| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 784,267 | 3,359,068 | +2,574,801 | 0.00 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 980,400 | 2,052,900 | +1,072,500 | 0.73 | 1.21 | +0.48 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 449,003 | 1,339,971 | +890,968 | 3.41 | 6.24 | +2.84 | buy |
| Nantahala Capital Management, LLC | 113,285 | 895,481 | +782,196 | 0.25 | 1.51 | +1.27 | buy |
| Point72 Asset Management, L.P. | 1,207,220 | 1,911,433 | +704,213 | 0.07 | 0.09 | +0.02 | buy |
| Troluce Capital Advisors LLC | 0 | 655,000 | +655,000 | 0.00 | 1.88 | +1.88 | buy |
| Laurion Capital Management LP | 1,713,485 | 2,232,040 | +518,555 | 4.24 | 5.67 | +1.43 | buy |
| ARMISTICE CAPITAL, LLC | 676,035 | 1,176,000 | +499,965 | 0.60 | 1.05 | +0.45 | buy |
| MILLENNIUM MANAGEMENT LLC | 78,625 | 525,260 | +446,635 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 496,549 | 914,728 | +418,179 | 0.03 | 0.04 | +0.01 | buy |
| Capital World Investors | 0 | 398,179 | +398,179 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 7,323,750 | 7,692,750 | +369,000 | 2.72 | 2.21 | -0.51 | buy |
| Pale Fire Capital SE | 10,354 | 365,626 | +355,272 | 0.05 | 0.87 | +0.82 | buy |
| STEMPOINT CAPITAL LP | 290,049 | 533,378 | +243,329 | 1.81 | 2.78 | +0.97 | buy |
| ALGERT GLOBAL LLC | 47,500 | 260,264 | +212,764 | 0.03 | 0.11 | +0.08 | buy |
| MORGAN STANLEY | 639,507 | 849,184 | +209,677 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 399,919 | 600,041 | +200,122 | 0.01 | 0.01 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 200,000 | +200,000 | 0.00 | 0.16 | +0.16 | buy |
| Pictet Asset Management Holding SA | 852,883 | 1,034,438 | +181,555 | 0.03 | 0.03 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 46,246 | 221,305 | +175,059 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,327,678 | 4,481,582 | +153,904 | 0.00 | 0.00 | -0.00 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 50,000 | 202,000 | +152,000 | 0.60 | 1.61 | +1.01 | buy |
| MARK ASSET MANAGEMENT LP | 0 | 144,875 | +144,875 | 0.00 | 0.52 | +0.52 | buy |
| NORTHERN TRUST CORP | 299,863 | 442,874 | +143,011 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 49,821 | 177,585 | +127,764 | 0.01 | 0.04 | +0.03 | buy |
| Candriam S.C.A. | 678,387 | 801,904 | +123,517 | 0.12 | 0.11 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 142,571 | 263,071 | +120,500 | 0.48 | 0.88 | +0.40 | buy |
| TUDOR INVESTMENT CORP ET AL | 39,046 | 155,740 | +116,694 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 987,280 | 1,100,372 | +113,092 | 0.00 | 0.00 | -0.00 | buy |
| Catalio Capital Management, LP | 331,849 | 439,041 | +107,192 | 2.13 | 2.48 | +0.36 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 112,672 | 216,089 | +103,417 | 0.00 | 0.01 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 102,202 | +102,202 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 31,359 | 132,099 | +100,740 | 0.03 | 0.07 | +0.04 | buy |
| Polar Capital Holdings Plc | 1,401,141 | 1,500,749 | +99,608 | 0.23 | 0.18 | -0.05 | buy |
| PFM Health Sciences, LP | 47,637 | 142,677 | +95,040 | 0.18 | 0.41 | +0.23 | buy |
| AQR CAPITAL MANAGEMENT LLC | 62,300 | 149,086 | +86,786 | 0.00 | 0.00 | +0.00 | buy |
| 22NW, LP | 358,325 | 444,325 | +86,000 | 5.47 | 8.25 | +2.78 | buy |
| CenterBook Partners LP | 26,000 | 89,330 | +63,330 | 0.05 | 0.13 | +0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 322,100 | 382,800 | +60,700 | 0.02 | 0.02 | -0.00 | buy |
| HRT FINANCIAL LP | 37,236 | 95,920 | +58,684 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 922,516 | 975,961 | +53,445 | 0.01 | 0.01 | +0.00 | buy |
| J. Goldman & Co LP | 47,288 | 94,101 | +46,813 | 0.07 | 0.12 | +0.05 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 275 | 46,835 | +46,560 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,257,582 | 1,301,135 | +43,553 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 175,361 | 203,504 | +28,143 | 0.01 | 0.01 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,600 | 51,400 | +21,800 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 730,000 | 750,000 | +20,000 | 1.90 | 1.19 | -0.71 | buy |
