| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 799,000 | 2,248,000 | +1,449,000 | 0.26 | 0.46 | +0.20 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,003,046 | 5,199,219 | +1,196,173 | 9.23 | 7.37 | -1.87 | buy |
| VANGUARD GROUP INC | 6,308,853 | 7,271,846 | +962,993 | 0.01 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 1,150,000 | 2,040,853 | +890,853 | 0.96 | 1.15 | +0.19 | buy |
| STATE STREET CORP | 2,890,115 | 3,649,914 | +759,799 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,262,771 | 1,877,032 | +614,261 | 0.07 | 0.06 | -0.00 | buy |
| Woodline Partners LP | 208,478 | 807,087 | +598,609 | 0.11 | 0.27 | +0.16 | buy |
| ARMISTICE CAPITAL, LLC | 799,263 | 1,396,968 | +597,705 | 1.16 | 1.27 | +0.10 | buy |
| Avidity Partners Management LP | 75,000 | 450,000 | +375,000 | 0.15 | 0.66 | +0.52 | buy |
| BANK OF AMERICA CORP /DE/ | 181,195 | 552,719 | +371,524 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,528,661 | 1,854,187 | +325,526 | 0.01 | 0.00 | -0.00 | buy |
| Holocene Advisors, LP | 1,372,726 | 1,696,355 | +323,629 | 0.28 | 0.25 | -0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 191,603 | 511,237 | +319,634 | 0.01 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 310,116 | +310,116 | 0.00 | 0.04 | +0.04 | buy |
| Artal Group S.A. | 0 | 306,703 | +306,703 | 0.00 | 0.27 | +0.27 | buy |
| ARS Investment Partners, LLC | 636,371 | 940,512 | +304,141 | 3.47 | 3.12 | -0.35 | buy |
| JPMORGAN CHASE & CO | 137,648 | 436,711 | +299,063 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 256,332 | 540,426 | +284,094 | 0.02 | 0.03 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 6,227,423 | 6,480,577 | +253,154 | 0.39 | 0.25 | -0.13 | buy |
| Logos Global Management LP | 0 | 250,000 | +250,000 | 0.00 | 1.00 | +1.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 401,101 | 634,664 | +233,563 | 0.34 | 0.38 | +0.03 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 200,073 | +200,073 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 460,404 | 657,478 | +197,074 | 0.02 | 0.02 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 145,327 | 337,990 | +192,663 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,481,028 | 1,670,438 | +189,410 | 0.01 | 0.01 | -0.00 | buy |
| Cormorant Asset Management, LP | 616,963 | 801,963 | +185,000 | 1.49 | 1.62 | +0.13 | buy |
| JANUS HENDERSON GROUP PLC | 5,713,512 | 5,898,294 | +184,782 | 0.17 | 0.11 | -0.06 | buy |
| Hudson Bay Capital Management LP | 0 | 152,754 | +152,754 | 0.00 | 0.04 | +0.04 | buy |
| 5AM Venture Management, LLC | 319,972 | 469,972 | +150,000 | 3.92 | 3.65 | -0.27 | buy |
| STEMPOINT CAPITAL LP | 83,461 | 233,255 | +149,794 | 1.22 | 2.38 | +1.16 | buy |
| JANE STREET GROUP, LLC | 210,232 | 348,479 | +138,247 | 0.01 | 0.01 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 26,425 | 135,802 | +109,377 | 0.01 | 0.04 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 154,254 | 263,150 | +108,896 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 675,080 | 780,670 | +105,590 | 0.01 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 118,730 | 218,730 | +100,000 | 1.48 | 1.81 | +0.34 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.86 | +0.86 | buy |
| Cubist Systematic Strategies, LLC | 0 | 97,902 | +97,902 | 0.00 | 0.06 | +0.06 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 90,833 | +90,833 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 1,701 | 87,877 | +86,176 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 238,717 | 319,218 | +80,501 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 7,429 | 82,319 | +74,890 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 246,637 | 321,127 | +74,490 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 648,392 | 718,802 | +70,410 | 0.00 | 0.00 | -0.00 | buy |
| Clearbridge Investments, LLC | 410,189 | 479,369 | +69,180 | 0.02 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 535,180 | 599,921 | +64,741 | 0.01 | 0.00 | -0.00 | buy |
| FIL Ltd | 0 | 61,860 | +61,860 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 59,371 | +59,371 | 0.00 | 0.04 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 0 | 57,903 | +57,903 | 0.00 | 0.02 | +0.02 | buy |
