| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 0 | 1,250,786 | +1,250,786 | 0.00 | 0.45 | +0.45 | buy |
| JANUS HENDERSON GROUP PLC | 3,163,992 | 3,763,195 | +599,203 | 0.03 | 0.02 | -0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 370,407 | +370,407 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 421,392 | 777,320 | +355,928 | 0.05 | 0.05 | -0.00 | buy |
| Blackstone Inc. | 805,757 | 1,158,617 | +352,860 | 0.06 | 0.05 | -0.01 | buy |
| Ikarian Capital, LLC | 0 | 257,216 | +257,216 | 0.00 | 0.72 | +0.72 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 296,612 | 553,247 | +256,635 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 0 | 250,583 | +250,583 | 0.00 | 0.54 | +0.54 | buy |
| MORGAN STANLEY | 0 | 241,828 | +241,828 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 629,919 | 864,711 | +234,792 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,558,611 | 2,723,363 | +164,752 | 0.04 | 0.03 | -0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 139,835 | +139,835 | 0.00 | 0.03 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 107,484 | +107,484 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 94,907 | 200,099 | +105,192 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 88,148 | +88,148 | 0.00 | 0.54 | +0.54 | buy |
| STATE STREET CORP | 196,272 | 253,946 | +57,674 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 1,300 | 57,166 | +55,866 | 0.00 | 0.09 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 26,853 | 76,751 | +49,898 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 38,785 | +38,785 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,861 | 63,874 | +33,013 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 19,153 | 50,210 | +31,057 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 30,725 | +30,725 | 0.00 | 0.02 | +0.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 30,346 | +30,346 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 22,101 | 51,892 | +29,791 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 824,074 | 851,961 | +27,887 | 0.13 | 0.07 | -0.06 | buy |
| PDT Partners, LLC | 0 | 26,608 | +26,608 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 31,806 | 47,983 | +16,177 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 11,545 | 23,105 | +11,560 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 10,278 | +10,278 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 840,000 | 850,000 | +10,000 | 1.00 | 0.61 | -0.40 | buy |
| JANE STREET GROUP, LLC | 26,759 | 35,677 | +8,918 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,881 | 12,869 | +7,988 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,420 | 14,223 | +7,803 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,357 | 21,070 | +7,713 | 0.00 | 0.00 | -0.00 | buy |
| Values First Advisors, Inc. | 0 | 7,446 | +7,446 | 0.00 | 0.04 | +0.04 | buy |
| Corebridge Financial, Inc. | 5,507 | 12,600 | +7,093 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,750 | 15,970 | +5,220 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,341 | 7,442 | +4,101 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,950 | 5,541 | +3,591 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,010 | 2,527 | +1,517 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,023 | 2,387 | +1,364 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 742 | 1,735 | +993 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 135 | 595 | +460 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,560 | 4,848 | +288 | 0.00 | 0.00 | -0.00 | buy |
| Avior Wealth Management, LLC | 0 | 174 | +174 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,597,736 | 2,597,736 | 0 | 0.08 | 0.04 | -0.04 | hold |
| LAZARD ASSET MANAGEMENT LLC | 33 | 33 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CAXTON CORP | 17,851 | 17,851 | 0 | 1.45 | 0.67 | -0.78 | hold |
| Arax Advisory Partners | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 2,355,904 | 2,355,904 | 0 | 28.00 | 13.31 | -14.69 | hold |
| D1 Capital Partners L.P. | 2,506,607 | 2,506,607 | 0 | 0.68 | 0.44 | -0.24 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,187 | 4,187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 623 | 623 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 16 | 0 | -16 | 0.00 | 0.00 | 0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,575 | 1,417 | -158 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 37,466 | 37,114 | -352 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 65,300 | 59,800 | -5,500 | 0.03 | 0.01 | -0.01 | sell |
| EntryPoint Capital, LLC | 10,542 | 0 | -10,542 | 0.08 | 0.00 | -0.08 | sell |
| FRANKLIN RESOURCES INC | 14,035 | 0 | -14,035 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 672,712 | 546,554 | -126,158 | 0.14 | 0.06 | -0.09 | sell |
| TUDOR INVESTMENT CORP ET AL | 132,187 | 0 | -132,187 | 0.02 | 0.00 | -0.02 | sell |
| Laurion Capital Management LP | 453,582 | 260,228 | -193,354 | 0.24 | 0.15 | -0.09 | sell |
| Novo Holdings A/S | 1,450,500 | 1,122,581 | -327,919 | 1.25 | 0.50 | -0.75 | sell |
| Artal Group S.A. | 603,435 | 0 | -603,435 | 0.25 | 0.00 | -0.25 | sell |
| BRAIDWELL LP | 1,382,481 | 728,777 | -653,704 | 0.70 | 0.19 | -0.51 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,369,147 | 1,855,986 | -1,513,161 | 0.93 | 0.29 | -0.64 | sell |