| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,003,046 | 5,199,219 | +1,196,173 | 8.13 | 6.63 | -1.50 | buy |
| Bellevue Group AG | 1,150,000 | 2,040,853 | +890,853 | 0.96 | 1.15 | +0.19 | buy |
| CITADEL ADVISORS LLC | 1,262,771 | 1,877,032 | +614,261 | 0.10 | 0.09 | -0.01 | buy |
| Woodline Partners LP | 208,478 | 807,087 | +598,609 | 0.11 | 0.27 | +0.16 | buy |
| ARMISTICE CAPITAL, LLC | 799,263 | 1,396,968 | +597,705 | 0.58 | 0.61 | +0.03 | buy |
| Avidity Partners Management LP | 75,000 | 450,000 | +375,000 | 0.15 | 0.66 | +0.52 | buy |
| Holocene Advisors, LP | 1,372,726 | 1,696,355 | +323,629 | 0.28 | 0.25 | -0.03 | buy |
| ARS Investment Partners, LLC | 636,371 | 940,512 | +304,141 | 3.47 | 3.12 | -0.35 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 401,101 | 634,664 | +233,563 | 0.34 | 0.38 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 145,327 | 337,990 | +192,663 | 0.02 | 0.03 | 0.00 | buy |
| Cormorant Asset Management, LP | 616,963 | 801,963 | +185,000 | 1.48 | 1.61 | +0.13 | buy |
| JANUS HENDERSON GROUP PLC | 5,713,512 | 5,898,294 | +184,782 | 0.17 | 0.11 | 0.00 | buy |
| 5AM Venture Management, LLC | 319,972 | 469,972 | +150,000 | 3.92 | 3.65 | -0.27 | buy |
| STEMPOINT CAPITAL LP | 83,461 | 233,255 | +149,794 | 1.22 | 2.38 | +1.16 | buy |
| DAFNA Capital Management LLC | 118,730 | 218,730 | +100,000 | 1.48 | 1.81 | +0.34 | buy |
| Clearbridge Investments, LLC | 410,189 | 479,369 | +69,180 | 0.02 | 0.01 | -0.00 | buy |
| Rafferty Asset Management, LLC | 158,192 | 195,660 | +37,468 | 0.03 | 0.03 | -0.01 | buy |
| Hood River Capital Management LLC | 336,454 | 368,902 | +32,448 | 0.41 | 0.27 | -0.15 | buy |
| OAK RIDGE INVESTMENTS LLC | 7,393 | 22,000 | +14,607 | 0.04 | 0.07 | +0.03 | buy |
| PROFUND ADVISORS LLC | 25,453 | 36,239 | +10,786 | 0.05 | 0.05 | 0.00 | buy |
| SeaBridge Investment Advisors LLC | 27,451 | 36,226 | +8,775 | 0.40 | 0.33 | -0.07 | buy |
| GABELLI FUNDS LLC | 26,000 | 20,500 | +5,500 | 0.01 | 0.01 | -0.01 | sell |
| E Fund Management Co., Ltd. | 7,476 | 11,883 | +4,407 | 0.03 | 0.02 | -0.00 | buy |
| Quarry LP | 700 | 5,000 | +4,300 | 0.02 | 0.07 | 0.00 | buy |
| Inspire Investing, LLC | 6,444 | 10,150 | +3,706 | 0.04 | 0.04 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 7,900 | 11,000 | +3,100 | 0.03 | 0.03 | +0.00 | buy |
| TRANSATLANTIQUE PRIVATE WEALTH LLC | 5,050 | 7,707 | +2,657 | 0.12 | 0.11 | -0.01 | buy |
| Advisors Asset Management, Inc. | 14,273 | 16,903 | +2,630 | 0.02 | 0.01 | 0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 14,001 | 15,733 | +1,732 | 0.07 | 0.04 | 0.00 | buy |
| VELA Investment Management, LLC | 12,664 | 13,958 | +1,294 | 0.25 | 0.17 | -0.08 | buy |
| Rock Springs Capital Management LP | 126,984 | 127,558 | +574 | 0.18 | 0.13 | -0.04 | buy |
| Canton Hathaway, LLC | 21,350 | 21,850 | +500 | 0.31 | 0.21 | -0.11 | buy |
| MYDA Advisors LLC | 106,515 | 107,000 | +485 | 1.67 | 0.81 | -0.86 | buy |
| VIRTUS ADVISERS, LLC | 2,303 | 2,710 | +407 | 0.07 | 0.05 | -0.02 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 6,025 | 6,024 | -1 | 0.06 | 0.04 | -0.02 | sell |
| SIMON QUICK ADVISORS, LLC | 73,897 | 71,815 | -2,082 | 0.30 | 0.18 | -0.13 | sell |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 13,640 | 11,010 | -2,630 | 1.77 | 0.14 | -1.63 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 221,232 | 213,031 | -8,201 | 0.25 | 0.16 | -0.09 | sell |
| Susquehanna Portfolio Strategies, LLC | 36,227 | 27,227 | -9,000 | 0.05 | 0.04 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 51,104 | 40,294 | -10,810 | 0.01 | 0.01 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 321,836 | 295,842 | -25,994 | 0.02 | 0.01 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 280,302 | 244,421 | -35,881 | 0.15 | 0.08 | -0.07 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,964,008 | 1,913,309 | -50,699 | 0.20 | 0.12 | -0.08 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,347,022 | 3,284,479 | -62,543 | 0.02 | 0.01 | -0.01 | sell |
| First Turn Management, LLC | 432,342 | 366,019 | -66,323 | 3.54 | 2.07 | -1.47 | sell |
| Redmile Group, LLC | 1,163,241 | 1,087,576 | -75,665 | 2.33 | 2.28 | -0.05 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 804,850 | 700,450 | -104,400 | 29.25 | 22.68 | -6.57 | sell |
| Nicholas Investment Partners, LP | 182,663 | 45,966 | -136,697 | 1.02 | 0.17 | -0.86 | sell |
| Capital World Investors | 420,950 | 250,000 | -170,950 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,725,047 | 1,485,232 | -239,815 | 1.65 | 1.24 | -0.41 | sell |