| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Catalys Pacific, LLC | 7,903,838 | 7,903,838 | 0 | 92.37 | 92.81 | +0.44 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,323,750 | 7,692,750 | +369,000 | 2.72 | 2.21 | -0.51 | buy |
| Samsara BioCapital, LLC | 5,871,018 | 5,871,018 | 0 | 21.98 | 15.45 | -6.53 | hold |
| FMR LLC | 5,057,509 | 4,861,104 | -196,405 | 0.01 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 4,327,678 | 4,481,582 | +153,904 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 784,267 | 3,359,068 | +2,574,801 | 0.00 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 3,184,999 | 2,935,940 | -249,059 | 0.00 | 0.00 | -0.00 | sell |
| Caligan Partners LP | 2,772,654 | 2,772,654 | 0 | 9.21 | 5.31 | -3.90 | hold |
| Laurion Capital Management LP | 1,713,485 | 2,232,040 | +518,555 | 4.24 | 5.67 | +1.43 | buy |
| ORBIMED ADVISORS LLC | 980,400 | 2,052,900 | +1,072,500 | 0.73 | 1.21 | +0.48 | buy |
| Point72 Asset Management, L.P. | 1,207,220 | 1,911,433 | +704,213 | 0.07 | 0.09 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 1,788,747 | 1,784,662 | -4,085 | 0.02 | 0.01 | -0.00 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 1,563,966 | 1,563,966 | 0 | 8.03 | 4.63 | -3.41 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,538,662 | 1,538,662 | 0 | 1.39 | 1.13 | -0.26 | hold |
| Polar Capital Holdings Plc | 1,401,141 | 1,500,749 | +99,608 | 0.23 | 0.18 | -0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,325,120 | 1,343,313 | +18,193 | 0.01 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 449,003 | 1,339,971 | +890,968 | 3.41 | 6.24 | +2.84 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,257,582 | 1,301,135 | +43,553 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,258,653 | 1,266,174 | +7,521 | 0.03 | 0.02 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 676,035 | 1,176,000 | +499,965 | 0.60 | 1.05 | +0.45 | buy |
| BANK OF AMERICA CORP /DE/ | 987,280 | 1,100,372 | +113,092 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 852,883 | 1,034,438 | +181,555 | 0.03 | 0.03 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 992,082 | 1,001,728 | +9,646 | 0.92 | 0.63 | -0.30 | buy |
| ALLIANCEBERNSTEIN L.P. | 922,516 | 975,961 | +53,445 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 496,549 | 914,728 | +418,179 | 0.03 | 0.04 | +0.01 | buy |
| Nantahala Capital Management, LLC | 113,285 | 895,481 | +782,196 | 0.25 | 1.51 | +1.27 | buy |
| D. E. Shaw & Co., Inc. | 1,150,670 | 887,192 | -263,478 | 0.03 | 0.02 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 908,093 | 884,107 | -23,986 | 0.02 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 639,507 | 849,184 | +209,677 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 678,387 | 801,904 | +123,517 | 0.12 | 0.11 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,450,933 | 785,043 | -665,890 | 0.01 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 730,000 | 750,000 | +20,000 | 1.90 | 1.19 | -0.71 | buy |
| Integral Health Asset Management, LLC | 750,000 | 750,000 | 0 | 1.38 | 1.08 | -0.30 | hold |
| Troluce Capital Advisors LLC | 0 | 655,000 | +655,000 | 0.00 | 1.88 | +1.88 | buy |
| CITADEL ADVISORS LLC | 399,919 | 600,041 | +200,122 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 290,049 | 533,378 | +243,329 | 1.81 | 2.78 | +0.97 | buy |
| MILLENNIUM MANAGEMENT LLC | 78,625 | 525,260 | +446,635 | 0.00 | 0.01 | +0.01 | buy |
| 22NW, LP | 358,325 | 444,325 | +86,000 | 5.47 | 8.25 | +2.78 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461,300 | 443,898 | -17,402 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 299,863 | 442,874 | +143,011 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 427,596 | 439,751 | +12,155 | 0.80 | 0.70 | -0.09 | buy |
| Catalio Capital Management, LP | 331,849 | 439,041 | +107,192 | 2.13 | 2.48 | +0.36 | buy |
| Capital World Investors | 0 | 398,179 | +398,179 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 322,100 | 382,800 | +60,700 | 0.02 | 0.02 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 410,249 | 380,137 | -30,112 | 1.42 | 1.07 | -0.35 | sell |
| Pale Fire Capital SE | 10,354 | 365,626 | +355,272 | 0.05 | 0.87 | +0.82 | buy |
| TimesSquare Capital Management, LLC | 380,100 | 338,798 | -41,302 | 0.21 | 0.16 | -0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 610,403 | 311,488 | -298,915 | 0.03 | 0.01 | -0.03 | sell |
