| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,222,407 | 13,210,585 | +1,988,178 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,286,937 | 10,286,937 | 0 | 2.36 | 3.22 | +0.86 | hold |
| STIFEL FINANCIAL CORP | 9,940,885 | 9,941,165 | +280 | 0.08 | 0.12 | +0.05 | buy |
| Woodline Partners LP | 300,389 | 7,660,280 | +7,359,891 | 0.01 | 0.35 | +0.34 | buy |
| STATE STREET CORP | 6,618,803 | 6,947,034 | +328,231 | 0.00 | 0.00 | +0.00 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 6,250,000 | 6,250,000 | 0 | 6.62 | 9.46 | +2.84 | hold |
| D. E. Shaw & Co., Inc. | 2,847,193 | 4,190,195 | +1,343,002 | 0.02 | 0.04 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,975,516 | 4,150,616 | +2,175,100 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,767,763 | 3,323,190 | +555,427 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,359,047 | 2,964,630 | +605,583 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 1,760,000 | 2,610,000 | +850,000 | 0.75 | 1.99 | +1.24 | buy |
| GOLDMAN SACHS GROUP INC | 2,513,181 | 2,583,046 | +69,865 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,426,427 | 2,518,827 | +1,092,400 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,445,416 | 1,879,734 | -565,682 | 0.04 | 0.05 | +0.01 | sell |
| TCG Crossover Management, LLC | 4,631,317 | 1,779,952 | -2,851,365 | 1.12 | 0.64 | -0.48 | sell |
| Nuveen, LLC | 745,748 | 1,744,334 | +998,586 | 0.00 | 0.01 | +0.00 | buy |
| Rubric Capital Management LP | 0 | 1,721,493 | +1,721,493 | 0.00 | 0.23 | +0.23 | buy |
| CITADEL ADVISORS LLC | 1,723,107 | 1,619,676 | -103,431 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 759,425 | 1,477,838 | +718,413 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,217,175 | 1,456,851 | -760,324 | 0.00 | 0.00 | +0.00 | sell |
| ARS Investment Partners, LLC | 1,378,828 | 1,374,185 | -4,643 | 0.61 | 0.89 | +0.29 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,544,338 | 1,224,422 | -319,916 | 0.01 | 0.01 | +0.00 | sell |
| Capital Research Global Investors | 1,332,792 | 1,199,545 | -133,247 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,001,410 | 1,186,211 | +184,801 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 1,225,000 | 1,150,000 | -75,000 | 2.45 | 4.16 | +1.71 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 1,109,283 | +1,109,283 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 941,077 | 1,109,283 | +168,206 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 1,594,491 | 1,064,200 | -530,291 | 2.59 | 2.74 | +0.15 | sell |
| Simplify Asset Management Inc. | 898,400 | 1,040,255 | +141,855 | 0.12 | 0.22 | +0.10 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,497,793 | 1,000,000 | -497,793 | 0.02 | 0.02 | +0.00 | sell |
| Qube Research & Technologies Ltd | 1,540,445 | 905,935 | -634,510 | 0.02 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,219,830 | 882,724 | -337,106 | 0.04 | 0.06 | +0.01 | sell |
| MORGAN STANLEY | 1,026,932 | 841,351 | -185,581 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 412,481 | 748,181 | +335,700 | 0.50 | 1.82 | +1.32 | buy |
| 5AM Venture Management, LLC | 738,972 | 738,972 | 0 | 1.74 | 3.82 | +2.08 | hold |
| Erste Asset Management GmbH | 693,300 | 737,300 | +44,000 | 0.05 | 0.09 | +0.03 | buy |
| Integral Health Asset Management, LLC | 1,000,000 | 700,000 | -300,000 | 0.45 | 0.43 | -0.02 | sell |
| MARSHALL WACE, LLP | 352,605 | 651,349 | +298,744 | 0.00 | 0.01 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 599,903 | +599,903 | 0.00 | 0.26 | +0.26 | buy |
| Sarissa Capital Management LP | 563,184 | 582,312 | +19,128 | 3.02 | 4.87 | +1.85 | buy |
| Eversept Partners, LP | 0 | 515,804 | +515,804 | 0.00 | 0.42 | +0.42 | buy |
| PFIZER INC | 505,645 | 505,645 | 0 | 1.77 | 4.70 | +2.93 | hold |
| Trexquant Investment LP | 877,774 | 503,694 | -374,080 | 0.05 | 0.05 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 44,777 | 501,687 | +456,910 | 0.02 | 0.35 | +0.33 | buy |
| Burkehill Global Management, LP | 500,000 | 500,000 | 0 | 0.21 | 0.27 | +0.06 | hold |
| Point72 Asset Management, L.P. | 373,099 | 491,918 | +118,819 | 0.01 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 278,704 | 475,865 | +197,161 | 0.01 | 0.03 | +0.02 | buy |
