| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 809,448 | 1,979,169 | +1,169,721 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 6,877,355 | 7,667,188 | +789,833 | 0.01 | 0.01 | -0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,642,589 | 4,428,167 | +785,578 | 1.00 | 0.87 | -0.13 | buy |
| JANUS HENDERSON GROUP PLC | 6,226,393 | 6,982,425 | +756,032 | 0.16 | 0.13 | -0.03 | buy |
| VANGUARD GROUP INC | 7,785,909 | 8,414,120 | +628,211 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 126,095 | 747,720 | +621,625 | 0.00 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,199,495 | 1,672,298 | +472,803 | 1.57 | 1.45 | -0.11 | buy |
| PFM Health Sciences, LP | 0 | 431,916 | +431,916 | 0.00 | 1.23 | +1.23 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,199,219 | 5,620,271 | +421,052 | 9.32 | 7.78 | -1.55 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 243,167 | 634,055 | +390,888 | 0.00 | 0.00 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 361,420 | +361,420 | 0.00 | 4.55 | +4.55 | buy |
| EMERALD ADVISERS, LLC | 0 | 360,538 | +360,538 | 0.00 | 0.52 | +0.52 | buy |
| FMR LLC | 1,841,095 | 2,114,280 | +273,185 | 0.01 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 3,256,636 | 3,512,478 | +255,842 | 0.01 | 0.01 | -0.00 | buy |
| Holocene Advisors, LP | 852,627 | 1,088,842 | +236,215 | 0.17 | 0.13 | -0.04 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 226,394 | +226,394 | 0.00 | 0.51 | +0.51 | buy |
| MORGAN STANLEY | 563,877 | 782,657 | +218,780 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,714,612 | 1,905,366 | +190,754 | 0.01 | 0.01 | -0.00 | buy |
| Altium Capital Management LLC | 75,000 | 250,000 | +175,000 | 1.12 | 2.91 | +1.79 | buy |
| GOLDMAN SACHS GROUP INC | 642,376 | 816,823 | +174,447 | 0.01 | 0.01 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 399,827 | 560,056 | +160,229 | 0.34 | 0.38 | +0.04 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 148,879 | +148,879 | 0.00 | 0.16 | +0.16 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 705,250 | 851,770 | +146,520 | 28.17 | 21.36 | -6.81 | buy |
| AMERIPRISE FINANCIAL INC | 363,351 | 508,682 | +145,331 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 763,523 | 902,565 | +139,042 | 0.01 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 676,276 | 811,155 | +134,879 | 0.01 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 4,240 | 129,465 | +125,225 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 268,077 | 392,727 | +124,650 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 106,665 | +106,665 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 307,069 | 405,848 | +98,779 | 0.02 | 0.02 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 97,532 | +97,532 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 220,983 | 310,559 | +89,576 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 119,905 | 193,760 | +73,855 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 632,690 | 701,314 | +68,624 | 0.01 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 46,351 | 106,351 | +60,000 | 0.01 | 0.01 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 0 | 56,713 | +56,713 | 0.00 | 0.29 | +0.29 | buy |
| STIFEL FINANCIAL CORP | 6,509,261 | 6,559,313 | +50,052 | 0.34 | 0.26 | -0.09 | buy |
| AMERICAN CENTURY COMPANIES INC | 510,475 | 558,761 | +48,286 | 0.01 | 0.01 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 58,142 | 104,567 | +46,425 | 0.01 | 0.02 | +0.00 | buy |
| Clearbridge Investments, LLC | 479,249 | 521,099 | +41,850 | 0.02 | 0.02 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 41,762 | +41,762 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 508,622 | 548,575 | +39,953 | 0.01 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 135,786 | 169,773 | +33,987 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 187,130 | 220,235 | +33,105 | 2.21 | 2.09 | -0.12 | buy |
| Magnetar Financial LLC | 6,558 | 39,260 | +32,702 | 0.01 | 0.03 | +0.03 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 30,746 | +30,746 | 0.00 | 0.05 | +0.05 | buy |
| Hudson Bay Capital Management LP | 12,500 | 42,931 | +30,431 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 28,159 | +28,159 | 0.00 | 0.79 | +0.79 | buy |
