| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,620,271 | 10,286,937 | +4,666,666 | 2.56 | 2.90 | +0.34 | buy |
| STIFEL FINANCIAL CORP | 6,611,350 | 9,939,856 | +3,328,506 | 0.09 | 0.10 | +0.01 | buy |
| BlackRock, Inc. | 7,874,891 | 9,448,040 | +1,573,149 | 0.00 | 0.00 | -0.00 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 1,700,000 | 6,250,000 | +4,550,000 | 4.69 | 10.44 | +5.75 | buy |
| STATE STREET CORP | 4,258,283 | 5,716,487 | +1,458,204 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 0 | 4,631,317 | +4,631,317 | 0.00 | 1.73 | +1.73 | buy |
| VANGUARD GROUP INC | 2,875,190 | 4,395,946 | +1,520,756 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,266,792 | 2,694,234 | +1,427,442 | 0.02 | 0.02 | +0.01 | buy |
| FMR LLC | 2,426,904 | 2,682,234 | +255,330 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,060,208 | 2,392,277 | +332,069 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 843,564 | 2,093,816 | +1,250,252 | 0.01 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,009,611 | 2,018,550 | +8,939 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,578,390 | 1,962,206 | +383,816 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 788,331 | 1,792,443 | +1,004,112 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 997,793 | 1,743,993 | +746,200 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 40,886 | 1,606,777 | +1,565,891 | 0.00 | 0.09 | +0.09 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 380,874 | 1,591,054 | +1,210,180 | 0.01 | 0.03 | +0.02 | buy |
| Qube Research & Technologies Ltd | 1,265,597 | 1,570,610 | +305,013 | 0.03 | 0.03 | -0.00 | buy |
| Integral Health Asset Management, LLC | 650,000 | 1,500,000 | +850,000 | 0.71 | 0.86 | +0.15 | buy |
| AQR CAPITAL MANAGEMENT LLC | 213,267 | 1,460,108 | +1,246,841 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 6,772,113 | 1,407,365 | -5,364,748 | 0.05 | 0.01 | -0.04 | sell |
| Capital Research Global Investors | 1,011,530 | 1,332,792 | +321,262 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 968,153 | 1,324,247 | +356,094 | 0.01 | 0.01 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 153,638 | 1,318,775 | +1,165,137 | 0.01 | 0.05 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 799,600 | 1,259,031 | +459,431 | 0.02 | 0.02 | +0.00 | buy |
| MYDA Advisors LLC | 75,000 | 1,250,000 | +1,175,000 | 0.34 | 3.97 | +3.63 | buy |
| Sio Capital Management, LLC | 0 | 1,244,764 | +1,244,764 | 0.00 | 2.33 | +2.33 | buy |
| ARS Investment Partners, LLC | 1,102,549 | 1,239,600 | +137,051 | 1.09 | 0.82 | -0.27 | buy |
| ExodusPoint Capital Management, LP | 166,858 | 1,192,026 | +1,025,168 | 0.04 | 0.15 | +0.11 | buy |
| UBS Group AG | 1,119,665 | 1,188,358 | +68,693 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 545,815 | 975,196 | +429,381 | 0.00 | 0.00 | +0.00 | buy |
| Iron Triangle Partners LP | 0 | 958,336 | +958,336 | 0.00 | 1.24 | +1.24 | buy |
| Simplify Asset Management Inc. | 109,685 | 958,202 | +848,517 | 0.03 | 0.18 | +0.14 | buy |
| DAFNA Capital Management LLC | 235,235 | 955,235 | +720,000 | 0.87 | 2.51 | +1.63 | buy |
| Walleye Capital LLC | 70,855 | 854,424 | +783,569 | 0.01 | 0.06 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 749,721 | 847,412 | +97,691 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 775,895 | 840,285 | +64,390 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 799,278 | 839,517 | +40,239 | 0.01 | 0.01 | -0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 739,986 | 772,181 | +32,195 | 7.75 | 5.71 | -2.04 | buy |
| 5AM Venture Management, LLC | 478,972 | 738,972 | +260,000 | 2.63 | 2.62 | -0.01 | buy |
| Nuveen, LLC | 376,339 | 731,953 | +355,614 | 0.00 | 0.00 | +0.00 | buy |
| Fiera Capital Corp | 561,354 | 724,551 | +163,197 | 0.03 | 0.03 | -0.00 | buy |
| Kynam Capital Management, LP | 0 | 702,884 | +702,884 | 0.00 | 0.52 | +0.52 | buy |
| Aberdeen Group plc | 0 | 693,452 | +693,452 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 93,300 | 693,300 | +600,000 | 0.01 | 0.07 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 665,918 | 685,584 | +19,666 | 0.01 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 781,323 | 669,136 | -112,187 | 0.04 | 0.02 | -0.02 | sell |
| Anson Funds Management LP | 0 | 667,381 | +667,381 | 0.00 | 1.01 | +1.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 377,119 | 651,603 | +274,484 | 0.28 | 0.33 | +0.05 | buy |
