| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 1,658,151 | 6,308,853 | +4,650,702 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 6,225,811 | 6,227,423 | +1,612 | 0.34 | 0.39 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 5,901,343 | 5,713,512 | -187,831 | 0.15 | 0.17 | +0.02 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,572,836 | 4,003,046 | -569,790 | 8.95 | 9.23 | +0.29 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,134,323 | 3,347,022 | +212,699 | 0.02 | 0.02 | +0.00 | buy |
| RP Management, LLC | 2,936,507 | 2,936,507 | 0 | 84.51 | 89.15 | +4.64 | hold |
| STATE STREET CORP | 3,870,839 | 2,890,115 | -980,724 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,020,644 | 1,964,008 | -56,636 | 0.18 | 0.20 | +0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 1,725,047 | 1,725,047 | 0 | 1.65 | 1.66 | +0.01 | hold |
| FMR LLC | 1,928,992 | 1,528,661 | -400,331 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,426,446 | 1,481,028 | +54,582 | 0.01 | 0.01 | +0.00 | buy |
| Darwin Global Management, Ltd. | 0 | 1,476,974 | +1,476,974 | 0.00 | 10.75 | +10.75 | buy |
| Holocene Advisors, LP | 1,441,361 | 1,372,726 | -68,635 | 0.24 | 0.28 | +0.04 | sell |
| CITADEL ADVISORS LLC | 1,296,438 | 1,262,771 | -33,667 | 0.06 | 0.07 | +0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 1,234,152 | +1,234,152 | 0.00 | 0.04 | +0.04 | buy |
| Redmile Group, LLC | 1,444,365 | 1,163,241 | -281,124 | 2.21 | 2.33 | +0.12 | sell |
| Bellevue Group AG | 1,075,000 | 1,150,000 | +75,000 | 0.70 | 0.96 | +0.26 | buy |
| GOLDMAN SACHS GROUP INC | 945,715 | 940,434 | -5,281 | 0.01 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 2,483,567 | 909,600 | -1,573,967 | 0.32 | 0.14 | -0.18 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 716,427 | 804,850 | +88,423 | 33.49 | 35.44 | +1.95 | buy |
| ARMISTICE CAPITAL, LLC | 1,500,000 | 799,263 | -700,737 | 1.71 | 1.16 | -0.54 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 750,000 | 799,000 | +49,000 | 0.20 | 0.26 | +0.06 | buy |
| MARSHALL WACE, LLP | 388,517 | 783,292 | +394,775 | 0.03 | 0.07 | +0.04 | buy |
| NORGES BANK | 31,888 | 675,080 | +643,192 | 0.00 | 0.01 | +0.01 | buy |
| Capital International Investors | 669,351 | 671,414 | +2,063 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 590,982 | 648,392 | +57,410 | 0.00 | 0.00 | +0.00 | buy |
| ARS Investment Partners, LLC | 633,964 | 636,371 | +2,407 | 3.01 | 3.47 | +0.46 | buy |
| NORTHERN TRUST CORP | 641,968 | 632,908 | -9,060 | 0.00 | 0.01 | +0.00 | sell |
| Cormorant Asset Management, LP | 81,963 | 616,963 | +535,000 | 0.17 | 1.49 | +1.32 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 518,904 | 535,180 | +16,276 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 332,895 | 460,404 | +127,509 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 439,206 | 440,506 | +1,300 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 477,314 | 432,342 | -44,972 | 2.93 | 3.54 | +0.60 | sell |
| Capital World Investors | 420,950 | 420,950 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearbridge Investments, LLC | 432,064 | 410,189 | -21,875 | 0.02 | 0.02 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 401,101 | 401,101 | 0 | 0.28 | 0.34 | +0.06 | hold |
| Hood River Capital Management LLC | 324,201 | 336,454 | +12,253 | 0.38 | 0.41 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 276,172 | 321,836 | +45,664 | 0.01 | 0.02 | +0.00 | buy |
| 5AM Venture Management, LLC | 399,972 | 319,972 | -80,000 | 4.54 | 3.92 | -0.62 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 375,229 | 280,302 | -94,927 | 0.19 | 0.15 | -0.04 | sell |
| JENNISON ASSOCIATES LLC | 266,391 | 265,819 | -572 | 0.01 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 250,270 | 257,105 | +6,835 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 209,881 | 256,332 | +46,451 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 268,171 | 246,637 | -21,534 | 0.00 | 0.00 | +0.00 | sell |
| NewEdge Wealth, LLC | 243,503 | 243,503 | 0 | 0.27 | 0.22 | -0.05 | hold |
| UBS Group AG | 0 | 238,717 | +238,717 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 221,232 | +221,232 | 0.00 | 0.25 | +0.25 | buy |
