| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,620,271 | 10,286,937 | +4,666,666 | 2.16 | 2.38 | +0.22 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 1,700,000 | 6,250,000 | +4,550,000 | 4.69 | 10.44 | +5.75 | buy |
| MYDA Advisors LLC | 75,000 | 1,250,000 | +1,175,000 | 0.24 | 2.69 | +2.44 | buy |
| Integral Health Asset Management, LLC | 650,000 | 1,500,000 | +850,000 | 0.71 | 0.86 | +0.15 | buy |
| Simplify Asset Management Inc. | 109,685 | 958,202 | +848,517 | 0.03 | 0.18 | +0.14 | buy |
| DAFNA Capital Management LLC | 235,235 | 955,235 | +720,000 | 0.87 | 2.51 | +1.63 | buy |
| Erste Asset Management GmbH | 93,300 | 693,300 | +600,000 | 0.01 | 0.07 | +0.05 | buy |
| Capital Research Global Investors | 1,011,530 | 1,332,792 | +321,262 | 0.00 | 0.00 | -0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 377,119 | 651,603 | +274,484 | 0.28 | 0.33 | +0.05 | buy |
| 5AM Venture Management, LLC | 478,972 | 738,972 | +260,000 | 2.63 | 2.62 | -0.01 | buy |
| Quinn Opportunity Partners LLC | 30,000 | 210,326 | +180,326 | 0.03 | 0.10 | +0.07 | buy |
| Fiera Capital Corp | 561,354 | 724,551 | +163,197 | 0.03 | 0.03 | -0.00 | buy |
| ARS Investment Partners, LLC | 1,102,549 | 1,239,600 | +137,051 | 1.09 | 0.82 | -0.27 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 22,900 | 133,900 | +111,000 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 163,569 | 209,306 | +45,737 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 35,398 | 77,279 | +41,881 | 0.02 | 0.03 | 0.00 | buy |
| WINTON GROUP Ltd | 27,099 | 64,028 | +36,929 | 0.02 | 0.02 | +0.01 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 739,986 | 772,181 | +32,195 | 6.94 | 5.19 | -1.75 | buy |
| Lion Point Capital, LP | 22,700 | 51,700 | +29,000 | 1.94 | 3.02 | +1.08 | buy |
| Virtus Investment Advisers, LLC | 7,299 | 23,072 | +15,773 | 0.03 | 0.07 | +0.04 | buy |
| Inspire Investing, LLC | 30,479 | 41,150 | +10,671 | 0.04 | 0.04 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 33,727 | 44,266 | +10,539 | 0.02 | 0.02 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 24,341 | 34,277 | +9,936 | 0.04 | 0.03 | -0.01 | buy |
| QTR Family Wealth, LLC | 332,288 | 334,833 | +2,545 | 2.37 | 1.80 | -0.57 | buy |
| Quarry LP | 10,000 | 9,250 | +750 | 0.04 | 0.02 | 0.00 | sell |
| Optimize Financial Inc | 26,768 | 27,156 | +388 | 0.21 | 0.15 | -0.05 | buy |
| WEYBOSSET RESEARCH & MANAGEMENT LLC | 22,940 | 22,990 | +50 | 0.11 | 0.08 | -0.03 | buy |
| SIMON QUICK ADVISORS, LLC | 69,997 | 69,897 | -100 | 0.05 | 0.03 | -0.01 | sell |
| OAK RIDGE INVESTMENTS LLC | 19,059 | 15,646 | -3,413 | 0.02 | 0.01 | -0.01 | sell |
| Canton Hathaway, LLC | 26,400 | 22,500 | -3,900 | 0.08 | 0.05 | -0.03 | sell |
| ELKHORN PARTNERS LIMITED PARTNERSHIP | 5,900 | 1,500 | -4,400 | 0.06 | 0.01 | -0.05 | sell |
| Coastal Bridge Advisors, LLC | 33,772 | 24,797 | -8,975 | 0.04 | 0.02 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 20,000 | 8,000 | -12,000 | 0.02 | 0.01 | -0.02 | sell |
| Empowered Funds, LLC | 155,843 | 143,328 | -12,515 | 0.02 | 0.03 | +0.00 | sell |
| DCF Advisers, LLC | 171,500 | 151,500 | -20,000 | 0.97 | 0.56 | -0.41 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 51,672 | 25,471 | -26,201 | 0.12 | 0.04 | -0.08 | sell |
| Susquehanna Portfolio Strategies, LLC | 178,910 | 110,840 | -68,070 | 0.04 | 0.02 | -0.02 | sell |
| EMERALD ADVISERS, LLC | 311,881 | 11,088 | -300,793 | 0.15 | 0.00 | -0.15 | sell |
| Holocene Advisors, LP | 765,874 | 56,610 | -709,264 | 0.03 | 0.00 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,260,033 | 150,000 | -1,110,033 | 0.03 | 0.00 | -0.03 | sell |