| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 17,259,548 | 22,970,388 | +5,710,840 | 12.19 | 17.06 | +4.87 | buy |
| Vestal Point Capital, LP | 500,000 | 1,150,000 | +650,000 | 0.43 | 0.76 | +0.33 | buy |
| Rubric Capital Management LP | 4,338,444 | 4,710,551 | +372,107 | 0.93 | 0.89 | -0.03 | buy |
| Prosight Management, LP | 957,229 | 1,309,904 | +352,675 | 3.75 | 4.01 | +0.26 | buy |
| Blackstone Inc. | 1,382,587 | 1,656,790 | +274,203 | 0.07 | 0.09 | +0.02 | buy |
| Opaleye Management Inc. | 175,000 | 210,000 | +35,000 | 0.46 | 0.53 | +0.07 | buy |
| NEOS Investment Management LLC | 33,001 | 51,855 | +18,854 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 33,001 | 51,855 | +18,854 | 0.12 | 0.17 | +0.06 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 321,949 | 304,666 | +17,283 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 68,459 | 83,655 | +15,196 | 0.95 | 1.47 | +0.52 | buy |
| Tejara Capital Ltd | 189,409 | 200,150 | +10,741 | 1.11 | 1.16 | +0.05 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 136,319 | 146,954 | +10,635 | 0.04 | 0.04 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 44,175 | 54,075 | +9,900 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 12,101 | 9,296 | +2,805 | 0.01 | 0.00 | 0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 282,345 | 280,726 | +1,619 | 0.03 | 0.02 | 0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 26,775 | 27,109 | +334 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,816 | 13,996 | +180 | 0.02 | 0.02 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 28,941 | 29,040 | +99 | 0.01 | 0.01 | -0.00 | buy |
| Fisher Asset Management, LLC | 71,974 | 71,979 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 12,448 | 12,168 | -280 | 0.00 | 0.00 | -0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 208,029 | 207,602 | -427 | 0.04 | 0.03 | -0.02 | sell |
| Virtus Investment Advisers, LLC | 13,006 | 7,178 | -5,828 | 0.04 | 0.03 | -0.01 | sell |
| Granahan Investment Management, LLC | 407,589 | 380,783 | -26,806 | 0.24 | 0.19 | -0.05 | sell |
| Hillsdale Investment Management Inc. | 236,925 | 205,022 | -31,903 | 0.14 | 0.09 | -0.05 | sell |
| RITHOLTZ WEALTH MANAGEMENT | 60,494 | 25,235 | -35,259 | 0.02 | 0.01 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 278,658 | 238,391 | -40,267 | 0.19 | 0.20 | +0.01 | sell |
| Samsara BioCapital, LLC | 666,667 | 310,300 | -356,367 | 1.42 | 0.80 | -0.62 | sell |
| PERCEPTIVE ADVISORS LLC | 1,864,672 | 1,275,274 | -589,398 | 0.78 | 0.59 | -0.19 | sell |
| Redmile Group, LLC | 4,788,945 | 4,150,627 | -638,318 | 5.39 | 5.54 | +0.15 | sell |