| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 6,105,527 | 5,509,635 | -595,892 | 0.02 | 0.02 | +0.01 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 5,000,000 | +5,000,000 | 0.00 | 0.51 | +0.51 | buy |
| BlackRock, Inc. | 2,171,092 | 4,907,563 | +2,736,471 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 4,763,198 | +4,763,198 | 0.00 | 1.27 | +1.27 | buy |
| Vestal Point Capital, LP | 3,250,000 | 4,475,000 | +1,225,000 | 0.98 | 1.63 | +0.65 | buy |
| Frazier Life Sciences Management, L.P. | 4,424,725 | 4,424,725 | 0 | 0.88 | 1.18 | +0.30 | hold |
| VANGUARD GROUP INC | 2,226,290 | 3,894,310 | +1,668,020 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,719,043 | 3,774,317 | +55,274 | 0.02 | 0.03 | +0.01 | buy |
| Avoro Capital Advisors LLC | 0 | 3,300,000 | +3,300,000 | 0.00 | 0.32 | +0.32 | buy |
| Affinity Asset Advisors, LLC | 3,870,527 | 3,200,000 | -670,527 | 2.39 | 2.28 | -0.11 | sell |
| Woodline Partners LP | 2,572,162 | 3,197,760 | +625,598 | 0.08 | 0.12 | +0.04 | buy |
| STATE STREET CORP | 544,845 | 3,187,722 | +2,642,877 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 2,125,000 | +2,125,000 | 0.00 | 0.43 | +0.43 | buy |
| Point72 Asset Management, L.P. | 1,941,849 | 1,894,722 | -47,127 | 0.03 | 0.03 | +0.00 | sell |
| Octagon Capital Advisors LP | 0 | 1,725,000 | +1,725,000 | 0.00 | 2.14 | +2.14 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,913,788 | 1,635,026 | -2,278,762 | 0.05 | 0.03 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 721,881 | 1,445,887 | +724,006 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 1,531,953 | 1,393,161 | -138,792 | 1.01 | 1.03 | +0.03 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 1,250,000 | +1,250,000 | 0.00 | 0.31 | +0.31 | buy |
| 683 Capital Management, LLC | 922,662 | 1,120,000 | +197,338 | 0.56 | 0.92 | +0.37 | buy |
| Nantahala Capital Management, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.59 | +0.59 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,313,642 | 908,024 | -1,405,618 | 0.01 | 0.01 | -0.01 | sell |
| Blackstone Inc. | 1,124,922 | 904,959 | -219,963 | 0.03 | 0.04 | +0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 912,533 | 862,892 | -49,641 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 142,402 | 781,855 | +639,453 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 603,435 | 720,622 | +117,187 | 0.16 | 0.21 | +0.06 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 778,611 | 617,608 | -161,003 | 0.75 | 0.89 | +0.14 | sell |
| Ikarian Capital, LLC | 567,601 | 513,011 | -54,590 | 0.76 | 0.66 | -0.10 | sell |
| D. E. Shaw & Co., Inc. | 12,818 | 480,205 | +467,387 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 463,029 | +463,029 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 236,453 | 457,052 | +220,599 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 414,863 | 428,458 | +13,595 | 0.02 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 84,763 | 400,567 | +315,804 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 358,083 | 340,859 | -17,224 | 0.59 | 0.79 | +0.20 | sell |
| AQR CAPITAL MANAGEMENT LLC | 347,923 | 337,386 | -10,537 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 249,909 | 281,083 | +31,174 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 30,727 | 257,417 | +226,690 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 166,538 | 243,294 | +76,756 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 231,163 | +231,163 | 0.00 | 0.05 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 149,300 | 217,772 | +68,472 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 33,102 | 211,529 | +178,427 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 192,356 | 192,550 | +194 | 0.23 | 0.35 | +0.12 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 105,760 | 192,210 | +86,450 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 111,579 | 188,754 | +77,175 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 71,677 | 166,749 | +95,072 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 160,288 | +160,288 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 129,472 | 140,096 | +10,624 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 139,835 | 139,835 | 0 | 0.03 | 0.03 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 180,744 | 136,377 | -44,367 | 0.03 | 0.03 | +0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 133,257 | +133,257 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 125,000 | +125,000 | 0.00 | 0.08 | +0.08 | buy |
| Rafferty Asset Management, LLC | 0 | 102,159 | +102,159 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 92,608 | +92,608 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 83,230 | +83,230 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 81,300 | +81,300 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,262 | 70,736 | +51,474 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 31,764 | 69,369 | +37,605 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 68,491 | +68,491 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 29,370 | 61,810 | +32,440 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,322 | 57,166 | +32,844 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 50,909 | +50,909 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 36,154 | 45,988 | +9,834 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 38,054 | +38,054 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 37,009 | +37,009 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 35,721 | +35,721 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,453 | 35,257 | +23,804 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 34,297 | 34,297 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,965 | 33,872 | +21,907 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 32,898 | +32,898 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 14,359 | 29,861 | +15,502 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 27,230 | +27,230 | 0.00 | 0.07 | +0.07 | buy |
| WINTON GROUP Ltd | 0 | 26,900 | +26,900 | 0.00 | 0.01 | +0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 26,209 | +26,209 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 22,909 | 26,205 | +3,296 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 33,581 | 24,692 | -8,889 | 0.00 | 0.00 | +0.00 | sell |
| Cerity Partners LLC | 23,590 | 22,439 | -1,151 | 0.00 | 0.00 | +0.00 | sell |
| Pale Fire Capital SE | 33,650 | 22,302 | -11,348 | 0.02 | 0.03 | +0.00 | sell |
| OMERS ADMINISTRATION Corp | 0 | 20,900 | +20,900 | 0.00 | 0.00 | +0.00 | buy |
| Soltis Investment Advisors LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,187 | 19,887 | +15,700 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 19,147 | +19,147 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 18,864 | 18,953 | +89 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 18,640 | +18,640 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 16,595 | 16,436 | -159 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 6,040 | 16,373 | +10,333 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 16,025 | +16,025 | 0.00 | 0.08 | +0.08 | buy |
| CITIGROUP INC | 7,432 | 15,293 | +7,861 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 14,752 | +14,752 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 14,244 | 14,330 | +86 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 11,871 | 14,188 | +2,317 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 17,332 | 13,943 | -3,389 | 0.50 | 3.24 | +2.73 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,400 | 13,400 | -35,000 | 0.01 | 0.00 | -0.00 | sell |
| FMR LLC | 13,433 | 13,388 | -45 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 499 | 13,031 | +12,532 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 12,538 | +12,538 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,466 | 11,893 | +2,427 | 0.01 | 0.01 | +0.00 | buy |
| AlphaQuest LLC | 0 | 11,726 | +11,726 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,075 | 11,555 | +480 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 11,463 | +11,463 | 0.00 | 0.01 | +0.01 | buy |
| Ethic Inc. | 11,319 | 11,449 | +130 | 0.00 | 0.00 | +0.00 | buy |