| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,763,195 | 4,339,254 | +576,059 | 0.02 | 0.01 | -0.00 | buy |
| Altium Capital Management LLC | 0 | 405,000 | +405,000 | 0.00 | 0.83 | +0.83 | buy |
| Point72 Asset Management, L.P. | 370,407 | 750,235 | +379,828 | 0.01 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 850,000 | 1,200,000 | +350,000 | 0.61 | 0.47 | -0.14 | buy |
| VANGUARD GROUP INC | 864,711 | 1,118,879 | +254,168 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 257,216 | 499,301 | +242,085 | 0.72 | 0.94 | +0.22 | buy |
| STATE STREET CORP | 253,946 | 457,403 | +203,457 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,630,287 | 1,821,966 | +191,679 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 250,583 | 393,083 | +142,500 | 0.54 | 0.66 | +0.12 | buy |
| Privium Fund Management B.V. | 0 | 138,115 | +138,115 | 0.00 | 0.21 | +0.21 | buy |
| Opaleye Management Inc. | 0 | 130,000 | +130,000 | 0.00 | 0.15 | +0.15 | buy |
| ADAR1 Capital Management, LLC | 57,166 | 169,505 | +112,339 | 0.09 | 0.23 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 37,114 | 141,951 | +104,837 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 65,000 | +65,000 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 61,930 | +61,930 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 52,616 | +52,616 | 0.00 | 0.30 | +0.30 | buy |
| UBS Group AG | 0 | 51,054 | +51,054 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 107,484 | 147,807 | +40,323 | 0.03 | 0.03 | +0.00 | buy |
| Aristides Capital LLC | 0 | 29,285 | +29,285 | 0.00 | 0.06 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,541 | 34,527 | +28,986 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 51,892 | 76,981 | +25,089 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 20,400 | +20,400 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 17,794 | +17,794 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 16,100 | +16,100 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 200,099 | 214,284 | +14,185 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 76,751 | 90,901 | +14,150 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 553,247 | 567,383 | +14,136 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 0 | 13,771 | +13,771 | 0.00 | 0.05 | +0.05 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 11,565 | +11,565 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 10,960 | +10,960 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,710 | +10,710 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 10,425 | +10,425 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,848 | 13,226 | +8,378 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 7,011 | +7,011 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 851,961 | 858,691 | +6,730 | 0.07 | 0.04 | -0.03 | buy |
| BARCLAYS PLC | 50,210 | 55,161 | +4,951 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 21,070 | 25,197 | +4,127 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,442 | 11,156 | +3,714 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 10,278 | 13,371 | +3,093 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 47,983 | 50,660 | +2,677 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 23,105 | 24,924 | +1,819 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 1,726 | +1,726 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 1,465 | +1,465 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 595 | 2,003 | +1,408 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,102 | +1,102 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 785 | +785 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,869 | 13,477 | +608 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 416 | +416 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 396 | +396 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 245 | +245 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,417 | 1,655 | +238 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 174 | 185 | +11 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,387 | 2,387 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,735 | 1,735 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 15,970 | 15,970 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 33 | 33 | 0 | 0.00 | 0.00 | 0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 139,835 | 139,835 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Sterling Capital Management LLC | 27 | 27 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 546,554 | 546,554 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Novo Holdings A/S | 1,122,581 | 1,122,581 | 0 | 0.50 | 0.45 | -0.06 | hold |
| CAXTON CORP | 17,851 | 17,851 | 0 | 0.67 | 0.71 | +0.04 | hold |
| Laurion Capital Management LP | 260,228 | 260,228 | 0 | 0.15 | 0.11 | -0.04 | hold |
| Blackstone Inc. | 1,158,617 | 1,158,617 | 0 | 0.05 | 0.04 | -0.01 | hold |
| CITADEL ADVISORS LLC | 2,723,363 | 2,723,363 | 0 | 0.03 | 0.02 | -0.01 | hold |
| MetLife Investment Management, LLC | 14,223 | 14,223 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 603,435 | 603,435 | 0 | 0.27 | 0.18 | -0.10 | hold |
| Legal & General Group Plc | 2,527 | 2,527 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,187 | 4,187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 63,874 | 63,874 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 623 | 623 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 12,600 | 11,715 | -885 | 0.00 | 0.00 | -0.00 | sell |
| Values First Advisors, Inc. | 7,446 | 0 | -7,446 | 0.04 | 0.00 | -0.04 | sell |
| PDT Partners, LLC | 26,608 | 0 | -26,608 | 0.02 | 0.00 | -0.02 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 30,346 | 0 | -30,346 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 30,725 | 0 | -30,725 | 0.02 | 0.00 | -0.02 | sell |
| JANE STREET GROUP, LLC | 35,677 | 0 | -35,677 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 38,785 | 0 | -38,785 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 59,800 | 0 | -59,800 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 777,320 | 709,900 | -67,420 | 0.05 | 0.02 | -0.02 | sell |
| Exome Asset Management LLC | 88,148 | 0 | -88,148 | 0.54 | 0.00 | -0.54 | sell |
| MORGAN STANLEY | 241,828 | 0 | -241,828 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,250,786 | 955,515 | -295,271 | 0.45 | 0.26 | -0.19 | sell |
| D1 Capital Partners L.P. | 2,506,607 | 2,203,900 | -302,707 | 0.44 | 0.24 | -0.20 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,597,736 | 2,209,615 | -388,121 | 0.04 | 0.03 | -0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,855,986 | 1,234,834 | -621,152 | 0.29 | 0.15 | -0.14 | sell |
| BRAIDWELL LP | 728,777 | 0 | -728,777 | 0.19 | 0.00 | -0.19 | sell |
| Omega Fund Management, LLC | 2,355,904 | 1,184,636 | -1,171,268 | 13.31 | 5.06 | -8.25 | sell |