| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAR1 Capital Management, LLC | 25,366 | 729,401 | +704,035 | 0.06 | 1.48 | +1.42 | buy |
| Caligan Partners LP | 745,758 | 981,155 | +235,397 | 2.04 | 3.77 | +1.73 | buy |
| Pale Fire Capital SE | 34,888 | 136,897 | +102,009 | 0.05 | 0.26 | +0.21 | buy |
| Nantahala Capital Management, LLC | 532,506 | 632,506 | +100,000 | 0.36 | 0.39 | +0.02 | buy |
| NEOS Investment Management LLC | 72,813 | 123,498 | +50,685 | 0.04 | 0.05 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 59,931 | 31,068 | +28,863 | 0.04 | 0.03 | 0.00 | sell |
| DAFNA Capital Management LLC | 119,000 | 146,500 | +27,500 | 0.33 | 0.42 | +0.09 | buy |
| Affinity Asset Advisors, LLC | 327,959 | 350,000 | +22,041 | 0.60 | 0.66 | +0.05 | buy |
| JENNISON ASSOCIATES LLC | 683,257 | 696,280 | +13,023 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,832 | 9,564 | +3,732 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,134 | 7,267 | +133 | 0.04 | 0.04 | +0.00 | buy |
| ALPS ADVISORS INC | 38,735 | 38,264 | -471 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 17,499 | 16,499 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 2,021,424 | 2,002,939 | -18,485 | 0.47 | 0.44 | -0.03 | sell |
| Laurion Capital Management LP | 1,456,804 | 1,412,389 | -44,415 | 0.20 | 0.23 | +0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 438,748 | 329,513 | -109,235 | 2.09 | 2.36 | +0.27 | sell |
| ADAMS STREET PARTNERS LLC | 1,688,712 | 1,532,654 | -156,058 | 8.14 | 10.21 | +2.07 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 442,752 | 272,472 | -170,280 | 0.71 | 0.53 | -0.18 | sell |
| Blue Owl Capital Holdings LP | 450,339 | 196,132 | -254,207 | 1.47 | 0.46 | -1.00 | sell |
| Catalys Pacific, LLC | 9,194,579 | 8,644,579 | -550,000 | 81.19 | 83.48 | +2.29 | sell |
| TCG Crossover Management, LLC | 3,185,185 | 2,470,265 | -714,920 | 3.88 | 2.53 | -1.35 | sell |