| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,250,000 | 6,384,200 | +5,134,200 | 0.19 | 0.62 | +0.43 | buy |
| Affinity Asset Advisors, LLC | 5,050,211 | 5,807,611 | +757,400 | 1.70 | 1.32 | -0.38 | buy |
| BlackRock, Inc. | 5,110,871 | 5,739,455 | +628,584 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,000,000 | 5,000,000 | 0 | 0.30 | 0.20 | -0.10 | hold |
| Frazier Life Sciences Management, L.P. | 4,424,725 | 4,824,725 | +400,000 | 0.65 | 0.49 | -0.16 | buy |
| STATE STREET CORP | 3,568,242 | 4,354,757 | +786,515 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 4,475,000 | 4,320,000 | -155,000 | 0.72 | 0.47 | -0.25 | sell |
| Paradigm Biocapital Advisors LP | 6,184,134 | 4,175,382 | -2,008,752 | 0.73 | 0.36 | -0.36 | sell |
| ORBIMED ADVISORS LLC | 3,602,450 | 3,947,850 | +345,400 | 0.45 | 0.35 | -0.10 | buy |
| CITADEL ADVISORS LLC | 3,834,999 | 3,898,570 | +63,571 | 0.02 | 0.01 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,612,780 | 2,833,622 | +1,220,842 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 2,750,532 | 2,500,532 | -250,000 | 0.06 | 0.04 | -0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,589,585 | 2,412,742 | +823,157 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,949,885 | 2,149,612 | +199,727 | 0.00 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 1,200,000 | 1,875,000 | +675,000 | 0.64 | 0.80 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,513,777 | 1,747,959 | +234,182 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 1,467,350 | 1,565,950 | +98,600 | 0.51 | 0.34 | -0.16 | buy |
| Avoro Capital Advisors LLC | 1,875,000 | 1,489,189 | -385,811 | 0.11 | 0.06 | -0.04 | sell |
| Qube Research & Technologies Ltd | 465,515 | 1,376,222 | +910,707 | 0.00 | 0.01 | +0.00 | buy |
| Nantahala Capital Management, LLC | 1,200,000 | 1,300,000 | +100,000 | 0.43 | 0.37 | -0.06 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,103,584 | 1,287,185 | +183,601 | 0.00 | 0.00 | -0.00 | buy |
| Blackstone Inc. | 904,959 | 904,959 | 0 | 0.02 | 0.01 | -0.01 | hold |
| NORTHERN TRUST CORP | 493,666 | 867,391 | +373,725 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 245,904 | 675,092 | +429,188 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 513,011 | 513,011 | 0 | 0.42 | 0.39 | -0.03 | hold |
| BANK OF AMERICA CORP /DE/ | 491,532 | 490,331 | -1,201 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 402,924 | 395,102 | -7,822 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 228,201 | 388,398 | +160,197 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 377,059 | 377,059 | 0 | 0.49 | 0.33 | -0.16 | hold |
| UBS Group AG | 321,737 | 354,044 | +32,307 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 314,891 | +314,891 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 319,090 | 294,774 | -24,316 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 0 | 265,697 | +265,697 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 339,623 | 256,661 | -82,962 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 250,365 | +250,365 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 172,703 | 202,383 | +29,680 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 182,975 | 200,417 | +17,442 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 158,899 | 183,883 | +24,984 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 172,609 | +172,609 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 182,069 | 172,609 | -9,460 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 112,982 | 161,062 | +48,080 | 0.01 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 205,000 | 155,000 | -50,000 | 0.24 | 0.13 | -0.11 | sell |
| XTX Topco Ltd | 100,607 | 145,556 | +44,949 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 24,388 | 141,146 | +116,758 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 136,377 | 136,377 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Burkehill Global Management, LP | 125,000 | 125,000 | 0 | 0.04 | 0.02 | -0.01 | hold |
| RAYMOND JAMES FINANCIAL INC | 15,585 | 117,388 | +101,803 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 114,743 | +114,743 | 0.00 | 0.11 | +0.11 | buy |
| Fisher Asset Management, LLC | 0 | 114,322 | +114,322 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 16,560 | 103,648 | +87,088 | 0.03 | 0.12 | +0.09 | buy |
| JPMORGAN CHASE & CO | 93,163 | 96,290 | +3,127 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 13,320 | 93,743 | +80,423 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 63,051 | 82,293 | +19,242 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 72,082 | 79,809 | +7,727 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,810 | 77,860 | +16,050 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 63,518 | 76,219 | +12,701 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 27,910 | 74,874 | +46,964 | 0.04 | 0.08 | +0.04 | buy |
| Walleye Capital LLC | 0 | 73,868 | +73,868 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 67,079 | 72,625 | +5,546 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 100,896 | 67,535 | -33,361 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 24,993 | 59,365 | +34,372 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 43,132 | 58,194 | +15,062 | 0.00 | 0.00 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 25,577 | 49,988 | +24,411 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 48,324 | +48,324 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 37,071 | 48,176 | +11,105 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,071 | 40,485 | +3,414 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 35,584 | 39,548 | +3,964 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 45,161 | 34,317 | -10,844 | 0.01 | 0.00 | -0.01 | sell |
| Russell Investments Group, Ltd. | 6,639 | 33,015 | +26,376 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 32,651 | +32,651 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 112,172 | 27,880 | -84,292 | 0.01 | 0.00 | -0.01 | sell |
| Police & Firemen's Retirement System of New Jersey | 16,373 | 25,535 | +9,162 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 24,293 | +24,293 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 22,500 | +22,500 | 0.00 | 0.01 | +0.01 | buy |
| Soltis Investment Advisors LLC | 20,000 | 20,016 | +16 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,887 | 19,887 | 0 | 0.00 | 0.00 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 30,477 | 19,866 | -10,611 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,738 | 19,805 | +2,067 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 17,565 | 19,466 | +1,901 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 18,855 | +18,855 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 18,500 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,504 | 17,817 | +1,313 | 0.00 | 0.00 | -0.00 | buy |
| CAXTON CORP | 13,943 | 16,962 | +3,019 | 1.99 | 4.26 | +2.27 | buy |
| Jain Global LLC | 0 | 16,585 | +16,585 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 12,165 | 16,257 | +4,092 | 0.00 | 0.00 | -0.00 | buy |
| Spark Investment Management LLC | 0 | 15,000 | +15,000 | 0.00 | 0.14 | +0.14 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,705 | 14,230 | +3,525 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 21,027 | 13,911 | -7,116 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 15,991 | 12,745 | -3,246 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,952 | 12,497 | -455 | 0.01 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 12,852 | 11,853 | -999 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 11,585 | +11,585 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 13,620 | 11,123 | -2,497 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 10,555 | +10,555 | 0.00 | 0.00 | +0.00 | buy |
| Tyche Wealth Partners LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 5,631 | 6,882 | +1,251 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 9,485 | 5,237 | -4,248 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 5,121 | 5,121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 4,915 | +4,915 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,807 | 3,512 | -295 | 0.00 | 0.00 | -0.00 | sell |