| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,763,195 | 4,339,254 | +576,059 | 0.02 | 0.01 | 0.00 | buy |
| Vestal Point Capital, LP | 850,000 | 1,200,000 | +350,000 | 0.61 | 0.47 | -0.14 | buy |
| Ikarian Capital, LLC | 257,216 | 499,301 | +242,085 | 0.72 | 0.94 | +0.22 | buy |
| DAFNA Capital Management LLC | 250,583 | 393,083 | +142,500 | 0.54 | 0.66 | +0.12 | buy |
| ADAR1 Capital Management, LLC | 57,166 | 169,505 | +112,339 | 0.09 | 0.23 | +0.14 | buy |
| Woodline Partners LP | 851,961 | 858,691 | +6,730 | 0.07 | 0.04 | -0.03 | buy |
| Frazier Life Sciences Management, L.P. | 1,250,786 | 955,515 | -295,271 | 0.45 | 0.26 | -0.19 | sell |
| D1 Capital Partners L.P. | 2,506,607 | 2,203,900 | -302,707 | 0.44 | 0.24 | -0.20 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,597,736 | 2,209,615 | -388,121 | 0.04 | 0.03 | -0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,855,986 | 1,234,834 | -621,152 | 0.29 | 0.15 | -0.14 | sell |