| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Catalys Pacific, LLC | 8,903,838 | 8,903,838 | 0 | 95.08 | 91.50 | -3.58 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,147,280 | 6,147,280 | 0 | 1.63 | 1.40 | -0.23 | hold |
| Samsara BioCapital, LLC | 5,674,916 | 5,674,916 | 0 | 16.07 | 15.70 | -0.37 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 3,127,933 | 3,127,933 | 0 | 12.76 | 9.17 | -3.59 | hold |
| BlackRock, Inc. | 2,450,027 | 3,097,760 | +647,733 | 0.00 | 0.00 | -0.00 | buy |
| Capital International Investors | 0 | 2,899,020 | +2,899,020 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 2,300,000 | 2,700,000 | +400,000 | 4.05 | 3.41 | -0.63 | buy |
| VANGUARD GROUP INC | 2,035,506 | 2,326,449 | +290,943 | 0.00 | 0.00 | -0.00 | buy |
| Caligan Partners LP | 2,149,667 | 2,017,352 | -132,315 | 7.12 | 5.30 | -1.82 | sell |
| FRANKLIN RESOURCES INC | 1,780,041 | 1,803,597 | +23,556 | 0.01 | 0.01 | -0.00 | buy |
| Laurion Capital Management LP | 1,898,184 | 1,762,582 | -135,602 | 2.32 | 2.75 | +0.43 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,667,759 | 1,744,492 | +76,733 | 1.07 | 0.89 | -0.18 | buy |
| STATE STREET CORP | 520,180 | 1,443,559 | +923,379 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,214,373 | 1,267,993 | +53,620 | 0.02 | 0.02 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,979,033 | 1,235,322 | -743,711 | 0.02 | 0.01 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 802,000 | 954,560 | +152,560 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 1,100,000 | 900,000 | -200,000 | 2.73 | 1.80 | -0.93 | sell |
| AMERICAN CENTURY COMPANIES INC | 823,616 | 834,781 | +11,165 | 0.01 | 0.01 | -0.00 | buy |
| Candriam S.C.A. | 882,833 | 824,187 | -58,646 | 0.09 | 0.06 | -0.02 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 923,403 | 816,926 | -106,477 | 0.51 | 0.34 | -0.17 | sell |
| ORBIMED ADVISORS LLC | 0 | 760,351 | +760,351 | 0.00 | 0.26 | +0.26 | buy |
| STEMPOINT CAPITAL LP | 0 | 631,586 | +631,586 | 0.00 | 2.75 | +2.75 | buy |
| GOLDMAN SACHS GROUP INC | 298,395 | 626,787 | +328,392 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 619,748 | 587,830 | -31,918 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 478,430 | 574,207 | +95,777 | 0.01 | 0.01 | -0.00 | buy |
| 22NW, LP | 461,344 | 560,042 | +98,698 | 4.91 | 4.77 | -0.14 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 465,526 | 480,974 | +15,448 | 1.82 | 1.70 | -0.12 | buy |
| Parkman Healthcare Partners LLC | 293,928 | 463,601 | +169,673 | 0.55 | 0.73 | +0.17 | buy |
| DEUTSCHE BANK AG\ | 296,015 | 456,914 | +160,899 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 399,498 | 446,626 | +47,128 | 0.76 | 0.63 | -0.13 | buy |
| Swedbank AB | 327,700 | 383,800 | +56,100 | 0.01 | 0.01 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 370,513 | 382,415 | +11,902 | 4.58 | 3.42 | -1.16 | buy |
| DAFNA Capital Management LLC | 309,200 | 371,523 | +62,323 | 1.39 | 1.39 | -0.00 | buy |
| Nantahala Capital Management, LLC | 787,740 | 353,982 | -433,758 | 1.03 | 0.34 | -0.70 | sell |
| PRUDENTIAL FINANCIAL INC | 127,410 | 352,225 | +224,815 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 351,113 | +351,113 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 265,056 | 339,025 | +73,969 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 206,296 | 335,944 | +129,648 | 1.06 | 1.47 | +0.41 | buy |
| Rock Springs Capital Management LP | 320,813 | 324,513 | +3,700 | 0.29 | 0.27 | -0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 270,175 | 324,205 | +54,030 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 304,758 | 304,886 | +128 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 263,425 | 302,125 | +38,700 | 0.80 | 0.66 | -0.14 | buy |
| BANK OF AMERICA CORP /DE/ | 147,222 | 263,356 | +116,134 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 217,462 | 253,199 | +35,737 | 0.02 | 0.03 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 424,691 | 243,569 | -181,122 | 0.01 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 149,273 | 205,723 | +56,450 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.18 | 0.14 | -0.04 | hold |
