| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 13,437,473 | 13,437,473 | 0 | 3.59 | 3.50 | -0.09 | hold |
| BVF INC/IL | 5,870,000 | 5,870,000 | 0 | 1.70 | 1.40 | -0.30 | hold |
| Redmile Group, LLC | 5,560,798 | 5,211,037 | -349,761 | 2.15 | 2.68 | +0.53 | sell |
| MORGAN STANLEY | 5,111,144 | 4,239,447 | -871,697 | 0.00 | 0.00 | -0.00 | sell |
| Rubric Capital Management LP | 3,475,384 | 3,917,331 | +441,947 | 1.08 | 0.88 | -0.20 | buy |
| VANGUARD GROUP INC | 2,458,105 | 2,697,372 | +239,267 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 889,250 | 2,358,189 | +1,468,939 | 0.00 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,907,714 | 1,930,887 | +23,173 | 0.05 | 0.04 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 56,301 | 1,902,401 | +1,846,100 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,074,807 | 1,667,711 | +592,904 | 0.20 | 0.34 | +0.14 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,601,000 | 1,601,000 | 0 | 0.10 | 0.08 | -0.02 | hold |
| Prosight Management, LP | 410,948 | 1,180,000 | +769,052 | 1.20 | 3.00 | +1.80 | buy |
| STATE STREET CORP | 1,048,732 | 1,104,376 | +55,644 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 1.20 | 0.95 | -0.25 | hold |
| Samsara BioCapital, LLC | 1,458,875 | 1,000,000 | -458,875 | 2.37 | 1.78 | -0.59 | sell |
| Granahan Investment Management, LLC | 656,607 | 737,501 | +80,894 | 0.24 | 0.25 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 702,683 | 725,543 | +22,860 | 0.15 | 0.14 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 314,564 | 715,632 | +401,068 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 668,984 | 712,950 | +43,966 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 716,482 | 651,728 | -64,754 | 0.03 | 0.02 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,305,057 | 614,195 | -690,862 | 0.05 | 0.02 | -0.03 | sell |
| CITADEL ADVISORS LLC | 1,064,987 | 599,382 | -465,605 | 0.01 | 0.01 | -0.01 | sell |
| Sio Capital Management, LLC | 0 | 491,128 | +491,128 | 0.00 | 1.58 | +1.58 | buy |
| Vestal Point Capital, LP | 0 | 440,000 | +440,000 | 0.00 | 0.28 | +0.28 | buy |
| JUPITER ASSET MANAGEMENT LTD | 426,944 | 426,944 | 0 | 0.04 | 0.03 | -0.01 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 393,021 | 398,144 | +5,123 | 0.03 | 0.02 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 418,376 | 373,002 | -45,374 | 0.18 | 0.13 | -0.05 | sell |
| NORTHERN TRUST CORP | 418,248 | 364,414 | -53,834 | 0.00 | 0.00 | -0.00 | sell |
| Monaco Asset Management SAM | 292,500 | 336,344 | +43,844 | 1.36 | 1.43 | +0.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 286,595 | 334,781 | +48,186 | 0.00 | 0.00 | -0.00 | buy |
| Empowered Funds, LLC | 295,783 | 318,643 | +22,860 | 0.06 | 0.05 | -0.01 | buy |
| Bank of New York Mellon Corp | 294,878 | 309,703 | +14,825 | 0.00 | 0.00 | -0.00 | buy |
| Tejara Capital Ltd | 210,212 | 270,212 | +60,000 | 0.82 | 0.84 | +0.02 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 284,378 | 244,758 | -39,620 | 0.13 | 0.09 | -0.04 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 115,600 | 236,781 | +121,181 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 599,000 | 235,900 | -363,100 | 0.02 | 0.01 | -0.02 | sell |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asset Management, L.P. | 0 | 197,760 | +197,760 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 191,127 | +191,127 | 0.00 | 0.26 | +0.26 | buy |
| FEDERATED HERMES, INC. | 180,547 | 179,381 | -1,166 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 0 | 174,389 | +174,389 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 270,546 | 173,601 | -96,945 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 238,687 | 170,073 | -68,614 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 154,362 | 145,522 | -8,840 | 0.03 | 0.03 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 141,793 | 137,326 | -4,467 | 0.00 | 0.00 | -0.00 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 255,497 | 133,245 | -122,252 | 0.03 | 0.01 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,491 | 132,148 | +6,657 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 67,424 | 125,674 | +58,250 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 160,299 | 101,398 | -58,901 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 60,547 | 99,836 | +39,289 | 0.00 | 0.00 | +0.00 | buy |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.19 | 0.16 | -0.03 | hold |
