 | 0.35 | 0.24 | -0.11 | buy |
| Nuveen, LLC | 211,529 | 182,975 | -28,554 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 192,210 | 182,069 | -10,141 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 400,567 | 181,676 | -218,891 | 0.01 | 0.00 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 83,230 | 172,703 | +89,473 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 166,749 | 158,899 | -7,850 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 231,163 | 142,571 | -88,592 | 0.05 | 0.02 | -0.04 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 136,377 | 136,377 | 0 | 0.03 | 0.02 | -0.02 | hold |
| Burkehill Global Management, LP | 125,000 | 125,000 | 0 | 0.08 | 0.04 | -0.05 | hold |
| Susquehanna Portfolio Strategies, LLC | 26,205 | 112,982 | +86,777 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 112,172 | +112,172 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 102,159 | 100,896 | -1,263 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 11,144 | 100,607 | +89,463 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 29,861 | 93,163 | +63,302 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 69,369 | 72,082 | +2,713 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 10,358 | 67,079 | +56,721 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 463,029 | 63,518 | -399,511 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 57,166 | 63,051 | +5,885 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,810 | 61,810 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRW Securities, LLC | 0 | 47,988 | +47,988 | 0.00 | 0.02 | +0.02 | buy |
| Bleakley Financial Group, LLC | 0 | 47,964 | +47,964 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 38,054 | 45,161 | +7,107 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,872 | 43,132 | +9,260 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,555 | 37,071 | +25,516 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,257 | 37,071 | +1,814 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 35,721 | 35,584 | -137 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 34,297 | 34,297 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 11,463 | 34,269 | +22,806 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 480,205 | 30,477 | -449,728 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 27,230 | 27,910 | +680 | 0.07 | 0.04 | -0.03 | buy |
| AXQ CAPITAL, LP | 0 | 26,119 | +26,119 | 0.00 | 0.02 | +0.02 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 26,209 | 25,577 | -632 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 70,736 | 24,993 | -45,743 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 13,388 | 24,388 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 24,221 | +24,221 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 22,439 | 21,027 | -1,412 | 0.00 | 0.00 | -0.00 | sell |
| Soltis Investment Advisors LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,887 | 19,887 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 18,953 | 18,317 | -636 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,147 | 17,738 | -1,409 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 16,436 | 17,565 | +1,129 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 16,560 | +16,560 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,188 | 16,504 | +2,316 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,373 | 16,373 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 14,330 | 15,991 | +1,661 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 12,538 | 15,585 | +3,047 | 0.00 | 0.00 | -0.00 | buy |
| CAXTON CORP | 13,943 | 13,943 | 0 | 3.24 | 1.99 | -1.25 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 11,234 | 13,620 | +2,386 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 13,400 | 13,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 15,293 | 13,320 | -1,973 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,893 | 12,952 | +1,059 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 14,752 | 12,852 | -1,900 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 0 | 12,683 | +12,683 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 188,754 | 12,165 | -176,589 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 11,901 | +11,901 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 11,449 | 11,132 | -317 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,976 | 10,705 | -271 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 826 | 9,485 | +8,659 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 5,872 | 6,639 | +767 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 5,631 | 5,631 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,121 | 5,121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,765 | 4,865 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,547 | 3,807 | +260 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,884 | 3,595 | -289 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,462 | +2,462 | 0.00 | 0.00 | +0.00 | buy |