| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 3,510,078 | 4,182,953 | +672,875 | 1.74 | 1.70 | -0.04 | buy |
| Assenagon Asset Management S.A. | 727,986 | 1,252,027 | +524,041 | 0.03 | 0.04 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 340,363 | +340,363 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 9,256 | 308,187 | +298,931 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 152,416 | +152,416 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 539,049 | 674,434 | +135,385 | 2.21 | 3.04 | +0.82 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 66,106 | 155,579 | +89,473 | 0.00 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 250,773 | 336,157 | +85,384 | 0.30 | 0.31 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 83,455 | +83,455 | 0.00 | 0.04 | +0.04 | buy |
| LMR Partners LLP | 0 | 82,500 | +82,500 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 511,937 | 593,590 | +81,653 | 0.02 | 0.02 | -0.00 | buy |
| STATE STREET CORP | 1,011,777 | 1,088,216 | +76,439 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 71,874 | +71,874 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 163,649 | 223,766 | +60,117 | 0.03 | 0.04 | +0.01 | buy |
| Manatuck Hill Partners, LLC | 40,000 | 100,000 | +60,000 | 0.33 | 0.87 | +0.54 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 32,764 | 73,282 | +40,518 | 0.02 | 0.05 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 10,702 | 50,825 | +40,123 | 0.07 | 0.31 | +0.24 | buy |
| Hillsdale Investment Management Inc. | 345,622 | 382,922 | +37,300 | 0.24 | 0.23 | -0.01 | buy |
| FMR LLC | 667,153 | 702,568 | +35,415 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 659,940 | 692,410 | +32,470 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 189,636 | 217,199 | +27,563 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 25,956 | +25,956 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 25,608 | +25,608 | 0.00 | 0.01 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 45,726 | 66,836 | +21,110 | 0.01 | 0.02 | +0.01 | buy |
| Man Group plc | 189,890 | 210,779 | +20,889 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 90,669 | 111,282 | +20,613 | 0.00 | 0.00 | -0.00 | buy |
| BetterWealth, LLC | 0 | 18,622 | +18,622 | 0.00 | 0.09 | +0.09 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 18,185 | +18,185 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 1,336 | 19,431 | +18,095 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 114,327 | 131,441 | +17,114 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 26,209 | 43,160 | +16,951 | 0.00 | 0.00 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 56,107 | 71,660 | +15,553 | 0.04 | 0.05 | +0.01 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 256,690 | 271,343 | +14,653 | 0.07 | 0.07 | -0.00 | buy |
| Jain Global LLC | 0 | 10,010 | +10,010 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 9,569 | +9,569 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 47,360 | 56,278 | +8,918 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 32,223 | 40,948 | +8,725 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 8,313 | +8,313 | 0.00 | 0.05 | +0.05 | buy |
| Magnetar Financial LLC | 0 | 8,292 | +8,292 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 40,419 | 48,675 | +8,256 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 74,222 | 82,264 | +8,042 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 39,640 | 47,642 | +8,002 | 0.00 | 0.00 | -0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 11,935 | 19,435 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 124,105 | 131,106 | +7,001 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 78,547 | 84,990 | +6,443 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,031 | 32,052 | +6,021 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 54,883 | 60,874 | +5,991 | 0.08 | 0.08 | +0.01 | buy |
| FEDERATED HERMES, INC. | 182,410 | 187,995 | +5,585 | 0.01 | 0.01 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 82,726 | 87,745 | +5,019 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 3,893 | +3,893 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,487 | 38,486 | +2,999 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 2,998 | +2,998 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 37,129 | 39,534 | +2,405 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 18,374 | 20,603 | +2,229 | 0.00 | 0.00 | +0.00 | buy |
| Asset Management One Co., Ltd. | 0 | 1,659 | +1,659 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 216 | 1,309 | +1,093 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 17,468 | 18,416 | +948 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 320,210 | 321,073 | +863 | 0.00 | 0.00 | -0.00 | buy |
| Tidal Investments LLC | 104,931 | 105,615 | +684 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 104,931 | 105,615 | +684 | 0.18 | 0.09 | -0.09 | buy |
| STIFEL FINANCIAL CORP | 76,756 | 77,214 | +458 | 0.00 | 0.00 | -0.00 | buy |
| Janney Montgomery Scott LLC | 11,487 | 11,865 | +378 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 465 | 837 | +372 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,389 | 37,744 | +355 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 8,993 | 9,334 | +341 | 0.00 | 0.00 | -0.00 | buy |
| NBC SECURITIES, INC. | 623 | 962 | +339 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 0 | 332 | +332 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27,354 | 27,670 | +316 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 11 | 312 | +301 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 295 | +295 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 8,507 | 8,762 | +255 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 210 | +210 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 42,404 | 42,524 | +120 | 0.00 | 0.00 | -0.00 | buy |
| HUNTINGTON NATIONAL BANK | 343 | 460 | +117 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 116 | +116 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 958 | 1,039 | +81 | 0.00 | 0.00 | -0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 554 | 581 | +27 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 1,097 | 1,114 | +17 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 28 | 40 | +12 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| AGF MANAGEMENT LTD | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,164 | 4,164 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 55,896 | 55,896 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 105,184 | 105,184 | 0 | 0.66 | 0.68 | +0.01 | hold |
| Redmile Group, LLC | 491,654 | 491,654 | 0 | 0.82 | 0.86 | +0.05 | hold |
| DekaBank Deutsche Girozentrale | 3,843 | 3,843 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 74,200 | 74,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 22,970,388 | 22,970,388 | 0 | 24.58 | 29.77 | +5.19 | hold |
| Nextech Invest, Ltd. | 1,113,946 | 1,113,946 | 0 | 1.96 | 1.38 | -0.58 | hold |
| IFP Advisors, Inc | 96 | 96 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rubric Capital Management LP | 7,000,000 | 7,000,000 | 0 | 2.15 | 1.68 | -0.47 | hold |
| RITHOLTZ WEALTH MANAGEMENT | 24,243 | 24,243 | 0 | 0.01 | 0.01 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 8,000 | 8,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 971 | 971 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Larson Financial Group LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 61 | 61 | 0 | 0.00 | 0.00 | -0.00 | hold |
| North Growth Management Ltd. | 46,000 | 46,000 | 0 | 0.17 | 0.15 | -0.02 | hold |
| Physician Wealth Advisors, Inc. | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |