| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Catalys Pacific, LLC | 7,903,838 | 7,903,838 | 0 | 92.81 | 92.94 | +0.13 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,692,750 | 7,692,750 | 0 | 2.21 | 1.80 | -0.40 | hold |
| BlackRock, Inc. | 4,481,582 | 5,887,038 | +1,405,456 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 5,871,018 | 5,871,018 | 0 | 15.45 | 13.01 | -2.44 | hold |
| FMR LLC | 4,861,104 | 4,511,689 | -349,415 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 2,935,940 | 4,141,636 | +1,205,696 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 3,958,000 | +3,958,000 | 0.00 | 1.11 | +1.11 | buy |
| Laurion Capital Management LP | 2,232,040 | 2,506,152 | +274,112 | 5.67 | 4.90 | -0.77 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,343,313 | 2,262,476 | +919,163 | 0.00 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,052,900 | 2,110,300 | +57,400 | 1.21 | 1.08 | -0.13 | buy |
| Capital World Investors | 398,179 | 1,997,607 | +1,599,428 | 0.00 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,176,000 | 1,736,000 | +560,000 | 1.05 | 1.30 | +0.24 | buy |
| Troluce Capital Advisors LLC | 655,000 | 1,728,753 | +1,073,753 | 1.88 | 17.47 | +15.59 | buy |
| FRANKLIN RESOURCES INC | 1,784,662 | 1,635,520 | -149,142 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,301,135 | 1,584,326 | +283,191 | 0.00 | 0.00 | +0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 1,563,966 | 1,563,966 | 0 | 4.63 | 4.06 | -0.57 | hold |
| BANK OF AMERICA CORP /DE/ | 1,100,372 | 1,505,547 | +405,175 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,339,971 | 1,469,971 | +130,000 | 6.24 | 5.68 | -0.57 | buy |
| GOLDMAN SACHS GROUP INC | 785,043 | 1,458,676 | +673,633 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,034,438 | 1,430,649 | +396,211 | 0.03 | 0.04 | +0.01 | buy |
| Polar Capital Holdings Plc | 1,500,749 | 1,420,854 | -79,895 | 0.18 | 0.11 | -0.07 | sell |
| MILLENNIUM MANAGEMENT LLC | 525,260 | 1,221,758 | +696,498 | 0.01 | 0.02 | +0.01 | buy |
| Ghisallo Capital Management LLC | 0 | 1,125,000 | +1,125,000 | 0.00 | 0.60 | +0.60 | buy |
| Invesco Ltd. | 42,311 | 1,091,180 | +1,048,869 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 975,961 | 1,067,541 | +91,580 | 0.01 | 0.01 | -0.00 | buy |
| Logos Global Management LP | 0 | 1,050,000 | +1,050,000 | 0.00 | 1.22 | +1.22 | buy |
| AMERICAN CENTURY COMPANIES INC | 884,107 | 1,036,767 | +152,660 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 849,184 | 917,213 | +68,029 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 801,904 | 857,037 | +55,133 | 0.11 | 0.10 | -0.01 | buy |
| Nantahala Capital Management, LLC | 895,481 | 820,481 | -75,000 | 1.51 | 1.34 | -0.18 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,359,068 | 806,716 | -2,552,352 | 0.02 | 0.00 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 750,000 | 750,000 | 0 | 1.19 | 0.99 | -0.20 | hold |
| TUDOR INVESTMENT CORP ET AL | 155,740 | 738,370 | +582,630 | 0.02 | 0.08 | +0.06 | buy |
| Aberdeen Group plc | 0 | 689,235 | +689,235 | 0.00 | 0.03 | +0.03 | buy |
| ALGERT GLOBAL LLC | 260,264 | 649,027 | +388,763 | 0.11 | 0.21 | +0.10 | buy |
| Catalio Capital Management, LP | 439,041 | 648,722 | +209,681 | 2.48 | 3.29 | +0.80 | buy |
| Pale Fire Capital SE | 365,626 | 614,284 | +248,658 | 0.87 | 1.18 | +0.31 | buy |
| STEMPOINT CAPITAL LP | 533,378 | 602,686 | +69,308 | 2.78 | 2.81 | +0.04 | buy |
| NORTHERN TRUST CORP | 442,874 | 551,491 | +108,617 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 521,216 | +521,216 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 443,898 | 521,216 | +77,318 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 439,751 | 484,951 | +45,200 | 0.70 | 0.64 | -0.06 | buy |
| CITADEL ADVISORS LLC | 600,041 | 467,598 | -132,443 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 137,433 | 463,387 | +325,954 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 750,000 | 450,000 | -300,000 | 1.08 | 0.50 | -0.58 | sell |
| Prosight Management, LP | 0 | 449,795 | +449,795 | 0.00 | 2.09 | +2.09 | buy |
| Rhenman & Partners Asset Management AB | 263,071 | 416,371 | +153,300 | 0.88 | 1.06 | +0.18 | buy |
| Caption Management, LLC | 0 | 413,087 | +413,087 | 0.00 | 0.39 | +0.39 | buy |
| JENNISON ASSOCIATES LLC | 1,266,174 | 382,747 | -883,427 | 0.02 | 0.01 | -0.02 | sell |
