| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,667,711 | 2,180,020 | +512,309 | 0.34 | 0.58 | +0.24 | buy |
| Vestal Point Capital, LP | 440,000 | 615,000 | +175,000 | 0.28 | 0.61 | +0.33 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 46,033 | 70,169 | +24,136 | 0.01 | 0.03 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 725,543 | 742,561 | +17,018 | 0.15 | 0.20 | 0.00 | buy |
| Empowered Funds, LLC | 318,643 | 335,661 | +17,018 | 0.05 | 0.07 | +0.02 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,930,887 | 1,945,491 | +14,604 | 0.04 | 0.06 | +0.02 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 133,245 | 144,848 | +11,603 | 0.01 | 0.02 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 8,306 | 13,665 | +5,359 | 0.01 | 0.02 | +0.01 | buy |
| SHELL ASSET MANAGEMENT CO | 13,070 | 12,357 | +713 | 0.01 | 0.01 | 0.00 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 10,302 | 10,679 | +377 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,937 | 10,114 | +177 | 0.04 | 0.06 | +0.02 | buy |
| Frazier Financial Advisors, LLC | 207 | 226 | +19 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 244,758 | 244,656 | -102 | 0.08 | 0.10 | +0.02 | sell |
| One Wealth Advisors, LLC | 24,926 | 24,345 | -581 | 0.05 | 0.05 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 81,789 | 79,856 | -1,933 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 145,522 | 143,580 | -1,942 | 0.03 | 0.04 | +0.01 | sell |
| Virtus Investment Advisers, LLC | 17,000 | 9,819 | -7,181 | 0.12 | 0.10 | -0.03 | sell |
| Monaco Asset Management SAM | 336,344 | 300,000 | -36,344 | 1.43 | 1.58 | +0.14 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 373,002 | 327,522 | -45,480 | 0.13 | 0.19 | +0.06 | sell |
| J. Goldman & Co LP | 174,389 | 119,956 | -54,433 | 0.04 | 0.04 | +0.00 | sell |
| Redmile Group, LLC | 5,211,037 | 5,101,911 | -109,126 | 2.68 | 3.77 | +1.09 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 398,144 | 285,115 | -113,029 | 0.02 | 0.02 | +0.00 | sell |
| Granahan Investment Management, LLC | 737,501 | 613,503 | -123,998 | 0.25 | 0.30 | +0.05 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 651,728 | 522,640 | -129,088 | 0.02 | 0.03 | +0.00 | sell |
| Prosight Management, LP | 1,180,000 | 917,599 | -262,401 | 3.00 | 2.83 | -0.17 | sell |
| BVF INC/IL | 5,870,000 | 4,607,935 | -1,262,065 | 1.40 | 1.69 | +0.29 | sell |