| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 0 | 2,067,227 | +2,067,227 | 0.00 | 0.06 | +0.06 | buy |
| Point72 Asset Management, L.P. | 0 | 1,799,628 | +1,799,628 | 0.00 | 0.15 | +0.15 | buy |
| FMR LLC | 304,886 | 2,071,255 | +1,766,369 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,673,053 | +1,673,053 | 0.00 | 0.36 | +0.36 | buy |
| Holocene Advisors, LP | 0 | 1,205,377 | +1,205,377 | 0.00 | 0.11 | +0.11 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,147,280 | 7,323,750 | +1,176,470 | 1.40 | 3.42 | +2.02 | buy |
| Polar Capital Holdings Plc | 0 | 1,058,776 | +1,058,776 | 0.00 | 0.19 | +0.19 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,067 | 882,415 | +855,348 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 587,830 | 1,376,998 | +789,168 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 2,017,352 | 2,772,654 | +755,302 | 5.30 | 14.59 | +9.29 | buy |
| ORBIMED ADVISORS LLC | 760,351 | 1,469,494 | +709,143 | 0.26 | 1.34 | +1.08 | buy |
| VANGUARD GROUP INC | 2,326,449 | 3,018,999 | +692,550 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 115,448 | 783,445 | +667,997 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,108 | 626,148 | +622,040 | 0.00 | 0.02 | +0.02 | buy |
| Samsara BioCapital, LLC | 5,674,916 | 6,263,151 | +588,235 | 15.70 | 31.01 | +15.30 | buy |
| BlackRock, Inc. | 3,097,760 | 3,671,614 | +573,854 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 143,884 | 653,830 | +509,946 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 263,356 | 768,265 | +504,909 | 0.00 | 0.00 | +0.00 | buy |
| Nearwater Capital Markets, Ltd | 0 | 450,000 | +450,000 | 0.00 | 0.23 | +0.23 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,744,492 | 2,132,133 | +387,641 | 0.89 | 2.45 | +1.56 | buy |
| ARMISTICE CAPITAL, LLC | 178,000 | 507,650 | +329,650 | 0.09 | 0.60 | +0.51 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 0 | 250,000 | +250,000 | 0.00 | 4.33 | +4.33 | buy |
| Simplify Asset Management Inc. | 0 | 218,726 | +218,726 | 0.00 | 0.17 | +0.17 | buy |
| Atika Capital Management LLC | 0 | 174,000 | +174,000 | 0.00 | 0.56 | +0.56 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 954,560 | 1,123,411 | +168,851 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 165,000 | +165,000 | 0.00 | 0.12 | +0.12 | buy |
| Rhenman & Partners Asset Management AB | 0 | 165,000 | +165,000 | 0.00 | 0.69 | +0.69 | buy |
| Invesco Ltd. | 25,743 | 187,986 | +162,243 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 243,569 | 404,589 | +161,020 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 25,500 | 183,680 | +158,180 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 150,000 | +150,000 | 0.00 | 0.32 | +0.32 | buy |
| CITIGROUP INC | 27,118 | 163,168 | +136,050 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 127,547 | +127,547 | 0.00 | 0.55 | +0.55 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 816,926 | 942,626 | +125,700 | 0.34 | 0.90 | +0.56 | buy |
| HRT FINANCIAL LP | 10,077 | 134,038 | +123,961 | 0.00 | 0.02 | +0.02 | buy |
| Jain Global LLC | 0 | 120,854 | +120,854 | 0.00 | 0.06 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 105,000 | +105,000 | 0.00 | 0.01 | +0.01 | buy |
| Greenland Capital Management LP | 10,000 | 105,853 | +95,853 | 0.02 | 0.59 | +0.57 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 50,476 | 138,526 | +88,050 | 0.00 | 0.01 | +0.00 | buy |
| Pale Fire Capital SE | 446,626 | 532,407 | +85,781 | 0.63 | 2.21 | +1.58 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 324,205 | 409,187 | +84,982 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 626,787 | 711,661 | +84,874 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 324,513 | 408,313 | +83,800 | 0.27 | 0.91 | +0.63 | buy |
| Hudson Bay Capital Management LP | 0 | 75,768 | +75,768 | 0.00 | 0.02 | +0.02 | buy |
| HighVista Strategies LLC | 150,138 | 209,829 | +59,691 | 0.75 | 1.95 | +1.20 | buy |
| Cinctive Capital Management LP | 16,113 | 71,713 | +55,600 | 0.01 | 0.14 | +0.12 | buy |
