| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 3,185,185 | +3,185,185 | 0.00 | 3.25 | +3.25 | buy |
| ORBIMED ADVISORS LLC | 0 | 2,021,424 | +2,021,424 | 0.00 | 0.48 | +0.48 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 3,178,476 | 4,850,984 | +1,672,508 | 0.43 | 0.80 | +0.37 | buy |
| Samsara BioCapital, LLC | 4,519,361 | 5,074,916 | +555,555 | 6.05 | 10.14 | +4.09 | buy |
| VR Adviser, LLC | 0 | 555,554 | +555,554 | 0.00 | 0.34 | +0.34 | buy |
| Octagon Capital Advisors LP | 0 | 550,000 | +550,000 | 0.00 | 0.86 | +0.86 | buy |
| Nantahala Capital Management, LLC | 0 | 332,506 | +332,506 | 0.00 | 0.42 | +0.42 | buy |
| Affinity Asset Advisors, LLC | 0 | 327,959 | +327,959 | 0.00 | 0.69 | +0.69 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 1,794,600 | 2,016,822 | +222,222 | 6.48 | 7.15 | +0.67 | buy |
| FRANKLIN RESOURCES INC | 699,467 | 907,511 | +208,044 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 1,156,068 | 1,304,216 | +148,148 | 0.36 | 0.47 | +0.11 | buy |
| DAFNA Capital Management LLC | 15,200 | 90,000 | +74,800 | 0.03 | 0.26 | +0.23 | buy |
| Lion Point Capital, LP | 0 | 60,000 | +60,000 | 0.00 | 1.48 | +1.48 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 56,944 | +56,944 | 0.00 | 0.21 | +0.21 | buy |
| ExodusPoint Capital Management, LP | 73,940 | 122,206 | +48,266 | 0.01 | 0.02 | +0.01 | buy |
| NEOS Investment Management LLC | 23,973 | 70,740 | +46,767 | 0.02 | 0.06 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 679,261 | 719,970 | +40,709 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 48,755 | 82,458 | +33,703 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 24,000 | +24,000 | 0.00 | 0.08 | +0.08 | buy |
| STATE STREET CORP | 282,084 | 305,686 | +23,602 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 14,992 | +14,992 | 0.00 | 0.03 | +0.03 | buy |
| Bellevue Group AG | 0 | 9,200 | +9,200 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 8,333 | +8,333 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 376,322 | 382,764 | +6,442 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,018 | 14,423 | +6,405 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 25,500 | 31,700 | +6,200 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 977,980 | 982,932 | +4,952 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,513 | 8,442 | +4,929 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 45,585 | 49,291 | +3,706 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,750 | 7,931 | +3,181 | 0.01 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 26,675 | 28,989 | +2,314 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 46,932 | 49,128 | +2,196 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 20,469 | 22,560 | +2,091 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 972 | 1,872 | +900 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 724 | 1,025 | +301 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,811 | 3,956 | +145 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 319 | 319 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 15,860 | 15,860 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 11,400 | 11,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 125,000 | 125,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 11,416 | 11,416 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 5,891 | 5,891 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 129 | 129 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 63 | 63 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CreativeOne Wealth, LLC | 10,750 | 10,750 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Avion Wealth | 78 | 78 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Wealth Management Group, LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Catalys Pacific, LLC | 9,194,579 | 9,194,579 | 0 | 74.13 | 80.13 | +6.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,238 | 1,238 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,682 | 1,682 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 690 | 690 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,872 | 120,862 | -10 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 9,656 | 9,573 | -83 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Middle East FZE | 135 | 0 | -135 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 159 | 22 | -137 | 0.00 | 0.00 | -0.00 | sell |
| Glassman Wealth Services | 372 | 0 | -372 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 11,222 | 10,501 | -721 | 0.06 | 0.07 | +0.01 | sell |
| STRS OHIO | 2,500 | 1,600 | -900 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,742 | 501 | -1,241 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,197 | 1,953 | -1,244 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 21,600 | 19,719 | -1,881 | 0.00 | 0.00 | +0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,122 | 2,211 | -1,911 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 6,652 | 4,632 | -2,020 | 0.05 | 0.05 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,879 | 295 | -2,584 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 149,780 | 146,121 | -3,659 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 23,563 | 18,738 | -4,825 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 5,779 | 17 | -5,762 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 34,743 | 28,915 | -5,828 | 0.05 | 0.05 | +0.01 | sell |
| SG Americas Securities, LLC | 10,093 | 0 | -10,093 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,514 | 0 | -11,514 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 26,774 | 13,661 | -13,113 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 535,518 | 522,009 | -13,509 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 13,912 | 0 | -13,912 | 0.01 | 0.00 | -0.01 | sell |
| FEDERATED HERMES, INC. | 20,032 | 6,000 | -14,032 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 17,397 | 2,823 | -14,574 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 20,500 | 0 | -20,500 | 0.01 | 0.00 | -0.01 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 22,209 | 0 | -22,209 | 0.03 | 0.00 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 206,265 | 183,297 | -22,968 | 0.02 | 0.02 | +0.00 | sell |
| Blue Owl Capital Holdings LP | 568,379 | 541,080 | -27,299 | 1.17 | 1.40 | +0.23 | sell |
| FMR LLC | 31,287 | 1,544 | -29,743 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 37,500 | 0 | -37,500 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 64,723 | 15,624 | -49,099 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 605,606 | 552,256 | -53,350 | 2.24 | 2.80 | +0.56 | sell |
| Walleye Capital LLC | 55,971 | 0 | -55,971 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 129,900 | 47,800 | -82,100 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 743,591 | 658,803 | -84,788 | 1.19 | 1.38 | +0.19 | sell |
| CITADEL ADVISORS LLC | 115,303 | 0 | -115,303 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 186,168 | 58,474 | -127,694 | 0.05 | 0.02 | -0.03 | sell |
| Woodline Partners LP | 175,000 | 0 | -175,000 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 380,759 | 37,340 | -343,419 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,167,492 | 792,615 | -374,877 | 0.25 | 0.26 | +0.01 | sell |
| ADAMS STREET PARTNERS LLC | 2,302,329 | 1,876,492 | -425,837 | 6.10 | 9.62 | +3.52 | sell |
| BRAIDWELL LP | 2,023,900 | 1,147,154 | -876,746 | 0.64 | 0.48 | -0.16 | sell |