| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 0 | 745,758 | +745,758 | 0.00 | 2.04 | +2.04 | buy |
| JENNISON ASSOCIATES LLC | 0 | 683,257 | +683,257 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 907,511 | 1,482,591 | +575,080 | 0.00 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 424,183 | +424,183 | 0.00 | 0.15 | +0.15 | buy |
| FMR LLC | 1,544 | 271,095 | +269,551 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 982,932 | 1,219,062 | +236,130 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 332,506 | 532,506 | +200,000 | 0.42 | 0.63 | +0.21 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 382,764 | 582,326 | +199,562 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 305,686 | 465,139 | +159,453 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 1,304,216 | 1,456,804 | +152,588 | 0.47 | 0.56 | +0.09 | buy |
| ExodusPoint Capital Management, LP | 122,206 | 274,316 | +152,110 | 0.02 | 0.04 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,862 | 203,935 | +83,073 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 183,297 | 257,371 | +74,074 | 0.02 | 0.03 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 67,650 | +67,650 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 550,000 | 600,000 | +50,000 | 0.86 | 1.16 | +0.30 | buy |
| Bank of New York Mellon Corp | 49,128 | 84,762 | +35,634 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 31,700 | 61,800 | +30,100 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 82,458 | 111,535 | +29,077 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 90,000 | 119,000 | +29,000 | 0.26 | 0.33 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 37,340 | 65,538 | +28,198 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 719,970 | 743,140 | +23,170 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 146,121 | 167,801 | +21,680 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 20,953 | +20,953 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 60,000 | 79,000 | +19,000 | 1.48 | 2.89 | +1.41 | buy |
| RHUMBLINE ADVISERS | 22,560 | 41,079 | +18,519 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 13,034 | +13,034 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 12,432 | +12,432 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 28,989 | 38,735 | +9,746 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 9,200 | 17,499 | +8,299 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 49,291 | 56,823 | +7,532 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 15,860 | 22,960 | +7,100 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 6,000 | 12,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 28,915 | 34,888 | +5,973 | 0.05 | 0.05 | -0.01 | buy |
| MetLife Investment Management, LLC | 11,416 | 17,124 | +5,708 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,423 | 19,691 | +5,268 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,956 | 7,759 | +3,803 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 4,632 | 7,956 | +3,324 | 0.05 | 0.04 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 8,333 | 11,632 | +3,299 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 295 | 3,371 | +3,076 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,600 | 3,800 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 70,740 | 72,813 | +2,073 | 0.06 | 0.04 | -0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,482 | +1,482 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 58,474 | 59,931 | +1,457 | 0.02 | 0.02 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 24,000 | 25,366 | +1,366 | 0.08 | 0.06 | -0.02 | buy |
| Ameritas Investment Partners, Inc. | 1,872 | 2,798 | +926 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,682 | 2,582 | +900 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,624 | 16,134 | +510 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 357 | +357 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 501 | 682 | +181 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 133 | +133 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,953 | 2,069 | +116 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 4 | 66 | +62 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,021,424 | 2,021,424 | 0 | 0.48 | 0.47 | -0.01 | hold |
| MassMutual Private Wealth & Trust, FSB | 319 | 319 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 11,400 | 11,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,850,984 | 4,850,984 | 0 | 0.80 | 0.75 | -0.05 | hold |
| Ensign Peak Advisors, Inc | 125,000 | 125,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 152 | 152 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 129 | 129 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 63 | 63 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CreativeOne Wealth, LLC | 10,750 | 10,750 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Samsara BioCapital, LLC | 5,074,916 | 5,074,916 | 0 | 10.14 | 12.43 | +2.29 | hold |
| Affinity Asset Advisors, LLC | 327,959 | 327,959 | 0 | 0.69 | 0.60 | -0.08 | hold |
| Avion Wealth | 78 | 78 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TCG Crossover Management, LLC | 3,185,185 | 3,185,185 | 0 | 3.25 | 3.88 | +0.63 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 2,016,822 | 2,016,822 | 0 | 7.15 | 7.39 | +0.24 | hold |
| Farther Finance Advisors, LLC | 17 | 17 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalys Pacific, LLC | 9,194,579 | 9,194,579 | 0 | 80.13 | 81.19 | +1.06 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,211 | 2,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 5,891 | 5,885 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 17 | 0 | -17 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 36 | 0 | -36 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 690 | 644 | -46 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,442 | 7,764 | -678 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,025 | 0 | -1,025 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,238 | 0 | -1,238 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,931 | 5,832 | -2,099 | 0.01 | 0.01 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 2,823 | 0 | -2,823 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 10,501 | 7,134 | -3,367 | 0.07 | 0.04 | -0.03 | sell |
| BARCLAYS PLC | 13,661 | 10,010 | -3,651 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 19,719 | 10,787 | -8,932 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 9,573 | 0 | -9,573 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,992 | 0 | -14,992 | 0.03 | 0.00 | -0.03 | sell |
| JPMORGAN CHASE & CO | 18,738 | 0 | -18,738 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 47,800 | 0 | -47,800 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 522,009 | 471,524 | -50,485 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 56,944 | 0 | -56,944 | 0.21 | 0.00 | -0.21 | sell |
| Blue Owl Capital Holdings LP | 541,080 | 450,339 | -90,741 | 1.40 | 1.47 | +0.07 | sell |
| SECTORAL ASSET MANAGEMENT INC | 552,256 | 438,748 | -113,508 | 2.80 | 2.09 | -0.72 | sell |
| ADAMS STREET PARTNERS LLC | 1,876,492 | 1,688,712 | -187,780 | 9.62 | 8.14 | -1.48 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 658,803 | 442,752 | -216,051 | 1.38 | 0.84 | -0.53 | sell |
| Rock Springs Capital Management LP | 792,615 | 378,932 | -413,683 | 0.26 | 0.13 | -0.13 | sell |
| VR Adviser, LLC | 555,554 | 0 | -555,554 | 0.34 | 0.00 | -0.34 | sell |
| BRAIDWELL LP | 1,147,154 | 0 | -1,147,154 | 0.48 | 0.00 | -0.48 | sell |