| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | 22,970,388 | 0 | 27.61 | 24.58 | -3.03 | hold |
| Rubric Capital Management LP | 5,750,000 | 7,000,000 | +1,250,000 | 1.81 | 2.15 | +0.34 | buy |
| BlackRock, Inc. | 4,595,548 | 4,553,888 | -41,660 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 3,938,641 | 3,734,142 | -204,499 | 3.49 | 2.98 | -0.51 | sell |
| PERCEPTIVE ADVISORS LLC | 3,261,850 | 3,510,078 | +248,228 | 1.57 | 1.74 | +0.16 | buy |
| MORGAN STANLEY | 2,593,080 | 2,480,568 | -112,512 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,822,048 | 1,908,039 | +85,991 | 0.06 | 0.06 | +0.00 | buy |
| CITADEL ADVISORS LLC | 255,351 | 1,150,018 | +894,667 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,159,215 | 1,139,135 | -20,080 | 0.01 | 0.01 | -0.00 | sell |
| Nextech Invest, Ltd. | 1,113,946 | 1,113,946 | 0 | 2.84 | 1.96 | -0.87 | hold |
| STATE STREET CORP | 1,037,642 | 1,011,777 | -25,865 | 0.00 | 0.00 | -0.00 | sell |
| Capricorn Fund Managers Ltd | 1,022,840 | 1,007,210 | -15,630 | 6.49 | 3.93 | -2.56 | sell |
| DEUTSCHE BANK AG\ | 1,595,833 | 921,250 | -674,583 | 0.01 | 0.01 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 700,002 | 743,898 | +43,896 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 647,374 | 727,986 | +80,612 | 0.03 | 0.03 | +0.00 | buy |
| FMR LLC | 560,086 | 667,153 | +107,067 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 647,970 | 659,940 | +11,970 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 648,326 | 651,662 | +3,336 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 420,207 | 599,486 | +179,279 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 565,249 | +565,249 | 0.00 | 1.09 | +1.09 | buy |
| Prosight Management, LP | 530,393 | 539,049 | +8,656 | 2.89 | 2.21 | -0.67 | buy |
| Qube Research & Technologies Ltd | 474,290 | 511,937 | +37,647 | 0.02 | 0.02 | +0.00 | buy |
| Redmile Group, LLC | 491,654 | 491,654 | 0 | 0.95 | 0.82 | -0.14 | hold |
| Hillsdale Investment Management Inc. | 237,922 | 345,622 | +107,700 | 0.17 | 0.24 | +0.06 | buy |
| SummitTX Capital, L.P. | 224,268 | 321,427 | +97,159 | 0.18 | 0.26 | +0.08 | buy |
| NORTHERN TRUST CORP | 307,979 | 320,210 | +12,231 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 320,261 | 319,385 | -876 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 0 | 299,202 | +299,202 | 0.00 | 0.07 | +0.07 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 244,798 | 256,690 | +11,892 | 0.07 | 0.07 | -0.00 | buy |
| Granahan Investment Management, LLC | 224,408 | 250,773 | +26,365 | 0.25 | 0.30 | +0.05 | buy |
| HRT FINANCIAL LP | 121,064 | 237,889 | +116,825 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 89,524 | 236,754 | +147,230 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 223,786 | 235,621 | +11,835 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 70,445 | 226,967 | +156,522 | 0.00 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 78,336 | 206,854 | +128,518 | 0.01 | 0.02 | +0.01 | buy |
| Man Group plc | 75,318 | 189,890 | +114,572 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 208,313 | 189,636 | -18,677 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 220,909 | 185,124 | -35,785 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 152,689 | 182,410 | +29,721 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 187,685 | 176,411 | -11,274 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 278,854 | 171,779 | -107,075 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 181,790 | 163,649 | -18,141 | 0.03 | 0.03 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 145,534 | 148,226 | +2,692 | 0.08 | 0.08 | -0.00 | buy |
| XTX Topco Ltd | 93,469 | 143,882 | +50,413 | 0.06 | 0.06 | -0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 142,132 | +142,132 | 0.00 | 1.47 | +1.47 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 181,705 | 138,690 | -43,015 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 257,580 | 125,630 | -131,950 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 128,131 | 124,105 | -4,026 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 111,207 | 114,327 | +3,120 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 35,008 | 114,072 | +79,064 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 105,184 | 105,184 | 0 | 0.64 | 0.66 | +0.02 | hold |
| Tidal Investments LLC | 0 | 104,931 | +104,931 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 75,975 | 104,931 | +28,956 | 0.16 | 0.18 | +0.02 | buy |
| Fisher Asset Management, LLC | 68,197 | 101,439 | +33,242 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 99,795 | 99,795 | 0 | 0.04 | 0.04 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 91,075 | 90,669 | -406 | 0.00 | 0.00 | -0.00 | sell |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 88,800 | 88,800 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Squarepoint Ops LLC | 0 | 83,146 | +83,146 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 45,460 | 82,726 | +37,266 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 78,547 | +78,547 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 58,987 | 77,659 | +18,672 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 75,847 | 76,756 | +909 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 75,498 | 75,399 | -99 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 113,141 | 74,222 | -38,919 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 74,200 | 74,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 58,832 | 70,851 | +12,019 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 75,566 | 66,106 | -9,460 | 0.00 | 0.00 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 48,318 | 56,107 | +7,789 | 0.04 | 0.04 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 55,896 | +5,866 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 33,588 | 54,883 | +21,295 | 0.04 | 0.08 | +0.04 | buy |
| Russell Investments Group, Ltd. | 58,350 | 47,450 | -10,900 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 55,055 | 47,360 | -7,695 | 0.00 | 0.00 | -0.00 | sell |
| North Growth Management Ltd. | 45,000 | 46,000 | +1,000 | 0.19 | 0.17 | -0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 45,726 | +45,726 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 42,786 | +42,786 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 42,905 | 42,404 | -501 | 0.00 | 0.00 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 40,812 | 40,419 | -393 | 0.00 | 0.00 | -0.00 | sell |
| Manatuck Hill Partners, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.33 | +0.33 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 387 | 39,750 | +39,363 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 28,883 | 39,640 | +10,757 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,421 | 39,355 | +18,934 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 37,919 | +37,919 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 17,868 | 37,777 | +19,909 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,761 | 37,389 | -372 | 0.00 | 0.00 | -0.00 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 43,052 | 37,129 | -5,923 | 0.01 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 30,324 | 36,875 | +6,551 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 36,262 | +36,262 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 7,346 | 35,935 | +28,589 | 0.09 | 0.35 | +0.26 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,784 | 35,487 | +6,703 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 34,085 | +34,085 | 0.00 | 0.24 | +0.24 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 32,764 | +32,764 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 28,293 | 32,394 | +4,101 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 32,223 | +32,223 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,433 | 31,592 | +14,159 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 31,548 | +31,548 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32,815 | 30,432 | -2,383 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 26,600 | 30,100 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 28,630 | 29,653 | +1,023 | 0.00 | 0.00 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 29,050 | 29,050 | 0 | 0.02 | 0.02 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 97,907 | 28,349 | -69,558 | 0.00 | 0.00 | -0.00 | sell |