| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 751,820 | 1,725,047 | +973,227 | 0.65 | 1.65 | +1.00 | buy |
| Redmile Group, LLC | 518,924 | 1,444,365 | +925,441 | 0.64 | 2.21 | +1.57 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,343,142 | 3,134,323 | +791,181 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,242,075 | 2,020,644 | +778,569 | 0.07 | 0.18 | +0.11 | buy |
| JANUS HENDERSON GROUP PLC | 5,325,581 | 5,901,343 | +575,762 | 0.09 | 0.15 | 0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,005,600 | 4,572,836 | +567,236 | 5.63 | 8.85 | +3.22 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 39,402 | 375,229 | +335,827 | 0.01 | 0.19 | +0.18 | buy |
| Woodline Partners LP | 536,073 | 743,115 | +207,042 | 0.16 | 0.35 | +0.18 | buy |
| DAFNA Capital Management LLC | 35,000 | 168,772 | +133,772 | 0.28 | 1.73 | +1.45 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 607,527 | 716,427 | +108,900 | 4.85 | 18.65 | +13.80 | buy |
| TD ASSET MANAGEMENT INC | 210,746 | 276,172 | +65,426 | 0.01 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 10,000 | 70,695 | +60,695 | 0.10 | 0.93 | +0.84 | buy |
| MYDA Advisors LLC | 85,000 | 125,000 | +40,000 | 0.71 | 1.79 | +1.07 | buy |
| SIMON QUICK ADVISORS, LLC | 55,000 | 74,968 | +19,968 | 0.13 | 0.28 | +0.15 | buy |
| PROFUND ADVISORS LLC | 57,514 | 44,513 | +13,001 | 0.08 | 0.08 | 0.00 | sell |
| ARS Investment Partners, LLC | 624,349 | 633,964 | +9,615 | 2.01 | 3.01 | +0.99 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 24,002 | 29,552 | +5,550 | 0.13 | 0.24 | +0.11 | buy |
| GILDER GAGNON HOWE & CO LLC | 25,530 | 29,852 | +4,322 | 0.01 | 0.02 | +0.01 | buy |
| Informed Momentum Co LLC | 87,552 | 91,851 | +4,299 | 0.44 | 0.70 | +0.26 | buy |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 12,140 | 13,640 | +1,500 | 0.13 | 0.21 | +0.08 | buy |
| Clearbridge Investments, LLC | 431,973 | 432,064 | +91 | 0.01 | 0.02 | +0.01 | buy |
| Quantum Private Wealth, LLC | 31,005 | 30,856 | -149 | 0.39 | 0.55 | +0.17 | sell |
| Canton Hathaway, LLC | 21,850 | 21,350 | -500 | 0.18 | 0.28 | +0.10 | sell |
| HARVEST MANAGEMENT LLC | 15,600 | 15,100 | -500 | 0.21 | 0.60 | +0.39 | sell |
| OAK RIDGE INVESTMENTS LLC | 8,437 | 7,802 | -635 | 0.03 | 0.04 | +0.01 | sell |
| VIRTUS ADVISERS, LLC | 4,057 | 2,459 | -1,598 | 0.06 | 0.07 | +0.00 | sell |
| Inspire Investing, LLC | 11,602 | 9,022 | -2,580 | 0.04 | 0.04 | +0.00 | sell |
| E Fund Management Co., Ltd. | 17,608 | 14,528 | -3,080 | 0.03 | 0.04 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 70,721 | 66,964 | -3,757 | 0.01 | 0.02 | +0.00 | sell |
| Hudson Bay Capital Management LP | 10,000 | 5,000 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Sigma Planning Corp | 12,865 | 6,418 | -6,447 | 0.01 | 0.02 | +0.01 | sell |
| Affinity Asset Advisors, LLC | 30,156 | 20,866 | -9,290 | 0.26 | 0.18 | -0.08 | sell |
| Eversept Partners, LP | 131,103 | 66,898 | -64,205 | 0.29 | 0.25 | -0.04 | sell |
| Rafferty Asset Management, LLC | 342,861 | 271,577 | -71,284 | 0.05 | 0.05 | -0.00 | sell |
| Avidity Partners Management LP | 1,285,400 | 1,148,308 | -137,092 | 1.35 | 1.88 | +0.53 | sell |
| Opaleye Management Inc. | 439,000 | 200,000 | -239,000 | 3.71 | 2.28 | -1.44 | sell |
| Nicholas Investment Partners, LP | 592,547 | 119,512 | -473,035 | 1.15 | 0.60 | -0.55 | sell |
| Holocene Advisors, LP | 1,969,752 | 1,441,361 | -528,391 | 0.22 | 0.24 | +0.02 | sell |
| ARMISTICE CAPITAL, LLC | 2,036,000 | 1,500,000 | -536,000 | 0.81 | 0.88 | +0.07 | sell |