| JANE STREET GROUP, LLC | 124,774 | 210,232 | +85,458 | 0.01 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 158,513 | 209,438 | +50,925 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 743,115 | 208,478 | -534,637 | 0.35 | 0.11 | -0.24 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,076 | 200,286 | +162,210 | 0.00 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 334,998 | 191,603 | -143,395 | 0.01 | 0.01 | -0.00 | sell |
| Nicholas Investment Partners, LP | 119,512 | 182,663 | +63,151 | 0.60 | 1.02 | +0.42 | buy |
| BANK OF AMERICA CORP /DE/ | 111,619 | 181,195 | +69,576 | 0.00 | 0.00 | +0.00 | buy |
| QVT Financial LP | 214,409 | 170,006 | -44,403 | 0.55 | 0.87 | +0.31 | sell |
| CITIGROUP INC | 114,753 | 165,500 | +50,747 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 149,369 | 163,618 | +14,249 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 271,577 | 158,192 | -113,385 | 0.05 | 0.03 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 45,714 | 154,254 | +108,540 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 240,690 | 148,490 | -92,200 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 348,061 | 145,327 | -202,734 | 0.04 | 0.02 | -0.02 | sell |
| Swiss National Bank | 134,100 | 142,500 | +8,400 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 140,000 | 140,000 | 0 | 0.55 | 0.80 | +0.24 | hold |
| Altium Capital Management LLC | 0 | 140,000 | +140,000 | 0.00 | 3.42 | +3.42 | buy |
| JPMORGAN CHASE & CO | 119,986 | 137,648 | +17,662 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 133,046 | +133,046 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 0 | 126,984 | +126,984 | 0.00 | 0.18 | +0.18 | buy |
| DAFNA Capital Management LLC | 168,772 | 118,730 | -50,042 | 1.73 | 1.48 | -0.25 | sell |
| TWO SIGMA ADVISERS, LP | 146,200 | 117,500 | -28,700 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 109,305 | 112,292 | +2,987 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 163,733 | 109,531 | -54,202 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 122,117 | 109,060 | -13,057 | 0.07 | 0.06 | -0.01 | sell |
| MYDA Advisors LLC | 125,000 | 106,515 | -18,485 | 2.29 | 2.03 | -0.26 | sell |
| Global IMC LLC | 130,957 | 104,204 | -26,753 | 1.35 | 1.32 | -0.04 | sell |
| Candriam S.C.A. | 0 | 100,000 | +100,000 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 226,903 | 85,934 | -140,969 | 0.01 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 111,354 | 83,461 | -27,893 | 1.28 | 1.22 | -0.06 | sell |
| DEUTSCHE BANK AG\ | 45,878 | 82,175 | +36,297 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 1,148,308 | 75,000 | -1,073,308 | 1.88 | 0.15 | -1.73 | sell |
| SIMON QUICK ADVISORS, LLC | 74,968 | 73,897 | -1,071 | 0.28 | 0.30 | +0.02 | sell |
| Legal & General Group Plc | 66,928 | 73,026 | +6,098 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 71,891 | 71,887 | -4 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 66,393 | +66,393 | 0.00 | 0.13 | +0.13 | buy |
| FEDERATED HERMES, INC. | 9,898 | 63,142 | +53,244 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,620 | 62,463 | -3,157 | 0.01 | 0.01 | +0.00 | sell |
| State of New Jersey Common Pension Fund D | 0 | 60,375 | +60,375 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 11,269 | 58,458 | +47,189 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 91,851 | 58,364 | -33,487 | 0.70 | 0.50 | -0.20 | sell |
| FRED ALGER MANAGEMENT, LLC | 66,964 | 51,104 | -15,860 | 0.02 | 0.01 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 41,276 | 48,320 | +7,044 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 27,900 | 46,900 | +19,000 | 0.02 | 0.04 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 39,344 | +39,344 | 0.00 | 0.10 | +0.10 | buy |
| LPL Financial LLC | 22,518 | 37,943 | +15,425 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 37,500 | +37,500 | 0.00 | 0.23 | +0.23 | buy |
| Susquehanna Portfolio Strategies, LLC | 36,227 | 36,227 | 0 | 0.03 | 0.05 | +0.02 | hold |
| WELLS FARGO & COMPANY/MN | 24,288 | 35,609 | +11,321 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 36,024 | 35,188 | -836 | 0.01 | 0.01 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 34,005 | 33,716 | -289 | 0.01 | 0.01 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 40,094 | 31,826 | -8,268 | 0.00 | 0.00 | -0.00 | sell |
| Quantum Private Wealth, LLC | 30,856 | 30,856 | 0 | 0.55 | 0.62 | +0.07 | hold |