| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 1,667,759 | +1,667,759 | 0.00 | 1.07 | +1.07 | buy |
| Integral Health Asset Management, LLC | 875,000 | 2,300,000 | +1,425,000 | 0.95 | 4.05 | +3.09 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 4,850,984 | 6,147,280 | +1,296,296 | 0.79 | 1.63 | +0.84 | buy |
| Pictet Asset Management Holding SA | 0 | 1,214,373 | +1,214,373 | 0.00 | 0.02 | +0.02 | buy |
| Caligan Partners LP | 1,011,155 | 2,149,667 | +1,138,512 | 3.15 | 7.12 | +3.97 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 2,016,822 | 3,127,933 | +1,111,111 | 6.05 | 12.76 | +6.71 | buy |
| JENNISON ASSOCIATES LLC | 1,082,006 | 1,979,033 | +897,027 | 0.01 | 0.02 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 1,100,000 | +750,000 | 0.67 | 2.73 | +2.06 | buy |
| VANGUARD GROUP INC | 1,432,042 | 2,035,506 | +603,464 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 5,074,916 | 5,674,916 | +600,000 | 8.57 | 16.07 | +7.49 | buy |
| Candriam S.C.A. | 305,272 | 882,833 | +577,561 | 0.02 | 0.09 | +0.07 | buy |
| Laurion Capital Management LP | 1,412,389 | 1,898,184 | +485,795 | 1.08 | 2.32 | +1.24 | buy |
| D. E. Shaw & Co., Inc. | 0 | 478,430 | +478,430 | 0.00 | 0.01 | +0.01 | buy |
| 22NW, LP | 0 | 461,344 | +461,344 | 0.00 | 4.91 | +4.91 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 0 | 400,000 | +400,000 | 0.00 | 3.05 | +3.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 338,354 | +338,354 | 0.00 | 1.12 | +1.12 | buy |
| Swedbank AB | 0 | 327,700 | +327,700 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 0 | 320,813 | +320,813 | 0.00 | 0.29 | +0.29 | buy |
| BlackRock, Inc. | 2,138,522 | 2,450,027 | +311,505 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 308,310 | +308,310 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 293,928 | +293,928 | 0.00 | 0.55 | +0.55 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 279,500 | +279,500 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 190,672 | 465,526 | +274,854 | 0.43 | 1.82 | +1.39 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 650,023 | 923,403 | +273,380 | 0.24 | 0.51 | +0.27 | buy |
| DEUTSCHE BANK AG\ | 26,732 | 296,015 | +269,283 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 136,897 | 399,498 | +262,601 | 0.39 | 0.76 | +0.37 | buy |
| Catalys Pacific, LLC | 8,644,579 | 8,903,838 | +259,259 | 91.82 | 95.08 | +3.26 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 217,462 | +217,462 | 0.00 | 0.02 | +0.02 | buy |
| Blue Owl Capital Holdings LP | 0 | 206,296 | +206,296 | 0.00 | 1.06 | +1.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 200,000 | +200,000 | 0.00 | 0.18 | +0.18 | buy |
| GOLDMAN SACHS GROUP INC | 111,915 | 298,395 | +186,480 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 620,033 | 802,000 | +181,967 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 178,304 | +178,304 | 0.00 | 0.10 | +0.10 | buy |
| Informed Momentum Co LLC | 0 | 164,273 | +164,273 | 0.00 | 0.45 | +0.45 | buy |
| DAFNA Capital Management LLC | 146,500 | 309,200 | +162,700 | 0.46 | 1.39 | +0.93 | buy |
| Nantahala Capital Management, LLC | 632,506 | 787,740 | +155,234 | 0.54 | 1.03 | +0.49 | buy |
| Velan Capital Investment Management LP | 0 | 150,600 | +150,600 | 0.00 | 2.46 | +2.46 | buy |
| CITADEL ADVISORS LLC | 0 | 144,362 | +144,362 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 17,786 | 149,273 | +131,487 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 126,535 | +126,535 | 0.00 | 0.02 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 112,500 | +112,500 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 112,457 | +112,457 | 0.00 | 0.21 | +0.21 | buy |
| Quadrature Capital Ltd | 0 | 73,008 | +73,008 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 16,412 | 80,792 | +64,380 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 62,893 | +62,893 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 62,144 | +62,144 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 119,500 | 177,300 | +57,800 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,895 | 61,193 | +57,298 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 214,906 | 270,175 | +55,269 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 48,532 | +48,532 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 47,662 | +47,662 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 28,068 | 73,348 | +45,280 | 0.01 | 0.03 | +0.02 | buy |
| Erste Asset Management GmbH | 0 | 45,000 | +45,000 | 0.00 | 0.01 | +0.01 | buy |
| Jain Global LLC | 0 | 43,765 | +43,765 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 107,703 | 147,222 | +39,519 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 37,493 | +37,493 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 34,615 | +34,615 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,745,597 | 1,780,041 | +34,444 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 589,444 | 619,748 | +30,304 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 91,529 | 121,557 | +30,028 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 337 | 25,543 | +25,206 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 25,203 | +25,203 | 0.00 | 0.02 | +0.02 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 20,005 | +20,005 | 0.00 | 0.01 | +0.01 | buy |
| Greenland Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 246,113 | 265,056 | +18,943 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 18,245 | +18,245 | 0.00 | 0.12 | +0.12 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 16,058 | +16,058 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 504,533 | 520,180 | +15,647 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 15,288 | +15,288 | 0.00 | 0.02 | +0.02 | buy |
| Man Group plc | 0 | 14,559 | +14,559 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 14,219 | +14,219 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 13,785 | +13,785 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 13,494 | +13,494 | 0.00 | 0.06 | +0.06 | buy |
| Quantinno Capital Management LP | 0 | 12,738 | +12,738 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 12,704 | +12,704 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 11,175 | +11,175 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 10,375 | +10,375 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 10,254 | +10,254 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 7,800 | +7,800 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 7,000 | +7,000 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 23,714 | 26,883 | +3,169 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5,237 | 8,342 | +3,105 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 65,318 | 67,868 | +2,550 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 125,650 | 127,410 | +1,760 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 103 | 1,607 | +1,504 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 1,500 | +1,500 | 0.00 | 0.01 | +0.01 | buy |
| SBI Securities Co., Ltd. | 400 | 1,590 | +1,190 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 779 | +779 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 15,222 | 15,925 | +703 | 0.02 | 0.03 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,383 | 17,085 | +702 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,715 | 12,417 | +702 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 304,184 | 304,758 | +574 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 91 | 556 | +465 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 53 | 431 | +378 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 682 | 985 | +303 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,045 | 1,274 | +229 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,005 | 1,174 | +169 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 18 | 114 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Avion Wealth | 0 | 78 | +78 | 0.00 | 0.00 | 0.00 | buy |