| LORD, ABBETT & CO. LLC | 312,396 | 300,913 | -11,483 | 0.03 | 0.03 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 142,571 | 263,071 | +120,500 | 0.48 | 0.88 | +0.40 | buy |
| ALGERT GLOBAL LLC | 47,500 | 260,264 | +212,764 | 0.03 | 0.11 | +0.08 | buy |
| SG Americas Securities, LLC | 230,795 | 225,833 | -4,962 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 46,246 | 221,305 | +175,059 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 112,672 | 216,089 | +103,417 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 175,361 | 203,504 | +28,143 | 0.01 | 0.01 | -0.00 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 50,000 | 202,000 | +152,000 | 0.60 | 1.61 | +1.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 200,000 | +200,000 | 0.00 | 0.16 | +0.16 | buy |
| Schonfeld Strategic Advisors LLC | 49,821 | 177,585 | +127,764 | 0.01 | 0.04 | +0.03 | buy |
| TUDOR INVESTMENT CORP ET AL | 39,046 | 155,740 | +116,694 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 136,231 | 154,686 | +18,455 | 0.37 | 0.25 | -0.12 | buy |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.36 | 0.20 | -0.16 | hold |
| AQR CAPITAL MANAGEMENT LLC | 62,300 | 149,086 | +86,786 | 0.00 | 0.00 | +0.00 | buy |
| MARK ASSET MANAGEMENT LP | 0 | 144,875 | +144,875 | 0.00 | 0.52 | +0.52 | buy |
| PFM Health Sciences, LP | 47,637 | 142,677 | +95,040 | 0.18 | 0.41 | +0.23 | buy |
| Artia Global Partners LP | 137,800 | 137,800 | 0 | 0.80 | 0.84 | +0.04 | hold |
| DIMENSIONAL FUND ADVISORS LP | 137,636 | 137,433 | -203 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 31,359 | 132,099 | +100,740 | 0.03 | 0.07 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 130,592 | 130,592 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 131,839 | 129,964 | -1,875 | 0.00 | 0.00 | -0.00 | sell |
| Swedbank AB | 221,400 | 122,100 | -99,300 | 0.01 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 112,190 | 112,190 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Nuveen, LLC | 122,947 | 112,007 | -10,940 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 246,804 | 105,491 | -141,313 | 0.02 | 0.01 | -0.01 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 659,076 | 104,961 | -554,115 | 2.12 | 0.24 | -1.88 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 102,202 | +102,202 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 201,280 | 98,029 | -103,251 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 37,236 | 95,920 | +58,684 | 0.00 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 83,840 | 95,122 | +11,282 | 0.02 | 0.02 | +0.01 | buy |
| Rafferty Asset Management, LLC | 127,917 | 94,358 | -33,559 | 0.02 | 0.01 | -0.01 | sell |
| J. Goldman & Co LP | 47,288 | 94,101 | +46,813 | 0.07 | 0.12 | +0.05 | buy |
| Brevan Howard Capital Management LP | 139,293 | 90,929 | -48,364 | 0.10 | 0.02 | -0.07 | sell |
| Swiss National Bank | 90,100 | 90,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CenterBook Partners LP | 26,000 | 89,330 | +63,330 | 0.05 | 0.13 | +0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,897 | 79,537 | +3,640 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 78,092 | 78,092 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Hennion & Walsh Asset Management, Inc. | 69,362 | 70,189 | +827 | 0.09 | 0.06 | -0.02 | buy |
| XTX Topco Ltd | 73,678 | 68,407 | -5,271 | 0.07 | 0.03 | -0.04 | sell |
| ALPS ADVISORS INC | 64,987 | 64,419 | -568 | 0.01 | 0.01 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,941 | 64,138 | +14,197 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,348 | 61,266 | +17,918 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 89,065 | 59,555 | -29,510 | 0.00 | 0.00 | -0.00 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 111,753 | 59,242 | -52,511 | 0.00 | 0.00 | -0.00 | sell |
| Greenland Capital Management LP | 69,000 | 57,500 | -11,500 | 0.36 | 0.31 | -0.05 | sell |
| RHUMBLINE ADVISERS | 54,284 | 57,444 | +3,160 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 112,788 | 57,200 | -55,588 | 0.04 | 0.01 | -0.03 | sell |
| JPMORGAN CHASE & CO | 46,683 | 51,922 | +5,239 | 0.00 | 0.00 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,600 | 51,400 | +21,800 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 275 | 46,835 | +46,560 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 124,544 | 46,778 | -77,766 | 1.16 | 0.35 | -0.81 | sell |
| Erste Asset Management GmbH | 45,000 | 45,000 | 0 | 0.01 | 0.01 | -0.00 | hold |