| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7,535,273 | 7,874,891 | +339,618 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 5,053,528 | 6,772,113 | +1,718,585 | 0.03 | 0.05 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 6,607,511 | 6,611,350 | +3,839 | 0.09 | 0.09 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,620,271 | 5,620,271 | 0 | 2.99 | 2.56 | -0.43 | hold |
| STATE STREET CORP | 3,538,163 | 4,258,283 | +720,120 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 9,249,597 | 2,875,190 | -6,374,407 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 2,802,853 | 2,802,853 | 0 | 0.87 | 0.87 | +0.00 | hold |
| FMR LLC | 1,664,913 | 2,426,904 | +761,991 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,030,919 | 2,060,208 | +29,289 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,171,235 | 2,009,611 | -1,161,624 | 0.01 | 0.00 | -0.00 | sell |
| INFINITUM ASSET MANAGEMENT, LLC | 550,000 | 1,700,000 | +1,150,000 | 1.72 | 4.69 | +2.97 | buy |
| GOLDMAN SACHS GROUP INC | 979,917 | 1,578,390 | +598,473 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,572,042 | 1,335,455 | -1,236,587 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 518,779 | 1,266,792 | +748,013 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 135,440 | 1,265,597 | +1,130,157 | 0.00 | 0.03 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 630,033 | 1,260,033 | +630,000 | 0.01 | 0.03 | +0.01 | buy |
| UBS Group AG | 529,821 | 1,119,665 | +589,844 | 0.00 | 0.00 | +0.00 | buy |
| ARS Investment Partners, LLC | 1,188,126 | 1,102,549 | -85,577 | 1.22 | 1.09 | -0.13 | sell |
| STEMPOINT CAPITAL LP | 174,754 | 1,017,311 | +842,557 | 0.79 | 3.08 | +2.29 | buy |
| Capital Research Global Investors | 484,193 | 1,011,530 | +527,337 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 323,351 | 997,793 | +674,442 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,627,539 | 968,153 | -659,386 | 0.02 | 0.01 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 628,622 | 843,564 | +214,942 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 73,631 | 799,600 | +725,969 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 265,751 | 799,278 | +533,527 | 0.01 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 420,501 | 788,331 | +367,830 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 33,312 | 781,323 | +748,011 | 0.00 | 0.04 | +0.04 | buy |
| NORTHERN TRUST CORP | 776,495 | 775,895 | -600 | 0.00 | 0.00 | -0.00 | sell |
| Holocene Advisors, LP | 1,495,641 | 765,874 | -729,767 | 0.05 | 0.03 | -0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 712,055 | 749,721 | +37,666 | 0.00 | 0.00 | +0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 673,166 | 739,986 | +66,820 | 8.22 | 7.75 | -0.47 | buy |
| BROWN ADVISORY INC | 1,121,744 | 674,651 | -447,093 | 0.02 | 0.01 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 661,281 | 665,918 | +4,637 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 300,000 | 650,000 | +350,000 | 0.40 | 0.71 | +0.32 | buy |
| Caption Management, LLC | 423,761 | 627,862 | +204,101 | 0.55 | 0.55 | +0.00 | buy |
| Prosight Management, LP | 539,071 | 600,000 | +60,929 | 1.85 | 2.16 | +0.31 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 703,309 | 571,911 | -131,398 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 257,877 | 569,543 | +311,666 | 0.01 | 0.01 | +0.01 | buy |
| Fiera Capital Corp | 575,110 | 561,354 | -13,756 | 0.03 | 0.03 | -0.00 | sell |
| MORGAN STANLEY | 737,676 | 545,815 | -191,861 | 0.00 | 0.00 | -0.00 | sell |
| PFIZER INC | 505,645 | 505,645 | 0 | 1.24 | 1.73 | +0.50 | hold |
| 5AM Venture Management, LLC | 478,972 | 478,972 | 0 | 2.60 | 2.63 | +0.03 | hold |
| Clearbridge Investments, LLC | 509,041 | 430,377 | -78,664 | 0.01 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 380,874 | +380,874 | 0.00 | 0.01 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 330,532 | 377,119 | +46,587 | 0.19 | 0.28 | +0.08 | buy |
| Nuveen, LLC | 445,660 | 376,339 | -69,321 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 347,163 | 346,844 | -319 | 0.00 | 0.00 | -0.00 | sell |
| QTR Family Wealth, LLC | 332,147 | 332,288 | +141 | 2.90 | 2.37 | -0.54 | buy |
