| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 17,259,548 | 22,970,388 | +5,710,840 | 12.21 | 17.08 | +4.88 | buy |
| VANGUARD GROUP INC | 1,767,041 | 2,464,693 | +697,652 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 500,000 | 1,150,000 | +650,000 | 0.43 | 0.76 | +0.33 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 476,000 | +476,000 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 198,812 | 654,916 | +456,104 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 38,409 | 441,690 | +403,281 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 4,338,444 | 4,710,551 | +372,107 | 0.93 | 0.95 | +0.02 | buy |
| Prosight Management, LP | 957,229 | 1,309,904 | +352,675 | 3.75 | 4.01 | +0.26 | buy |
| Blackstone Inc. | 1,382,587 | 1,656,790 | +274,203 | 0.07 | 0.09 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 200,047 | 428,857 | +228,810 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 63,099 | 255,291 | +192,192 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 0 | 175,121 | +175,121 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 119,962 | +119,962 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 0 | 118,104 | +118,104 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 48,485 | 166,143 | +117,658 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 41,198 | 155,998 | +114,800 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,079,458 | 1,192,432 | +112,974 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 4,073,463 | 4,177,614 | +104,151 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 63,602 | 155,599 | +91,997 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 85,728 | +85,728 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 450,600 | 533,300 | +82,700 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 69,874 | +69,874 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 100,309 | 166,428 | +66,119 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 180,670 | 246,155 | +65,485 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 54,171 | +54,171 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 75,430 | 122,820 | +47,390 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 46,300 | +46,300 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 214,300 | 251,510 | +37,210 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 36,497 | +36,497 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 175,000 | 210,000 | +35,000 | 0.46 | 0.53 | +0.07 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 34,293 | +34,293 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 33,559 | +33,559 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 62,131 | 90,378 | +28,247 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 26,667 | +26,667 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 3,053 | 28,312 | +25,259 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.10 | +0.10 | buy |
| Man Group plc | 10,859 | 35,406 | +24,547 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 21,660 | +21,660 | 0.00 | 0.01 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 21,355 | +21,355 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 33,001 | 51,855 | +18,854 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 33,001 | 51,855 | +18,854 | 0.12 | 0.17 | +0.06 | buy |
| ROYAL BANK OF CANADA | 56,771 | 72,983 | +16,212 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 68,459 | 83,655 | +15,196 | 0.95 | 1.47 | +0.52 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 14,985 | +14,985 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 14,169 | +14,169 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,822 | 25,389 | +13,567 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 120,727 | 133,090 | +12,363 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 78,206 | 89,371 | +11,165 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 20,205 | 31,021 | +10,816 | 0.01 | 0.02 | +0.00 | buy |
| Tejara Capital Ltd | 189,409 | 200,150 | +10,741 | 1.11 | 1.16 | +0.05 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 136,319 | 146,954 | +10,635 | 0.04 | 0.04 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 10,628 | +10,628 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 44,175 | 54,075 | +9,900 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 116,711 | 124,435 | +7,724 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 12,399 | 18,941 | +6,542 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 6,311 | +6,311 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,000 | 10,307 | +6,307 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,299 | 8,570 | +6,271 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,531 | 29,934 | +5,403 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 82,738 | 86,083 | +3,345 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,085,133 | 1,088,459 | +3,326 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,113 | 26,816 | +2,703 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 67,030 | 69,730 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 42,570 | 44,965 | +2,395 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,168 | 6,445 | +2,277 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 25,912 | 27,642 | +1,730 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,816 | 4,947 | +1,131 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 332 | 968 | +636 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 564 | +564 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,330 | 2,692 | +362 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 181,912 | 182,270 | +358 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 26,775 | 27,109 | +334 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 705,035 | 705,364 | +329 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 543 | 810 | +267 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,816 | 13,996 | +180 | 0.02 | 0.02 | +0.00 | buy |
| Trexquant Investment LP | 220,809 | 220,982 | +173 | 0.03 | 0.03 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 13 | 181 | +168 | 0.00 | 0.00 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 28,941 | 29,040 | +99 | 0.01 | 0.01 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 96 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| Kilter Group LLC | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 110 | 122 | +12 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 71,974 | 71,979 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,616 | 5,616 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 4,308,935 | 4,308,935 | 0 | 2.09 | 1.93 | -0.16 | hold |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JUPITER ASSET MANAGEMENT LTD | 369,499 | 369,499 | 0 | 0.04 | 0.04 | -0.00 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 280,726 | 280,726 | 0 | 0.02 | 0.02 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.72 | 0.70 | -0.03 | hold |
| JANUS HENDERSON GROUP PLC | 18,200 | 18,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Janney Montgomery Scott LLC | 11,567 | 11,567 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 3,843 | 3,843 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 286 | 286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 33,309 | 33,309 | 0 | 0.00 | 0.00 | +0.00 | hold |