| AQR CAPITAL MANAGEMENT LLC | 489,502 | 94,272 | -395,230 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 53,308 | 92,016 | +38,708 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 83,000 | 90,200 | +7,200 | 0.00 | 0.00 | -0.00 | buy |
| SummerHaven Investment Management, LLC | 88,386 | 90,158 | +1,772 | 0.58 | 0.50 | -0.08 | buy |
| RHUMBLINE ADVISERS | 79,702 | 86,912 | +7,210 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 81,789 | +81,789 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 14,608 | 73,324 | +58,716 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 72,435 | 72,114 | -321 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 231,181 | 67,738 | -163,443 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 69,014 | 65,628 | -3,386 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 0 | 63,600 | +63,600 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 36,065 | 63,121 | +27,056 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 65,909 | 62,684 | -3,225 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 64,673 | 60,983 | -3,690 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 52,500 | 60,600 | +8,100 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,294 | 60,379 | +25,085 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 55,079 | 59,523 | +4,444 | 0.03 | 0.01 | -0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 37,646 | 58,310 | +20,664 | 0.03 | 0.03 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 47,200 | 58,300 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 20,713 | 54,711 | +33,998 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 0 | 50,600 | +50,600 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 68,388 | 50,501 | -17,887 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 50,250 | 50,030 | -220 | 0.00 | 0.00 | -0.00 | sell |
| RITHOLTZ WEALTH MANAGEMENT | 80,879 | 46,033 | -34,846 | 0.03 | 0.01 | -0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,420 | 45,923 | +2,503 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 45,769 | +45,769 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 27,113 | 43,756 | +16,643 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 40,260 | 43,160 | +2,900 | 0.00 | 0.00 | -0.00 | buy |
| Marex Group plc | 50,000 | 40,000 | -10,000 | 0.02 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 36,579 | 39,473 | +2,894 | 0.00 | 0.00 | -0.00 | buy |
| Pennant Investors, LP | 38,700 | 38,700 | 0 | 0.11 | 0.09 | -0.02 | hold |
| Legal & General Group Plc | 39,938 | 35,540 | -4,398 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 27,666 | 35,062 | +7,396 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 28,898 | 31,893 | +2,995 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 31,440 | 31,277 | -163 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 25,971 | 30,642 | +4,671 | 0.00 | 0.00 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 30,363 | +30,363 | 0.00 | 0.02 | +0.02 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 28,846 | 28,897 | +51 | 0.01 | 0.01 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 34,166 | 28,166 | -6,000 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 48,304 | 26,789 | -21,515 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 26,374 | +26,374 | 0.00 | 0.00 | +0.00 | buy |
| One Wealth Advisors, LLC | 25,370 | 24,926 | -444 | 0.05 | 0.05 | +0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 27,197 | 24,671 | -2,526 | 0.01 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,042 | 22,695 | +2,653 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 26,456 | 20,180 | -6,276 | 0.01 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 18,171 | 19,838 | +1,667 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,977 | 19,571 | -7,406 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 18,539 | 18,200 | -339 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 28,348 | 17,082 | -11,266 | 0.00 | 0.00 | -0.00 | sell |