| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 13,437,473 | 13,437,473 | 0 | 3.62 | 3.59 | -0.04 | hold |
| BVF INC/IL | 5,870,000 | 5,870,000 | 0 | 1.53 | 1.70 | +0.17 | hold |
| Redmile Group, LLC | 5,790,230 | 5,560,798 | -229,432 | 2.15 | 2.15 | -0.00 | sell |
| MORGAN STANLEY | 4,861,286 | 5,111,144 | +249,858 | 0.00 | 0.00 | -0.00 | buy |
| Rubric Capital Management LP | 3,475,384 | 3,475,384 | 0 | 1.35 | 1.08 | -0.27 | hold |
| VANGUARD GROUP INC | 2,394,712 | 2,458,105 | +63,393 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,771,776 | 1,907,714 | +135,938 | 0.05 | 0.05 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,756,000 | 1,601,000 | -155,000 | 0.11 | 0.10 | -0.02 | sell |
| Samsara BioCapital, LLC | 1,458,875 | 1,458,875 | 0 | 2.36 | 2.37 | +0.02 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,254,021 | 1,305,057 | +51,036 | 0.05 | 0.05 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 1.06 | 1.20 | +0.15 | hold |
| PERCEPTIVE ADVISORS LLC | 1,074,807 | 1,074,807 | 0 | 0.25 | 0.20 | -0.05 | hold |
| CITADEL ADVISORS LLC | 173,573 | 1,064,987 | +891,414 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,007,812 | 1,048,732 | +40,920 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 888,635 | 889,250 | +615 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 368,041 | 716,482 | +348,441 | 0.02 | 0.03 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 680,316 | 702,683 | +22,367 | 0.15 | 0.15 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 639,672 | 668,984 | +29,312 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 700,558 | 656,607 | -43,951 | 0.24 | 0.24 | +0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 599,000 | +599,000 | 0.00 | 0.02 | +0.02 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 367,018 | 581,558 | +214,540 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 686,190 | 489,502 | -196,688 | 0.01 | 0.01 | -0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 495,582 | 426,944 | -68,638 | 0.05 | 0.04 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 409,839 | 418,376 | +8,537 | 0.17 | 0.18 | +0.00 | buy |
| NORTHERN TRUST CORP | 417,146 | 418,248 | +1,102 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 0 | 410,948 | +410,948 | 0.00 | 1.20 | +1.20 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 375,848 | 393,021 | +17,173 | 0.03 | 0.03 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 342,215 | 314,564 | -27,651 | 0.00 | 0.00 | -0.00 | sell |
| Empowered Funds, LLC | 273,416 | 295,783 | +22,367 | 0.07 | 0.06 | -0.02 | buy |
| Bank of New York Mellon Corp | 276,899 | 294,878 | +17,979 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 350,000 | 292,500 | -57,500 | 1.40 | 1.36 | -0.03 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 205,246 | 286,595 | +81,349 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 356,906 | 284,378 | -72,528 | 0.17 | 0.13 | -0.05 | sell |
| GOLDMAN SACHS GROUP INC | 200,621 | 270,546 | +69,925 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 168,700 | 255,497 | +86,797 | 0.02 | 0.03 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 238,246 | 238,687 | +441 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 57,093 | 231,181 | +174,088 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 255,575 | 210,212 | -45,363 | 1.11 | 0.82 | -0.29 | sell |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 398 | 180,547 | +180,149 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 166,549 | +166,549 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 65,910 | 160,299 | +94,389 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 156,034 | 154,362 | -1,672 | 0.04 | 0.03 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 227,625 | 143,215 | -84,410 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 122,926 | 141,793 | +18,867 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,491 | 125,491 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 14,700 | 115,600 | +100,900 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 44,182 | 114,458 | +70,276 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 85,878 | 99,064 | +13,186 | 0.00 | 0.00 | +0.00 | buy |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.21 | 0.19 | -0.02 | hold |
| Advantage Alpha Capital Partners LP | 136,819 | 92,307 | -44,512 | 0.27 | 0.18 | -0.09 | sell |
| WINTON GROUP Ltd | 49,985 | 91,685 | +41,700 | 0.04 | 0.07 | +0.03 | buy |
| SummerHaven Investment Management, LLC | 87,509 | 88,386 | +877 | 0.58 | 0.58 | -0.00 | buy |
| Swiss National Bank | 73,600 | 83,000 | +9,400 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 31,689 | 80,879 | +49,190 | 0.01 | 0.03 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 82,474 | 80,701 | -1,773 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 77,597 | 79,702 | +2,105 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 70,025 | 72,435 | +2,410 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 85,187 | 69,014 | -16,173 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 27,004 | 68,388 | +41,384 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 64,414 | 67,424 | +3,010 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 49,760 | 65,909 | +16,149 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 56,323 | 64,673 | +8,350 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,649 | 60,547 | +8,898 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 56,363 | 56,363 | 0 | 0.44 | 0.42 | -0.01 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 56,301 | 56,301 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 55,079 | +55,079 | 0.00 | 0.03 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 136,313 | 54,457 | -81,856 | 0.04 | 0.02 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 94,643 | 53,308 | -41,335 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 56,900 | 52,500 | -4,400 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,790 | 50,250 | +14,460 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 40,000 | 50,000 | +10,000 | 0.02 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 93,329 | 48,304 | -45,025 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 47,200 | +47,200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,205 | 43,420 | +1,215 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 236,260 | 40,260 | -196,000 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 40,208 | 39,938 | -270 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 42,769 | 39,583 | -3,186 | 0.00 | 0.00 | -0.00 | sell |
| Pennant Investors, LP | 38,700 | 38,700 | 0 | 0.12 | 0.11 | -0.01 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 37,646 | +37,646 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 49,684 | 36,579 | -13,105 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 46,770 | 36,065 | -10,705 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,740 | 35,294 | -41,446 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 25,666 | 34,166 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 34,058 | +34,058 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 31,440 | +31,440 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 28,898 | 28,898 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JOURNEY STRATEGIC WEALTH LLC | 28,846 | 28,846 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,439 | 28,348 | +15,909 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 27,666 | +27,666 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 26,966 | 27,555 | +589 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 27,197 | 27,197 | 0 | 0.01 | 0.01 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 0 | 27,113 | +27,113 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,950 | 26,977 | +5,027 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 20,617 | 26,456 | +5,839 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 36,300 | 26,430 | -9,870 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 25,971 | +25,971 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 25,593 | 25,744 | +151 | 0.00 | 0.00 | -0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 25,709 | 25,709 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Castleview Partners, LLC | 0 | 25,584 | +25,584 | 0.00 | 0.15 | +0.15 | buy |