| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Catalys Pacific, LLC | 8,903,838 | 8,903,838 | 0 | 91.50 | 96.09 | +4.59 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,147,280 | 7,323,750 | +1,176,470 | 1.40 | 3.42 | +2.02 | buy |
| Samsara BioCapital, LLC | 5,674,916 | 6,263,151 | +588,235 | 15.70 | 31.01 | +15.30 | buy |
| BlackRock, Inc. | 3,097,760 | 3,671,614 | +573,854 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,326,449 | 3,018,999 | +692,550 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 2,017,352 | 2,772,654 | +755,302 | 5.30 | 14.59 | +9.29 | buy |
| Capital International Investors | 2,899,020 | 2,393,396 | -505,624 | 0.01 | 0.01 | +0.01 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,744,492 | 2,132,133 | +387,641 | 0.89 | 2.45 | +1.56 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 3,127,933 | 2,113,933 | -1,014,000 | 9.17 | 11.59 | +2.42 | sell |
| FMR LLC | 304,886 | 2,071,255 | +1,766,369 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 2,067,227 | +2,067,227 | 0.00 | 0.06 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 1,803,597 | 1,809,768 | +6,171 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 1,799,628 | +1,799,628 | 0.00 | 0.15 | +0.15 | buy |
| Laurion Capital Management LP | 1,762,582 | 1,720,445 | -42,137 | 2.75 | 8.90 | +6.15 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,673,053 | +1,673,053 | 0.00 | 0.36 | +0.36 | buy |
| Integral Health Asset Management, LLC | 2,700,000 | 1,500,000 | -1,200,000 | 3.41 | 4.15 | +0.73 | sell |
| ORBIMED ADVISORS LLC | 760,351 | 1,469,494 | +709,143 | 0.26 | 1.34 | +1.08 | buy |
| MORGAN STANLEY | 587,830 | 1,376,998 | +789,168 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,443,559 | 1,303,023 | -140,536 | 0.00 | 0.00 | +0.00 | sell |
| Holocene Advisors, LP | 0 | 1,205,377 | +1,205,377 | 0.00 | 0.11 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 954,560 | 1,123,411 | +168,851 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 1,058,776 | +1,058,776 | 0.00 | 0.19 | +0.19 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 816,926 | 942,626 | +125,700 | 0.34 | 0.90 | +0.56 | buy |
| Pictet Asset Management Holding SA | 1,267,993 | 929,169 | -338,824 | 0.02 | 0.03 | +0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 27,067 | 882,415 | +855,348 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 834,781 | 879,682 | +44,901 | 0.01 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 115,448 | 783,445 | +667,997 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 263,356 | 768,265 | +504,909 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 900,000 | 750,000 | -150,000 | 1.80 | 2.65 | +0.85 | sell |
| GOLDMAN SACHS GROUP INC | 626,787 | 711,661 | +84,874 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 143,884 | 653,830 | +509,946 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,108 | 626,148 | +622,040 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 574,207 | 610,923 | +36,716 | 0.01 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 824,187 | 567,781 | -256,406 | 0.06 | 0.11 | +0.05 | sell |
| Pale Fire Capital SE | 446,626 | 532,407 | +85,781 | 0.63 | 2.21 | +1.58 | buy |
| ARMISTICE CAPITAL, LLC | 178,000 | 507,650 | +329,650 | 0.09 | 0.60 | +0.51 | buy |
| Parkman Healthcare Partners LLC | 463,601 | 455,523 | -8,078 | 0.73 | 1.90 | +1.17 | sell |
| Nearwater Capital Markets, Ltd | 0 | 450,000 | +450,000 | 0.00 | 0.23 | +0.23 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 324,205 | 409,187 | +84,982 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 324,513 | 408,313 | +83,800 | 0.27 | 0.91 | +0.63 | buy |
| MILLENNIUM MANAGEMENT LLC | 243,569 | 404,589 | +161,020 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 339,025 | 390,807 | +51,782 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,235,322 | 376,346 | -858,976 | 0.01 | 0.01 | -0.00 | sell |
| 22NW, LP | 560,042 | 358,325 | -201,717 | 4.77 | 6.40 | +1.63 | sell |
| Swedbank AB | 383,800 | 299,300 | -84,500 | 0.01 | 0.01 | +0.01 | sell |
| FINDELL CAPITAL MANAGEMENT LLC | 0 | 250,000 | +250,000 | 0.00 | 4.33 | +4.33 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 480,974 | 219,910 | -261,064 | 1.70 | 1.98 | +0.28 | sell |
| Simplify Asset Management Inc. | 0 | 218,726 | +218,726 | 0.00 | 0.17 | +0.17 | buy |
