| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,365,111 | 3,879,945 | +2,514,834 | 0.00 | 0.01 | +0.01 | buy |
| EcoR1 Capital, LLC | 15,028,079 | 17,259,548 | +2,231,469 | 8.79 | 12.21 | +3.42 | buy |
| Blackstone Inc. | 569,715 | 1,382,587 | +812,872 | 0.04 | 0.07 | +0.03 | buy |
| Rubric Capital Management LP | 3,917,331 | 4,338,444 | +421,113 | 1.04 | 0.93 | -0.12 | buy |
| Vestal Point Capital, LP | 185,000 | 500,000 | +315,000 | 0.16 | 0.43 | +0.26 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,516 | 351,161 | +299,645 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 295,606 | +295,606 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 175,000 | +175,000 | 0.00 | 0.46 | +0.46 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 285,700 | 450,600 | +164,900 | 0.01 | 0.01 | +0.00 | buy |
| Tejara Capital Ltd | 38,537 | 189,409 | +150,872 | 0.37 | 1.11 | +0.74 | buy |
| Prosight Management, LP | 820,000 | 957,229 | +137,229 | 3.36 | 3.75 | +0.38 | buy |
| ExodusPoint Capital Management, LP | 0 | 133,320 | +133,320 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 58,358 | 180,670 | +122,312 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 101,996 | 220,809 | +118,813 | 0.02 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 23,127 | 135,763 | +112,636 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 972,742 | 1,079,458 | +106,716 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 105,829 | +105,829 | 0.00 | 0.06 | +0.06 | buy |
| Verition Fund Management LLC | 15,814 | 114,156 | +98,342 | 0.00 | 0.01 | +0.01 | buy |
| Aquilo Capital Management, LLC | 0 | 84,482 | +84,482 | 0.00 | 2.71 | +2.71 | buy |
| SG Americas Securities, LLC | 26,782 | 98,165 | +71,383 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 63,602 | +63,602 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,137,653 | 2,197,879 | +60,226 | 0.08 | 0.07 | -0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 60,642 | 116,711 | +56,069 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 43,708 | 95,394 | +51,686 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.11 | +0.11 | buy |
| UBS Group AG | 166,896 | 214,300 | +47,404 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 20,840 | 63,099 | +42,259 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 41,607 | +41,607 | 0.00 | 0.19 | +0.19 | buy |
| NEOS Investment Management LLC | 0 | 33,001 | +33,001 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 33,001 | +33,001 | 0.00 | 0.12 | +0.12 | buy |
| FRANKLIN RESOURCES INC | 0 | 32,160 | +32,160 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 31,700 | 62,131 | +30,431 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 2,808 | 31,676 | +28,868 | 0.01 | 0.04 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 19,660 | 42,570 | +22,910 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 26,074 | 48,485 | +22,411 | 0.00 | 0.00 | +0.00 | buy |
| Duncan Williams Asset Management, LLC | 0 | 22,095 | +22,095 | 0.00 | 0.10 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 689,884 | 705,035 | +15,151 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 0 | 14,245 | +14,245 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 13,006 | +13,006 | 0.00 | 0.04 | +0.04 | buy |
| Magnetar Financial LLC | 0 | 12,448 | +12,448 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 12,399 | +12,399 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 12,102 | +12,102 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 57 | 11,822 | +11,765 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 10,859 | +10,859 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 69,382 | 78,206 | +8,824 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 63,600 | 71,974 | +8,374 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 759,653 | 766,944 | +7,291 | 0.25 | 0.23 | -0.02 | buy |
| Empowered Funds, LLC | 352,753 | 360,044 | +7,291 | 0.08 | 0.06 | -0.01 | buy |
| Hillsdale Investment Management Inc. | 230,025 | 236,925 | +6,900 | 0.17 | 0.14 | -0.03 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,960 | 37,642 | +6,682 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 33,858 | 40,263 | +6,405 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,546,772 | 1,552,612 | +5,840 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,611 | 24,531 | +4,920 | 0.00 | 0.00 | +0.00 | buy |
| Northwest & Ethical Investments L.P. | 5,471 | 10,030 | +4,559 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 3,787 | +3,787 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,087 | 4,168 | +3,081 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 64,330 | 67,030 | +2,700 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,583 | 24,113 | +2,530 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 131,306 | 133,639 | +2,333 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 193 | 2,299 | +2,106 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 2,049 | +2,049 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 206,569 | 208,029 | +1,460 | 0.09 | 0.08 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,958 | 32,385 | +1,427 | 0.00 | 0.00 | -0.00 | buy |
| Janney Montgomery Scott LLC | 10,267 | 11,567 | +1,300 | 0.00 | 0.00 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 67,240 | 68,459 | +1,219 | 0.99 | 0.95 | -0.04 | buy |
| Wayfinding Financial, LLC | 0 | 981 | +981 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 60 | 870 | +810 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,446 | 1,763 | +317 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 181,626 | 181,912 | +286 | 0.01 | 0.00 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 206 | +206 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,084,961 | 1,085,133 | +172 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 243 | 401 | +158 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 156 | +156 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 70 | 217 | +147 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 129 | +129 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,799 | 1,880 | +81 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 34 | 110 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 52 | 106 | +54 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 50 | 100 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 120,683 | 120,727 | +44 | 0.00 | 0.00 | -0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 28,897 | 28,941 | +44 | 0.02 | 0.01 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,295 | 2,330 | +35 | 0.00 | 0.00 | -0.00 | buy |
| Stephens Consulting, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| AMERIFLEX GROUP, INC. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 533 | 543 | +10 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 10 | 13 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,616 | 5,616 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 4,308,935 | 4,308,935 | 0 | 2.14 | 2.09 | -0.05 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,783 | 43,783 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JUPITER ASSET MANAGEMENT LTD | 369,499 | 369,499 | 0 | 0.05 | 0.04 | -0.01 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 1.07 | 0.72 | -0.34 | hold |
| JANUS HENDERSON GROUP PLC | 18,200 | 18,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 3,843 | 3,843 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 286 | 286 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |