| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8,420,792 | 9,249,597 | +828,805 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 7,482,855 | 7,535,273 | +52,418 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 6,605,612 | 6,607,511 | +1,899 | 0.17 | 0.09 | -0.08 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,620,271 | 5,620,271 | 0 | 5.47 | 2.99 | -2.48 | hold |
| JANUS HENDERSON GROUP PLC | 6,438,229 | 5,053,528 | -1,384,701 | 0.10 | 0.03 | -0.06 | sell |
| STATE STREET CORP | 3,422,349 | 3,538,163 | +115,814 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,822,974 | 3,171,235 | +348,261 | 0.01 | 0.01 | -0.00 | buy |
| Bellevue Group AG | 2,040,853 | 2,802,853 | +762,000 | 1.10 | 0.87 | -0.23 | buy |
| JPMORGAN CHASE & CO | 1,959,833 | 2,572,042 | +612,209 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,673,422 | 2,136,000 | +462,578 | 1.08 | 1.14 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,958,980 | 2,030,919 | +71,939 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,911,270 | 1,664,913 | -246,357 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 901,258 | 1,627,539 | +726,281 | 0.02 | 0.02 | -0.00 | buy |
| Holocene Advisors, LP | 1,255,752 | 1,495,641 | +239,889 | 0.09 | 0.05 | -0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 146,799 | 1,439,120 | +1,292,321 | 0.01 | 0.07 | +0.06 | buy |
| ARS Investment Partners, LLC | 1,039,871 | 1,188,126 | +148,255 | 3.51 | 1.22 | -2.29 | buy |
| BROWN ADVISORY INC | 1,020,117 | 1,121,744 | +101,627 | 0.04 | 0.02 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 803,926 | 979,917 | +175,991 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 902,565 | 902,565 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 800,588 | 776,495 | -24,093 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 958,913 | 737,676 | -221,237 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 867,454 | 729,515 | -137,939 | 1.97 | 1.10 | -0.88 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 687,501 | 712,055 | +24,554 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 589,615 | 703,309 | +113,694 | 0.00 | 0.00 | -0.00 | buy |
| Logos Global Management LP | 0 | 700,000 | +700,000 | 0.00 | 1.32 | +1.32 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 665,945 | 673,166 | +7,221 | 10.42 | 8.22 | -2.20 | buy |
| AMERICAN CENTURY COMPANIES INC | 566,501 | 661,281 | +94,780 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 658,355 | +658,355 | 0.00 | 0.10 | +0.10 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 551,361 | 630,033 | +78,672 | 0.02 | 0.01 | -0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,881 | 628,622 | +619,741 | 0.00 | 0.01 | +0.01 | buy |
| Fiera Capital Corp | 581,675 | 575,110 | -6,565 | 0.05 | 0.03 | -0.02 | sell |
| INFINITUM ASSET MANAGEMENT, LLC | 300,000 | 550,000 | +250,000 | 2.31 | 1.72 | -0.59 | buy |
| Prosight Management, LP | 100,000 | 539,071 | +439,071 | 0.79 | 1.85 | +1.07 | buy |
| UBS Group AG | 636,873 | 529,821 | -107,052 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 34,562 | 518,779 | +484,217 | 0.00 | 0.01 | +0.01 | buy |
| Clearbridge Investments, LLC | 510,824 | 509,041 | -1,783 | 0.01 | 0.01 | -0.00 | sell |
| PFIZER INC | 505,645 | 505,645 | 0 | 2.43 | 1.24 | -1.19 | hold |
| Capital Research Global Investors | 0 | 484,193 | +484,193 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 478,972 | 478,972 | 0 | 4.35 | 2.60 | -1.76 | hold |
| Nuveen, LLC | 498,384 | 445,660 | -52,724 | 0.01 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 47,578 | 423,761 | +376,183 | 0.05 | 0.55 | +0.50 | buy |
| BANK OF AMERICA CORP /DE/ | 371,084 | 420,501 | +49,417 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 163,618 | 347,163 | +183,545 | 0.00 | 0.00 | +0.00 | buy |
| QTR Family Wealth, LLC | 332,222 | 332,147 | -75 | 6.02 | 2.90 | -3.12 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 330,532 | +330,532 | 0.00 | 0.19 | +0.19 | buy |
| CITADEL ADVISORS LLC | 1,227,373 | 323,351 | -904,022 | 0.03 | 0.00 | -0.02 | sell |
| EMERALD ADVISERS, LLC | 354,953 | 321,009 | -33,944 | 0.38 | 0.17 | -0.22 | sell |
| Woodline Partners LP | 600,449 | 300,389 | -300,060 | 0.09 | 0.02 | -0.07 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 560,056 | 300,000 | -260,056 | 0.27 | 0.07 | -0.19 | sell |
