| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 1,025,495 | 2,483,567 | +1,458,072 | 0.09 | 0.32 | +0.23 | buy |
| Bellevue Group AG | 0 | 1,075,000 | +1,075,000 | 0.00 | 0.70 | +0.70 | buy |
| PERCEPTIVE ADVISORS LLC | 751,820 | 1,725,047 | +973,227 | 0.66 | 1.65 | +0.99 | buy |
| Redmile Group, LLC | 518,924 | 1,444,365 | +925,441 | 0.64 | 2.21 | +1.57 | buy |
| CITADEL ADVISORS LLC | 474,062 | 1,296,438 | +822,376 | 0.01 | 0.06 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,343,142 | 3,134,323 | +791,181 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,242,075 | 2,020,644 | +778,569 | 0.07 | 0.18 | +0.11 | buy |
| JANUS HENDERSON GROUP PLC | 5,325,581 | 5,901,343 | +575,762 | 0.09 | 0.15 | +0.06 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,005,600 | 4,572,836 | +567,236 | 5.63 | 8.95 | +3.32 | buy |
| STIFEL FINANCIAL CORP | 5,769,749 | 6,225,811 | +456,062 | 0.21 | 0.34 | +0.12 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 401,101 | +401,101 | 0.00 | 0.28 | +0.28 | buy |
| 5AM Venture Management, LLC | 0 | 399,972 | +399,972 | 0.00 | 4.54 | +4.54 | buy |
| First Light Asset Management, LLC | 0 | 383,757 | +383,757 | 0.00 | 1.32 | +1.32 | buy |
| TWO SIGMA INVESTMENTS, LP | 8,100 | 348,061 | +339,961 | 0.00 | 0.04 | +0.04 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 39,402 | 375,229 | +335,827 | 0.01 | 0.19 | +0.18 | buy |
| Hood River Capital Management LLC | 0 | 324,201 | +324,201 | 0.00 | 0.38 | +0.38 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 23,524 | 332,895 | +309,371 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 266,391 | +266,391 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,163,190 | 1,426,446 | +263,256 | 0.00 | 0.01 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 253,000 | +253,000 | 0.00 | 0.04 | +0.04 | buy |
| MORGAN STANLEY | 351,020 | 590,982 | +239,962 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,428,983 | 1,658,151 | +229,168 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 25,257 | 250,270 | +225,013 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 536,073 | 743,115 | +207,042 | 0.16 | 0.35 | +0.18 | buy |
| D. E. Shaw & Co., Inc. | 11,044 | 209,881 | +198,837 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 158,513 | +158,513 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 146,200 | +146,200 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 35,000 | 168,772 | +133,772 | 0.28 | 1.73 | +1.45 | buy |
| Global IMC LLC | 0 | 130,957 | +130,957 | 0.00 | 1.35 | +1.35 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 121,693 | +121,693 | 0.00 | 0.04 | +0.04 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 607,527 | 716,427 | +108,900 | 24.28 | 33.49 | +9.21 | buy |
| JANE STREET GROUP, LLC | 27,501 | 124,774 | +97,273 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 552,822 | 641,968 | +89,146 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 73,871 | 162,539 | +88,668 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 432,014 | 518,904 | +86,890 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 873,865 | 945,715 | +71,850 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 69,255 | +69,255 | 0.00 | 0.04 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 210,746 | 276,172 | +65,426 | 0.01 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 10,000 | 70,695 | +60,695 | 0.10 | 0.93 | +0.84 | buy |
| BARCLAYS PLC | 175,913 | 226,903 | +50,990 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 99,429 | 149,369 | +49,940 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 48,404 | +48,404 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 394,384 | 439,206 | +44,822 | 0.00 | 0.01 | +0.00 | buy |
| MYDA Advisors LLC | 85,000 | 125,000 | +40,000 | 0.83 | 2.29 | +1.46 | buy |
| Bank of New York Mellon Corp | 233,348 | 268,171 | +34,823 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 129,170 | 163,733 | +34,563 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 31,888 | +31,888 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 30,964 | +30,964 | 0.00 | 0.10 | +0.10 | buy |
| AMERIPRISE FINANCIAL INC | 22,575 | 45,714 | +23,139 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 22,700 | +22,700 | 0.00 | 0.02 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 7,771 | 27,809 | +20,038 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.09 | +0.09 | buy |
| SIMON QUICK ADVISORS, LLC | 55,000 | 74,968 | +19,968 | 0.13 | 0.28 | +0.15 | buy |
| Laurion Capital Management LP | 0 | 15,580 | +15,580 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 14,710 | +14,710 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,513 | 65,620 | +14,107 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 95,276 | 109,305 | +14,029 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 13,907 | +13,907 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 13,866 | +13,866 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 54,808 | 66,928 | +12,120 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,324 | +11,324 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 16,509 | 27,813 | +11,304 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,234 | +10,234 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 9,898 | +9,898 | 0.00 | 0.00 | +0.00 | buy |
| ARS Investment Partners, LLC | 624,349 | 633,964 | +9,615 | 2.01 | 3.01 | +0.99 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 18,930 | 27,935 | +9,005 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,276 | 41,276 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,117 | 71,891 | +7,774 | 0.00 | 0.00 | +0.00 | buy |
| Constitution Capital LLC | 0 | 7,000 | +7,000 | 0.00 | 0.18 | +0.18 | buy |
| PDT Partners, LLC | 0 | 6,931 | +6,931 | 0.00 | 0.03 | +0.03 | buy |
| Advisors Asset Management, Inc. | 699 | 7,380 | +6,681 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 9,199 | 15,853 | +6,654 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 127,500 | 134,100 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 24,002 | 29,552 | +5,550 | 0.13 | 0.24 | +0.11 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 5,486 | +5,486 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 5,388 | +5,388 | 0.00 | 0.00 | +0.00 | buy |
| PREVAIL INNOVATIVE WEALTH ADVISORS, LLC | 0 | 5,385 | +5,385 | 0.00 | 0.11 | +0.11 | buy |
| HighTower Advisors, LLC | 0 | 5,317 | +5,317 | 0.00 | 0.00 | +0.00 | buy |
| THOMPSON DAVIS & CO., INC. | 0 | 5,000 | +5,000 | 0.00 | 0.18 | +0.18 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,923 | 15,863 | +4,940 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 29,083 | 34,005 | +4,922 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 4,685 | +4,685 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 25,530 | 29,852 | +4,322 | 0.01 | 0.02 | +0.01 | buy |
| Informed Momentum Co LLC | 87,552 | 91,851 | +4,299 | 0.44 | 0.70 | +0.26 | buy |
| MetLife Investment Management, LLC | 31,772 | 36,024 | +4,252 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 41,737 | 45,878 | +4,141 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,849 | 5,757 | +3,908 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 3,763 | +3,763 | 0.00 | 0.01 | +0.01 | buy |
| Arizona State Retirement System | 16,511 | 19,028 | +2,517 | 0.00 | 0.01 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 8,884 | 11,358 | +2,474 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 38,071 | 40,094 | +2,023 | 0.00 | 0.00 | +0.00 | buy |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 12,140 | 13,640 | +1,500 | 0.13 | 0.21 | +0.08 | buy |
| Ameritas Investment Partners, Inc. | 5,790 | 7,082 | +1,292 | 0.01 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,756 | 17,766 | +1,010 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 1,031 | 1,724 | +693 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,393 | 3,907 | +514 | 0.00 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,290 | 4,654 | +364 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 10,920 | 11,269 | +349 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 11 | 314 | +303 | 0.00 | 0.00 | +0.00 | buy |