| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 15,028,079 | 17,259,548 | +2,231,469 | 8.32 | 12.19 | +3.87 | buy |
| Blackstone Inc. | 569,715 | 1,382,587 | +812,872 | 0.04 | 0.07 | +0.03 | buy |
| Rubric Capital Management LP | 3,917,331 | 4,338,444 | +421,113 | 0.74 | 0.93 | +0.19 | buy |
| Vestal Point Capital, LP | 185,000 | 500,000 | +315,000 | 0.16 | 0.43 | +0.26 | buy |
| Tejara Capital Ltd | 38,537 | 189,409 | +150,872 | 0.37 | 1.11 | +0.74 | buy |
| Prosight Management, LP | 820,000 | 957,229 | +137,229 | 3.32 | 3.75 | +0.43 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 116,100 | 44,175 | +71,925 | 0.01 | 0.00 | 0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 2,137,653 | 2,197,879 | +60,226 | 0.08 | 0.07 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 337,161 | 321,949 | +15,212 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 63,600 | 71,974 | +8,374 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 759,653 | 766,944 | +7,291 | 0.25 | 0.23 | 0.00 | buy |
| Empowered Funds, LLC | 352,753 | 360,044 | +7,291 | 0.08 | 0.06 | -0.01 | buy |
| Hillsdale Investment Management Inc. | 230,025 | 236,925 | +6,900 | 0.17 | 0.14 | -0.03 | buy |
| Northwest & Ethical Investments L.P. | 5,471 | 10,030 | +4,559 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 206,569 | 208,029 | +1,460 | 0.06 | 0.04 | -0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 67,240 | 68,459 | +1,219 | 0.99 | 0.95 | -0.04 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,446 | 1,763 | +317 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 12,357 | 12,101 | +256 | 0.01 | 0.01 | 0.00 | sell |
| Truvestments Capital LLC | 434 | 309 | +125 | 0.00 | 0.00 | 0.00 | sell |
| JOURNEY STRATEGIC WEALTH LLC | 28,897 | 28,941 | +44 | 0.02 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27,385 | 26,775 | -610 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 14,605 | 13,816 | -789 | 0.02 | 0.02 | -0.00 | sell |
| CURIO WEALTH, LLC | 1,000 | 1 | -999 | 0.01 | 0.01 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 282,345 | 280,726 | -1,619 | 0.03 | 0.02 | -0.00 | sell |
| Granahan Investment Management, LLC | 411,120 | 407,589 | -3,531 | 0.25 | 0.24 | -0.01 | sell |
| One Wealth Advisors, LLC | 13,979 | 10,404 | -3,575 | 0.03 | 0.02 | -0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 139,953 | 136,319 | -3,634 | 0.05 | 0.04 | -0.01 | sell |
| RITHOLTZ WEALTH MANAGEMENT | 74,466 | 60,494 | -13,972 | 0.03 | 0.02 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 306,460 | 278,658 | -27,802 | 0.26 | 0.19 | -0.07 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 132,577 | 96,329 | -36,248 | 0.02 | 0.01 | -0.01 | sell |
| Redmile Group, LLC | 4,840,463 | 4,788,945 | -51,518 | 4.94 | 5.39 | +0.45 | sell |
| PERCEPTIVE ADVISORS LLC | 2,130,020 | 1,864,672 | -265,348 | 0.86 | 0.78 | -0.07 | sell |
| Samsara BioCapital, LLC | 1,000,000 | 666,667 | -333,333 | 2.01 | 1.42 | -0.59 | sell |