| Trexquant Investment LP | 199,851 | 604,182 | +404,331 | 0.03 | 0.06 | +0.03 | buy |
| JPMORGAN CHASE & CO | 1,335,455 | 589,565 | -745,890 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 571,911 | 574,478 | +2,567 | 0.00 | 0.00 | -0.00 | buy |
| Sarissa Capital Management LP | 0 | 513,184 | +513,184 | 0.00 | 2.60 | +2.60 | buy |
| PFIZER INC | 505,645 | 505,645 | 0 | 1.73 | 2.41 | +0.68 | hold |
| Burkehill Global Management, LP | 0 | 500,000 | +500,000 | 0.00 | 0.37 | +0.37 | buy |
| RAYMOND JAMES FINANCIAL INC | 92,045 | 436,796 | +344,751 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 81,000 | 387,799 | +306,799 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 212,800 | 358,700 | +145,900 | 0.01 | 0.01 | +0.00 | buy |
| QTR Family Wealth, LLC | 332,288 | 334,833 | +2,545 | 2.37 | 1.80 | -0.57 | buy |
| BARCLAYS PLC | 346,844 | 320,846 | -25,998 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 300,389 | 300,389 | 0 | 0.02 | 0.01 | -0.01 | hold |
| ALGERT GLOBAL LLC | 136,290 | 293,270 | +156,980 | 0.03 | 0.05 | +0.02 | buy |
| Bank of New York Mellon Corp | 284,439 | 272,156 | -12,283 | 0.00 | 0.00 | -0.00 | sell |
| Capital World Investors | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Massar Capital Management, LP | 0 | 247,400 | +247,400 | 0.00 | 0.55 | +0.55 | buy |
| NewEdge Wealth, LLC | 246,553 | 246,503 | -50 | 0.03 | 0.03 | +0.00 | sell |
| Jump Financial, LLC | 20,877 | 245,891 | +225,014 | 0.00 | 0.03 | +0.03 | buy |
| Swiss National Bank | 168,300 | 229,200 | +60,900 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 212,481 | +212,481 | 0.00 | 0.31 | +0.31 | buy |
| Quinn Opportunity Partners LLC | 30,000 | 210,326 | +180,326 | 0.03 | 0.10 | +0.07 | buy |
| Rafferty Asset Management, LLC | 163,569 | 209,306 | +45,737 | 0.01 | 0.01 | +0.00 | buy |
| Jain Global LLC | 0 | 208,987 | +208,987 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 122,521 | 194,751 | +72,230 | 0.00 | 0.00 | -0.00 | buy |
| Voleon Capital Management LP | 0 | 174,035 | +174,035 | 0.00 | 0.04 | +0.04 | buy |
| QVT Financial LP | 170,006 | 170,006 | 0 | 0.28 | 0.18 | -0.10 | hold |
| IEQ CAPITAL, LLC | 0 | 163,388 | +163,388 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 160,251 | 160,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 112,127 | 151,516 | +39,389 | 0.00 | 0.00 | -0.00 | buy |
| DCF Advisers, LLC | 171,500 | 151,500 | -20,000 | 0.97 | 0.56 | -0.41 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,260,033 | 150,000 | -1,110,033 | 0.03 | 0.00 | -0.03 | sell |
| Graham Capital Management, L.P. | 33,624 | 145,852 | +112,228 | 0.02 | 0.06 | +0.04 | buy |
| Eversept Partners, LP | 0 | 145,431 | +145,431 | 0.00 | 0.09 | +0.09 | buy |
| Empowered Funds, LLC | 155,843 | 143,328 | -12,515 | 0.02 | 0.01 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 136,028 | 141,678 | +5,650 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 140,000 | 140,000 | 0 | 0.08 | 0.08 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 124,413 | 138,649 | +14,236 | 0.00 | 0.00 | -0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 22,900 | 133,900 | +111,000 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,301 | 133,081 | -1,220 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 139,572 | 122,581 | -16,991 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 133,920 | 116,597 | -17,323 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 97,479 | 113,426 | +15,947 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 111,838 | +111,838 | 0.00 | 0.04 | +0.04 | buy |
| Susquehanna Portfolio Strategies, LLC | 178,910 | 110,840 | -68,070 | 0.04 | 0.02 | -0.02 | sell |
| Knott David M Jr | 0 | 110,720 | +110,720 | 0.00 | 0.58 | +0.58 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 80,150 | 110,361 | +30,211 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 26,933 | 105,518 | +78,585 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 152,886 | 104,574 | -48,312 | 0.02 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 96,392 | 96,236 | -156 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 0 | 84,700 | +84,700 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 63,639 | 83,455 | +19,816 | 0.05 | 0.02 | -0.02 | buy |