| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Catalys Pacific, LLC | 8,644,579 | 8,644,579 | 0 | 83.48 | 91.82 | +8.34 | hold |
| Samsara BioCapital, LLC | 5,074,916 | 5,074,916 | 0 | 11.81 | 8.57 | -3.24 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,850,984 | 4,850,984 | 0 | 0.68 | 0.79 | +0.12 | hold |
| TCG Crossover Management, LLC | 2,470,265 | 2,470,265 | 0 | 2.53 | 2.97 | +0.44 | hold |
| BlackRock, Inc. | 2,144,168 | 2,138,522 | -5,646 | 0.00 | 0.00 | -0.00 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 2,016,822 | 2,016,822 | 0 | 4.90 | 6.05 | +1.16 | hold |
| FRANKLIN RESOURCES INC | 1,745,513 | 1,745,597 | +84 | 0.01 | 0.01 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 2,002,939 | 1,611,637 | -391,302 | 0.44 | 0.41 | -0.03 | sell |
| VANGUARD GROUP INC | 1,363,231 | 1,432,042 | +68,811 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 1,412,389 | 1,412,389 | 0 | 1.10 | 1.08 | -0.02 | hold |
| ADAMS STREET PARTNERS LLC | 1,532,654 | 1,129,807 | -402,847 | 10.21 | 12.33 | +2.11 | sell |
| MILLENNIUM MANAGEMENT LLC | 98,733 | 1,101,674 | +1,002,941 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 696,280 | 1,082,006 | +385,726 | 0.01 | 0.01 | +0.00 | buy |
| Caligan Partners LP | 981,155 | 1,011,155 | +30,000 | 3.77 | 3.15 | -0.61 | buy |
| Integral Health Asset Management, LLC | 356,000 | 875,000 | +519,000 | 0.51 | 0.95 | +0.45 | buy |
| AMERICAN CENTURY COMPANIES INC | 931,650 | 848,630 | -83,020 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 729,401 | 841,541 | +112,140 | 1.48 | 2.14 | +0.65 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 605,956 | 650,023 | +44,067 | 0.22 | 0.24 | +0.02 | buy |
| Nantahala Capital Management, LLC | 632,506 | 632,506 | 0 | 0.64 | 0.54 | -0.10 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 620,853 | 620,033 | -820 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 515,813 | 589,444 | +73,631 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 483,766 | 504,533 | +20,767 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 21,416 | 503,590 | +482,174 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 400,101 | +400,101 | 0.00 | 1.24 | +1.24 | buy |
| SECTORAL ASSET MANAGEMENT INC | 329,513 | 380,883 | +51,370 | 2.36 | 3.13 | +0.77 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 350,000 | 0 | 0.66 | 0.67 | +0.02 | hold |
| Ikarian Capital, LLC | 180,000 | 332,390 | +152,390 | 0.68 | 1.17 | +0.49 | buy |
| Candriam S.C.A. | 0 | 305,272 | +305,272 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 303,758 | 304,184 | +426 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 244,425 | 246,113 | +1,688 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213,599 | 214,906 | +1,307 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 272,472 | 190,672 | -81,800 | 0.54 | 0.43 | -0.11 | sell |
| DAFNA Capital Management LLC | 146,500 | 146,500 | 0 | 0.42 | 0.46 | +0.04 | hold |
| Pale Fire Capital SE | 136,897 | 136,897 | 0 | 0.26 | 0.39 | +0.13 | hold |
| PRUDENTIAL FINANCIAL INC | 67,650 | 125,650 | +58,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 103,800 | 119,500 | +15,700 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 89,451 | 111,915 | +22,464 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 96,154 | 107,703 | +11,549 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 40,500 | 99,100 | +58,600 | 0.01 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 63,998 | 91,529 | +27,531 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 123,498 | 89,529 | -33,969 | 0.05 | 0.03 | -0.02 | sell |
| Lion Point Capital, LP | 79,000 | 79,000 | 0 | 3.84 | 5.09 | +1.25 | hold |
| Bank of New York Mellon Corp | 63,607 | 65,318 | +1,711 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 16,100 | 48,885 | +32,785 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 38,218 | 46,396 | +8,178 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 39,861 | 40,556 | +695 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 38,264 | 40,248 | +1,984 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 31,068 | 28,068 | -3,000 | 0.01 | 0.01 | -0.00 | sell |
| STRS OHIO | 26,900 | 26,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 16,468 | 26,732 | +10,264 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,912 | 23,714 | +3,802 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 21,973 | 23,364 | +1,391 | 0.00 | 0.00 | +0.00 | buy |
| Proficio Capital Partners LLC | 0 | 23,192 | +23,192 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 22,960 | 23,024 | +64 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,116 | 19,961 | +10,845 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 17,786 | +17,786 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 17,124 | 17,124 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 11,400 | 16,500 | +5,100 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 16,499 | 16,499 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 0 | 16,412 | +16,412 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,699 | 16,383 | +684 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 16,848 | 15,516 | -1,332 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 556 | 15,222 | +14,666 | 0.00 | 0.02 | +0.02 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 14,965 | 14,965 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 15,268 | 14,197 | -1,071 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 0 | 12,487 | +12,487 | 0.00 | 0.06 | +0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,144 | 11,797 | -347 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 11,715 | +11,715 | 0.00 | 0.00 | +0.00 | buy |
| CreativeOne Wealth, LLC | 10,750 | 10,750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 9,564 | 10,553 | +989 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 0 | 10,405 | +10,405 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,764 | 7,764 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIRTUS ADVISERS, LLC | 7,267 | 5,842 | -1,425 | 0.04 | 0.03 | -0.01 | sell |
| CWM, LLC | 5,223 | 5,237 | +14 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 3,895 | +3,895 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,798 | 2,798 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,582 | 2,582 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,211 | 2,185 | -26 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,069 | 2,069 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Smartleaf Asset Management LLC | 1,537 | 1,905 | +368 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,799 | 1,658 | -141 | 0.00 | 0.00 | -0.00 | sell |
| GeoWealth Management, LLC | 1,439 | 1,439 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MEEDER ASSET MANAGEMENT INC | 0 | 1,338 | +1,338 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,674 | 1,005 | -1,669 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 77 | 723 | +646 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 682 | 682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 644 | 644 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 304 | 337 | +33 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 319 | 319 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 152 | 152 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 129 | 129 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 108 | 108 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 30 | 105 | +75 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5 | 103 | +98 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 75 | 91 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 63 | 53 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Private Wealth Management Group, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 133 | 28 | -105 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |