| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 376,346 | 1,258,653 | +882,307 | 0.01 | 0.03 | +0.02 | buy |
| Holocene Advisors, LP | 1,205,377 | 1,602,035 | +396,658 | 0.10 | 0.12 | +0.02 | buy |
| Polar Capital Holdings Plc | 1,058,776 | 1,401,141 | +342,365 | 0.19 | 0.23 | +0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 219,910 | 449,003 | +229,093 | 1.76 | 3.15 | +1.39 | buy |
| ARMISTICE CAPITAL, LLC | 507,650 | 676,035 | +168,385 | 0.29 | 0.29 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 158,112 | 290,049 | +131,937 | 1.21 | 1.81 | +0.60 | buy |
| Candriam S.C.A. | 567,781 | 678,387 | +110,606 | 0.11 | 0.12 | +0.01 | buy |
| Rafferty Asset Management, LLC | 31,685 | 127,917 | +96,232 | 0.00 | 0.02 | +0.01 | buy |
| Artia Global Partners LP | 56,600 | 137,800 | +81,200 | 0.38 | 0.80 | +0.43 | buy |
| ADAR1 Capital Management, LLC | 78,238 | 136,231 | +57,993 | 0.29 | 0.37 | +0.08 | buy |
| PROFUND ADVISORS LLC | 7,256 | 47,024 | +39,768 | 0.01 | 0.05 | 0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 879,682 | 908,093 | +28,411 | 0.02 | 0.02 | -0.00 | buy |
| Rock Springs Capital Management LP | 408,313 | 427,596 | +19,283 | 0.90 | 0.80 | -0.11 | buy |
| Hennion & Walsh Asset Management, Inc. | 52,848 | 69,362 | +16,514 | 0.07 | 0.09 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 80,000 | 94,983 | +14,983 | 0.44 | 0.50 | +0.06 | buy |
| Y-Intercept (Hong Kong) Ltd | 36,373 | 31,359 | +5,014 | 0.04 | 0.03 | 0.00 | sell |
| FORA Capital, LLC | 6,325 | 11,050 | +4,725 | 0.04 | 0.05 | +0.01 | buy |
| J. Goldman & Co LP | 43,868 | 47,288 | +3,420 | 0.04 | 0.05 | +0.00 | buy |
| AlphaQuest LLC | 12,605 | 11,328 | +1,277 | 0.04 | 0.03 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,621 | 12,896 | +1,275 | 0.04 | 0.04 | -0.00 | buy |
| Optimize Financial Inc | 12,207 | 12,383 | +176 | 0.24 | 0.23 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,426 | 1,555 | +129 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 7,626 | 7,209 | -417 | 0.08 | 0.07 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 33,885 | 31,625 | -2,260 | 0.79 | 0.92 | +0.13 | sell |
| Bellevue Group AG | 26,605 | 19,826 | -6,779 | 0.02 | 0.01 | -0.01 | sell |
| Laurion Capital Management LP | 1,720,445 | 1,713,485 | -6,960 | 1.12 | 2.32 | +1.19 | sell |
| KINGSWOOD WEALTH ADVISORS, LLC | 16,143 | 7,074 | -9,069 | 0.04 | 0.01 | -0.02 | sell |
| Affinity Asset Advisors, LLC | 750,000 | 730,000 | -20,000 | 2.65 | 1.90 | -0.74 | sell |
| Rhenman & Partners Asset Management AB | 165,000 | 142,571 | -22,429 | 0.69 | 0.48 | -0.21 | sell |
| Velan Capital Investment Management LP | 175,600 | 151,000 | -24,600 | 6.25 | 3.19 | -3.07 | sell |
| Lion Point Capital, LP | 39,000 | 10,500 | -28,500 | 8.40 | 1.97 | -6.43 | sell |
| Informed Momentum Co LLC | 127,547 | 96,135 | -31,412 | 0.55 | 0.39 | -0.16 | sell |
| Blue Owl Capital Holdings LP | 100,944 | 65,944 | -35,000 | 1.19 | 0.74 | -0.45 | sell |
| Greenland Capital Management LP | 105,853 | 69,000 | -36,853 | 0.59 | 0.36 | -0.23 | sell |
| Zimmer Partners, LP | 100,000 | 57,500 | -42,500 | 0.08 | 0.05 | -0.03 | sell |
| DAFNA Capital Management LLC | 83,490 | 38,490 | -45,000 | 0.78 | 0.32 | -0.46 | sell |
| Parkman Healthcare Partners LLC | 455,523 | 410,249 | -45,274 | 1.90 | 1.42 | -0.48 | sell |
| Nantahala Capital Management, LLC | 158,713 | 113,285 | -45,428 | 0.21 | 0.14 | -0.07 | sell |
| Cinctive Capital Management LP | 71,713 | 7,037 | -64,676 | 0.14 | 0.01 | -0.12 | sell |
| Swedbank AB | 299,300 | 221,400 | -77,900 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 209,829 | 124,544 | -85,285 | 1.95 | 1.16 | -0.79 | sell |
| Simplify Asset Management Inc. | 218,726 | 114,182 | -104,544 | 0.17 | 0.07 | -0.10 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 165,000 | 60,000 | -105,000 | 0.09 | 0.03 | -0.05 | sell |
| FINDELL CAPITAL MANAGEMENT LLC | 250,000 | 50,000 | -200,000 | 4.33 | 0.60 | -3.73 | sell |
| Samsara BioCapital, LLC | 6,263,151 | 5,871,018 | -392,133 | 31.01 | 21.98 | -9.03 | sell |
| ORBIMED ADVISORS LLC | 1,469,494 | 980,400 | -489,094 | 1.34 | 0.73 | -0.61 | sell |
| Pale Fire Capital SE | 532,407 | 10,354 | -522,053 | 2.21 | 0.05 | -2.16 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 2,113,933 | 1,563,966 | -549,967 | 11.59 | 8.03 | -3.56 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,132,133 | 1,538,662 | -593,471 | 2.07 | 1.14 | -0.93 | sell |
| Integral Health Asset Management, LLC | 1,500,000 | 750,000 | -750,000 | 4.15 | 1.38 | -2.77 | sell |
| Catalys Pacific, LLC | 8,903,838 | 7,903,838 | -1,000,000 | 96.09 | 92.37 | -3.72 | sell |
| Capital International Investors | 2,393,396 | 1,163,290 | -1,230,106 | 0.01 | 0.01 | -0.01 | sell |