| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 17,259,548 | 22,970,388 | +5,710,840 | 12.21 | 17.08 | +4.88 | buy |
| Rubric Capital Management LP | 4,338,444 | 4,710,551 | +372,107 | 0.93 | 0.95 | +0.02 | buy |
| BVF INC/IL | 4,308,935 | 4,308,935 | 0 | 2.09 | 1.93 | -0.16 | hold |
| MORGAN STANLEY | 4,073,463 | 4,177,614 | +104,151 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 4,788,945 | 4,150,627 | -638,318 | 5.39 | 5.54 | +0.15 | sell |
| BlackRock, Inc. | 4,089,421 | 3,794,272 | -295,149 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,767,041 | 2,464,693 | +697,652 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,879,945 | 2,459,513 | -1,420,432 | 0.01 | 0.01 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 2,197,879 | 2,039,656 | -158,223 | 0.07 | 0.06 | -0.01 | sell |
| Blackstone Inc. | 1,382,587 | 1,656,790 | +274,203 | 0.07 | 0.09 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 1,552,612 | 1,544,763 | -7,849 | 0.01 | 0.01 | -0.00 | sell |
| Prosight Management, LP | 957,229 | 1,309,904 | +352,675 | 3.75 | 4.01 | +0.26 | buy |
| PERCEPTIVE ADVISORS LLC | 1,864,672 | 1,275,274 | -589,398 | 0.79 | 0.60 | -0.19 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,079,458 | 1,192,432 | +112,974 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 500,000 | 1,150,000 | +650,000 | 0.43 | 0.76 | +0.33 | buy |
| Nextech Invest, Ltd. | 1,113,946 | 1,113,946 | 0 | 3.08 | 2.65 | -0.44 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.72 | 0.70 | -0.03 | hold |
| STATE STREET CORP | 1,085,133 | 1,088,459 | +3,326 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 705,035 | 705,364 | +329 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 198,812 | 654,916 | +456,104 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 450,600 | 533,300 | +82,700 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 495,067 | 492,780 | -2,287 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 476,000 | +476,000 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 38,409 | 441,690 | +403,281 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 200,047 | 428,857 | +228,810 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 407,589 | 380,783 | -26,806 | 0.24 | 0.19 | -0.05 | sell |
| JUPITER ASSET MANAGEMENT LTD | 369,499 | 369,499 | 0 | 0.04 | 0.04 | -0.00 | hold |
| NORTHERN TRUST CORP | 386,923 | 349,799 | -37,124 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 666,667 | 310,300 | -356,367 | 1.42 | 0.80 | -0.62 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 321,949 | 304,666 | -17,283 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 280,726 | 280,726 | 0 | 0.02 | 0.02 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 351,161 | 259,137 | -92,024 | 0.01 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 63,099 | 255,291 | +192,192 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 214,300 | 251,510 | +37,210 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 180,670 | 246,155 | +65,485 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 278,658 | 238,391 | -40,267 | 0.19 | 0.20 | +0.01 | sell |
| Trexquant Investment LP | 220,809 | 220,982 | +173 | 0.03 | 0.03 | +0.00 | buy |
| Opaleye Management Inc. | 175,000 | 210,000 | +35,000 | 0.46 | 0.53 | +0.07 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 208,029 | 207,602 | -427 | 0.08 | 0.04 | -0.05 | sell |
| Hillsdale Investment Management Inc. | 236,925 | 205,022 | -31,903 | 0.14 | 0.09 | -0.05 | sell |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tejara Capital Ltd | 189,409 | 200,150 | +10,741 | 1.11 | 1.16 | +0.05 | buy |
| FEDERATED HERMES, INC. | 181,912 | 182,270 | +358 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 182,246 | 180,690 | -1,556 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 0 | 175,121 | +175,121 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 100,309 | 166,428 | +66,119 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 48,485 | 166,143 | +117,658 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 41,198 | 155,998 | +114,800 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 63,602 | 155,599 | +91,997 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 136,319 | 146,954 | +10,635 | 0.04 | 0.04 | +0.01 | buy |
| Bank of New York Mellon Corp | 120,727 | 133,090 | +12,363 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 116,711 | 124,435 | +7,724 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 133,639 | 124,204 | -9,435 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 75,430 | 122,820 | +47,390 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 119,962 | +119,962 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 0 | 118,104 | +118,104 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 295,606 | 116,102 | -179,504 | 0.00 | 0.00 | -0.00 | sell |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.24 | 0.23 | -0.02 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 105,829 | 96,989 | -8,840 | 0.06 | 0.05 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 62,131 | 90,378 | +28,247 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 78,206 | 89,371 | +11,165 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 82,738 | 86,083 | +3,345 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 85,728 | +85,728 | 0.00 | 0.02 | +0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 68,459 | 83,655 | +15,196 | 0.95 | 1.47 | +0.52 | buy |
| Swiss National Bank | 80,100 | 73,100 | -7,000 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 56,771 | 72,983 | +16,212 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 71,974 | 71,979 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 69,874 | +69,874 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 67,030 | 69,730 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 54,171 | +54,171 | 0.00 | 0.01 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 44,175 | 54,075 | +9,900 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 33,001 | 51,855 | +18,854 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 33,001 | 51,855 | +18,854 | 0.12 | 0.17 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 133,320 | 51,669 | -81,651 | 0.02 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 0 | 46,300 | +46,300 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 42,570 | 44,965 | +2,395 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 46,790 | 43,763 | -3,027 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,783 | 42,873 | -910 | 0.00 | 0.00 | -0.00 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 96,329 | 41,224 | -55,105 | 0.01 | 0.00 | -0.01 | sell |
| HSBC HOLDINGS PLC | 0 | 36,497 | +36,497 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 10,859 | 35,406 | +24,547 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 44,270 | 34,610 | -9,660 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 34,293 | +34,293 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 33,559 | +33,559 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,309 | 33,309 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HRT FINANCIAL LP | 65,380 | 32,758 | -32,622 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 37,642 | 32,170 | -5,472 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 31,147 | 31,147 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XTX Topco Ltd | 20,205 | 31,021 | +10,816 | 0.01 | 0.02 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,531 | 29,934 | +5,403 | 0.00 | 0.00 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 28,941 | 29,040 | +99 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 3,053 | 28,312 | +25,259 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 25,912 | 27,642 | +1,730 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 26,775 | 27,109 | +334 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,385 | 26,863 | -5,522 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,113 | 26,816 | +2,703 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 26,667 | +26,667 | 0.00 | 0.03 | +0.03 | buy |
| Creative Planning | 11,822 | 25,389 | +13,567 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 60,494 | 25,235 | -35,259 | 0.02 | 0.01 | -0.01 | sell |