| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | 22,970,388 | 0 | 24.58 | 29.77 | +5.19 | hold |
| Rubric Capital Management LP | 7,000,000 | 7,000,000 | 0 | 2.15 | 1.68 | -0.47 | hold |
| BlackRock, Inc. | 4,553,888 | 4,251,030 | -302,858 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 3,510,078 | 4,182,953 | +672,875 | 1.74 | 1.70 | -0.04 | buy |
| BVF INC/IL | 3,734,142 | 3,649,142 | -85,000 | 2.98 | 2.44 | -0.54 | sell |
| MORGAN STANLEY | 2,480,568 | 2,231,260 | -249,308 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,908,039 | 1,781,116 | -126,923 | 0.06 | 0.05 | -0.01 | sell |
| Assenagon Asset Management S.A. | 727,986 | 1,252,027 | +524,041 | 0.03 | 0.04 | +0.01 | buy |
| Nextech Invest, Ltd. | 1,113,946 | 1,113,946 | 0 | 1.96 | 1.38 | -0.58 | hold |
| STATE STREET CORP | 1,011,777 | 1,088,216 | +76,439 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,139,135 | 994,955 | -144,180 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,150,018 | 914,136 | -235,882 | 0.02 | 0.01 | -0.01 | sell |
| FMR LLC | 667,153 | 702,568 | +35,415 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 659,940 | 692,410 | +32,470 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 539,049 | 674,434 | +135,385 | 2.21 | 3.04 | +0.82 | buy |
| Qube Research & Technologies Ltd | 511,937 | 593,590 | +81,653 | 0.02 | 0.02 | -0.00 | buy |
| Redmile Group, LLC | 491,654 | 491,654 | 0 | 0.82 | 0.86 | +0.05 | hold |
| Capricorn Fund Managers Ltd | 1,007,210 | 486,529 | -520,681 | 3.93 | 1.02 | -2.91 | sell |
| GOLDMAN SACHS GROUP INC | 599,486 | 470,822 | -128,664 | 0.00 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 743,898 | 418,497 | -325,401 | 0.01 | 0.00 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 921,250 | 397,190 | -524,060 | 0.01 | 0.00 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 345,622 | 382,922 | +37,300 | 0.24 | 0.23 | -0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 340,363 | +340,363 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 250,773 | 336,157 | +85,384 | 0.30 | 0.31 | +0.01 | buy |
| NORTHERN TRUST CORP | 320,210 | 321,073 | +863 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 9,256 | 308,187 | +298,931 | 0.00 | 0.01 | +0.01 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 256,690 | 271,343 | +14,653 | 0.07 | 0.07 | -0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 163,649 | 223,766 | +60,117 | 0.03 | 0.04 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 236,754 | 219,071 | -17,683 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 189,636 | 217,199 | +27,563 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 321,427 | 210,802 | -110,625 | 0.26 | 0.15 | -0.11 | sell |
| Man Group plc | 189,890 | 210,779 | +20,889 | 0.01 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 182,410 | 187,995 | +5,585 | 0.01 | 0.01 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 176,411 | 166,416 | -9,995 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 66,106 | 155,579 | +89,473 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 152,416 | +152,416 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 185,124 | 152,416 | -32,708 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 148,226 | 145,386 | -2,840 | 0.08 | 0.07 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 235,621 | 144,807 | -90,814 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 142,132 | 142,132 | 0 | 1.47 | 1.31 | -0.16 | hold |
| CITIGROUP INC | 114,327 | 131,441 | +17,114 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 124,105 | 131,106 | +7,001 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 143,882 | 125,877 | -18,005 | 0.06 | 0.04 | -0.02 | sell |
| Nuveen, LLC | 651,662 | 119,389 | -532,273 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 206,854 | 118,603 | -88,251 | 0.02 | 0.01 | -0.01 | sell |
| UBS Group AG | 171,779 | 115,095 | -56,684 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 125,630 | 112,212 | -13,418 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 90,669 | 111,282 | +20,613 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 138,690 | 110,014 | -28,676 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 114,072 | 106,398 | -7,674 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 104,931 | 105,615 | +684 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 104,931 | 105,615 | +684 | 0.18 | 0.09 | -0.09 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 105,184 | 105,184 | 0 | 0.66 | 0.68 | +0.01 | hold |
| Manatuck Hill Partners, LLC | 40,000 | 100,000 | +60,000 | 0.33 | 0.87 | +0.54 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 88,800 | 88,800 | 0 | 0.05 | 0.05 | +0.00 | hold |
| MACKENZIE FINANCIAL CORP | 82,726 | 87,745 | +5,019 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 78,547 | 84,990 | +6,443 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 83,455 | +83,455 | 0.00 | 0.04 | +0.04 | buy |
| LMR Partners LLP | 0 | 82,500 | +82,500 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 74,222 | 82,264 | +8,042 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 319,385 | 81,359 | -238,026 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 76,756 | 77,214 | +458 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 77,659 | 76,528 | -1,131 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 75,399 | 75,066 | -333 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 74,200 | 74,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 32,764 | 73,282 | +40,518 | 0.02 | 0.05 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 71,874 | +71,874 | 0.00 | 0.00 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 56,107 | 71,660 | +15,553 | 0.04 | 0.05 | +0.01 | buy |
| Fisher Asset Management, LLC | 101,439 | 70,775 | -30,664 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 45,726 | 66,836 | +21,110 | 0.01 | 0.02 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 99,795 | 65,248 | -34,547 | 0.04 | 0.03 | -0.01 | sell |
| Campbell & CO Investment Adviser LLC | 54,883 | 60,874 | +5,991 | 0.08 | 0.08 | +0.01 | buy |
| ROYAL BANK OF CANADA | 47,360 | 56,278 | +8,918 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 55,896 | 55,896 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtus Investment Advisers, LLC | 10,702 | 50,825 | +40,123 | 0.07 | 0.31 | +0.24 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 40,419 | 48,675 | +8,256 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 39,640 | 47,642 | +8,002 | 0.00 | 0.00 | -0.00 | buy |
| North Growth Management Ltd. | 46,000 | 46,000 | 0 | 0.17 | 0.15 | -0.02 | hold |
| Legal & General Group Plc | 26,209 | 43,160 | +16,951 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 42,404 | 42,524 | +120 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 32,223 | 40,948 | +8,725 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 37,129 | 39,534 | +2,405 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,487 | 38,486 | +2,999 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 47,450 | 38,060 | -9,390 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,389 | 37,744 | +355 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 42,786 | 36,922 | -5,864 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 36,875 | 36,471 | -404 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 36,262 | 36,100 | -162 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 35,935 | 35,935 | 0 | 0.35 | 0.30 | -0.05 | hold |
| HighVista Strategies LLC | 34,085 | 34,013 | -72 | 0.24 | 0.20 | -0.03 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,031 | 32,052 | +6,021 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,592 | 30,886 | -706 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 32,394 | 29,731 | -2,663 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 29,653 | 27,884 | -1,769 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27,354 | 27,670 | +316 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 30,100 | 26,500 | -3,600 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 25,956 | +25,956 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 25,608 | +25,608 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 39,355 | 25,162 | -14,193 | 0.00 | 0.00 | -0.00 | sell |
| RITHOLTZ WEALTH MANAGEMENT | 24,243 | 24,243 | 0 | 0.01 | 0.01 | -0.00 | hold |