| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 6,438,229 | 5,053,528 | +1,384,701 | 0.10 | 0.04 | 0.00 | sell |
| Bellevue Group AG | 2,040,853 | 2,802,853 | +762,000 | 1.10 | 0.87 | -0.23 | buy |
| ARMISTICE CAPITAL, LLC | 1,673,422 | 2,136,000 | +462,578 | 0.60 | 0.52 | -0.08 | buy |
| Prosight Management, LP | 100,000 | 539,071 | +439,071 | 0.79 | 1.85 | +1.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,822,974 | 3,171,235 | +348,261 | 0.01 | 0.01 | -0.00 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 300,000 | 550,000 | +250,000 | 2.31 | 1.72 | -0.59 | buy |
| Holocene Advisors, LP | 1,255,752 | 1,495,641 | +239,889 | 0.09 | 0.05 | -0.04 | buy |
| Y-Intercept (Hong Kong) Ltd | 26,846 | 251,882 | +225,036 | 0.04 | 0.09 | 0.00 | buy |
| ARS Investment Partners, LLC | 1,039,871 | 1,188,126 | +148,255 | 3.51 | 1.22 | -2.29 | buy |
| Integral Health Asset Management, LLC | 175,000 | 300,000 | +125,000 | 0.47 | 0.40 | -0.07 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 551,361 | 630,033 | +78,672 | 0.02 | 0.01 | -0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 99,784 | 145,372 | +45,588 | 0.55 | 0.48 | -0.07 | buy |
| Erste Asset Management GmbH | 51,300 | 93,300 | +42,000 | 0.02 | 0.01 | -0.01 | buy |
| TD ASSET MANAGEMENT INC | 249,712 | 291,028 | +41,316 | 0.01 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 94,579 | 129,243 | +34,664 | 0.01 | 0.01 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 271,822 | 291,928 | +20,106 | 0.02 | 0.01 | -0.01 | buy |
| DAFNA Capital Management LLC | 220,235 | 235,235 | +15,000 | 1.50 | 0.92 | -0.59 | buy |
| Inspire Investing, LLC | 14,249 | 27,692 | +13,443 | 0.04 | 0.04 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 22,641 | 32,341 | +9,700 | 0.10 | 0.07 | -0.03 | buy |
| Canton Hathaway, LLC | 21,350 | 30,500 | +9,150 | 0.10 | 0.09 | -0.02 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 665,945 | 673,166 | +7,221 | 8.08 | 6.51 | -1.56 | buy |
| AXQ CAPITAL, LP | 11,015 | 17,602 | +6,587 | 0.11 | 0.08 | -0.03 | buy |
| DCF Advisers, LLC | 50,500 | 56,500 | +6,000 | 0.65 | 0.38 | -0.27 | buy |
| DnB Asset Management AS | 9,576 | 15,137 | +5,561 | 0.00 | 0.00 | -0.00 | buy |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 16,880 | 19,280 | +2,400 | 0.14 | 0.09 | -0.05 | buy |
| E Fund Management Co., Ltd. | 11,185 | 13,492 | +2,307 | 0.01 | 0.01 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 4,083 | 6,032 | +1,949 | 0.03 | 0.03 | +0.00 | buy |
| Rafferty Asset Management, LLC | 119,686 | 121,189 | +1,503 | 0.01 | 0.01 | -0.01 | buy |
| ELKHORN PARTNERS LIMITED PARTNERSHIP | 4,600 | 5,800 | +1,200 | 0.07 | 0.06 | -0.01 | buy |
| PROFUND ADVISORS LLC | 25,286 | 25,764 | +478 | 0.03 | 0.01 | -0.01 | buy |
| Main Management ETF Advisors, LLC | 21,630 | 21,990 | +360 | 0.03 | 0.01 | -0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 17,170 | 17,399 | +229 | 0.06 | 0.04 | -0.02 | buy |
| NewEdge Wealth, LLC | 243,532 | 243,503 | -29 | 0.11 | 0.06 | -0.05 | sell |
| SIERRA OCEAN, LLC | 151 | 100 | -51 | 0.00 | 0.00 | -0.00 | sell |
| SIMON QUICK ADVISORS, LLC | 70,032 | 69,979 | -53 | 0.10 | 0.05 | -0.05 | sell |
| QTR Family Wealth, LLC | 332,222 | 332,147 | -75 | 6.02 | 2.90 | -3.12 | sell |
| OAK RIDGE INVESTMENTS LLC | 20,364 | 19,246 | -1,118 | 0.04 | 0.02 | -0.02 | sell |
| TRANSATLANTIQUE PRIVATE WEALTH LLC | 13,975 | 12,746 | -1,229 | 0.13 | 0.07 | -0.07 | sell |
| Clearbridge Investments, LLC | 510,824 | 509,041 | -1,783 | 0.01 | 0.01 | -0.00 | sell |
| Fiera Capital Corp | 581,675 | 575,110 | -6,565 | 0.05 | 0.03 | -0.02 | sell |
| SeaBridge Investment Advisors LLC | 38,829 | 18,923 | -19,906 | 0.20 | 0.05 | -0.15 | sell |
| F/m Investments LLC | 42,249 | 21,819 | -20,430 | 0.04 | 0.01 | -0.03 | sell |
| EMERALD ADVISERS, LLC | 354,953 | 321,009 | -33,944 | 0.38 | 0.17 | -0.22 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 238,361 | 172,999 | -65,362 | 0.41 | 0.15 | -0.26 | sell |
| STEMPOINT CAPITAL LP | 250,564 | 174,754 | -75,810 | 1.92 | 0.79 | -1.13 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 176,271 | 61,988 | -114,283 | 0.06 | 0.02 | -0.04 | sell |
| Redmile Group, LLC | 867,454 | 729,515 | -137,939 | 1.97 | 1.10 | -0.88 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 560,056 | 300,000 | -260,056 | 0.27 | 0.07 | -0.19 | sell |
| Woodline Partners LP | 600,449 | 300,389 | -300,060 | 0.09 | 0.02 | -0.07 | sell |
| T. Rowe Price Investment Management, Inc. | 643,946 | 311 | -643,635 | 0.01 | 0.00 | -0.01 | sell |