| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 81,963 | 616,963 | +535,000 | 0.17 | 1.48 | +1.31 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,134,323 | 3,347,022 | +212,699 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 348,061 | 145,327 | +202,734 | 0.04 | 0.02 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 5,901,343 | 5,713,512 | +187,831 | 0.15 | 0.17 | 0.00 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 716,427 | 804,850 | +88,423 | 18.65 | 29.25 | +10.60 | buy |
| Bellevue Group AG | 1,075,000 | 1,150,000 | +75,000 | 0.70 | 0.96 | +0.26 | buy |
| Nicholas Investment Partners, LP | 119,512 | 182,663 | +63,151 | 0.60 | 1.02 | +0.42 | buy |
| TD ASSET MANAGEMENT INC | 276,172 | 321,836 | +45,664 | 0.01 | 0.02 | +0.00 | buy |
| PROFUND ADVISORS LLC | 44,513 | 25,453 | +19,060 | 0.08 | 0.05 | 0.00 | sell |
| Erste Asset Management GmbH | 27,900 | 46,900 | +19,000 | 0.02 | 0.04 | +0.02 | buy |
| Hood River Capital Management LLC | 324,201 | 336,454 | +12,253 | 0.38 | 0.41 | +0.03 | buy |
| Belvedere Trading LLC | 3,763 | 14,338 | +10,575 | 0.00 | 0.00 | +0.00 | buy |
| VELA Investment Management, LLC | 9,269 | 12,664 | +3,395 | 0.16 | 0.25 | +0.09 | buy |
| ARS Investment Partners, LLC | 633,964 | 636,371 | +2,407 | 3.01 | 3.47 | +0.46 | buy |
| Capital International Investors | 669,351 | 671,414 | +2,063 | 0.01 | 0.01 | +0.00 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 100 | 62 | -38 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,459 | 2,303 | -156 | 0.07 | 0.07 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 7,802 | 7,393 | -409 | 0.04 | 0.04 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 266,391 | 265,819 | -572 | 0.01 | 0.01 | +0.00 | sell |
| SIMON QUICK ADVISORS, LLC | 74,968 | 73,897 | -1,071 | 0.28 | 0.30 | +0.02 | sell |
| HARVEST MANAGEMENT LLC | 15,100 | 13,850 | -1,250 | 0.60 | 0.51 | -0.09 | sell |
| Inspire Investing, LLC | 9,022 | 6,444 | -2,578 | 0.04 | 0.04 | -0.01 | sell |
| E Fund Management Co., Ltd. | 14,528 | 7,476 | -7,052 | 0.04 | 0.03 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 29,852 | 20,673 | -9,179 | 0.02 | 0.01 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 66,964 | 51,104 | -15,860 | 0.02 | 0.01 | -0.00 | sell |
| MYDA Advisors LLC | 125,000 | 106,515 | -18,485 | 1.79 | 1.67 | -0.12 | sell |
| Clearbridge Investments, LLC | 432,064 | 410,189 | -21,875 | 0.02 | 0.02 | +0.00 | sell |
| Global IMC LLC | 130,957 | 104,204 | -26,753 | 1.35 | 1.32 | -0.04 | sell |
| STEMPOINT CAPITAL LP | 111,354 | 83,461 | -27,893 | 1.28 | 1.22 | -0.06 | sell |
| Informed Momentum Co LLC | 91,851 | 58,364 | -33,487 | 0.70 | 0.50 | -0.20 | sell |
| QVT Financial LP | 214,409 | 170,006 | -44,403 | 0.52 | 0.79 | +0.27 | sell |
| First Turn Management, LLC | 477,314 | 432,342 | -44,972 | 2.93 | 3.54 | +0.60 | sell |
| DAFNA Capital Management LLC | 168,772 | 118,730 | -50,042 | 1.73 | 1.48 | -0.25 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,020,644 | 1,964,008 | -56,636 | 0.18 | 0.20 | +0.02 | sell |
| Holocene Advisors, LP | 1,441,361 | 1,372,726 | -68,635 | 0.24 | 0.28 | +0.04 | sell |
| 5AM Venture Management, LLC | 399,972 | 319,972 | -80,000 | 4.54 | 3.92 | -0.62 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 375,229 | 280,302 | -94,927 | 0.19 | 0.15 | -0.04 | sell |
| Rafferty Asset Management, LLC | 271,577 | 158,192 | -113,385 | 0.05 | 0.03 | -0.02 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 253,000 | 15,500 | -237,500 | 0.04 | 0.00 | -0.03 | sell |
| Redmile Group, LLC | 1,444,365 | 1,163,241 | -281,124 | 2.21 | 2.33 | +0.12 | sell |
| Woodline Partners LP | 743,115 | 208,478 | -534,637 | 0.35 | 0.11 | -0.24 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,572,836 | 4,003,046 | -569,790 | 8.85 | 8.13 | -0.72 | sell |
| ARMISTICE CAPITAL, LLC | 1,500,000 | 799,263 | -700,737 | 0.88 | 0.58 | -0.30 | sell |
| Avidity Partners Management LP | 1,148,308 | 75,000 | -1,073,308 | 1.88 | 0.15 | -1.73 | sell |