| F/m Investments LLC | 0 | 26,338 | +26,338 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 50,850 | 76,868 | +26,018 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 44,359 | 69,082 | +24,723 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 270,375 | 295,078 | +24,703 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 23,671 | +23,671 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 133,323 | 156,494 | +23,171 | 1.09 | 1.08 | -0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 11,307 | 34,165 | +22,858 | 0.01 | 0.01 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 16,726 | 38,488 | +21,762 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 19,352 | +19,352 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 18,710 | +18,710 | 0.00 | 0.07 | +0.07 | buy |
| GROUP ONE TRADING LLC | 0 | 17,982 | +17,982 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 138,000 | 154,800 | +16,800 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 16,779 | +16,779 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 15,396 | +15,396 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 103,188 | 117,595 | +14,407 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,124 | 54,271 | +13,147 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 399 | 12,180 | +11,781 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 79,200 | 90,847 | +11,647 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 310,842 | 321,866 | +11,024 | 0.01 | 0.01 | -0.00 | buy |
| ARS Investment Partners, LLC | 1,030,239 | 1,040,712 | +10,473 | 4.61 | 3.50 | -1.11 | buy |
| WELLS FARGO & COMPANY/MN | 33,418 | 43,650 | +10,232 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 14,190 | 24,189 | +9,999 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 9,508 | +9,508 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 8,403 | +8,403 | 0.00 | 0.03 | +0.03 | buy |
| MetLife Investment Management, LLC | 43,489 | 51,737 | +8,248 | 0.01 | 0.01 | -0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 8,037 | +8,037 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 968,359 | 975,585 | +7,226 | 0.06 | 0.05 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,139 | 74,144 | +7,005 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 192,677 | 199,183 | +6,506 | 0.01 | 0.01 | -0.00 | buy |
| CWM, LLC | 962 | 7,279 | +6,317 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 16,558 | 22,615 | +6,057 | 0.02 | 0.02 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 4,609 | 10,613 | +6,004 | 0.02 | 0.03 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 90,285 | 96,236 | +5,951 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 5,611 | +5,611 | 0.00 | 0.04 | +0.04 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,720 | 23,320 | +5,600 | 0.00 | 0.00 | -0.00 | buy |
| RWA WEALTH PARTNERS, LLC | 6,500 | 11,800 | +5,300 | 0.00 | 0.01 | +0.00 | buy |
| DCF Advisers, LLC | 31,000 | 36,000 | +5,000 | 0.80 | 0.68 | -0.12 | buy |
| Handelsbanken Fonder AB | 20,700 | 25,000 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| FIL Ltd | 85,204 | 89,391 | +4,187 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 18 | 3,703 | +3,685 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,431 | 20,823 | +3,392 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 74,106 | 77,387 | +3,281 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 48,798 | 51,814 | +3,016 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 3,000 | +3,000 | 0.00 | 0.02 | +0.02 | buy |
| Inspire Investing, LLC | 8,197 | 10,895 | +2,698 | 0.04 | 0.05 | +0.00 | buy |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 11,010 | 13,645 | +2,635 | 0.19 | 0.17 | -0.01 | buy |
| Corebridge Financial, Inc. | 40,149 | 42,701 | +2,552 | 0.01 | 0.01 | -0.00 | buy |
| Arizona State Retirement System | 20,339 | 22,845 | +2,506 | 0.01 | 0.01 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 199,385 | 201,788 | +2,403 | 0.05 | 0.03 | -0.01 | buy |
| Rock Springs Capital Management LP | 127,558 | 129,858 | +2,300 | 0.21 | 0.18 | -0.02 | buy |
| LPL Financial LLC | 40,526 | 42,190 | +1,664 | 0.00 | 0.00 | -0.00 | buy |
| Spire Wealth Management | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |