| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 13,437,473 | 13,437,473 | 0 | 3.50 | 5.77 | +2.28 | hold |
| MORGAN STANLEY | 4,239,447 | 5,106,869 | +867,422 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 5,211,037 | 5,101,911 | -109,126 | 2.68 | 3.77 | +1.09 | sell |
| BVF INC/IL | 5,870,000 | 4,607,935 | -1,262,065 | 1.40 | 1.69 | +0.29 | sell |
| Rubric Capital Management LP | 3,917,331 | 3,917,331 | 0 | 0.88 | 0.80 | -0.07 | hold |
| VANGUARD GROUP INC | 2,697,372 | 2,858,514 | +161,142 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,667,711 | 2,180,020 | +512,309 | 0.34 | 0.59 | +0.24 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,930,887 | 1,945,491 | +14,604 | 0.04 | 0.06 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 2,358,189 | 1,528,923 | -829,266 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,902,401 | 1,524,084 | -378,317 | 0.00 | 0.00 | +0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 1,601,000 | 1,361,000 | -240,000 | 0.08 | 0.09 | +0.01 | sell |
| STATE STREET CORP | 1,104,376 | 1,171,777 | +67,401 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.95 | 0.99 | +0.03 | hold |
| Samsara BioCapital, LLC | 1,000,000 | 1,000,000 | 0 | 1.78 | 2.41 | +0.63 | hold |
| Prosight Management, LP | 1,180,000 | 917,599 | -262,401 | 3.00 | 2.92 | -0.08 | sell |
| DIMENSIONAL FUND ADVISORS LP | 715,632 | 849,502 | +133,870 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 725,543 | 742,561 | +17,018 | 0.14 | 0.20 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 712,950 | 713,915 | +965 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 440,000 | 615,000 | +175,000 | 0.28 | 0.61 | +0.33 | buy |
| Granahan Investment Management, LLC | 737,501 | 613,503 | -123,998 | 0.25 | 0.30 | +0.05 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 651,728 | 522,640 | -129,088 | 0.02 | 0.03 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 614,195 | 445,776 | -168,419 | 0.02 | 0.02 | +0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 426,944 | 426,944 | 0 | 0.03 | 0.05 | +0.01 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 407,771 | +407,771 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 364,414 | 370,927 | +6,513 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 318,643 | 335,661 | +17,018 | 0.05 | 0.07 | +0.02 | buy |
| Assenagon Asset Management S.A. | 0 | 331,144 | +331,144 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 373,002 | 327,522 | -45,480 | 0.13 | 0.19 | +0.06 | sell |
| Monaco Asset Management SAM | 336,344 | 300,000 | -36,344 | 1.43 | 1.58 | +0.14 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 398,144 | 285,115 | -113,029 | 0.02 | 0.02 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 173,601 | 251,477 | +77,876 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 309,703 | 249,991 | -59,712 | 0.00 | 0.00 | +0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 244,758 | 244,656 | -102 | 0.09 | 0.12 | +0.03 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 334,781 | 243,189 | -91,592 | 0.00 | 0.00 | +0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 235,900 | 235,900 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MARSHALL WACE, LLP | 0 | 209,765 | +209,765 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 236,781 | 184,600 | -52,181 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 179,381 | 178,259 | -1,122 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 170,073 | 177,410 | +7,337 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 67,738 | 163,039 | +95,301 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 26,789 | 154,384 | +127,595 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 133,245 | 144,848 | +11,603 | 0.01 | 0.02 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 145,522 | 143,580 | -1,942 | 0.03 | 0.04 | +0.01 | sell |
| AMERIPRISE FINANCIAL INC | 137,326 | 137,326 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS Group AG | 125,674 | 135,555 | +9,881 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,148 | 132,798 | +650 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 174,389 | 119,956 | -54,433 | 0.06 | 0.07 | +0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 100,866 | +100,866 | 0.00 | 0.01 | +0.01 | buy |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.16 | 0.23 | +0.06 | hold |
| Swiss National Bank | 90,200 | 90,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 86,912 | 87,956 | +1,044 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 99,836 | 85,158 | -14,678 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 63,121 | 80,326 | +17,205 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 54,711 | 79,890 | +25,179 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 81,789 | 79,856 | -1,933 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 72,114 | 73,654 | +1,540 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 46,033 | 70,169 | +24,136 | 0.01 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 92,016 | 69,730 | -22,286 | 0.00 | 0.00 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 62,684 | 65,678 | +2,994 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 63,600 | 63,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROYAL BANK OF CANADA | 65,628 | 61,878 | -3,750 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 60,983 | 60,983 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 58,300 | 54,390 | -3,910 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 50,501 | 49,771 | -730 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 197,760 | 49,583 | -148,177 | 0.01 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 49,546 | +49,546 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 48,808 | +48,808 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,923 | 44,166 | -1,757 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 35,540 | 39,571 | +4,031 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 50,600 | 39,389 | -11,211 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 39,473 | 39,280 | -193 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 73,324 | 33,438 | -39,886 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 31,893 | 31,893 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,659 | 30,665 | +3,006 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 30,063 | 29,878 | -185 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 29,841 | +29,841 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 11,854 | 29,512 | +17,658 | 0.00 | 0.00 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 28,897 | 28,897 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BANK OF MONTREAL /CAN/ | 35,062 | 28,585 | -6,477 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 28,166 | 26,666 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| Blackstone Inc. | 0 | 25,082 | +25,082 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 94,272 | 24,862 | -69,410 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 24,671 | 24,671 | 0 | 0.01 | 0.02 | +0.01 | hold |
| One Wealth Advisors, LLC | 24,926 | 24,345 | -581 | 0.05 | 0.05 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,695 | 22,047 | -648 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 43,756 | 21,782 | -21,974 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 21,160 | +21,160 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 599,382 | 20,808 | -578,574 | 0.01 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 10,593 | 20,543 | +9,950 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,838 | 19,342 | -496 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,069 | 18,348 | +1,279 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 18,200 | 18,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,082 | 17,082 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,465 | +16,465 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,379 | 16,386 | -43,993 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,340 | 15,340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Castleview Partners, LLC | 15,219 | 15,219 | 0 | 0.07 | 0.07 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 8,306 | 13,665 | +5,359 | 0.01 | 0.02 | +0.01 | buy |