| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 4,009,137 | +4,009,137 | 0.00 | 0.04 | +0.04 | buy |
| Frazier Life Sciences Management, L.P. | 955,515 | 4,424,725 | +3,469,210 | 0.15 | 0.71 | +0.56 | buy |
| Affinity Asset Advisors, LLC | 1,480,881 | 3,589,355 | +2,108,474 | 0.80 | 2.13 | +1.33 | buy |
| Vestal Point Capital, LP | 1,136,249 | 3,228,161 | +2,091,912 | 0.28 | 0.68 | +0.40 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,071,489 | 2,836,292 | +1,764,803 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 837,014 | 2,572,162 | +1,735,148 | 0.02 | 0.05 | +0.04 | buy |
| VANGUARD GROUP INC | 1,099,285 | 2,002,866 | +903,581 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,723,363 | 3,607,967 | +884,604 | 0.01 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 867,302 | +867,302 | 0.00 | 2.90 | +2.90 | buy |
| UBS Group AG | 0 | 271,904 | +271,904 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 50,337 | 188,635 | +138,298 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 20,300 | 106,200 | +85,900 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 46,667 | 116,142 | +69,475 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 56,303 | +56,303 | 0.00 | 0.07 | +0.07 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 47,023 | +47,023 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 469,728 | 513,026 | +43,298 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 36,624 | 69,242 | +32,618 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 29,779 | +29,779 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 29,667 | +29,667 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 22,259 | +22,259 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 160,198 | 178,356 | +18,158 | 0.14 | 0.16 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 38,400 | 53,400 | +15,000 | 0.00 | 0.01 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 14,528 | +14,528 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 50,644 | 65,152 | +14,508 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 15,970 | 29,370 | +13,400 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 11,370 | 23,922 | +12,552 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 12,475 | +12,475 | 0.00 | 0.02 | +0.02 | buy |
| Cerity Partners LLC | 0 | 12,447 | +12,447 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 11,851 | +11,851 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 0 | 10,726 | +10,726 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 10,190 | +10,190 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 18,900 | 27,650 | +8,750 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 40,211 | 48,434 | +8,223 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 56,174 | 64,220 | +8,046 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 4,135 | 10,351 | +6,216 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 3,852 | +3,852 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 339 | 2,765 | +2,426 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 11,340 | 13,682 | +2,342 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 9,864 | 11,753 | +1,889 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 30,192 | 31,990 | +1,798 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 197 | 1,197 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 27 | 645 | +618 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 979 | 1,282 | +303 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 376 | 657 | +281 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 219 | +219 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 6 | 107 | +101 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,632 | 6,667 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,387 | 2,387 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,735 | 1,735 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 139,835 | 139,835 | 0 | 0.02 | 0.02 | +0.00 | hold |
| DAFNA Capital Management LLC | 378,083 | 378,083 | 0 | 0.37 | 0.42 | +0.05 | hold |
| Verition Fund Management LLC | 414,863 | 414,863 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 163,172 | 163,172 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Omega Fund Management, LLC | 1,184,636 | 1,184,636 | 0 | 2.43 | 3.08 | +0.66 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FNY Investment Advisers, LLC | 5,000 | 5,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| D1 Capital Partners L.P. | 978,652 | 978,652 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Ikarian Capital, LLC | 550,029 | 550,029 | 0 | 0.62 | 0.73 | +0.11 | hold |
| Soltis Investment Advisors LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Caitong International Asset Management Co., Ltd | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Siren, L.L.C. | 603,435 | 603,435 | 0 | 0.12 | 0.13 | +0.01 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,040 | 6,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 820 | 820 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,425 | 10,425 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,187 | 4,187 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 34,741 | 34,741 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 623 | 623 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 19 | 3 | -16 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 93 | 0 | -93 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 2,527 | 2,032 | -495 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON CORP | 17,851 | 17,332 | -519 | 1.22 | 0.71 | -0.51 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,101 | 13,477 | -624 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,865 | 5,094 | -771 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 1,761 | 0 | -1,761 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 36,050 | 33,102 | -2,948 | 0.00 | 0.00 | -0.00 | sell |
| Allostery Investments LP | 5,054 | 0 | -5,054 | 0.03 | 0.00 | -0.03 | sell |
| NORTHERN TRUST CORP | 206,093 | 200,786 | -5,307 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 586,516 | 578,081 | -8,435 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 23,327 | 14,748 | -8,579 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 11,544 | 0 | -11,544 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 12,711 | 0 | -12,711 | 0.15 | 0.00 | -0.15 | sell |
| BlackRock, Inc. | 1,842,232 | 1,827,964 | -14,268 | 0.00 | 0.00 | +0.00 | sell |
| Ground Swell Capital, LLC | 23,123 | 0 | -23,123 | 0.18 | 0.00 | -0.18 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 24,648 | 0 | -24,648 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 170,448 | 145,109 | -25,339 | 0.11 | 0.09 | -0.02 | sell |
| Blackstone Inc. | 1,158,617 | 1,124,922 | -33,695 | 0.02 | 0.02 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 79,108 | 36,368 | -42,740 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 43,296 | 0 | -43,296 | 0.04 | 0.00 | -0.04 | sell |
| MARSHALL WACE, LLP | 81,009 | 0 | -81,009 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 96,100 | 0 | -96,100 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 237,953 | 0 | -237,953 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 260,228 | 0 | -260,228 | 0.07 | 0.00 | -0.07 | sell |
| Point72 Asset Management, L.P. | 1,098,143 | 647,880 | -450,263 | 0.01 | 0.01 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 546,554 | 0 | -546,554 | 0.03 | 0.00 | -0.03 | sell |
| Avidity Partners Management LP | 645,000 | 0 | -645,000 | 0.46 | 0.00 | -0.46 | sell |
| JANUS HENDERSON GROUP PLC | 4,557,920 | 3,684,383 | -873,537 | 0.01 | 0.01 | -0.00 | sell |
| Novo Holdings A/S | 1,122,581 | 0 | -1,122,581 | 0.30 | 0.00 | -0.30 | sell |