| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 6,308,853 | 7,271,846 | +962,993 | 0.01 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 6,227,423 | 6,480,577 | +253,154 | 0.39 | 0.25 | -0.13 | buy |
| JANUS HENDERSON GROUP PLC | 5,713,512 | 5,898,294 | +184,782 | 0.17 | 0.11 | -0.06 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,003,046 | 5,199,219 | +1,196,173 | 9.23 | 7.37 | -1.87 | buy |
| STATE STREET CORP | 2,890,115 | 3,649,914 | +759,799 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,347,022 | 3,284,479 | -62,543 | 0.02 | 0.01 | -0.01 | sell |
| RP Management, LLC | 2,936,507 | 2,936,507 | 0 | 89.15 | 57.00 | -32.15 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 799,000 | 2,248,000 | +1,449,000 | 0.26 | 0.46 | +0.20 | buy |
| Bellevue Group AG | 1,150,000 | 2,040,853 | +890,853 | 0.96 | 1.15 | +0.19 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,964,008 | 1,913,309 | -50,699 | 0.20 | 0.12 | -0.08 | sell |
| CITADEL ADVISORS LLC | 1,262,771 | 1,877,032 | +614,261 | 0.07 | 0.06 | -0.00 | buy |
| FMR LLC | 1,528,661 | 1,854,187 | +325,526 | 0.01 | 0.00 | -0.00 | buy |
| Holocene Advisors, LP | 1,372,726 | 1,696,355 | +323,629 | 0.28 | 0.25 | -0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,481,028 | 1,670,438 | +189,410 | 0.01 | 0.01 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,725,047 | 1,485,232 | -239,815 | 1.66 | 1.24 | -0.42 | sell |
| ARMISTICE CAPITAL, LLC | 799,263 | 1,396,968 | +597,705 | 1.16 | 1.27 | +0.10 | buy |
| Redmile Group, LLC | 1,163,241 | 1,087,576 | -75,665 | 2.33 | 2.28 | -0.05 | sell |
| ARS Investment Partners, LLC | 636,371 | 940,512 | +304,141 | 3.47 | 3.12 | -0.35 | buy |
| Woodline Partners LP | 208,478 | 807,087 | +598,609 | 0.11 | 0.27 | +0.16 | buy |
| Cormorant Asset Management, LP | 616,963 | 801,963 | +185,000 | 1.49 | 1.62 | +0.13 | buy |
| NORGES BANK | 675,080 | 780,670 | +105,590 | 0.01 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 940,434 | 729,159 | -211,275 | 0.01 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 648,392 | 718,802 | +70,410 | 0.00 | 0.00 | -0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 804,850 | 700,450 | -104,400 | 35.44 | 26.09 | -9.35 | sell |
| Capital International Investors | 671,414 | 671,414 | 0 | 0.01 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 460,404 | 657,478 | +197,074 | 0.02 | 0.02 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 401,101 | 634,664 | +233,563 | 0.34 | 0.38 | +0.03 | buy |
| NORTHERN TRUST CORP | 632,908 | 626,657 | -6,251 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 535,180 | 599,921 | +64,741 | 0.01 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 181,195 | 552,719 | +371,524 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 256,332 | 540,426 | +284,094 | 0.02 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 191,603 | 511,237 | +319,634 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 410,189 | 479,369 | +69,180 | 0.02 | 0.01 | -0.00 | buy |
| 5AM Venture Management, LLC | 319,972 | 469,972 | +150,000 | 3.92 | 3.65 | -0.27 | buy |
| Avidity Partners Management LP | 75,000 | 450,000 | +375,000 | 0.15 | 0.66 | +0.52 | buy |
| JPMORGAN CHASE & CO | 137,648 | 436,711 | +299,063 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 336,454 | 368,902 | +32,448 | 0.41 | 0.27 | -0.15 | buy |
| First Turn Management, LLC | 432,342 | 366,019 | -66,323 | 3.54 | 2.07 | -1.47 | sell |
| JANE STREET GROUP, LLC | 210,232 | 348,479 | +138,247 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 145,327 | 337,990 | +192,663 | 0.02 | 0.03 | +0.01 | buy |
| Bank of New York Mellon Corp | 246,637 | 321,127 | +74,490 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 238,717 | 319,218 | +80,501 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 310,116 | +310,116 | 0.00 | 0.04 | +0.04 | buy |
| Artal Group S.A. | 0 | 306,703 | +306,703 | 0.00 | 0.27 | +0.27 | buy |
| TD ASSET MANAGEMENT INC | 321,836 | 295,842 | -25,994 | 0.02 | 0.01 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 154,254 | 263,150 | +108,896 | 0.00 | 0.00 | +0.00 | buy |
| Capital World Investors | 420,950 | 250,000 | -170,950 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 0 | 250,000 | +250,000 | 0.00 | 1.00 | +1.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 280,302 | 244,421 | -35,881 | 0.15 | 0.08 | -0.07 | sell |
