| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,407,365 | 17,534,612 | +16,127,247 | 0.01 | 0.07 | +0.06 | buy |
| BlackRock, Inc. | 9,448,040 | 11,222,407 | +1,774,367 | 0.00 | 0.00 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,286,937 | 10,286,937 | 0 | 2.90 | 2.36 | -0.54 | hold |
| STIFEL FINANCIAL CORP | 9,939,856 | 9,940,885 | +1,029 | 0.10 | 0.08 | -0.02 | buy |
| STATE STREET CORP | 5,716,487 | 6,618,803 | +902,316 | 0.00 | 0.00 | -0.00 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 6,250,000 | 6,250,000 | 0 | 10.44 | 6.62 | -3.82 | hold |
| TCG Crossover Management, LLC | 4,631,317 | 4,631,317 | 0 | 1.73 | 1.12 | -0.61 | hold |
| D. E. Shaw & Co., Inc. | 2,694,234 | 2,847,193 | +152,959 | 0.02 | 0.02 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,392,277 | 2,767,763 | +375,486 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,962,206 | 2,513,181 | +550,975 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,591,054 | 2,445,416 | +854,362 | 0.03 | 0.04 | +0.01 | buy |
| FMR LLC | 2,682,234 | 2,359,047 | -323,187 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,018,550 | 2,217,175 | +198,625 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,460,108 | 1,975,516 | +515,408 | 0.01 | 0.01 | -0.00 | buy |
| Cormorant Asset Management, LP | 10,000 | 1,760,000 | +1,750,000 | 0.01 | 0.75 | +0.74 | buy |
| CITADEL ADVISORS LLC | 1,743,993 | 1,723,107 | -20,886 | 0.01 | 0.01 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 1,594,491 | +1,594,491 | 0.00 | 2.59 | +2.59 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,093,816 | 1,544,338 | -549,478 | 0.01 | 0.01 | -0.01 | sell |
| Qube Research & Technologies Ltd | 1,570,610 | 1,540,445 | -30,165 | 0.03 | 0.02 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 1,192,026 | 1,501,099 | +309,073 | 0.15 | 0.13 | -0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 1,497,793 | +1,347,793 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,324,247 | 1,447,886 | +123,639 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 1,188,358 | 1,426,427 | +238,069 | 0.00 | 0.00 | -0.00 | buy |
| ARS Investment Partners, LLC | 1,239,600 | 1,378,828 | +139,228 | 0.82 | 0.61 | -0.21 | buy |
| Capital Research Global Investors | 1,332,792 | 1,332,792 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MYDA Advisors LLC | 1,250,000 | 1,225,000 | -25,000 | 3.97 | 2.45 | -1.52 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,318,775 | 1,219,830 | -98,945 | 0.05 | 0.04 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,259,031 | 1,186,714 | -72,317 | 0.02 | 0.01 | -0.01 | sell |
| Sio Capital Management, LLC | 1,244,764 | 1,163,926 | -80,838 | 2.33 | 1.42 | -0.91 | sell |
| MORGAN STANLEY | 975,196 | 1,026,932 | +51,736 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 840,285 | 1,001,410 | +161,125 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 1,500,000 | 1,000,000 | -500,000 | 0.86 | 0.45 | -0.41 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 847,412 | 941,077 | +93,665 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 958,202 | 898,400 | -59,802 | 0.18 | 0.12 | -0.06 | sell |
| Trexquant Investment LP | 604,182 | 877,774 | +273,592 | 0.06 | 0.05 | -0.01 | buy |
| DAFNA Capital Management LLC | 955,235 | 845,735 | -109,500 | 2.51 | 1.63 | -0.88 | sell |
| HRT FINANCIAL LP | 669,136 | 833,666 | +164,530 | 0.02 | 0.02 | -0.01 | buy |
| Fiera Capital Corp | 724,551 | 774,168 | +49,617 | 0.03 | 0.02 | -0.00 | buy |
| Aberdeen Group plc | 693,452 | 771,452 | +78,000 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,792,443 | 759,425 | -1,033,018 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 731,953 | 745,748 | +13,795 | 0.00 | 0.00 | -0.00 | buy |
| 5AM Venture Management, LLC | 738,972 | 738,972 | 0 | 2.62 | 1.74 | -0.89 | hold |
| Kynam Capital Management, LP | 702,884 | 702,884 | 0 | 0.52 | 0.38 | -0.14 | hold |
| Erste Asset Management GmbH | 693,300 | 693,300 | 0 | 0.07 | 0.05 | -0.01 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 574,478 | 618,180 | +43,702 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 594,000 | +594,000 | 0.00 | 0.86 | +0.86 | buy |
| Sarissa Capital Management LP | 513,184 | 563,184 | +50,000 | 2.60 | 3.02 | +0.42 | buy |
| PFIZER INC | 505,645 | 505,645 | 0 | 2.41 | 1.77 | -0.64 | hold |
