| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Integral Health Asset Management, LLC | 875,000 | 2,300,000 | +1,425,000 | 0.95 | 4.05 | +3.09 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 4,850,984 | 6,147,280 | +1,296,296 | 0.79 | 1.63 | +0.84 | buy |
| Caligan Partners LP | 1,011,155 | 2,149,667 | +1,138,512 | 3.15 | 7.12 | +3.97 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 2,016,822 | 3,127,933 | +1,111,111 | 6.05 | 12.76 | +6.71 | buy |
| JENNISON ASSOCIATES LLC | 1,082,006 | 1,979,033 | +897,027 | 0.01 | 0.02 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 1,100,000 | +750,000 | 0.67 | 2.73 | +2.06 | buy |
| Samsara BioCapital, LLC | 5,074,916 | 5,674,916 | +600,000 | 8.57 | 16.07 | +7.49 | buy |
| Candriam S.C.A. | 305,272 | 882,833 | +577,561 | 0.02 | 0.09 | +0.07 | buy |
| Laurion Capital Management LP | 1,412,389 | 1,898,184 | +485,795 | 0.32 | 0.76 | +0.44 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 190,672 | 465,526 | +274,854 | 0.42 | 1.70 | +1.28 | buy |
| Pale Fire Capital SE | 136,897 | 399,498 | +262,601 | 0.39 | 0.76 | +0.37 | buy |
| Catalys Pacific, LLC | 8,644,579 | 8,903,838 | +259,259 | 91.82 | 95.08 | +3.26 | buy |
| DAFNA Capital Management LLC | 146,500 | 309,200 | +162,700 | 0.46 | 1.39 | +0.93 | buy |
| Nantahala Capital Management, LLC | 632,506 | 787,740 | +155,234 | 0.33 | 0.50 | +0.16 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 28,068 | 73,348 | +45,280 | 0.03 | 0.10 | 0.00 | buy |
| AlphaQuest LLC | 15,222 | 15,925 | +703 | 0.03 | 0.03 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,045 | 1,274 | +229 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 14,965 | 14,960 | -5 | 0.00 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,553 | 9,996 | -557 | 0.01 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 40,248 | 34,664 | -5,584 | 0.00 | 0.00 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 380,883 | 370,513 | -10,370 | 3.13 | 4.58 | +1.45 | sell |
| Polar Asset Management Partners Inc. | 99,100 | 20,130 | -78,970 | 0.01 | 0.01 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 841,541 | 263,425 | -578,116 | 2.14 | 0.80 | -1.33 | sell |