| NewEdge Wealth, LLC | 243,503 | 243,503 | 0 | 0.22 | 0.18 | -0.03 | hold |
| STEMPOINT CAPITAL LP | 83,461 | 233,255 | +149,794 | 1.22 | 2.38 | +1.16 | buy |
| DAFNA Capital Management LLC | 118,730 | 218,730 | +100,000 | 1.48 | 1.81 | +0.34 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 209,438 | 217,655 | +8,217 | 0.01 | 0.01 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 221,232 | 213,031 | -8,201 | 0.25 | 0.16 | -0.09 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 200,073 | +200,073 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 200,286 | 199,175 | -1,111 | 0.02 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 158,192 | 195,660 | +37,468 | 0.03 | 0.03 | -0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 163,618 | 183,772 | +20,154 | 0.01 | 0.01 | -0.00 | buy |
| Point72 Asset Management, L.P. | 909,600 | 177,362 | -732,238 | 0.14 | 0.02 | -0.12 | sell |
| TWO SIGMA ADVISERS, LP | 117,500 | 173,300 | +55,800 | 0.01 | 0.01 | -0.00 | buy |
| QVT Financial LP | 170,006 | 170,006 | 0 | 0.87 | 0.56 | -0.31 | hold |
| Hudson Bay Capital Management LP | 0 | 152,754 | +152,754 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 142,500 | 144,600 | +2,100 | 0.01 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 85,934 | 142,888 | +56,954 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 140,000 | 140,000 | 0 | 0.80 | 0.49 | -0.30 | hold |
| Schonfeld Strategic Advisors LLC | 26,425 | 135,802 | +109,377 | 0.01 | 0.04 | +0.03 | buy |
| Pictet Asset Management Holding SA | 148,490 | 134,539 | -13,951 | 0.01 | 0.01 | -0.00 | sell |
| Rock Springs Capital Management LP | 126,984 | 127,558 | +574 | 0.18 | 0.13 | -0.04 | buy |
| RHUMBLINE ADVISERS | 112,292 | 108,114 | -4,178 | 0.01 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 106,515 | 107,000 | +485 | 2.03 | 1.13 | -0.90 | buy |
| MARSHALL WACE, LLP | 783,292 | 105,568 | -677,724 | 0.07 | 0.01 | -0.07 | sell |
| Candriam S.C.A. | 100,000 | 100,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.86 | +0.86 | buy |
| Cubist Systematic Strategies, LLC | 0 | 97,902 | +97,902 | 0.00 | 0.06 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 82,175 | 97,815 | +15,640 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 109,531 | 97,185 | -12,346 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 90,833 | +90,833 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 1,701 | 87,877 | +86,176 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 109,060 | 83,997 | -25,063 | 0.06 | 0.03 | -0.03 | sell |
| Russell Investments Group, Ltd. | 7,429 | 82,319 | +74,890 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 58,458 | 79,293 | +20,835 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 23,633 | 79,048 | +55,415 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 73,026 | 78,319 | +5,293 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 440,506 | 76,668 | -363,838 | 0.01 | 0.00 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 21,640 | 73,856 | +52,216 | 0.01 | 0.03 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 71,887 | 71,885 | -2 | 0.00 | 0.00 | -0.00 | sell |
| SIMON QUICK ADVISORS, LLC | 73,897 | 71,815 | -2,082 | 0.30 | 0.18 | -0.13 | sell |
| FIL Ltd | 0 | 61,860 | +61,860 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 59,371 | +59,371 | 0.00 | 0.04 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 0 | 57,903 | +57,903 | 0.00 | 0.02 | +0.02 | buy |
| Exome Asset Management LLC | 0 | 57,800 | +57,800 | 0.00 | 1.79 | +1.79 | buy |
| State of New Jersey Common Pension Fund D | 60,375 | 56,070 | -4,305 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 16,260 | 54,361 | +38,101 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 62,463 | 53,269 | -9,194 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 165,500 | 53,104 | -112,396 | 0.01 | 0.00 | -0.01 | sell |
| DCF Advisers, LLC | 0 | 51,700 | +51,700 | 0.00 | 0.94 | +0.94 | buy |
| Invesco Ltd. | 257,105 | 48,433 | -208,672 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 46,900 | 46,900 | 0 | 0.04 | 0.02 | -0.01 | hold |
| Alyeska Investment Group, L.P. | 0 | 46,351 | +46,351 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 182,663 | 45,966 | -136,697 | 1.02 | 0.17 | -0.86 | sell |