| EMERALD ADVISERS, LLC | 321,009 | 311,881 | -9,128 | 0.17 | 0.15 | -0.02 | sell |
| Woodline Partners LP | 300,389 | 300,389 | 0 | 0.02 | 0.02 | -0.00 | hold |
| WCM INVESTMENT MANAGEMENT, LLC | 291,928 | 287,860 | -4,068 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 262,468 | 284,439 | +21,971 | 0.00 | 0.00 | +0.00 | buy |
| Capital World Investors | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Wealth, LLC | 243,503 | 246,553 | +3,050 | 0.06 | 0.03 | -0.03 | buy |
| Weiss Asset Management LP | 0 | 242,119 | +242,119 | 0.00 | 0.05 | +0.05 | buy |
| Squarepoint Ops LLC | 0 | 241,423 | +241,423 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 235,235 | 235,235 | 0 | 0.92 | 0.87 | -0.04 | hold |
| AQR CAPITAL MANAGEMENT LLC | 77,848 | 213,267 | +135,419 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 212,800 | +212,800 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 104,288 | 199,851 | +95,563 | 0.02 | 0.03 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 84,970 | 178,910 | +93,940 | 0.03 | 0.04 | +0.02 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 172,999 | 173,656 | +657 | 0.15 | 0.13 | -0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 251,882 | 172,216 | -79,666 | 0.09 | 0.06 | -0.02 | sell |
| DCF Advisers, LLC | 56,500 | 171,500 | +115,000 | 0.38 | 0.97 | +0.59 | buy |
| QVT Financial LP | 170,006 | 170,006 | 0 | 0.34 | 0.28 | -0.05 | hold |
| Swiss National Bank | 166,500 | 168,300 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 43,601 | 166,858 | +123,257 | 0.01 | 0.04 | +0.03 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 166,331 | 166,331 | 0 | 0.09 | 0.06 | -0.03 | hold |
| Rafferty Asset Management, LLC | 121,189 | 163,569 | +42,380 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 160,251 | 160,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 181,855 | 157,972 | -23,883 | 0.00 | 0.00 | -0.00 | sell |
| Empowered Funds, LLC | 99,399 | 155,843 | +56,444 | 0.02 | 0.02 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,439,120 | 153,638 | -1,285,482 | 0.07 | 0.01 | -0.07 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 261,181 | 152,886 | -108,295 | 0.04 | 0.02 | -0.02 | sell |
| Tri Locum Partners LP | 271,367 | 149,179 | -122,188 | 1.16 | 0.51 | -0.65 | sell |
| Verition Fund Management LLC | 122,456 | 146,180 | +23,724 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 140,000 | 140,000 | 0 | 0.10 | 0.08 | -0.02 | hold |
| ROYAL BANK OF CANADA | 148,031 | 139,572 | -8,459 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 115,540 | 136,290 | +20,750 | 0.03 | 0.03 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 291,028 | 136,028 | -155,000 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 236,154 | 134,301 | -101,853 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 137,404 | 133,920 | -3,484 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 129,243 | 128,845 | -398 | 0.01 | 0.01 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 145,253 | 126,291 | -18,962 | 0.02 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 161,986 | 124,413 | -37,573 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 89,912 | 122,521 | +32,609 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 105,466 | 112,127 | +6,661 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 96,389 | 109,685 | +13,296 | 0.08 | 0.03 | -0.05 | buy |
| Legal & General Group Plc | 98,516 | 97,479 | -1,037 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 96,236 | 96,392 | +156 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 658,355 | 93,791 | -564,564 | 0.10 | 0.02 | -0.08 | sell |
| Erste Asset Management GmbH | 93,300 | 93,300 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 32,614 | 92,045 | +59,431 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 145,372 | 91,155 | -54,217 | 0.54 | 0.32 | -0.21 | sell |
| Point72 Asset Management, L.P. | 0 | 81,000 | +81,000 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 80,300 | 80,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 74,486 | 80,150 | +5,664 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 80,000 | 80,000 | 0 | 0.29 | 0.21 | -0.08 | hold |
| MYDA Advisors LLC | 0 | 75,000 | +75,000 | 0.00 | 0.34 | +0.34 | buy |