| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hood River Capital Management LLC | 368,902 | 902,888 | +533,986 | 0.27 | 0.73 | +0.46 | buy |
| JANUS HENDERSON GROUP PLC | 5,898,294 | 6,226,393 | +328,099 | 0.11 | 0.16 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,284,479 | 3,438,526 | +154,047 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 807,087 | 923,807 | +116,720 | 0.27 | 0.39 | +0.12 | buy |
| ARS Investment Partners, LLC | 940,512 | 1,030,239 | +89,727 | 3.12 | 4.61 | +1.49 | buy |
| TWO SIGMA INVESTMENTS, LP | 337,990 | 280,765 | +57,225 | 0.03 | 0.03 | 0.00 | sell |
| D. E. Shaw & Co., Inc. | 540,426 | 577,723 | +37,297 | 0.03 | 0.04 | 0.00 | buy |
| FIL Ltd | 61,860 | 85,204 | +23,344 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 40,294 | 58,142 | +17,848 | 0.01 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 295,842 | 310,842 | +15,000 | 0.01 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 450,000 | 465,000 | +15,000 | 0.66 | 1.19 | +0.52 | buy |
| BAMCO INC /NY/ | 35,000 | 45,000 | +10,000 | 0.00 | 0.01 | +0.00 | buy |
| 5AM Venture Management, LLC | 469,972 | 478,972 | +9,000 | 3.65 | 4.95 | +1.30 | buy |
| PROFUND ADVISORS LLC | 36,239 | 27,588 | +8,651 | 0.05 | 0.05 | 0.00 | sell |
| GABELLI FUNDS LLC | 20,500 | 13,200 | +7,300 | 0.01 | 0.00 | -0.00 | sell |
| TRANSATLANTIQUE PRIVATE WEALTH LLC | 7,707 | 14,142 | +6,435 | 0.11 | 0.27 | +0.16 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 700,450 | 705,250 | +4,800 | 22.68 | 21.12 | -1.56 | buy |
| Erste Asset Management GmbH | 46,900 | 51,300 | +4,400 | 0.02 | 0.03 | +0.01 | buy |
| SeaBridge Investment Advisors LLC | 36,226 | 40,095 | +3,869 | 0.33 | 0.49 | +0.16 | buy |
| Pekin Hardy Strauss, Inc. | 13,300 | 16,975 | +3,675 | 0.06 | 0.11 | +0.04 | buy |
| VELA Investment Management, LLC | 13,958 | 17,530 | +3,572 | 0.17 | 0.30 | +0.13 | buy |
| EntryPoint Capital, LLC | 3,186 | 4,055 | +869 | 0.16 | 0.12 | -0.05 | buy |
| Advisors Asset Management, Inc. | 16,903 | 16,558 | +345 | 0.01 | 0.02 | 0.00 | sell |
| FARMERS & MERCHANTS INVESTMENTS INC | 500 | 300 | +200 | 0.00 | 0.00 | 0.00 | sell |
| Quantum Private Wealth, LLC | 30,856 | 31,056 | +200 | 0.38 | 0.53 | +0.15 | buy |
| NewEdge Wealth, LLC | 243,503 | 243,605 | +102 | 0.18 | 0.22 | +0.04 | buy |
| GHP Investment Advisors, Inc. | 100 | 200 | +100 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,710 | 2,760 | +50 | 0.05 | 0.06 | +0.02 | buy |
| SIMON QUICK ADVISORS, LLC | 71,815 | 71,862 | +47 | 0.18 | 0.23 | +0.05 | buy |
| Washington Trust Advisors, Inc. | 205 | 175 | -30 | 0.00 | 0.00 | +0.00 | sell |
| Clearbridge Investments, LLC | 479,369 | 479,249 | -120 | 0.01 | 0.02 | +0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 99,566 | -434 | 0.86 | 1.12 | +0.26 | sell |
| Canton Hathaway, LLC | 21,850 | 21,350 | -500 | 0.21 | 0.27 | +0.06 | sell |
| OAK RIDGE INVESTMENTS LLC | 22,000 | 21,146 | -854 | 0.07 | 0.09 | +0.02 | sell |
| DnB Asset Management AS | 8,220 | 6,955 | -1,265 | 0.00 | 0.00 | +0.00 | sell |
| ELKHORN PARTNERS LIMITED PARTNERSHIP | 3,600 | 2,200 | -1,400 | 0.09 | 0.07 | -0.02 | sell |
| Inspire Investing, LLC | 10,150 | 8,197 | -1,953 | 0.04 | 0.04 | +0.00 | sell |
| E Fund Management Co., Ltd. | 11,883 | 8,838 | -3,045 | 0.02 | 0.02 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 27,227 | 20,807 | -6,420 | 0.04 | 0.07 | +0.03 | sell |
| STEMPOINT CAPITAL LP | 233,255 | 216,440 | -16,815 | 2.38 | 3.24 | +0.86 | sell |
| Nicholas Investment Partners, LP | 45,966 | 25,449 | -20,517 | 0.17 | 0.12 | -0.05 | sell |
| DCF Advisers, LLC | 51,700 | 31,000 | -20,700 | 0.94 | 0.80 | -0.14 | sell |
| DAFNA Capital Management LLC | 218,730 | 187,130 | -31,600 | 1.81 | 2.21 | +0.40 | sell |
| MYDA Advisors LLC | 107,000 | 70,000 | -37,000 | 0.81 | 0.77 | -0.04 | sell |
| First Turn Management, LLC | 366,019 | 315,816 | -50,203 | 2.07 | 2.50 | +0.43 | sell |
| Magnetar Financial LLC | 59,371 | 6,558 | -52,813 | 0.04 | 0.01 | -0.04 | sell |
| Redmile Group, LLC | 1,087,576 | 1,034,219 | -53,357 | 2.28 | 3.04 | +0.76 | sell |
| Rafferty Asset Management, LLC | 195,660 | 137,551 | -58,109 | 0.03 | 0.02 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,877,032 | 1,755,121 | -121,911 | 0.09 | 0.14 | +0.05 | sell |
| Hudson Bay Capital Management LP | 152,754 | 12,500 | -140,254 | 0.02 | 0.00 | -0.02 | sell |
| ARMISTICE CAPITAL, LLC | 1,396,968 | 1,199,495 | -197,473 | 0.61 | 0.96 | +0.35 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 213,031 | 8,484 | -204,547 | 0.16 | 0.01 | -0.15 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 634,664 | 399,827 | -234,837 | 0.38 | 0.34 | -0.03 | sell |
| Cormorant Asset Management, LP | 801,963 | 401,963 | -400,000 | 1.61 | 1.07 | -0.54 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,913,309 | 1,482,485 | -430,824 | 0.12 | 0.13 | +0.01 | sell |
| Holocene Advisors, LP | 1,696,355 | 852,627 | -843,728 | 0.25 | 0.17 | -0.07 | sell |