| DIMENSIONAL FUND ADVISORS LP | 80,792 | 187,384 | +106,592 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 126,535 | 182,665 | +56,130 | 0.02 | 0.03 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 178,000 | +178,000 | 0.00 | 0.09 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 177,300 | 176,926 | -374 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 150,600 | 174,600 | +24,000 | 2.46 | 2.36 | -0.10 | buy |
| ExodusPoint Capital Management, LP | 0 | 172,552 | +172,552 | 0.00 | 0.03 | +0.03 | buy |
| Zimmer Partners, LP | 0 | 162,733 | +162,733 | 0.00 | 0.05 | +0.05 | buy |
| Susquehanna Portfolio Strategies, LLC | 18,245 | 161,134 | +142,889 | 0.12 | 0.05 | -0.08 | buy |
| HighVista Strategies LLC | 0 | 150,138 | +150,138 | 0.00 | 0.75 | +0.75 | buy |
| BARCLAYS PLC | 32,900 | 143,884 | +110,984 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 20,005 | 126,726 | +106,721 | 0.01 | 0.07 | +0.05 | buy |
| SG Americas Securities, LLC | 10,457 | 123,987 | +113,530 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 121,557 | 115,448 | -6,109 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 338,354 | 115,282 | -223,072 | 1.12 | 0.32 | -0.80 | sell |
| UBS Group AG | 37,161 | 115,139 | +77,978 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 37,493 | 107,640 | +70,147 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 67,868 | 96,415 | +28,547 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 47,662 | 87,868 | +40,206 | 0.00 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 73,348 | 79,723 | +6,375 | 0.03 | 0.03 | +0.00 | buy |
| Lion Point Capital, LP | 79,000 | 79,000 | 0 | 8.00 | 7.26 | -0.75 | hold |
| Nuveen, LLC | 67,877 | 77,647 | +9,770 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 73,921 | +73,921 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 61,900 | +61,900 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 178,304 | 57,635 | -120,669 | 0.10 | 0.02 | -0.08 | sell |
| Rafferty Asset Management, LLC | 0 | 57,375 | +57,375 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,144 | 56,086 | -6,058 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 39,361 | 53,596 | +14,235 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 50,857 | +50,857 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,058 | 50,476 | +34,418 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 15,288 | 48,401 | +33,113 | 0.02 | 0.05 | +0.02 | buy |
| Erste Asset Management GmbH | 45,000 | 45,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Artia Global Partners LP | 0 | 41,100 | +41,100 | 0.00 | 0.14 | +0.14 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,069 | 36,592 | +34,523 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,582 | 36,049 | +33,467 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 33,000 | +33,000 | 0.00 | 0.04 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 26,883 | 31,757 | +4,874 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 31,095 | +31,095 | 0.00 | 0.02 | +0.02 | buy |
| Mariner, LLC | 0 | 28,704 | +28,704 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 34,615 | 27,901 | -6,714 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 20,993 | 27,118 | +6,125 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 22,997 | 27,067 | +4,070 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 308,310 | 25,743 | -282,567 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 20,554 | 25,500 | +4,946 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 24,861 | +24,861 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,254 | 24,551 | +14,297 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7,800 | 24,404 | +16,604 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,085 | 24,237 | +7,152 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,782 | 24,014 | +7,232 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 22,874 | +22,874 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 14,559 | 21,852 | +7,293 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 21,629 | +21,629 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 21,280 | +21,280 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,417 | 19,568 | +7,151 | 0.00 | 0.00 | +0.00 | buy |