| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Catalys Pacific, LLC | 8,903,838 | 7,903,838 | -1,000,000 | 96.09 | 92.37 | -3.72 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 7,323,750 | 7,323,750 | 0 | 3.42 | 2.72 | -0.70 | hold |
| Samsara BioCapital, LLC | 6,263,151 | 5,871,018 | -392,133 | 31.01 | 21.98 | -9.03 | sell |
| FMR LLC | 2,071,255 | 5,057,509 | +2,986,254 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 3,671,614 | 4,327,678 | +656,064 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,018,999 | 3,352,880 | +333,881 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,303,023 | 3,184,999 | +1,881,976 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 2,772,654 | 2,772,654 | 0 | 14.59 | 9.21 | -5.38 | hold |
| FRANKLIN RESOURCES INC | 1,809,768 | 1,788,747 | -21,021 | 0.02 | 0.02 | -0.00 | sell |
| Laurion Capital Management LP | 1,720,445 | 1,713,485 | -6,960 | 8.90 | 4.24 | -4.66 | sell |
| Holocene Advisors, LP | 1,205,377 | 1,602,035 | +396,658 | 0.11 | 0.12 | +0.02 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 2,113,933 | 1,563,966 | -549,967 | 11.59 | 8.03 | -3.56 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,132,133 | 1,538,662 | -593,471 | 2.45 | 1.39 | -1.06 | sell |
| GOLDMAN SACHS GROUP INC | 711,661 | 1,450,933 | +739,272 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,058,776 | 1,401,141 | +342,365 | 0.19 | 0.23 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,383 | 1,325,120 | +1,303,737 | 0.00 | 0.01 | +0.01 | buy |
| SAMLYN CAPITAL, LLC | 0 | 1,304,932 | +1,304,932 | 0.00 | 0.76 | +0.76 | buy |
| JENNISON ASSOCIATES LLC | 376,346 | 1,258,653 | +882,307 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,123,411 | 1,257,582 | +134,171 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 19,848 | 1,213,265 | +1,193,417 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 1,799,628 | 1,207,220 | -592,408 | 0.15 | 0.07 | -0.08 | sell |
| Capital International Investors | 2,393,396 | 1,163,290 | -1,230,106 | 0.01 | 0.01 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 610,923 | 1,150,670 | +539,747 | 0.02 | 0.03 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 942,626 | 992,082 | +49,456 | 0.90 | 0.92 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 768,265 | 987,280 | +219,015 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,469,494 | 980,400 | -489,094 | 1.34 | 0.73 | -0.61 | sell |
| ALLIANCEBERNSTEIN L.P. | 882,415 | 922,516 | +40,101 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 879,682 | 908,093 | +28,411 | 0.02 | 0.02 | -0.00 | buy |
| Pictet Asset Management Holding SA | 929,169 | 852,883 | -76,286 | 0.03 | 0.03 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 1,673,053 | 823,296 | -849,757 | 0.36 | 0.16 | -0.20 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 783,445 | 784,267 | +822 | 0.01 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 1,500,000 | 750,000 | -750,000 | 4.15 | 1.38 | -2.77 | sell |
| Affinity Asset Advisors, LLC | 750,000 | 730,000 | -20,000 | 2.65 | 1.90 | -0.74 | sell |
| Siren, L.L.C. | 0 | 699,999 | +699,999 | 0.00 | 0.76 | +0.76 | buy |
| Candriam S.C.A. | 567,781 | 678,387 | +110,606 | 0.11 | 0.12 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 507,650 | 676,035 | +168,385 | 0.60 | 0.60 | -0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 659,076 | +659,076 | 0.00 | 2.12 | +2.12 | buy |
| MORGAN STANLEY | 1,376,998 | 639,507 | -737,491 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 610,403 | +610,403 | 0.00 | 0.03 | +0.03 | buy |
| Qube Research & Technologies Ltd | 180,426 | 496,549 | +316,123 | 0.01 | 0.03 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,187 | 461,300 | +52,113 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 219,910 | 449,003 | +229,093 | 1.98 | 3.41 | +1.43 | buy |
| Rock Springs Capital Management LP | 408,313 | 427,596 | +19,283 | 0.91 | 0.80 | -0.11 | buy |
| Parkman Healthcare Partners LLC | 455,523 | 410,249 | -45,274 | 1.90 | 1.42 | -0.48 | sell |
| CITADEL ADVISORS LLC | 2,067,227 | 399,919 | -1,667,308 | 0.06 | 0.01 | -0.05 | sell |
| TimesSquare Capital Management, LLC | 0 | 380,100 | +380,100 | 0.00 | 0.21 | +0.21 | buy |
| 22NW, LP | 358,325 | 358,325 | 0 | 6.40 | 5.47 | -0.93 | hold |
| TWO SIGMA ADVISERS, LP | 0 | 353,700 | +353,700 | 0.00 | 0.02 | +0.02 | buy |