| Parkman Healthcare Partners LLC | 380,137 | 380,354 | +217 | 1.07 | 1.05 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 382,800 | 378,300 | -4,500 | 0.02 | 0.01 | -0.00 | sell |
| CenterBook Partners LP | 89,330 | 365,630 | +276,300 | 0.13 | 0.48 | +0.35 | buy |
| UBS Group AG | 98,029 | 361,596 | +263,567 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,770 | 355,570 | +339,800 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 887,192 | 352,729 | -534,463 | 0.02 | 0.01 | -0.01 | sell |
| Eversept Partners, LP | 0 | 309,689 | +309,689 | 0.00 | 0.46 | +0.46 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 130,592 | 307,214 | +176,622 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 154,686 | 298,886 | +144,200 | 0.25 | 0.38 | +0.13 | buy |
| Longaeva Partners L.P. | 0 | 281,104 | +281,104 | 0.00 | 0.22 | +0.22 | buy |
| Nuveen, LLC | 112,007 | 274,843 | +162,836 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 914,728 | 249,776 | -664,952 | 0.04 | 0.01 | -0.03 | sell |
| TimesSquare Capital Management, LLC | 338,798 | 235,858 | -102,940 | 0.16 | 0.09 | -0.06 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,538,662 | 173,886 | -1,364,776 | 1.13 | 0.10 | -1.03 | sell |
| Trexquant Investment LP | 57,200 | 169,715 | +112,515 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 311,488 | 162,082 | -149,406 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 129,964 | 158,550 | +28,586 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 90,929 | 153,722 | +62,793 | 0.02 | 0.06 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 149,086 | 152,504 | +3,418 | 0.00 | 0.00 | -0.00 | buy |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.20 | 0.15 | -0.06 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,001,728 | 147,402 | -854,326 | 0.63 | 0.07 | -0.55 | sell |
| Artia Global Partners LP | 137,800 | 137,800 | 0 | 0.84 | 0.71 | -0.13 | hold |
| Russell Investments Group, Ltd. | 203,504 | 128,129 | -75,375 | 0.01 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 216,089 | 125,991 | -90,098 | 0.01 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 112,190 | 118,382 | +6,192 | 0.01 | 0.01 | -0.00 | buy |
| 22NW, LP | 444,325 | 113,840 | -330,485 | 8.25 | 2.93 | -5.32 | sell |
| Swiss National Bank | 90,100 | 111,600 | +21,500 | 0.00 | 0.00 | +0.00 | buy |
| MARK ASSET MANAGEMENT LP | 144,875 | 101,289 | -43,586 | 0.52 | 0.28 | -0.24 | sell |
| ExodusPoint Capital Management, LP | 0 | 101,052 | +101,052 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 15,085 | 99,332 | +84,247 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 177,585 | 95,242 | -82,343 | 0.04 | 0.01 | -0.03 | sell |
| ALPS ADVISORS INC | 64,419 | 88,976 | +24,557 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 105,491 | 86,327 | -19,164 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 46,778 | 86,085 | +39,307 | 0.35 | 0.53 | +0.18 | buy |
| BlueCrest Capital Management Ltd | 0 | 85,157 | +85,157 | 0.00 | 0.10 | +0.10 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 79,537 | 79,199 | -338 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 94,358 | 78,186 | -16,172 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,138 | 73,265 | +9,127 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 57,444 | 70,205 | +12,761 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 70,189 | 69,580 | -609 | 0.06 | 0.05 | -0.01 | sell |
| HRT FINANCIAL LP | 95,920 | 68,565 | -27,355 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,266 | 67,221 | +5,955 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,081 | 66,057 | +39,976 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 142,677 | 62,418 | -80,259 | 0.41 | 0.15 | -0.26 | sell |
| BARCLAYS PLC | 33,877 | 61,190 | +27,313 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 225,833 | 60,963 | -164,870 | 0.01 | 0.00 | -0.01 | sell |
| Man Group plc | 10,139 | 59,640 | +49,501 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 59,242 | 59,242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 40,116 | 58,877 | +18,761 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 26,347 | 56,347 | +30,000 | 0.29 | 0.54 | +0.24 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 51,400 | 51,400 | 0 | 0.00 | 0.00 | -0.00 | hold |