| JPMORGAN CHASE & CO | 589,565 | 503,565 | -86,000 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 500,000 | 500,000 | 0 | 0.37 | 0.21 | -0.16 | hold |
| RAYMOND JAMES FINANCIAL INC | 436,796 | 446,611 | +9,815 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 212,481 | 412,481 | +200,000 | 0.31 | 0.50 | +0.19 | buy |
| XTX Topco Ltd | 83,455 | 408,482 | +325,027 | 0.02 | 0.06 | +0.04 | buy |
| READYSTATE ASSET MANAGEMENT LP | 651,603 | 388,193 | -263,410 | 0.33 | 0.19 | -0.13 | sell |
| Point72 Asset Management, L.P. | 387,799 | 373,099 | -14,700 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 30,027 | 352,605 | +322,578 | 0.00 | 0.00 | +0.00 | buy |
| QTR Family Wealth, LLC | 334,833 | 335,980 | +1,147 | 1.80 | 1.46 | -0.34 | buy |
| ALGERT GLOBAL LLC | 293,270 | 322,750 | +29,480 | 0.05 | 0.04 | -0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 110,840 | 310,647 | +199,807 | 0.02 | 0.04 | +0.02 | buy |
| Bank of New York Mellon Corp | 272,156 | 307,244 | +35,088 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 305,567 | +305,567 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 300,389 | 300,389 | 0 | 0.01 | 0.01 | -0.00 | hold |
| IEQ CAPITAL, LLC | 163,388 | 278,704 | +115,316 | 0.01 | 0.01 | +0.01 | buy |
| Swiss National Bank | 229,200 | 258,600 | +29,400 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 194,751 | 252,931 | +58,180 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Wealth, LLC | 246,503 | 246,503 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Jump Financial, LLC | 245,891 | 237,373 | -8,518 | 0.03 | 0.03 | -0.01 | sell |
| JANE STREET GROUP, LLC | 839,517 | 228,444 | -611,073 | 0.01 | 0.00 | -0.01 | sell |
| Rafferty Asset Management, LLC | 209,306 | 204,548 | -4,758 | 0.01 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 854,424 | 203,477 | -650,947 | 0.06 | 0.01 | -0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 133,081 | 202,975 | +69,894 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 177,678 | +177,678 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 141,678 | 177,390 | +35,712 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 110,361 | 172,370 | +62,009 | 0.00 | 0.00 | +0.00 | buy |
| QVT Financial LP | 170,006 | 170,006 | 0 | 0.18 | 0.11 | -0.07 | hold |
| DEUTSCHE BANK AG\ | 138,649 | 162,813 | +24,164 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 161,876 | +161,876 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 160,952 | +160,952 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 160,251 | 160,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Empowered Funds, LLC | 143,328 | 148,756 | +5,428 | 0.01 | 0.01 | -0.00 | buy |
| CWM, LLC | 65,719 | 138,410 | +72,691 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 116,597 | 136,883 | +20,286 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 73,077 | 127,862 | +54,785 | 0.02 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 320,846 | 125,822 | -195,024 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 151,500 | 123,500 | -28,000 | 0.56 | 0.39 | -0.17 | sell |
| ROYAL BANK OF CANADA | 122,581 | 122,452 | -129 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 41,914 | 121,554 | +79,640 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 174,035 | 116,880 | -57,155 | 0.04 | 0.02 | -0.02 | sell |
| GSA CAPITAL PARTNERS LLP | 69,045 | 116,798 | +47,753 | 0.07 | 0.06 | -0.01 | buy |
| Cerity Partners LLC | 47,143 | 112,825 | +65,682 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 105,518 | 102,083 | -3,435 | 0.00 | 0.00 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 133,900 | 100,400 | -33,500 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 96,236 | 100,036 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 113,426 | 95,987 | -17,439 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 48,979 | 95,376 | +46,397 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 151,516 | 93,041 | -58,475 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 77,279 | 91,260 | +13,981 | 0.03 | 0.03 | +0.00 | buy |
| Fund 1 Investments, LLC | 0 | 90,000 | +90,000 | 0.00 | 0.10 | +0.10 | buy |
| PDT Partners, LLC | 84,700 | 84,700 | 0 | 0.06 | 0.04 | -0.02 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 83,336 | +83,336 | 0.00 | 0.00 | +0.00 | buy |