| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Integral Health Asset Management, LLC | 356,000 | 875,000 | +519,000 | 0.51 | 0.95 | +0.45 | buy |
| JENNISON ASSOCIATES LLC | 696,280 | 1,082,006 | +385,726 | 0.01 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 180,000 | 332,390 | +152,390 | 0.68 | 1.17 | +0.49 | buy |
| ADAR1 Capital Management, LLC | 729,401 | 841,541 | +112,140 | 1.48 | 2.14 | +0.65 | buy |
| Polar Asset Management Partners Inc. | 40,500 | 99,100 | +58,600 | 0.01 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 329,513 | 380,883 | +51,370 | 2.36 | 3.13 | +0.77 | buy |
| Caligan Partners LP | 981,155 | 1,011,155 | +30,000 | 3.77 | 3.15 | -0.61 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 11,400 | 16,500 | +5,100 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 31,068 | 28,068 | +3,000 | 0.03 | 0.03 | 0.00 | sell |
| ALPS ADVISORS INC | 38,264 | 40,248 | +1,984 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,564 | 10,553 | +989 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,267 | 5,842 | -1,425 | 0.04 | 0.03 | -0.01 | sell |
| NEOS Investment Management LLC | 123,498 | 89,529 | -33,969 | 0.05 | 0.03 | -0.02 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 272,472 | 190,672 | -81,800 | 0.53 | 0.42 | -0.10 | sell |
| ORBIMED ADVISORS LLC | 2,002,939 | 1,611,637 | -391,302 | 0.44 | 0.41 | -0.03 | sell |
| ADAMS STREET PARTNERS LLC | 1,532,654 | 1,129,807 | -402,847 | 10.21 | 12.33 | +2.11 | sell |