| Catalio Capital Management, LP | 0 | 331,849 | +331,849 | 0.00 | 2.13 | +2.13 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 47,400 | 322,100 | +274,700 | 0.00 | 0.02 | +0.02 | buy |
| LORD, ABBETT & CO. LLC | 0 | 312,396 | +312,396 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 390,807 | 299,863 | -90,944 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 158,112 | 290,049 | +131,937 | 1.21 | 1.81 | +0.60 | buy |
| Iron Triangle Partners LP | 0 | 257,085 | +257,085 | 0.00 | 1.07 | +1.07 | buy |
| MARSHALL WACE, LLP | 0 | 249,130 | +249,130 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 43,013 | 246,804 | +203,791 | 0.00 | 0.02 | +0.01 | buy |
| SG Americas Securities, LLC | 100,037 | 230,795 | +130,758 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 653,830 | 223,283 | -430,547 | 0.01 | 0.00 | -0.01 | sell |
| Swedbank AB | 299,300 | 221,400 | -77,900 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 89,504 | 201,280 | +111,776 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.94 | +0.94 | buy |
| Russell Investments Group, Ltd. | 3,264 | 175,361 | +172,097 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 626,148 | 172,929 | -453,219 | 0.02 | 0.00 | -0.01 | sell |
| Velan Capital Investment Management LP | 175,600 | 151,000 | -24,600 | 6.25 | 3.19 | -3.07 | sell |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.32 | 0.36 | +0.04 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,223 | 143,208 | +85,985 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 165,000 | 142,571 | -22,429 | 0.69 | 0.48 | -0.21 | sell |
| Brevan Howard Capital Management LP | 0 | 139,293 | +139,293 | 0.00 | 0.10 | +0.10 | buy |
| Artia Global Partners LP | 56,600 | 137,800 | +81,200 | 0.38 | 0.80 | +0.43 | buy |
| DIMENSIONAL FUND ADVISORS LP | 146,778 | 137,636 | -9,142 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 78,238 | 136,231 | +57,993 | 0.29 | 0.37 | +0.08 | buy |
| Bank of New York Mellon Corp | 113,797 | 131,839 | +18,042 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 130,592 | +130,592 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 31,685 | 127,917 | +96,232 | 0.00 | 0.02 | +0.01 | buy |
| HighVista Strategies LLC | 209,829 | 124,544 | -85,285 | 1.95 | 1.16 | -0.79 | sell |
| Nuveen, LLC | 86,916 | 122,947 | +36,031 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 218,726 | 114,182 | -104,544 | 0.17 | 0.07 | -0.10 | sell |
| Nantahala Capital Management, LLC | 158,713 | 113,285 | -45,428 | 0.37 | 0.25 | -0.13 | sell |
| Trexquant Investment LP | 43,973 | 112,788 | +68,815 | 0.02 | 0.04 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 138,526 | 112,672 | -25,854 | 0.01 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 107,640 | 112,190 | +4,550 | 0.01 | 0.01 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 111,753 | +111,753 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 127,547 | 96,135 | -31,412 | 0.55 | 0.39 | -0.16 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 80,000 | 94,983 | +14,983 | 0.44 | 0.50 | +0.06 | buy |
| Swiss National Bank | 88,500 | 90,100 | +1,600 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 50,425 | 89,065 | +38,640 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 18,463 | 83,840 | +65,377 | 0.00 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 404,589 | 78,625 | -325,964 | 0.01 | 0.00 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 78,092 | 78,092 | 0 | 0.05 | 0.04 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 59,042 | 75,897 | +16,855 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 18,840 | 73,678 | +54,838 | 0.04 | 0.07 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 52,848 | 69,362 | +16,514 | 0.07 | 0.09 | +0.01 | buy |
| Greenland Capital Management LP | 105,853 | 69,000 | -36,853 | 0.59 | 0.36 | -0.23 | sell |
| Blue Owl Capital Holdings LP | 100,944 | 65,944 | -35,000 | 1.19 | 0.74 | -0.45 | sell |
| ALPS ADVISORS INC | 0 | 64,987 | +64,987 | 0.00 | 0.01 | +0.01 | buy |
| WINTON GROUP Ltd | 0 | 64,806 | +64,806 | 0.00 | 0.08 | +0.08 | buy |
| AQR CAPITAL MANAGEMENT LLC | 18,122 | 62,300 | +44,178 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 165,000 | 60,000 | -105,000 | 0.12 | 0.04 | -0.08 | sell |
| Zimmer Partners, LP | 100,000 | 57,500 | -42,500 | 0.09 | 0.05 | -0.04 | sell |
| WELLS FARGO & COMPANY/MN | 30,054 | 56,756 | +26,702 | 0.00 | 0.00 | +0.00 | buy |