| HighVista Strategies LLC | 150,138 | 209,829 | +59,691 | 0.75 | 1.95 | +1.20 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.14 | 0.29 | +0.16 | hold |
| Invesco Ltd. | 25,743 | 187,986 | +162,243 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 25,500 | 183,680 | +158,180 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 351,113 | 180,426 | -170,687 | 0.01 | 0.01 | +0.00 | sell |
| Velan Capital Investment Management LP | 174,600 | 175,600 | +1,000 | 2.36 | 6.25 | +3.89 | buy |
| Atika Capital Management LLC | 0 | 174,000 | +174,000 | 0.00 | 0.56 | +0.56 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 165,000 | +165,000 | 0.00 | 0.12 | +0.12 | buy |
| Rhenman & Partners Asset Management AB | 0 | 165,000 | +165,000 | 0.00 | 0.69 | +0.69 | buy |
| CITIGROUP INC | 27,118 | 163,168 | +136,050 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 353,982 | 158,713 | -195,269 | 0.34 | 0.37 | +0.03 | sell |
| STEMPOINT CAPITAL LP | 631,586 | 158,112 | -473,474 | 2.75 | 1.21 | -1.54 | sell |
| Burkehill Global Management, LP | 0 | 150,000 | +150,000 | 0.00 | 0.32 | +0.32 | buy |
| DIMENSIONAL FUND ADVISORS LP | 187,384 | 146,778 | -40,606 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 50,476 | 138,526 | +88,050 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 10,077 | 134,038 | +123,961 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 127,547 | +127,547 | 0.00 | 0.55 | +0.55 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 126,726 | 126,726 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Jain Global LLC | 0 | 120,854 | +120,854 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 96,415 | 113,797 | +17,382 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 107,640 | 107,640 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Greenland Capital Management LP | 10,000 | 105,853 | +95,853 | 0.02 | 0.59 | +0.57 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 105,000 | +105,000 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 335,944 | 100,944 | -235,000 | 1.47 | 1.19 | -0.28 | sell |
| SG Americas Securities, LLC | 123,987 | 100,037 | -23,950 | 0.01 | 0.01 | +0.01 | sell |
| Zimmer Partners, LP | 162,733 | 100,000 | -62,733 | 0.05 | 0.09 | +0.04 | sell |
| AMERIPRISE FINANCIAL INC | 50,857 | 97,147 | +46,290 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 115,139 | 89,504 | -25,635 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 61,900 | 88,500 | +26,600 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 77,647 | 86,916 | +9,269 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 371,523 | 83,490 | -288,033 | 1.39 | 0.78 | -0.61 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 115,282 | 80,000 | -35,282 | 0.32 | 0.44 | +0.12 | sell |
| ADAR1 Capital Management, LLC | 302,125 | 78,238 | -223,887 | 0.66 | 0.29 | -0.37 | sell |
| Susquehanna Portfolio Strategies, LLC | 161,134 | 78,092 | -83,042 | 0.05 | 0.05 | -0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 75,768 | +75,768 | 0.00 | 0.02 | +0.02 | buy |
| Cinctive Capital Management LP | 16,113 | 71,713 | +55,600 | 0.01 | 0.14 | +0.12 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 24,404 | 59,042 | +34,638 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,086 | 57,223 | +1,137 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 41,100 | 56,600 | +15,500 | 0.14 | 0.38 | +0.23 | buy |
| RHUMBLINE ADVISERS | 53,596 | 55,291 | +1,695 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 31,095 | 52,848 | +21,753 | 0.02 | 0.07 | +0.06 | buy |
| PRUDENTIAL FINANCIAL INC | 352,225 | 50,425 | -301,800 | 0.01 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 47,500 | +47,500 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 176,926 | 47,400 | -129,526 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 36,049 | 45,429 | +9,380 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 45,000 | 45,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Trexquant Investment LP | 182,665 | 43,973 | -138,692 | 0.03 | 0.02 | -0.01 | sell |
| J. Goldman & Co LP | 57,635 | 43,868 | -13,767 | 0.02 | 0.06 | +0.04 | sell |
| Squarepoint Ops LLC | 11,515 | 43,013 | +31,498 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 42,276 | +42,276 | 0.00 | 0.01 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 0.79 | +0.79 | buy |
| Lion Point Capital, LP | 79,000 | 39,000 | -40,000 | 7.26 | 8.40 | +1.14 | sell |