| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 398,179 | 1,997,607 | +1,599,428 | 0.00 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,176,000 | 1,736,000 | +560,000 | 0.57 | 0.57 | +0.01 | buy |
| Laurion Capital Management LP | 2,232,040 | 2,506,152 | +274,112 | 2.64 | 1.73 | -0.90 | buy |
| Rhenman & Partners Asset Management AB | 263,071 | 416,371 | +153,300 | 0.88 | 1.06 | +0.18 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,339,971 | 1,469,971 | +130,000 | 5.76 | 5.17 | -0.59 | buy |
| Candriam S.C.A. | 801,904 | 857,037 | +55,133 | 0.11 | 0.10 | -0.01 | buy |
| Rock Springs Capital Management LP | 439,751 | 484,951 | +45,200 | 0.70 | 0.64 | -0.06 | buy |
| HighVista Strategies LLC | 46,778 | 86,085 | +39,307 | 0.35 | 0.53 | +0.18 | buy |
| DAFNA Capital Management LLC | 38,490 | 44,490 | +6,000 | 0.24 | 0.23 | -0.01 | buy |
| FNY Investment Advisers, LLC | 500 | 2,500 | +2,000 | 0.01 | 0.02 | +0.02 | buy |
| J.Safra Asset Management Corp | 250 | 206 | -44 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 70,189 | 69,580 | -609 | 0.06 | 0.05 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 14,044 | 13,130 | -914 | 0.03 | 0.02 | -0.01 | sell |
| Bellevue Group AG | 29,374 | 8,753 | -20,621 | 0.02 | 0.00 | -0.01 | sell |
| Nantahala Capital Management, LLC | 895,481 | 820,481 | -75,000 | 0.89 | 0.74 | -0.16 | sell |
| PFM Health Sciences, LP | 142,677 | 62,418 | -80,259 | 0.35 | 0.14 | -0.21 | sell |
| TimesSquare Capital Management, LLC | 338,798 | 235,858 | -102,940 | 100.00 | 93.59 | -6.41 | sell |
| 22NW, LP | 444,325 | 113,840 | -330,485 | 8.25 | 2.93 | -5.32 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,538,662 | 173,886 | -1,364,776 | 1.06 | 0.09 | -0.98 | sell |