| NORTHERN TRUST CORP | 339,025 | 390,807 | +51,782 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 47,500 | +47,500 | 0.00 | 0.03 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 50,857 | 97,147 | +46,290 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 834,781 | 879,682 | +44,901 | 0.01 | 0.02 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 42,276 | +42,276 | 0.00 | 0.01 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 0.79 | +0.79 | buy |
| JANE STREET GROUP, LLC | 0 | 37,145 | +37,145 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 574,207 | 610,923 | +36,716 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 24,404 | 59,042 | +34,638 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 11,515 | 43,013 | +31,498 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 28,524 | +28,524 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 61,900 | 88,500 | +26,600 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 31,095 | 52,848 | +21,753 | 0.02 | 0.07 | +0.06 | buy |
| Allianz Asset Management GmbH | 12,300 | 33,700 | +21,400 | 0.00 | 0.00 | +0.00 | buy |
| MARK ASSET MANAGEMENT LP | 0 | 19,465 | +19,465 | 0.00 | 0.08 | +0.08 | buy |
| XTX Topco Ltd | 0 | 18,840 | +18,840 | 0.00 | 0.04 | +0.04 | buy |
| Verition Fund Management LLC | 0 | 18,463 | +18,463 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 96,415 | 113,797 | +17,382 | 0.00 | 0.00 | +0.00 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 0 | 16,143 | +16,143 | 0.00 | 0.04 | +0.04 | buy |
| Artia Global Partners LP | 41,100 | 56,600 | +15,500 | 0.14 | 0.38 | +0.23 | buy |
| Y-Intercept (Hong Kong) Ltd | 21,280 | 36,373 | +15,093 | 0.01 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 14,249 | +14,249 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 12,207 | +12,207 | 0.00 | 0.24 | +0.24 | buy |
| Bellevue Group AG | 15,556 | 26,605 | +11,049 | 0.00 | 0.02 | +0.02 | buy |
| Arizona State Retirement System | 0 | 10,607 | +10,607 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 9,865 | +9,865 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 9,686 | +9,686 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 36,049 | 45,429 | +9,380 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 77,647 | 86,916 | +9,269 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 9,123 | +9,123 | 0.00 | 0.11 | +0.11 | buy |
| JANUS HENDERSON GROUP PLC | 11,600 | 19,848 | +8,248 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 7,964 | +7,964 | 0.00 | 0.11 | +0.11 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 7,561 | +7,561 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 6,338 | +6,338 | 0.00 | 0.07 | +0.07 | buy |
| FORA Capital, LLC | 0 | 6,325 | +6,325 | 0.00 | 0.04 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 1,803,597 | 1,809,768 | +6,171 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 5,707 | +5,707 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 13,597 | 18,627 | +5,030 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,764 | 12,564 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 4,423 | +4,423 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 4,037 | +4,037 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 23 | 3,264 | +3,241 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,551 | 26,926 | +2,375 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,568 | 21,383 | +1,815 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,234 | 10,966 | +1,732 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 53,596 | 55,291 | +1,695 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,302 | 7,626 | +1,324 | 0.03 | 0.08 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,086 | 57,223 | +1,137 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 174,600 | 175,600 | +1,000 | 2.36 | 6.25 | +3.89 | buy |
| Smartleaf Asset Management LLC | 341 | 1,017 | +676 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,749 | 3,371 | +622 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 286 | +286 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,274 | 1,426 | +152 | 0.00 | 0.00 | +0.00 | buy |