| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Integral Health Asset Management, LLC | 2,300,000 | 2,700,000 | +400,000 | 4.05 | 3.41 | -0.63 | buy |
| Parkman Healthcare Partners LLC | 293,928 | 463,601 | +169,673 | 0.55 | 0.73 | +0.17 | buy |
| Susquehanna Portfolio Strategies, LLC | 18,245 | 161,134 | +142,889 | 0.12 | 0.05 | -0.08 | buy |
| Blue Owl Capital Holdings LP | 206,296 | 335,944 | +129,648 | 1.06 | 1.47 | +0.41 | buy |
| 22NW, LP | 461,344 | 560,042 | +98,698 | 4.91 | 4.77 | -0.14 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,667,759 | 1,744,492 | +76,733 | 0.98 | 0.71 | -0.27 | buy |
| DAFNA Capital Management LLC | 309,200 | 371,523 | +62,323 | 1.39 | 1.39 | -0.00 | buy |
| Swedbank AB | 327,700 | 383,800 | +56,100 | 0.01 | 0.01 | -0.00 | buy |
| Pale Fire Capital SE | 399,498 | 446,626 | +47,128 | 0.76 | 0.63 | -0.13 | buy |
| Woodline Partners LP | 47,662 | 87,868 | +40,206 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 263,425 | 302,125 | +38,700 | 0.80 | 0.66 | -0.14 | buy |
| Velan Capital Investment Management LP | 150,600 | 174,600 | +24,000 | 2.46 | 2.36 | -0.10 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 465,526 | 480,974 | +15,448 | 1.70 | 1.53 | -0.18 | buy |
| SECTORAL ASSET MANAGEMENT INC | 370,513 | 382,415 | +11,902 | 4.58 | 3.42 | -1.16 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 73,348 | 79,723 | +6,375 | 0.10 | 0.06 | 0.00 | buy |
| Rock Springs Capital Management LP | 320,813 | 324,513 | +3,700 | 0.29 | 0.27 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 9,996 | 13,090 | +3,094 | 0.01 | 0.02 | +0.00 | buy |
| Cinctive Capital Management LP | 14,219 | 16,113 | +1,894 | 0.02 | 0.01 | -0.01 | buy |
| Bellevue Group AG | 16,499 | 15,556 | -943 | 0.01 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 13,494 | 6,302 | -7,192 | 0.06 | 0.03 | -0.03 | sell |
| Greenland Capital Management LP | 20,000 | 10,000 | -10,000 | 0.05 | 0.02 | -0.04 | sell |
| Candriam S.C.A. | 882,833 | 824,187 | -58,646 | 0.09 | 0.06 | -0.02 | sell |
| Quadrature Capital Ltd | 73,008 | 11,987 | -61,021 | 0.03 | 0.00 | -0.02 | sell |
| J. Goldman & Co LP | 178,304 | 57,635 | -120,669 | 0.07 | 0.02 | -0.05 | sell |
| Caligan Partners LP | 2,149,667 | 2,017,352 | -132,315 | 7.12 | 5.30 | -1.82 | sell |
| Laurion Capital Management LP | 1,898,184 | 1,762,582 | -135,602 | 0.76 | 0.43 | -0.33 | sell |
| Affinity Asset Advisors, LLC | 1,100,000 | 900,000 | -200,000 | 2.73 | 1.80 | -0.93 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 338,354 | 115,282 | -223,072 | 1.12 | 0.32 | -0.80 | sell |
| Nantahala Capital Management, LLC | 787,740 | 353,982 | -433,758 | 0.50 | 0.19 | -0.31 | sell |
| JENNISON ASSOCIATES LLC | 1,979,033 | 1,235,322 | -743,711 | 0.02 | 0.01 | -0.01 | sell |