| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Catalys Pacific, LLC | 9,194,579 | 8,644,579 | -550,000 | 81.19 | 83.48 | +2.29 | sell |
| Samsara BioCapital, LLC | 5,074,916 | 5,074,916 | 0 | 12.43 | 11.81 | -0.61 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,850,984 | 4,850,984 | 0 | 0.75 | 0.68 | -0.07 | hold |
| TCG Crossover Management, LLC | 3,185,185 | 2,470,265 | -714,920 | 3.88 | 2.53 | -1.35 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 2,016,822 | 2,016,822 | 0 | 7.39 | 4.90 | -2.49 | hold |
| ORBIMED ADVISORS LLC | 2,021,424 | 2,002,939 | -18,485 | 0.47 | 0.44 | -0.03 | sell |
| FRANKLIN RESOURCES INC | 1,482,591 | 1,745,513 | +262,922 | 0.01 | 0.01 | +0.00 | buy |
| ADAMS STREET PARTNERS LLC | 1,688,712 | 1,532,654 | -156,058 | 8.14 | 10.21 | +2.07 | sell |
| Laurion Capital Management LP | 1,456,804 | 1,412,389 | -44,415 | 0.56 | 1.10 | +0.54 | sell |
| VANGUARD GROUP INC | 1,219,062 | 1,363,231 | +144,169 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 745,758 | 981,155 | +235,397 | 2.04 | 3.77 | +1.73 | buy |
| AMERICAN CENTURY COMPANIES INC | 743,140 | 931,650 | +188,510 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 25,366 | 729,401 | +704,035 | 0.06 | 1.48 | +1.42 | buy |
| JENNISON ASSOCIATES LLC | 683,257 | 696,280 | +13,023 | 0.01 | 0.01 | +0.00 | buy |
| Nantahala Capital Management, LLC | 532,506 | 632,506 | +100,000 | 0.63 | 0.64 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 582,326 | 620,853 | +38,527 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 424,183 | 605,956 | +181,773 | 0.15 | 0.22 | +0.07 | buy |
| Octagon Capital Advisors LP | 600,000 | 600,000 | 0 | 1.16 | 1.16 | +0.00 | hold |
| MORGAN STANLEY | 471,524 | 515,813 | +44,289 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 465,139 | 483,766 | +18,627 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 356,000 | +356,000 | 0.00 | 0.51 | +0.51 | buy |
| Affinity Asset Advisors, LLC | 327,959 | 350,000 | +22,041 | 0.60 | 0.66 | +0.05 | buy |
| SECTORAL ASSET MANAGEMENT INC | 438,748 | 329,513 | -109,235 | 2.09 | 2.36 | +0.27 | sell |
| FMR LLC | 271,095 | 303,758 | +32,663 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 442,752 | 272,472 | -170,280 | 0.84 | 0.54 | -0.30 | sell |
| NORTHERN TRUST CORP | 167,801 | 244,425 | +76,624 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 203,935 | 213,599 | +9,664 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 450,339 | 196,132 | -254,207 | 1.47 | 0.46 | -1.00 | sell |
| Ikarian Capital, LLC | 0 | 180,000 | +180,000 | 0.00 | 0.68 | +0.68 | buy |
| DAFNA Capital Management LLC | 119,000 | 146,500 | +27,500 | 0.33 | 0.42 | +0.09 | buy |
| Pale Fire Capital SE | 34,888 | 136,897 | +102,009 | 0.05 | 0.26 | +0.21 | buy |
| Ensign Peak Advisors, Inc | 125,000 | 125,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEOS Investment Management LLC | 72,813 | 123,498 | +50,685 | 0.04 | 0.05 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 61,800 | 103,800 | +42,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 65,538 | 98,733 | +33,195 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 111,535 | 96,154 | -15,381 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 56,823 | 89,451 | +32,628 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 79,000 | 79,000 | 0 | 2.89 | 3.84 | +0.94 | hold |
| PRUDENTIAL FINANCIAL INC | 67,650 | 67,650 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 63,998 | +63,998 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 84,762 | 63,607 | -21,155 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 0 | 40,500 | +40,500 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 41,079 | 39,861 | -1,218 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 38,735 | 38,264 | -471 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 10,010 | 38,218 | +28,208 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 59,931 | 31,068 | -28,863 | 0.02 | 0.01 | -0.01 | sell |
| Verition Fund Management LLC | 20,953 | 27,361 | +6,408 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 3,800 | 26,900 | +23,100 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 22,960 | 22,960 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 7,759 | 21,973 | +14,214 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 21,416 | +21,416 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 20,505 | +20,505 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,691 | 19,912 | +221 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 17,124 | 17,124 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 12,000 | 16,848 | +4,848 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 17,499 | 16,499 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 11,632 | 16,468 | +4,836 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 10,787 | 16,100 | +5,313 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,762 | 15,699 | +5,937 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 15,362 | 15,268 | -94 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 14,965 | +14,965 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 12,238 | +12,238 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,432 | 12,144 | -288 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 11,400 | 11,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALGERT GLOBAL LLC | 0 | 11,196 | +11,196 | 0.00 | 0.00 | +0.00 | buy |
| CreativeOne Wealth, LLC | 10,750 | 10,750 | 0 | 0.01 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 5,832 | 9,564 | +3,732 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 9,116 | +9,116 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,764 | 7,764 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIRTUS ADVISERS, LLC | 7,134 | 7,267 | +133 | 0.04 | 0.04 | +0.00 | buy |
| CWM, LLC | 5,885 | 5,223 | -662 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 2,798 | 2,798 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 3,371 | 2,674 | -697 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 2,582 | 2,582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,211 | 2,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,069 | 2,069 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 1,482 | 1,799 | +317 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 357 | 1,537 | +1,180 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,472 | +1,472 | 0.00 | 0.00 | +0.00 | buy |
| GeoWealth Management, LLC | 0 | 1,439 | +1,439 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 682 | 682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 644 | 644 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 0 | 556 | +556 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 319 | 319 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 304 | +304 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 152 | 152 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 133 | 133 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 129 | 129 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 108 | 108 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avion Wealth | 78 | 78 | 0 | 0.00 | 0.00 | 0.00 | hold |
| GAMMA Investing LLC | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 63 | 63 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOISARD ASSET MANAGEMENT GROUP, INC. | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 30 | +10 | 0.00 | 0.00 | +0.00 | buy |
| BOKF, NA | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 17 | 17 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 66 | 5 | -61 | 0.00 | 0.00 | -0.00 | sell |