| Exome Asset Management LLC | 0 | 57,800 | +57,800 | 0.00 | 1.79 | +1.79 | buy |
| BARCLAYS PLC | 85,934 | 142,888 | +56,954 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 117,500 | 173,300 | +55,800 | 0.01 | 0.01 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 23,633 | 79,048 | +55,415 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 21,640 | 73,856 | +52,216 | 0.01 | 0.03 | +0.01 | buy |
| DCF Advisers, LLC | 0 | 51,700 | +51,700 | 0.00 | 0.94 | +0.94 | buy |
| Alyeska Investment Group, L.P. | 0 | 46,351 | +46,351 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 16,260 | 54,361 | +38,101 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 158,192 | 195,660 | +37,468 | 0.03 | 0.03 | -0.01 | buy |
| BAMCO INC /NY/ | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 336,454 | 368,902 | +32,448 | 0.41 | 0.27 | -0.15 | buy |
| FRANKLIN RESOURCES INC | 58,458 | 79,293 | +20,835 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 163,618 | 183,772 | +20,154 | 0.01 | 0.01 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 18,006 | +18,006 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 17,331 | +17,331 | 0.00 | 0.04 | +0.04 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 17,165 | +17,165 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 17,064 | +17,064 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 16,908 | +16,908 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 16,500 | +16,500 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 82,175 | 97,815 | +15,640 | 0.00 | 0.00 | -0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 7,393 | 22,000 | +14,607 | 0.04 | 0.07 | +0.03 | buy |
| CWM, LLC | 730 | 14,552 | +13,822 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 11,770 | 25,255 | +13,485 | 0.00 | 0.01 | +0.00 | buy |
| Pekin Hardy Strauss, Inc. | 0 | 13,300 | +13,300 | 0.00 | 0.06 | +0.06 | buy |
| Tower Research Capital LLC (TRC) | 4,526 | 15,579 | +11,053 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 25,453 | 36,239 | +10,786 | 0.05 | 0.05 | -0.01 | buy |
| SeaBridge Investment Advisors LLC | 27,451 | 36,226 | +8,775 | 0.40 | 0.33 | -0.07 | buy |
| MetLife Investment Management, LLC | 35,188 | 43,489 | +8,301 | 0.01 | 0.01 | -0.00 | buy |
| DnB Asset Management AS | 0 | 8,220 | +8,220 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 209,438 | 217,655 | +8,217 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 8,511 | 15,424 | +6,913 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 6,594 | +6,594 | 0.00 | 0.04 | +0.04 | buy |
| RWA WEALTH PARTNERS, LLC | 0 | 6,500 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 28,277 | 34,695 | +6,418 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 6,334 | +6,334 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 73,026 | 78,319 | +5,293 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 7,476 | 11,883 | +4,407 | 0.03 | 0.02 | -0.00 | buy |
| Quarry LP | 700 | 5,000 | +4,300 | 0.02 | 0.07 | +0.06 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 3,634 | 7,796 | +4,162 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 4,028 | +4,028 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 3,900 | +3,900 | 0.00 | 0.06 | +0.06 | buy |
| Inspire Investing, LLC | 6,444 | 10,150 | +3,706 | 0.04 | 0.04 | +0.00 | buy |
| ELKHORN PARTNERS LIMITED PARTNERSHIP | 0 | 3,600 | +3,600 | 0.00 | 0.09 | +0.09 | buy |
| EntryPoint Capital, LLC | 0 | 3,186 | +3,186 | 0.00 | 0.05 | +0.05 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 7,900 | 11,000 | +3,100 | 0.03 | 0.03 | +0.00 | buy |
| TRANSATLANTIQUE PRIVATE WEALTH LLC | 5,050 | 7,707 | +2,657 | 0.12 | 0.11 | -0.01 | buy |
| Advisors Asset Management, Inc. | 14,273 | 16,903 | +2,630 | 0.02 | 0.01 | -0.00 | buy |
| Venturi Wealth Management, LLC | 0 | 2,617 | +2,617 | 0.00 | 0.01 | +0.01 | buy |
| Private Advisor Group, LLC | 5,388 | 7,649 | +2,261 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 142,500 | 144,600 | +2,100 | 0.01 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 15,300 | 17,200 | +1,900 | 0.00 | 0.00 | -0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 1,750 | +1,750 | 0.00 | 0.05 | +0.05 | buy |