| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 6,226,393 | 6,982,425 | +756,032 | 0.16 | 0.13 | 0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,199,495 | 1,672,298 | +472,803 | 0.96 | 0.85 | -0.11 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,199,219 | 5,620,271 | +421,052 | 8.31 | 7.15 | -1.16 | buy |
| Holocene Advisors, LP | 852,627 | 1,088,842 | +236,215 | 0.17 | 0.13 | -0.04 | buy |
| Altium Capital Management LLC | 75,000 | 250,000 | +175,000 | 1.12 | 2.91 | +1.79 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 399,827 | 560,056 | +160,229 | 0.34 | 0.38 | +0.04 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 705,250 | 851,770 | +146,520 | 21.12 | 17.32 | -3.80 | buy |
| Alyeska Investment Group, L.P. | 46,351 | 106,351 | +60,000 | 0.01 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 58,142 | 104,567 | +46,425 | 0.01 | 0.02 | +0.00 | buy |
| Clearbridge Investments, LLC | 479,249 | 521,099 | +41,850 | 0.02 | 0.02 | -0.00 | buy |
| DAFNA Capital Management LLC | 187,130 | 220,235 | +33,105 | 2.21 | 2.09 | -0.12 | buy |
| Magnetar Financial LLC | 6,558 | 39,260 | +32,702 | 0.01 | 0.03 | +0.03 | buy |
| Hudson Bay Capital Management LP | 12,500 | 42,931 | +30,431 | 0.00 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 133,323 | 156,494 | +23,171 | 1.06 | 1.06 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 26,789 | 8,445 | +18,344 | 0.08 | 0.02 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 310,842 | 321,866 | +11,024 | 0.01 | 0.01 | -0.00 | buy |
| ARS Investment Partners, LLC | 1,030,239 | 1,040,712 | +10,473 | 4.61 | 3.50 | -1.11 | buy |
| ProShare Advisors LLC | 14,190 | 24,189 | +9,999 | 0.00 | 0.00 | 0.00 | buy |
| Advisors Asset Management, Inc. | 16,558 | 22,615 | +6,057 | 0.02 | 0.02 | 0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 363,615 | 357,765 | +5,850 | 0.02 | 0.01 | -0.00 | sell |
| RWA WEALTH PARTNERS, LLC | 6,500 | 11,800 | +5,300 | 0.00 | 0.01 | +0.00 | buy |
| DCF Advisers, LLC | 31,000 | 36,000 | +5,000 | 0.62 | 0.65 | +0.03 | buy |
| GABELLI FUNDS LLC | 13,200 | 9,000 | +4,200 | 0.00 | 0.00 | -0.00 | sell |
| FIL Ltd | 85,204 | 89,391 | +4,187 | 0.00 | 0.00 | -0.00 | buy |
| Inspire Investing, LLC | 8,197 | 10,895 | +2,698 | 0.04 | 0.05 | +0.00 | buy |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 11,010 | 13,645 | +2,635 | 0.19 | 0.17 | -0.01 | buy |
| Rock Springs Capital Management LP | 127,558 | 129,858 | +2,300 | 0.21 | 0.18 | -0.02 | buy |
| ELKHORN PARTNERS LIMITED PARTNERSHIP | 2,200 | 3,300 | +1,100 | 0.07 | 0.08 | +0.01 | buy |
| ALGERT GLOBAL LLC | 32,392 | 31,320 | +1,072 | 0.04 | 0.03 | 0.00 | sell |
| PROFUND ADVISORS LLC | 27,588 | 26,757 | +831 | 0.05 | 0.04 | 0.00 | sell |
| Diversified Trust Co | 4,790 | 5,585 | +795 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 8,838 | 9,613 | +775 | 0.02 | 0.02 | -0.00 | buy |
| DnB Asset Management AS | 6,955 | 7,526 | +571 | 0.00 | 0.00 | -0.00 | buy |
| FSC Wealth Advisors, LLC | 15,000 | 15,500 | +500 | 0.54 | 0.37 | -0.17 | buy |
| NewEdge Wealth, LLC | 243,605 | 243,546 | -59 | 0.22 | 0.16 | -0.06 | sell |
| GHP Investment Advisors, Inc. | 200 | 100 | -100 | 0.00 | 0.00 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 21,146 | 20,471 | -675 | 0.09 | 0.06 | -0.03 | sell |
| TRANSATLANTIQUE PRIVATE WEALTH LLC | 14,142 | 13,431 | -711 | 0.27 | 0.19 | -0.08 | sell |
| VIRTUS ADVISERS, LLC | 2,760 | 1,770 | -990 | 0.06 | 0.03 | -0.04 | sell |
| BAMCO INC /NY/ | 45,000 | 44,000 | -1,000 | 0.01 | 0.00 | -0.00 | sell |
| SeaBridge Investment Advisors LLC | 40,095 | 38,507 | -1,588 | 0.49 | 0.30 | -0.19 | sell |
| SIMON QUICK ADVISORS, LLC | 71,862 | 69,960 | -1,902 | 0.23 | 0.16 | -0.07 | sell |
| Rafferty Asset Management, LLC | 137,551 | 135,256 | -2,295 | 0.02 | 0.02 | -0.01 | sell |
| Pekin Hardy Strauss, Inc. | 16,975 | 12,275 | -4,700 | 0.11 | 0.06 | -0.05 | sell |
| Candriam S.C.A. | 100,000 | 95,179 | -4,821 | 0.02 | 0.02 | -0.00 | sell |
| Nicholas Investment Partners, LP | 25,449 | 18,673 | -6,776 | 0.12 | 0.06 | -0.06 | sell |
| Lion Point Capital, LP | 35,400 | 22,700 | -12,700 | 3.94 | 4.44 | +0.50 | sell |
| MYDA Advisors LLC | 70,000 | 54,000 | -16,000 | 0.77 | 0.51 | -0.26 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,438,526 | 3,412,191 | -26,335 | 0.02 | 0.01 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 216,440 | 186,413 | -30,027 | 3.24 | 1.75 | -1.50 | sell |
| Tri Locum Partners LP | 193,195 | 140,220 | -52,975 | 2.31 | 1.08 | -1.23 | sell |
| First Turn Management, LLC | 315,816 | 262,442 | -53,374 | 2.50 | 1.76 | -0.74 | sell |
| Hood River Capital Management LLC | 902,888 | 783,672 | -119,216 | 0.73 | 0.43 | -0.30 | sell |
| Redmile Group, LLC | 1,034,219 | 904,496 | -129,723 | 3.04 | 2.35 | -0.69 | sell |
| Avidity Partners Management LP | 465,000 | 222,900 | -242,100 | 1.19 | 0.82 | -0.37 | sell |
| Woodline Partners LP | 923,807 | 601,922 | -321,885 | 0.39 | 0.15 | -0.24 | sell |
| Cormorant Asset Management, LP | 401,963 | 55,539 | -346,424 | 1.07 | 0.11 | -0.95 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,482,485 | 575,000 | -907,485 | 0.13 | 0.04 | -0.09 | sell |