| JPMORGAN CHASE & CO | 503,565 | 469,832 | -33,733 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 446,611 | 465,895 | +19,284 | 0.00 | 0.00 | +0.00 | buy |
| Fiera Capital Corp | 774,168 | 445,769 | -328,399 | 0.02 | 0.02 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,186,714 | 443,775 | -742,939 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,447,886 | 417,534 | -1,030,352 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 307,244 | 386,939 | +79,695 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 771,452 | 365,519 | -405,933 | 0.01 | 0.01 | -0.00 | sell |
| QVT Financial LP | 170,006 | 354,206 | +184,200 | 0.11 | 0.34 | +0.22 | buy |
| QTR Family Wealth, LLC | 335,980 | 337,432 | +1,452 | 1.46 | 1.75 | +0.29 | buy |
| CITIGROUP INC | 35,237 | 314,453 | +279,216 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 252,931 | 309,068 | +56,137 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 322,750 | 308,980 | -13,770 | 0.04 | 0.05 | +0.01 | sell |
| ROYAL BANK OF CANADA | 122,452 | 290,401 | +167,949 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 310,647 | 269,967 | -40,680 | 0.04 | 0.06 | +0.02 | sell |
| HRT FINANCIAL LP | 833,666 | 268,529 | -565,137 | 0.02 | 0.01 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 55,340 | 268,227 | +212,887 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.18 | +0.18 | buy |
| Swiss National Bank | 258,600 | 249,000 | -9,600 | 0.00 | 0.00 | +0.00 | sell |
| NewEdge Wealth, LLC | 246,503 | 245,670 | -833 | 0.02 | 0.04 | +0.01 | sell |
| JANE STREET GROUP, LLC | 228,444 | 238,403 | +9,959 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 127,862 | 230,684 | +102,822 | 0.02 | 0.06 | +0.04 | buy |
| Mariner, LLC | 95,376 | 212,539 | +117,163 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 202,040 | +202,040 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 162,813 | 201,499 | +38,686 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 305,567 | 181,182 | -124,385 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 160,251 | 180,651 | +20,400 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,036 | 172,876 | +72,840 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 121,554 | 170,749 | +49,195 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 93,041 | 170,270 | +77,229 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 408,482 | 170,163 | -238,319 | 0.06 | 0.03 | -0.03 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 172,370 | 168,876 | -3,494 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 136,883 | 164,749 | +27,866 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 594,000 | 164,437 | -429,563 | 0.86 | 0.35 | -0.51 | sell |
| Cerity Partners LLC | 112,825 | 161,910 | +49,085 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 177,390 | 160,190 | -17,200 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 202,975 | 159,067 | -43,908 | 0.00 | 0.00 | +0.00 | sell |
| Empowered Funds, LLC | 148,756 | 152,060 | +3,304 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 160,952 | 150,752 | -10,200 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 75,339 | 145,000 | +69,661 | 0.03 | 0.08 | +0.05 | buy |
| DAFNA Capital Management LLC | 845,735 | 137,593 | -708,142 | 1.63 | 0.39 | -1.24 | sell |
| BARCLAYS PLC | 125,822 | 132,959 | +7,137 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 123,500 | 130,000 | +6,500 | 0.39 | 0.51 | +0.11 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 61,017 | 125,152 | +64,135 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 56,113 | 118,599 | +62,486 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 49,225 | 114,594 | +65,369 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 177,678 | 109,161 | -68,517 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 204,548 | 105,374 | -99,174 | 0.01 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 102,083 | 101,920 | -163 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 0 | 98,357 | +98,357 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 95,987 | 94,255 | -1,732 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 83,336 | 92,773 | +9,437 | 0.00 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 31,299 | 92,291 | +60,992 | 0.01 | 0.04 | +0.03 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 100,400 | 88,400 | -12,000 | 0.01 | 0.01 | +0.00 | sell |