| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,322,736 | 2,597,736 | +1,275,000 | 0.04 | 0.08 | +0.04 | buy |
| Woodline Partners LP | 12,051 | 824,074 | +812,023 | 0.00 | 0.13 | +0.13 | buy |
| Vestal Point Capital, LP | 175,000 | 840,000 | +665,000 | 0.23 | 1.00 | +0.78 | buy |
| JANUS HENDERSON GROUP PLC | 2,540,785 | 3,163,992 | +623,207 | 0.02 | 0.03 | +0.01 | buy |
| Verition Fund Management LLC | 60,843 | 421,392 | +360,549 | 0.01 | 0.05 | +0.04 | buy |
| VANGUARD GROUP INC | 481,755 | 629,919 | +148,164 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 132,187 | +132,187 | 0.00 | 0.02 | +0.02 | buy |
| Blackstone Inc. | 696,110 | 805,757 | +109,647 | 0.05 | 0.06 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 197,799 | 296,612 | +98,813 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 112,215 | 196,272 | +84,057 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 65,300 | +65,300 | 0.00 | 0.03 | +0.03 | buy |
| BRAIDWELL LP | 1,322,277 | 1,382,481 | +60,204 | 0.67 | 0.70 | +0.03 | buy |
| CITADEL ADVISORS LLC | 2,502,981 | 2,558,611 | +55,630 | 0.04 | 0.04 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 22,101 | +22,101 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 14,035 | +14,035 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 82,101 | 94,907 | +12,806 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 660,938 | 672,712 | +11,774 | 0.13 | 0.14 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 10,750 | +10,750 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 10,542 | +10,542 | 0.00 | 0.08 | +0.08 | buy |
| CAXTON CORP | 10,319 | 17,851 | +7,532 | 0.92 | 1.45 | +0.53 | buy |
| DEUTSCHE BANK AG\ | 0 | 4,560 | +4,560 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 9,730 | 13,357 | +3,627 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,361 | 30,861 | +3,500 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 28,323 | 31,806 | +3,483 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 23,559 | 26,853 | +3,294 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,300 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 507 | 1,575 | +1,068 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 5,821 | 6,420 | +599 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 863 | 1,010 | +147 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 13 | 135 | +122 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,100 | 4,187 | +87 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 33 | +33 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 16 | +16 | 0.00 | 0.00 | 0.00 | buy |
| GAMMA Investing LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,023 | 1,023 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,369,147 | 3,369,147 | 0 | 0.83 | 0.93 | +0.10 | hold |
| Omega Fund Management, LLC | 2,355,904 | 2,355,904 | 0 | 23.83 | 28.00 | +4.17 | hold |
| D1 Capital Partners L.P. | 2,506,607 | 2,506,607 | 0 | 0.60 | 0.68 | +0.08 | hold |
| AMALGAMATED BANK | 623 | 623 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 3,369 | 3,341 | -28 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,031 | 742 | -289 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 531 | 0 | -531 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 599 | 0 | -599 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 454,182 | 453,582 | -600 | 0.20 | 0.24 | +0.04 | sell |
| STRS OHIO | 1,800 | 0 | -1,800 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,781 | 1,950 | -2,831 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 22,929 | 19,153 | -3,776 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 5,053 | 0 | -5,053 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 10,367 | 0 | -10,367 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,041 | 0 | -12,041 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 39,933 | 26,759 | -13,174 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 14,576 | 0 | -14,576 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 14,894 | 0 | -14,894 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 49,177 | 11,545 | -37,632 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 111,186 | 0 | -111,186 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 1,638,298 | 1,450,500 | -187,798 | 1.77 | 1.25 | -0.52 | sell |
| Artal Group S.A. | 801,716 | 603,435 | -198,281 | 0.32 | 0.25 | -0.08 | sell |
| MILLENNIUM MANAGEMENT LLC | 593,722 | 37,466 | -556,256 | 0.01 | 0.00 | -0.01 | sell |