| Magnetar Financial LLC | 0 | 18,549 | +18,549 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 136,231 | 154,686 | +18,455 | 0.37 | 0.25 | -0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,325,120 | 1,343,313 | +18,193 | 0.01 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,348 | 61,266 | +17,918 | 0.00 | 0.00 | +0.00 | buy |
| Eleva Capital SAS | 0 | 17,081 | +17,081 | 0.00 | 0.13 | +0.13 | buy |
| SIMPLEX TRADING, LLC | 4,802 | 19,562 | +14,760 | 0.00 | 0.02 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,941 | 64,138 | +14,197 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 29,141 | 42,311 | +13,170 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 24 | 12,237 | +12,213 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 427,596 | 439,751 | +12,155 | 0.80 | 0.70 | -0.09 | buy |
| E Fund Management Co., Ltd. | 0 | 11,862 | +11,862 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 83,840 | 95,122 | +11,282 | 0.02 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,181 | 26,411 | +10,230 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 10,139 | +10,139 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 9,675 | +9,675 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 992,082 | 1,001,728 | +9,646 | 0.92 | 0.63 | -0.30 | buy |
| Bellevue Group AG | 19,826 | 29,374 | +9,548 | 0.01 | 0.02 | +0.01 | buy |
| Persistent Asset Partners Ltd | 7,416 | 15,401 | +7,985 | 0.13 | 0.16 | +0.03 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 11,997 | 19,689 | +7,692 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,258,653 | 1,266,174 | +7,521 | 0.03 | 0.02 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 520 | 7,923 | +7,403 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 46,683 | 51,922 | +5,239 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,897 | 79,537 | +3,640 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 21,103 | 24,301 | +3,198 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 54,284 | 57,444 | +3,160 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 8,780 | 11,692 | +2,912 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 37,245 | 40,116 | +2,871 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,564 | 15,364 | +2,800 | 0.00 | 0.00 | -0.00 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 7,074 | 9,600 | +2,526 | 0.01 | 0.01 | -0.00 | buy |
| Quantinno Capital Management LP | 18,243 | 20,541 | +2,298 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,348 | 19,641 | +2,293 | 0.00 | 0.00 | -0.00 | buy |
| DIADEMA PARTNERS LP | 25,000 | 26,347 | +1,347 | 0.54 | 0.29 | -0.25 | buy |
| KBC Group NV | 0 | 1,233 | +1,233 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,896 | 14,044 | +1,148 | 0.04 | 0.03 | -0.01 | buy |
| CWM, LLC | 5,098 | 6,051 | +953 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 837 | +837 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 69,362 | 70,189 | +827 | 0.09 | 0.06 | -0.02 | buy |
| MetLife Investment Management, LLC | 26,005 | 26,826 | +821 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 9,600 | 10,400 | +800 | 0.00 | 0.00 | -0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 784 | +784 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 1,003 | 1,639 | +636 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 500 | +500 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 134 | 555 | +421 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,949 | 2,359 | +410 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 9,350 | 9,750 | +400 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,846 | 4,128 | +282 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 32,881 | 33,141 | +260 | 0.00 | 0.00 | -0.00 | buy |
| FIL Ltd | 0 | 229 | +229 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,555 | 1,777 | +222 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 81 | 302 | +221 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,209 | 7,389 | +180 | 0.07 | 0.06 | -0.02 | buy |