| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 449,003 | 1,339,971 | +890,968 | 3.41 | 6.24 | +2.84 | buy |
| Nantahala Capital Management, LLC | 113,285 | 895,481 | +782,196 | 0.25 | 1.51 | +1.27 | buy |
| Laurion Capital Management LP | 1,713,485 | 2,232,040 | +518,555 | 4.24 | 5.67 | +1.43 | buy |
| ARMISTICE CAPITAL, LLC | 676,035 | 1,176,000 | +499,965 | 0.60 | 1.05 | +0.45 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 7,323,750 | 7,692,750 | +369,000 | 2.72 | 2.21 | -0.51 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 50,000 | 202,000 | +152,000 | 0.60 | 1.61 | +1.01 | buy |
| Candriam S.C.A. | 678,387 | 801,904 | +123,517 | 0.12 | 0.11 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 142,571 | 263,071 | +120,500 | 0.48 | 0.88 | +0.40 | buy |
| Polar Capital Holdings Plc | 1,401,141 | 1,500,749 | +99,608 | 0.23 | 0.18 | -0.05 | buy |
| PFM Health Sciences, LP | 47,637 | 142,677 | +95,040 | 0.18 | 0.41 | +0.23 | buy |
| 22NW, LP | 358,325 | 444,325 | +86,000 | 5.47 | 8.25 | +2.78 | buy |
| CenterBook Partners LP | 26,000 | 89,330 | +63,330 | 0.05 | 0.13 | +0.08 | buy |
| J. Goldman & Co LP | 47,288 | 94,101 | +46,813 | 0.07 | 0.12 | +0.05 | buy |
| Affinity Asset Advisors, LLC | 730,000 | 750,000 | +20,000 | 1.90 | 1.19 | -0.71 | buy |
| Rock Springs Capital Management LP | 427,596 | 439,751 | +12,155 | 0.80 | 0.70 | -0.09 | buy |
| Bellevue Group AG | 19,826 | 29,374 | +9,548 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 69,362 | 70,189 | +827 | 0.09 | 0.06 | -0.02 | buy |
| J.Safra Asset Management Corp | 81 | 250 | +169 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 31,625 | 31,618 | -7 | 0.92 | 0.74 | -0.18 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 14,526 | 12,670 | -1,856 | 0.08 | 0.05 | -0.03 | sell |
| Greenland Capital Management LP | 69,000 | 57,500 | -11,500 | 0.36 | 0.31 | -0.05 | sell |
| Parkman Healthcare Partners LLC | 410,249 | 380,137 | -30,112 | 1.42 | 1.07 | -0.35 | sell |
| TimesSquare Capital Management, LLC | 380,100 | 338,798 | -41,302 | 0.21 | 0.16 | -0.05 | sell |
| HighVista Strategies LLC | 124,544 | 46,778 | -77,766 | 1.16 | 0.35 | -0.81 | sell |
| Velan Capital Investment Management LP | 151,000 | 11,000 | -140,000 | 3.19 | 0.19 | -3.00 | sell |