| Integral Health Asset Management, LLC | 175,000 | 300,000 | +125,000 | 0.47 | 0.40 | -0.07 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 271,822 | 291,928 | +20,106 | 0.02 | 0.01 | -0.01 | buy |
| TD ASSET MANAGEMENT INC | 249,712 | 291,028 | +41,316 | 0.01 | 0.00 | -0.00 | buy |
| Tri Locum Partners LP | 0 | 271,367 | +271,367 | 0.00 | 1.16 | +1.16 | buy |
| JANE STREET GROUP, LLC | 49,542 | 265,751 | +216,209 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 302,280 | 262,468 | -39,812 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 14,000 | 261,181 | +247,181 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 158,043 | 257,877 | +99,834 | 0.01 | 0.01 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 26,846 | 251,882 | +225,036 | 0.04 | 0.09 | +0.04 | buy |
| Capital World Investors | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Wealth, LLC | 243,532 | 243,503 | -29 | 0.11 | 0.06 | -0.05 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 174,276 | 236,154 | +61,878 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 220,235 | 235,235 | +15,000 | 1.50 | 0.92 | -0.59 | buy |
| CITIGROUP INC | 270,996 | 230,631 | -40,365 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 535,079 | 181,855 | -353,224 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 250,564 | 174,754 | -75,810 | 1.92 | 0.79 | -1.13 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 238,361 | 172,999 | -65,362 | 0.41 | 0.15 | -0.26 | sell |
| QVT Financial LP | 170,006 | 170,006 | 0 | 0.39 | 0.34 | -0.05 | hold |
| Swiss National Bank | 166,500 | 166,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 56,627 | 166,331 | +109,704 | 0.06 | 0.09 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 164,653 | 161,986 | -2,667 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 160,251 | 160,251 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 3,238 | 155,456 | +152,218 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 116,398 | 148,031 | +31,633 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 99,784 | 145,372 | +45,588 | 0.59 | 0.54 | -0.06 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 145,253 | +145,253 | 0.00 | 0.02 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 140,000 | 140,000 | 0 | 0.19 | 0.10 | -0.09 | hold |
| RHUMBLINE ADVISERS | 124,839 | 137,404 | +12,565 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 136,155 | +136,155 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 0 | 135,440 | +135,440 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 94,579 | 129,243 | +34,664 | 0.01 | 0.01 | -0.00 | buy |
| Verition Fund Management LLC | 8,866 | 122,456 | +113,590 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 119,686 | 121,189 | +1,503 | 0.01 | 0.01 | -0.01 | buy |
| Graham Capital Management, L.P. | 0 | 119,293 | +119,293 | 0.00 | 0.05 | +0.05 | buy |
| ALGERT GLOBAL LLC | 9,940 | 115,540 | +105,600 | 0.01 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 102,657 | 105,466 | +2,809 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 104,288 | +104,288 | 0.00 | 0.02 | +0.02 | buy |
| Empowered Funds, LLC | 0 | 99,399 | +99,399 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 95,364 | 98,516 | +3,152 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 0 | 96,389 | +96,389 | 0.00 | 0.08 | +0.08 | buy |
| ALLIANCEBERNSTEIN L.P. | 96,236 | 96,236 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 51,300 | 93,300 | +42,000 | 0.02 | 0.01 | -0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,833 | 92,446 | +20,613 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 68,460 | 89,912 | +21,452 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 84,970 | +84,970 | 0.00 | 0.03 | +0.03 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 80,300 | +80,300 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 80,000 | +80,000 | 0.00 | 0.29 | +0.29 | buy |
| AQR CAPITAL MANAGEMENT LLC | 114,849 | 77,848 | -37,001 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,390 | 74,486 | -4,904 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 69,123 | 73,631 | +4,508 | 0.00 | 0.00 | -0.00 | buy |
| SIMON QUICK ADVISORS, LLC | 70,032 | 69,979 | -53 | 0.10 | 0.05 | -0.05 | sell |