| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 320,820 | 751,820 | +431,000 | 0.22 | 0.66 | +0.43 | buy |
| Woodline Partners LP | 291,581 | 536,073 | +244,492 | 0.08 | 0.16 | +0.08 | buy |
| ARMISTICE CAPITAL, LLC | 1,800,000 | 2,036,000 | +236,000 | 1.08 | 1.57 | +0.49 | buy |
| Nicholas Investment Partners, LP | 425,000 | 592,547 | +167,547 | 0.70 | 1.15 | +0.46 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,177,216 | 2,343,142 | +165,926 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 189,590 | 342,861 | +153,271 | 0.03 | 0.05 | +0.03 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,867,558 | 4,005,600 | +138,042 | 4.95 | 5.63 | +0.68 | buy |
| TD ASSET MANAGEMENT INC | 100,173 | 210,746 | +110,573 | 0.00 | 0.01 | +0.00 | buy |
| Monashee Investment Management LLC | 50,000 | 90,000 | +40,000 | 0.29 | 0.98 | +0.69 | buy |
| PROFUND ADVISORS LLC | 34,819 | 57,514 | +22,695 | 0.04 | 0.08 | +0.04 | buy |
| Erste Asset Management GmbH | 10,900 | 27,900 | +17,000 | 0.00 | 0.01 | +0.01 | buy |
| MYDA Advisors LLC | 70,000 | 85,000 | +15,000 | 0.63 | 0.83 | +0.20 | buy |
| DAFNA Capital Management LLC | 21,113 | 35,000 | +13,887 | 0.14 | 0.28 | +0.15 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 597,773 | 607,527 | +9,754 | 13.51 | 24.28 | +10.77 | buy |
| JANUS HENDERSON GROUP PLC | 5,316,799 | 5,325,581 | +8,782 | 0.08 | 0.09 | 0.00 | buy |
| E Fund Management Co., Ltd. | 10,193 | 17,608 | +7,415 | 0.02 | 0.03 | +0.02 | buy |
| EQUITEC PROPRIETARY MARKETS, LLC | 43,250 | 49,250 | +6,000 | 0.73 | 1.29 | +0.56 | buy |
| FSC Wealth Advisors, LLC | 10,000 | 15,000 | +5,000 | 0.22 | 0.40 | +0.19 | buy |
| Quantum Private Wealth, LLC | 27,005 | 31,005 | +4,000 | 0.30 | 0.39 | +0.09 | buy |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 10,140 | 12,140 | +2,000 | 0.09 | 0.13 | +0.04 | buy |
| ARS Investment Partners, LLC | 623,439 | 624,349 | +910 | 1.74 | 2.01 | +0.27 | buy |
| FARMERS & MERCHANTS INVESTMENTS INC | 1,000 | 500 | +500 | 0.00 | 0.00 | 0.00 | sell |
| Canton Hathaway, LLC | 21,350 | 21,850 | +500 | 0.16 | 0.18 | +0.02 | buy |
| SIMON QUICK ADVISORS, LLC | 55,011 | 55,000 | -11 | 0.12 | 0.13 | +0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 25,595 | 25,530 | -65 | 0.01 | 0.01 | +0.00 | sell |
| CSS LLC/IL | 150 | 50 | -100 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 24,189 | 24,002 | -187 | 0.12 | 0.13 | +0.02 | sell |
| OAK RIDGE INVESTMENTS LLC | 8,739 | 8,437 | -302 | 0.03 | 0.03 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 4,460 | 4,057 | -403 | 0.06 | 0.06 | +0.00 | sell |
| HARVEST MANAGEMENT LLC | 16,100 | 15,600 | -500 | 0.39 | 0.23 | -0.16 | sell |
| VELA Investment Management, LLC | 9,868 | 9,269 | -599 | 0.11 | 0.11 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,067 | 9,067 | -1,000 | 0.02 | 0.02 | +0.00 | sell |
| Inspire Investing, LLC | 12,926 | 11,602 | -1,324 | 0.04 | 0.04 | +0.00 | sell |
| Clearbridge Investments, LLC | 433,438 | 431,973 | -1,465 | 0.01 | 0.01 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 20,000 | 10,000 | -10,000 | 0.16 | 0.10 | -0.06 | sell |
| Informed Momentum Co LLC | 109,841 | 87,552 | -22,289 | 0.49 | 0.44 | -0.05 | sell |
| Avidity Partners Management LP | 1,325,000 | 1,285,400 | -39,600 | 1.11 | 1.35 | +0.24 | sell |
| FRED ALGER MANAGEMENT, LLC | 115,672 | 70,721 | -44,951 | 0.01 | 0.01 | -0.00 | sell |
| Holocene Advisors, LP | 2,063,988 | 1,969,752 | -94,236 | 0.22 | 0.23 | +0.01 | sell |
| Opaleye Management Inc. | 540,000 | 439,000 | -101,000 | 3.09 | 3.71 | +0.63 | sell |
| Hudson Bay Capital Management LP | 129,963 | 10,000 | -119,963 | 0.03 | 0.00 | -0.03 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,480,305 | 1,242,075 | -238,230 | 0.08 | 0.07 | -0.00 | sell |
| Capital International Investors | 930,162 | 669,351 | -260,811 | 0.01 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 427,417 | 106,138 | -321,279 | 3.61 | 1.02 | -2.58 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 435,847 | 39,402 | -396,445 | 0.13 | 0.01 | -0.12 | sell |