| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 4,239,447 | 5,106,869 | +867,422 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,667,711 | 2,180,020 | +512,309 | 0.34 | 0.59 | +0.24 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 407,771 | +407,771 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 331,144 | +331,144 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 209,765 | +209,765 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 440,000 | 615,000 | +175,000 | 0.28 | 0.61 | +0.33 | buy |
| VANGUARD GROUP INC | 2,697,372 | 2,858,514 | +161,142 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 715,632 | 849,502 | +133,870 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 26,789 | 154,384 | +127,595 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 100,866 | +100,866 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 67,738 | 163,039 | +95,301 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 173,601 | 251,477 | +77,876 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,104,376 | 1,171,777 | +67,401 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 49,546 | +49,546 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 48,808 | +48,808 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 29,841 | +29,841 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 54,711 | 79,890 | +25,179 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 25,082 | +25,082 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 46,033 | 70,169 | +24,136 | 0.01 | 0.03 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 21,160 | +21,160 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,854 | 29,512 | +17,658 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 63,121 | 80,326 | +17,205 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 725,543 | 742,561 | +17,018 | 0.14 | 0.20 | +0.06 | buy |
| Empowered Funds, LLC | 318,643 | 335,661 | +17,018 | 0.05 | 0.07 | +0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,465 | +16,465 | 0.00 | 0.05 | +0.05 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,930,887 | 1,945,491 | +14,604 | 0.04 | 0.06 | +0.02 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 133,245 | 144,848 | +11,603 | 0.01 | 0.02 | +0.01 | buy |
| SG Americas Securities, LLC | 10,593 | 20,543 | +9,950 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 125,674 | 135,555 | +9,881 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 9,561 | +9,561 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 170,073 | 177,410 | +7,337 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 364,414 | 370,927 | +6,513 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 6,300 | +6,300 | 0.00 | 0.04 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 8,306 | 13,665 | +5,359 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 35,540 | 39,571 | +4,031 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 3,843 | +3,843 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,659 | 30,665 | +3,006 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 62,684 | 65,678 | +2,994 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 72,114 | 73,654 | +1,540 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,811 | 3,336 | +1,525 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,061 | 11,527 | +1,466 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,069 | 18,348 | +1,279 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 86,912 | 87,956 | +1,044 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 712,950 | 713,915 | +965 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,148 | 132,798 | +650 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,111 | 2,570 | +459 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,841 | 13,234 | +393 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 10,302 | 10,679 | +377 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 112 | 433 | +321 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 259 | +259 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 147 | 349 | +202 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,937 | 10,114 | +177 | 0.04 | 0.06 | +0.02 | buy |
| Cornerstone Planning Group LLC | 0 | 161 | +161 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 142 | +142 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 31 | 72 | +41 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 30 | 60 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Financial Advisors, LLC | 207 | 226 | +19 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 60,983 | 60,983 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,616 | 5,616 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JUPITER ASSET MANAGEMENT LTD | 426,944 | 426,944 | 0 | 0.03 | 0.05 | +0.01 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.95 | 0.99 | +0.03 | hold |
| JANUS HENDERSON GROUP PLC | 18,200 | 18,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Janney Montgomery Scott LLC | 10,267 | 10,267 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,082 | 17,082 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Asset Dedication, LLC | 47 | 47 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 286 | 286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 31,893 | 31,893 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 235,900 | 235,900 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Allworth Financial LP | 34 | 34 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 90,200 | 90,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 216 | 216 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 13,437,473 | 13,437,473 | 0 | 3.50 | 5.77 | +2.28 | hold |
| Compagnie Lombard Odier SCmA | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rubric Capital Management LP | 3,917,331 | 3,917,331 | 0 | 0.88 | 0.80 | -0.07 | hold |
| Parallel Advisors, LLC | 329 | 329 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TPG Financial Advisors, LLC | 11,017 | 11,017 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Steward Partners Investment Advisory, LLC | 53 | 53 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Castleview Partners, LLC | 15,219 | 15,219 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Samsara BioCapital, LLC | 1,000,000 | 1,000,000 | 0 | 1.78 | 2.41 | +0.63 | hold |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.16 | 0.23 | +0.06 | hold |
| Stonehage Fleming Financial Services Holdings Ltd | 550 | 550 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 280 | 280 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Eagle Bay Advisors LLC | 110 | 110 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allspring Global Investments Holdings, LLC | 696 | 696 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CoreCap Advisors, LLC | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JOURNEY STRATEGIC WEALTH LLC | 28,897 | 28,897 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Farther Finance Advisors, LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 24,671 | 24,671 | 0 | 0.01 | 0.02 | +0.01 | hold |
| TD Waterhouse Canada Inc. | 311 | 311 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Northwest & Ethical Investments L.P. | 6,371 | 6,371 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JAMES INVESTMENT RESEARCH, INC. | 10,578 | 10,578 | 0 | 0.01 | 0.02 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 137,326 | 137,326 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fisher Asset Management, LLC | 63,600 | 63,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,799 | 1,799 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,340 | 15,340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 579 | 569 | -10 | 0.00 | 0.00 | +0.00 | sell |