| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 3,958,000 | +3,958,000 | 0.00 | 1.11 | +1.11 | buy |
| Capital World Investors | 398,179 | 1,997,607 | +1,599,428 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 4,481,582 | 5,887,038 | +1,405,456 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,935,940 | 4,141,636 | +1,205,696 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 1,125,000 | +1,125,000 | 0.00 | 0.60 | +0.60 | buy |
| Troluce Capital Advisors LLC | 655,000 | 1,728,753 | +1,073,753 | 1.88 | 17.47 | +15.59 | buy |
| Logos Global Management LP | 0 | 1,050,000 | +1,050,000 | 0.00 | 1.22 | +1.22 | buy |
| Invesco Ltd. | 42,311 | 1,091,180 | +1,048,869 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,343,313 | 2,262,476 | +919,163 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 525,260 | 1,221,758 | +696,498 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 0 | 689,235 | +689,235 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 785,043 | 1,458,676 | +673,633 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 155,740 | 738,370 | +582,630 | 0.02 | 0.08 | +0.06 | buy |
| ARMISTICE CAPITAL, LLC | 1,176,000 | 1,736,000 | +560,000 | 1.05 | 1.30 | +0.24 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 521,216 | +521,216 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 449,795 | +449,795 | 0.00 | 2.09 | +2.09 | buy |
| Caption Management, LLC | 0 | 413,087 | +413,087 | 0.00 | 0.39 | +0.39 | buy |
| BANK OF AMERICA CORP /DE/ | 1,100,372 | 1,505,547 | +405,175 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,034,438 | 1,430,649 | +396,211 | 0.03 | 0.04 | +0.01 | buy |
| ALGERT GLOBAL LLC | 260,264 | 649,027 | +388,763 | 0.11 | 0.21 | +0.10 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,770 | 355,570 | +339,800 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 137,433 | 463,387 | +325,954 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 309,689 | +309,689 | 0.00 | 0.46 | +0.46 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,301,135 | 1,584,326 | +283,191 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 281,104 | +281,104 | 0.00 | 0.22 | +0.22 | buy |
| CenterBook Partners LP | 89,330 | 365,630 | +276,300 | 0.13 | 0.48 | +0.35 | buy |
| Laurion Capital Management LP | 2,232,040 | 2,506,152 | +274,112 | 5.67 | 4.90 | -0.77 | buy |
| UBS Group AG | 98,029 | 361,596 | +263,567 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 365,626 | 614,284 | +248,658 | 0.87 | 1.18 | +0.31 | buy |
| Catalio Capital Management, LP | 439,041 | 648,722 | +209,681 | 2.48 | 3.29 | +0.80 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 130,592 | 307,214 | +176,622 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 112,007 | 274,843 | +162,836 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 263,071 | 416,371 | +153,300 | 0.88 | 1.06 | +0.18 | buy |
| AMERICAN CENTURY COMPANIES INC | 884,107 | 1,036,767 | +152,660 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 154,686 | 298,886 | +144,200 | 0.25 | 0.38 | +0.13 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,339,971 | 1,469,971 | +130,000 | 6.24 | 5.68 | -0.57 | buy |
| Trexquant Investment LP | 57,200 | 169,715 | +112,515 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 442,874 | 551,491 | +108,617 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 101,052 | +101,052 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 975,961 | 1,067,541 | +91,580 | 0.01 | 0.01 | -0.00 | buy |
| BlueCrest Capital Management Ltd | 0 | 85,157 | +85,157 | 0.00 | 0.10 | +0.10 | buy |
| CITIGROUP INC | 15,085 | 99,332 | +84,247 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 443,898 | 521,216 | +77,318 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 533,378 | 602,686 | +69,308 | 2.78 | 2.81 | +0.04 | buy |
| MORGAN STANLEY | 849,184 | 917,213 | +68,029 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 90,929 | 153,722 | +62,793 | 0.02 | 0.06 | +0.03 | buy |
| ORBIMED ADVISORS LLC | 2,052,900 | 2,110,300 | +57,400 | 1.21 | 1.08 | -0.13 | buy |
| Candriam S.C.A. | 801,904 | 857,037 | +55,133 | 0.11 | 0.10 | -0.01 | buy |
| Man Group plc | 10,139 | 59,640 | +49,501 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 439,751 | 484,951 | +45,200 | 0.70 | 0.64 | -0.06 | buy |
| WELLS FARGO & COMPANY/MN | 26,081 | 66,057 | +39,976 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 46,778 | 86,085 | +39,307 | 0.35 | 0.53 | +0.18 | buy |
| WINTON GROUP Ltd | 0 | 33,800 | +33,800 | 0.00 | 0.03 | +0.03 | buy |
| DIADEMA PARTNERS LP | 26,347 | 56,347 | +30,000 | 0.29 | 0.54 | +0.24 | buy |
| Bank of New York Mellon Corp | 129,964 | 158,550 | +28,586 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 33,877 | 61,190 | +27,313 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 25,471 | +25,471 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 64,419 | 88,976 | +24,557 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 90,100 | 111,600 | +21,500 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 40,116 | 58,877 | +18,761 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 19,562 | 35,979 | +16,417 | 0.02 | 0.03 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 15,413 | +15,413 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 14,100 | 27,200 | +13,100 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 57,444 | 70,205 | +12,761 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 12,678 | +12,678 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 18,549 | 30,337 | +11,788 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 0 | 10,052 | +10,052 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,138 | 73,265 | +9,127 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 20,541 | 29,629 | +9,088 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 8,987 | 18,000 | +9,013 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 8,886 | +8,886 | 0.00 | 0.01 | +0.01 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 7,633 | +7,633 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 26,826 | 33,755 | +6,929 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,389 | 13,853 | +6,464 | 0.06 | 0.09 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,185 | 35,510 | +6,325 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 112,190 | 118,382 | +6,192 | 0.01 | 0.01 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 6,077 | +6,077 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 38,490 | 44,490 | +6,000 | 0.24 | 0.23 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,266 | 67,221 | +5,955 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,411 | 32,007 | +5,596 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 5,239 | +5,239 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 24,301 | 29,215 | +4,914 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 10,180 | 15,020 | +4,840 | 0.01 | 0.02 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,364 | 20,164 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,683 | 16,927 | +4,244 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 149,086 | 152,504 | +3,418 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 12,542 | 15,357 | +2,815 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 10,000 | 12,616 | +2,616 | 0.05 | 0.05 | -0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 9,750 | 12,350 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 0 | 2,450 | +2,450 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 15,604 | 17,996 | +2,392 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 10,400 | 12,600 | +2,200 | 0.00 | 0.00 | -0.00 | buy |
| FNY Investment Advisers, LLC | 500 | 2,500 | +2,000 | 0.01 | 0.02 | +0.02 | buy |
| Ameritas Investment Partners, Inc. | 3,798 | 5,209 | +1,411 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,306 | +1,306 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 33,141 | 33,883 | +742 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 738 | +738 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 711 | +711 | 0.00 | 0.00 | +0.00 | buy |